AR017435A1 - Composicion que comprende mezclas de isomeros posicionalesde conjugados de polimero de alfa-interferon, un metodo para la preparacion de dicha composicion, el uso de dicha composicion para la preparacion de una composicion para la preparacion de un medicamento. - Google Patents

Composicion que comprende mezclas de isomeros posicionalesde conjugados de polimero de alfa-interferon, un metodo para la preparacion de dicha composicion, el uso de dicha composicion para la preparacion de una composicion para la preparacion de un medicamento.

Info

Publication number
AR017435A1
AR017435A1 ARP980106448A ARP980106448A AR017435A1 AR 017435 A1 AR017435 A1 AR 017435A1 AR P980106448 A ARP980106448 A AR P980106448A AR P980106448 A ARP980106448 A AR P980106448A AR 017435 A1 AR017435 A1 AR 017435A1
Authority
AR
Argentina
Prior art keywords
composition
preparation
alfa
interferon
medicinal product
Prior art date
Application number
ARP980106448A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25540857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR017435(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR017435A1 publication Critical patent/AR017435A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describen composiciones que contienen alfa interferon conjugado con un polímero sustancialmente no antigénico, donde uno de dichos conjugados incluyenadhesion covalente de alfa interferon al polímero sustancialmente no antigénico a una histidina.Asimimo se describe un procedimiento para preparar losconjugados. El procedimiento incluye poner en contacto un alfa interferon con un polímero sustancialmente no antigénico activado con carbonato de succinimidiloa un pH que es suficiente parafacil itar la adhesion covalente del polímero en una histidina del alfa interferon. También se describe el uso de dichacomposicion para la preparacion de un medicamento util para tratar una condicion susceptible a interferon en mamíferos.
ARP980106448A 1997-12-19 1998-12-17 Composicion que comprende mezclas de isomeros posicionalesde conjugados de polimero de alfa-interferon, un metodo para la preparacion de dicha composicion, el uso de dicha composicion para la preparacion de una composicion para la preparacion de un medicamento. AR017435A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/994,622 US5951974A (en) 1993-11-10 1997-12-19 Interferon polymer conjugates

Publications (1)

Publication Number Publication Date
AR017435A1 true AR017435A1 (es) 2001-09-05

Family

ID=25540857

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980106448A AR017435A1 (es) 1997-12-19 1998-12-17 Composicion que comprende mezclas de isomeros posicionalesde conjugados de polimero de alfa-interferon, un metodo para la preparacion de dicha composicion, el uso de dicha composicion para la preparacion de una composicion para la preparacion de un medicamento.

Country Status (23)

Country Link
US (2) US5951974A (es)
EP (1) EP1039922B1 (es)
JP (2) JP3747070B2 (es)
KR (1) KR100607388B1 (es)
AR (1) AR017435A1 (es)
AT (1) ATE218883T1 (es)
AU (1) AU739359B2 (es)
CA (1) CA2268433C (es)
CO (1) CO4870741A1 (es)
DE (1) DE69806055T2 (es)
DK (1) DK1039922T3 (es)
ES (1) ES2178297T3 (es)
HU (1) HU224696B1 (es)
IL (2) IL136290A0 (es)
MY (1) MY119581A (es)
NZ (1) NZ504735A (es)
PE (1) PE20000003A1 (es)
PT (1) PT1039922E (es)
SG (1) SG71179A1 (es)
SI (1) SI1039922T1 (es)
TW (1) TW570802B (es)
WO (1) WO1999032139A1 (es)
ZA (1) ZA9811590B (es)

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CO4870741A1 (es) 1999-12-27
KR20010024755A (ko) 2001-03-26
AU1916799A (en) 1999-07-12
KR100607388B1 (ko) 2006-08-02
CA2268433A1 (en) 1999-06-19
IL136290A0 (en) 2001-05-20
SI1039922T1 (en) 2002-10-31
IL136290A (en) 2008-03-20
US5951974A (en) 1999-09-14
MY119581A (en) 2005-06-30
DK1039922T3 (da) 2002-10-14
PE20000003A1 (es) 2000-01-17
AU739359B2 (en) 2001-10-11
ATE218883T1 (de) 2002-06-15
EP1039922A1 (en) 2000-10-04
CA2268433C (en) 2002-07-30
WO1999032139A1 (en) 1999-07-01
HUP0101532A2 (hu) 2001-08-28
DE69806055D1 (de) 2002-07-18
HU224696B1 (en) 2006-01-30
EP1039922A4 (en) 2000-10-04
PT1039922E (pt) 2002-10-31
DE69806055T2 (de) 2003-01-23
US6042822A (en) 2000-03-28
TW570802B (en) 2004-01-11
ZA9811590B (en) 1999-06-18
ES2178297T3 (es) 2002-12-16
NZ504735A (en) 2002-10-25
JP2000508356A (ja) 2000-07-04
JP3747070B2 (ja) 2006-02-22
JP2005015464A (ja) 2005-01-20
EP1039922B1 (en) 2002-06-12
HUP0101532A3 (en) 2004-08-30
SG71179A1 (en) 2000-03-21

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