AP344A - Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor - Google Patents

Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor Download PDF

Info

Publication number
AP344A
AP344A APAP/P/1992/000403A AP9200403A AP344A AP 344 A AP344 A AP 344A AP 9200403 A AP9200403 A AP 9200403A AP 344 A AP344 A AP 344A
Authority
AP
ARIPO
Prior art keywords
formula
tetrahydrocarbazole
compound
amino
carboxamido
Prior art date
Application number
APAP/P/1992/000403A
Other languages
English (en)
Other versions
AP9200403A0 (en
Inventor
Francis David King
Laramie Mary Gaster
Alberto Julio Kaumann
Rodney Christopher Young
Original Assignee
Vernalis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP344(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vernalis Ltd filed Critical Vernalis Ltd
Publication of AP9200403A0 publication Critical patent/AP9200403A0/xx
Application granted granted Critical
Publication of AP344A publication Critical patent/AP344A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
APAP/P/1992/000403A 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor AP344A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists

Publications (2)

Publication Number Publication Date
AP9200403A0 AP9200403A0 (en) 1992-07-31
AP344A true AP344A (en) 1994-07-05

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000403A AP344A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor

Country Status (34)

Country Link
US (2) US5464864A (no)
EP (1) EP0591280B1 (no)
JP (1) JP3261502B2 (no)
KR (1) KR100251571B1 (no)
CN (1) CN1034072C (no)
AP (1) AP344A (no)
AT (1) ATE170746T1 (no)
BR (2) BR9206237A (no)
CA (1) CA2113726C (no)
CZ (3) CZ282327B6 (no)
DE (2) DE69226953T2 (no)
DK (1) DK0591280T3 (no)
FI (1) FI103967B (no)
GB (1) GB9113802D0 (no)
HU (1) HU218907B (no)
IE (1) IE922062A1 (no)
IL (4) IL117105A0 (no)
LU (1) LU90939I2 (no)
MA (1) MA22563A1 (no)
MX (1) MX9203444A (no)
NL (1) NL300103I2 (no)
NO (2) NO304774B1 (no)
NZ (1) NZ243288A (no)
PL (3) PL169392B1 (no)
PT (1) PT100620B (no)
RU (1) RU2137474C1 (no)
SA (1) SA92130141B1 (no)
SG (1) SG47877A1 (no)
SI (1) SI9200125B (no)
SK (3) SK280907B6 (no)
TW (1) TW214544B (no)
UA (1) UA41254C2 (no)
WO (1) WO1993000086A1 (no)
ZA (1) ZA924658B (no)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
DE69610793T2 (de) * 1995-06-23 2001-05-03 Eli Lilly And Co., Indianapolis 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
WO2003029214A1 (en) * 2001-09-28 2003-04-10 F. Hoffmann-La Roche Ag Pseudopolymorphic forms of carvedilol
AU2003249584B9 (en) 2002-06-21 2008-05-15 Suven Life Sciences Limited Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
CA2490254C (en) 2002-06-21 2011-11-01 Suven Life Sciences Limited Novel tetracyclic arylsulfonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
DK1581492T3 (da) 2002-11-28 2008-11-10 Suven Life Sciences Ltd N-arylsulfonyl-3-substituerede indoler med serotoninreceptoraffinitet, fremgangsmåde til fremstilling heraf og en farmaceutisk sammensætning indeholdende disse
PT1567492E (pt) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
NZ540841A (en) 2002-12-18 2008-08-29 Suven Life Sciences Ltd Tetracyclic 3-substituted indoles having serotonin receptor affinity
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
NZ574705A (en) * 2006-08-07 2011-12-22 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
EP2813144A1 (en) 2006-10-09 2014-12-17 Charleston Laboratories, Inc. Analgesic compositions comprising an antihistamine
PT2425820E (pt) 2007-02-11 2015-08-04 Map Pharmaceuticals Inc Método de administração terapêutica de dhe para permitir o rápido alívio das enxaquecas ao mesmo tempo que minimiza o perfil de efeitos secundários
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
JP5714910B2 (ja) 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
US9204906B2 (en) 2009-10-22 2015-12-08 Nuvasive, Inc. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
WO2013016223A2 (en) 2011-07-22 2013-01-31 The University Of Chicago Treatments for migraine and related disorders
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
WO2025038666A2 (en) * 2023-08-13 2025-02-20 GATC Health Corp Compounds and methods for treating addiction
CN119499195A (zh) * 2024-11-26 2025-02-25 青岛国信制药有限公司 一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
EP0004342A1 (en) * 1978-03-17 1979-10-03 E.I. Du Pont De Nemours And Company Carbazoles, process for their preparation, pharmaceutical compositions containing them, and intermediates thereto

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
EP0004342A1 (en) * 1978-03-17 1979-10-03 E.I. Du Pont De Nemours And Company Carbazoles, process for their preparation, pharmaceutical compositions containing them, and intermediates thereto

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF NEUROCHEMISTRY VOL. 28 pp 995-1000 (1977) *
JOURNAL OF NEUROCHEMISTRY VOL. 35 pp 931-936 (1980) *

Also Published As

Publication number Publication date
CZ150696A3 (en) 1997-06-11
AU1977592A (en) 1993-01-25
MA22563A1 (fr) 1992-12-31
WO1993000086A1 (en) 1993-01-07
UA41254C2 (uk) 2001-09-17
IL117104A0 (en) 1996-06-18
GB9113802D0 (en) 1991-08-14
ATE170746T1 (de) 1998-09-15
SG47877A1 (en) 1998-04-17
IL117105A0 (en) 1996-06-18
IL117105A (en) 1998-01-04
NL300103I1 (nl) 2002-12-02
SK131993A3 (en) 1994-06-08
SI9200125B (en) 2001-12-31
IL117104A (en) 1997-09-30
US5637611A (en) 1997-06-10
KR100251571B1 (ko) 2000-07-01
US5464864A (en) 1995-11-07
DE69226953T2 (de) 1999-05-12
CN1069726A (zh) 1993-03-10
ZA924658B (en) 1993-12-24
SK280907B6 (sk) 2000-09-12
EP0591280B1 (en) 1998-09-09
TW214544B (no) 1993-10-11
CN1034072C (zh) 1997-02-19
CA2113726C (en) 2008-02-19
BR9206237A (pt) 1995-04-11
CZ282083B6 (cs) 1997-05-14
FI935842A0 (fi) 1993-12-23
MX9203444A (es) 1993-12-01
AU652842B2 (en) 1994-09-08
NO2005011I1 (no) 2005-05-18
PT100620B (pt) 1999-01-29
AP9200403A0 (en) 1992-07-31
PL169392B1 (pl) 1996-07-31
CZ282327B6 (cs) 1997-06-11
NO304774B1 (no) 1999-02-15
RU2137474C1 (ru) 1999-09-20
SK280906B6 (sk) 2000-09-12
SI9200125A (en) 1992-12-31
SA92130141B1 (ar) 2005-12-18
FI935842A7 (fi) 1993-12-23
IL102322A (en) 1997-09-30
EP0591280A1 (en) 1994-04-13
HK1014669A1 (en) 1999-09-30
DE10299042I2 (de) 2005-02-03
DE10299042I1 (de) 2003-02-20
JPH06508827A (ja) 1994-10-06
SK280905B6 (sk) 2000-09-12
FI103967B1 (fi) 1999-10-29
PT100620A (pt) 1993-09-30
LU90939I2 (fr) 2002-09-24
NZ243288A (en) 1994-09-27
CZ282061B6 (cs) 1997-05-14
CZ150596A3 (en) 1997-05-14
PL169410B1 (pl) 1996-07-31
PL171034B1 (en) 1997-02-28
HU218907B (hu) 2000-12-28
CZ286193A3 (en) 1994-07-13
DK0591280T3 (da) 1999-02-15
NO934800D0 (no) 1993-12-23
IE922062A1 (en) 1992-12-30
NO2005011I2 (no) 2008-02-11
IL102322A0 (en) 1993-01-14
NO934800L (no) 1993-12-23
HUT68961A (en) 1995-08-28
CA2113726A1 (en) 1993-01-07
BR1100460A (pt) 2000-07-18
NL300103I2 (nl) 2003-02-03
DE69226953D1 (de) 1998-10-15
FI103967B (fi) 1999-10-29
JP3261502B2 (ja) 2002-03-04

Similar Documents

Publication Publication Date Title
AP344A (en) Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor
AU688748B2 (en) Enantiomers of carbazole derivatives as 5-HT1-like agonists
US5827871A (en) Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
WO1998031669A1 (fr) Nouvelles arylpiperazines derivees de piperidine comme medicaments antidepresseurs
US5612331A (en) Tetrahydrocarbazole derivatives as 5-HT1-like agonists
EP0603432B1 (en) Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated
AU652842C (en) Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
HK1014669B (en) Use of tetrahydrocarbazole derivatives as 5ht1-receptor agonists
CA2756876A1 (en) A process for the preparation of frovatriptan and frovatriptan succinate and their synthetic intermediates
AU707990B2 (en) Enantiomers of carbazole derivatives as 5-HT1-like agonists