AP313A - New isosteric peptides. - Google Patents

New isosteric peptides. Download PDF

Info

Publication number
AP313A
AP313A APAP/P/1992/000418A AP9200418A AP313A AP 313 A AP313 A AP 313A AP 9200418 A AP9200418 A AP 9200418A AP 313 A AP313 A AP 313A
Authority
AP
ARIPO
Prior art keywords
arg
dcha
pro
hooc
phenyl
Prior art date
Application number
APAP/P/1992/000418A
Other languages
English (en)
Other versions
AP9200418A0 (en
Inventor
Butrus Atrash
David Michael Jones
Micheal Szelke
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Astra filed Critical Ab Astra
Publication of AP9200418A0 publication Critical patent/AP9200418A0/xx
Application granted granted Critical
Publication of AP313A publication Critical patent/AP313A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
APAP/P/1992/000418A 1991-08-28 1992-08-17 New isosteric peptides. AP313A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9102462A SE9102462D0 (sv) 1991-08-28 1991-08-28 New isosteric peptides

Publications (2)

Publication Number Publication Date
AP9200418A0 AP9200418A0 (en) 1992-10-31
AP313A true AP313A (en) 1994-02-10

Family

ID=20383557

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000418A AP313A (en) 1991-08-28 1992-08-17 New isosteric peptides.

Country Status (27)

Country Link
US (1) US5424291A (hu)
EP (2) EP0530167A1 (hu)
JP (1) JP3353297B2 (hu)
CN (1) CN1069736A (hu)
AP (1) AP313A (hu)
AT (1) ATE212643T1 (hu)
AU (1) AU2499092A (hu)
BG (1) BG98583A (hu)
CA (1) CA2116527A1 (hu)
CZ (1) CZ38094A3 (hu)
DE (1) DE69232394T2 (hu)
DZ (1) DZ1613A1 (hu)
FI (1) FI940945A (hu)
HU (1) HUT66060A (hu)
IL (1) IL102840A0 (hu)
IS (1) IS3906A (hu)
MA (1) MA22632A1 (hu)
MX (1) MX9204767A (hu)
NO (1) NO940669L (hu)
NZ (1) NZ243675A (hu)
SE (1) SE9102462D0 (hu)
SI (1) SI9200193A (hu)
SK (1) SK23394A3 (hu)
TN (1) TNSN92076A1 (hu)
TW (1) TW221816B (hu)
WO (1) WO1993005069A1 (hu)
ZA (1) ZA925737B (hu)

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ZA928581B (en) * 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
JPH06329627A (ja) * 1993-05-03 1994-11-29 Bristol Myers Squibb Co グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
SK104697A3 (en) * 1995-02-17 1998-11-04 Basf Ag Novel dipeptide amidines as thrombin inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
HUP0100082A3 (en) 1998-01-26 2001-12-28 Abbott Gmbh & Co Kg Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use
JP2003529528A (ja) 1998-04-24 2003-10-07 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
TR200102037T2 (tr) 1999-01-13 2001-10-22 Astrazeneca Ab Yeni amidinobenzilamin türevleri ve trombin engelleyiciler olarak kullanılmaları.
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AU1226001A (en) * 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
AU2015328385B2 (en) 2014-10-06 2020-06-11 Lighthouse Pharmaceuticals, Inc. Inhibitors of lysine gingipain
JP6877424B2 (ja) 2015-11-09 2021-05-26 コーテクシーミー， インコーポレイテッド アルギニンジンジパインの阻害剤
US10590084B2 (en) 2016-03-09 2020-03-17 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
EP3481835A4 (en) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. CALPAIN MODULATORS AND THEIR THERAPEUTIC USES
KR20190072530A (ko) 2016-09-16 2019-06-25 코텍자임, 인코포레이티드 리신 진지파인의 케톤 억제제
PE20191153A1 (es) 2016-09-28 2019-09-05 Blade Therapeutics Inc Moduladores de calpainas y usos terapeuticos de los mismos
SG11202008750XA (en) * 2018-03-28 2020-10-29 Blade Therapeutics Inc Calpain modulators and therapeutic uses thereof
US20220204457A1 (en) * 2019-03-21 2022-06-30 Cortexyme, Inc. Arginine gingipain inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
EP0192135A2 (de) * 1985-02-18 1986-08-27 BEHRINGWERKE Aktiengesellschaft Neue Oligopeptidylargininolderivate und deren Homologe, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
EP0192135A2 (de) * 1985-02-18 1986-08-27 BEHRINGWERKE Aktiengesellschaft Neue Oligopeptidylargininolderivate und deren Homologe, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel

Also Published As

Publication number Publication date
EP0605462B1 (en) 2002-01-30
HUT66060A (en) 1994-09-28
MX9204767A (es) 1993-05-01
ATE212643T1 (de) 2002-02-15
JP3353297B2 (ja) 2002-12-03
HU9400589D0 (en) 1994-05-30
DZ1613A1 (fr) 2002-02-17
AP9200418A0 (en) 1992-10-31
ZA925737B (en) 1993-03-01
DE69232394D1 (de) 2002-03-14
CN1069736A (zh) 1993-03-10
IL102840A0 (en) 1993-01-31
NO940669L (no) 1994-04-19
JPH06510059A (ja) 1994-11-10
EP0530167A1 (en) 1993-03-03
BG98583A (bg) 1994-09-30
FI940945A0 (fi) 1994-02-28
SE9102462D0 (sv) 1991-08-28
WO1993005069A1 (en) 1993-03-18
AU2499092A (en) 1993-04-05
FI940945A (fi) 1994-02-28
MA22632A1 (fr) 1993-04-01
NO940669D0 (no) 1994-02-25
US5424291A (en) 1995-06-13
SI9200193A (en) 1993-06-30
EP0605462A1 (en) 1994-07-13
CA2116527A1 (en) 1993-03-18
NZ243675A (en) 1994-06-27
DE69232394T2 (de) 2002-08-22
TNSN92076A1 (fr) 1993-06-08
CZ38094A3 (en) 1994-08-17
SK23394A3 (en) 1994-08-10
IS3906A (is) 1993-03-01
TW221816B (hu) 1994-03-21

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