NO940669L - Nye isosteriske peptider - Google Patents
Nye isosteriske peptiderInfo
- Publication number
- NO940669L NO940669L NO940669A NO940669A NO940669L NO 940669 L NO940669 L NO 940669L NO 940669 A NO940669 A NO 940669A NO 940669 A NO940669 A NO 940669A NO 940669 L NO940669 L NO 940669L
- Authority
- NO
- Norway
- Prior art keywords
- novel
- isosteric peptides
- peptides
- novel isosteric
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Nye konkurrerende inhibltorer til thrombin, synteser derev, farmasøytiske sammensetninger Inneholdende forbindelser som er aktive ingredienser og anvendelse av forbindelsene som antikoaguleringsmidler for profylakse og behandling av thromboemboliske sykdommer ifølge formel (1) hvor A er -CH2-, CH=CH, -CH2-CH2 eller -CH2-CH2-CH2; Y er O eller S(0)p, hvor p er 0.1 eller 2, R1, R2, R3, E3A, R4 og m er som definert i kravene, enten som disse eller l form av et fysiologisk akseptabelt salt og innbefattende stereolsomerer, er beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9102462A SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | New isosteric peptides |
PCT/SE1992/000584 WO1993005069A1 (en) | 1991-08-28 | 1992-08-25 | New isosteric peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
NO940669D0 NO940669D0 (no) | 1994-02-25 |
NO940669L true NO940669L (no) | 1994-04-19 |
Family
ID=20383557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO940669A NO940669L (no) | 1991-08-28 | 1994-02-25 | Nye isosteriske peptider |
Country Status (27)
Country | Link |
---|---|
US (1) | US5424291A (no) |
EP (2) | EP0605462B1 (no) |
JP (1) | JP3353297B2 (no) |
CN (1) | CN1069736A (no) |
AP (1) | AP313A (no) |
AT (1) | ATE212643T1 (no) |
AU (1) | AU2499092A (no) |
BG (1) | BG98583A (no) |
CA (1) | CA2116527A1 (no) |
CZ (1) | CZ38094A3 (no) |
DE (1) | DE69232394T2 (no) |
DZ (1) | DZ1613A1 (no) |
FI (1) | FI940945A0 (no) |
HU (1) | HUT66060A (no) |
IL (1) | IL102840A0 (no) |
IS (1) | IS3906A (no) |
MA (1) | MA22632A1 (no) |
MX (1) | MX9204767A (no) |
NO (1) | NO940669L (no) |
NZ (1) | NZ243675A (no) |
SE (1) | SE9102462D0 (no) |
SI (1) | SI9200193A (no) |
SK (1) | SK23394A3 (no) |
TN (1) | TNSN92076A1 (no) |
TW (1) | TW221816B (no) |
WO (1) | WO1993005069A1 (no) |
ZA (1) | ZA925737B (no) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA928581B (en) * | 1991-11-12 | 1994-05-06 | Lilly Co Eli | Antithrombotic agents |
SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
JPH06329627A (ja) * | 1993-05-03 | 1994-11-29 | Bristol Myers Squibb Co | グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター |
SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5783563A (en) * | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5484772A (en) * | 1994-03-04 | 1996-01-16 | Eli Lilly And Company | Antithrombotic agents |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
CA2143533A1 (en) * | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Antithrombotic agents |
US5439888A (en) * | 1994-03-04 | 1995-08-08 | Eli Lilly And Company | Antithrombotic agents |
US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
US5488037A (en) * | 1994-03-04 | 1996-01-30 | Eli Lilly And Company | Antithrombotic agents |
US5436229A (en) * | 1994-03-04 | 1995-07-25 | Eli Lilly And Company | Bisulfite adducts of arginine aldehydes |
DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
WO1996025426A1 (de) * | 1995-02-17 | 1996-08-22 | Basf Aktiengesellschaft | Neue dipeptidische amidine als thrombin-inhibitoren |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
AR005245A1 (es) * | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
CN1289341A (zh) | 1998-01-26 | 2001-03-28 | Basf公司 | 凝血酶抑制剂 |
US6417161B1 (en) | 1998-04-24 | 2002-07-09 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
SE9802973D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
CA2355792A1 (en) | 1999-01-13 | 2000-07-20 | Astrazeneca Ab | New amidinobenzylamine derivatives and their use as thrombin inhibitors |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
US6353032B1 (en) * | 1999-11-09 | 2002-03-05 | Alcon Universal Ltd. | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
US7781424B2 (en) | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
WO2016057413A2 (en) | 2014-10-06 | 2016-04-14 | Cortexyme, Inc. | Inhibitors of lysine gingipain |
WO2017083433A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
EP3426674A4 (en) | 2016-03-09 | 2019-08-14 | Blade Therapeutics, Inc. | CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
MX2019003087A (es) | 2016-09-16 | 2019-08-12 | Cortexyme Inc | Inhibidores cetónicos de gingipain de lisina. |
CA3038331A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
AU2019242387A1 (en) * | 2018-03-28 | 2020-11-19 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4318904A (en) * | 1980-04-25 | 1982-03-09 | Research Corporation | Peptide affinity labels for thrombin and other trypsin-like proteases |
GB8305985D0 (en) * | 1983-03-04 | 1983-04-07 | Szelke M | Enzyme inhibition |
DE3505555A1 (de) * | 1985-02-18 | 1986-09-11 | Behringwerke Ag, 3550 Marburg | Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
-
1991
- 1991-08-28 SE SE9102462A patent/SE9102462D0/xx unknown
-
1992
- 1992-07-22 NZ NZ243675A patent/NZ243675A/xx unknown
- 1992-07-30 ZA ZA925737A patent/ZA925737B/xx unknown
- 1992-08-17 AP APAP/P/1992/000418A patent/AP313A/en active
- 1992-08-17 IL IL102840A patent/IL102840A0/xx unknown
- 1992-08-18 MX MX9204767A patent/MX9204767A/es unknown
- 1992-08-18 DZ DZ920109A patent/DZ1613A1/fr active
- 1992-08-19 TW TW081106578A patent/TW221816B/zh active
- 1992-08-25 AT AT92918722T patent/ATE212643T1/de not_active IP Right Cessation
- 1992-08-25 EP EP92918722A patent/EP0605462B1/en not_active Expired - Lifetime
- 1992-08-25 WO PCT/SE1992/000584 patent/WO1993005069A1/en active IP Right Grant
- 1992-08-25 JP JP50513493A patent/JP3353297B2/ja not_active Expired - Fee Related
- 1992-08-25 SK SK233-94A patent/SK23394A3/sk unknown
- 1992-08-25 DE DE69232394T patent/DE69232394T2/de not_active Expired - Lifetime
- 1992-08-25 HU HU9400589A patent/HUT66060A/hu unknown
- 1992-08-25 CA CA002116527A patent/CA2116527A1/en not_active Abandoned
- 1992-08-25 AU AU24990/92A patent/AU2499092A/en not_active Abandoned
- 1992-08-25 EP EP92850201A patent/EP0530167A1/en active Pending
- 1992-08-25 CZ CS94380A patent/CZ38094A3/cs unknown
- 1992-08-26 MA MA22922A patent/MA22632A1/fr unknown
- 1992-08-27 SI SI19929200193A patent/SI9200193A/sl unknown
- 1992-08-27 TN TNTNSN92076A patent/TNSN92076A1/fr unknown
- 1992-08-27 IS IS3906A patent/IS3906A/is unknown
- 1992-08-28 CN CN92109600A patent/CN1069736A/zh active Pending
-
1994
- 1994-02-25 NO NO940669A patent/NO940669L/no unknown
- 1994-02-25 BG BG98583A patent/BG98583A/bg unknown
- 1994-02-28 FI FI940945A patent/FI940945A0/fi not_active Application Discontinuation
- 1994-08-10 US US08/288,657 patent/US5424291A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BG98583A (bg) | 1994-09-30 |
EP0605462A1 (en) | 1994-07-13 |
MX9204767A (es) | 1993-05-01 |
HU9400589D0 (en) | 1994-05-30 |
JPH06510059A (ja) | 1994-11-10 |
CN1069736A (zh) | 1993-03-10 |
AU2499092A (en) | 1993-04-05 |
SI9200193A (en) | 1993-06-30 |
MA22632A1 (fr) | 1993-04-01 |
TNSN92076A1 (fr) | 1993-06-08 |
AP313A (en) | 1994-02-10 |
TW221816B (no) | 1994-03-21 |
ATE212643T1 (de) | 2002-02-15 |
DZ1613A1 (fr) | 2002-02-17 |
FI940945A (fi) | 1994-02-28 |
AP9200418A0 (en) | 1992-10-31 |
IL102840A0 (en) | 1993-01-31 |
CA2116527A1 (en) | 1993-03-18 |
WO1993005069A1 (en) | 1993-03-18 |
EP0605462B1 (en) | 2002-01-30 |
DE69232394T2 (de) | 2002-08-22 |
FI940945A0 (fi) | 1994-02-28 |
SE9102462D0 (sv) | 1991-08-28 |
DE69232394D1 (de) | 2002-03-14 |
JP3353297B2 (ja) | 2002-12-03 |
US5424291A (en) | 1995-06-13 |
SK23394A3 (en) | 1994-08-10 |
ZA925737B (en) | 1993-03-01 |
IS3906A (is) | 1993-03-01 |
CZ38094A3 (en) | 1994-08-17 |
NO940669D0 (no) | 1994-02-25 |
EP0530167A1 (en) | 1993-03-03 |
HUT66060A (en) | 1994-09-28 |
NZ243675A (en) | 1994-06-27 |
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