ZA971525B - Tropane derivatives, their preparation and use. - Google Patents
Tropane derivatives, their preparation and use.Info
- Publication number
- ZA971525B ZA971525B ZA9701525A ZA971525A ZA971525B ZA 971525 B ZA971525 B ZA 971525B ZA 9701525 A ZA9701525 A ZA 9701525A ZA 971525 A ZA971525 A ZA 971525A ZA 971525 B ZA971525 B ZA 971525B
- Authority
- ZA
- South Africa
- Prior art keywords
- disorders
- derivatives
- preparation
- monoamine neurotransmitter
- uptake
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK19496 | 1996-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA971525B true ZA971525B (en) | 1997-10-21 |
Family
ID=8090830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9701525A ZA971525B (en) | 1996-02-22 | 1997-02-21 | Tropane derivatives, their preparation and use. |
Country Status (32)
Country | Link |
---|---|
US (3) | US6288079B1 (ru) |
EP (2) | EP1130020A1 (ru) |
JP (1) | JP3238414B2 (ru) |
KR (1) | KR100446571B1 (ru) |
CN (1) | CN1077574C (ru) |
AT (1) | ATE203023T1 (ru) |
AU (1) | AU720358B2 (ru) |
BG (1) | BG63945B1 (ru) |
BR (1) | BR9707636A (ru) |
CA (1) | CA2244773C (ru) |
CZ (1) | CZ287007B6 (ru) |
DE (1) | DE69705608T2 (ru) |
DK (1) | DK0885220T3 (ru) |
EE (1) | EE04751B1 (ru) |
ES (1) | ES2159839T3 (ru) |
GR (1) | GR3036829T3 (ru) |
HK (1) | HK1018957A1 (ru) |
HU (1) | HU228356B1 (ru) |
IL (1) | IL125146A (ru) |
IS (1) | IS1824B (ru) |
NO (1) | NO318731B1 (ru) |
NZ (1) | NZ330886A (ru) |
PL (1) | PL185132B1 (ru) |
PT (1) | PT885220E (ru) |
RU (1) | RU2167876C2 (ru) |
SG (1) | SG99853A1 (ru) |
SI (1) | SI0885220T1 (ru) |
SK (1) | SK281813B6 (ru) |
TR (1) | TR199801641T2 (ru) |
UA (1) | UA49872C2 (ru) |
WO (1) | WO1997030997A1 (ru) |
ZA (1) | ZA971525B (ru) |
Families Citing this family (77)
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CA2340218C (en) * | 1998-09-30 | 2008-10-14 | Nihon Medi-Physics Co., Ltd. | Process for producing optically active tropinonemonocarboxylic acid ester derivative |
AUPP627498A0 (en) | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
US20040106643A1 (en) * | 2001-05-23 | 2004-06-03 | Gouliaev Alex Haarh | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
DE20203103U1 (de) * | 2001-10-11 | 2002-07-11 | Organix, Inc., Woburn, Mass. | Serotonin-Wiederaufnahme-Inhibitoren |
WO2003037313A2 (en) * | 2001-10-31 | 2003-05-08 | Recovery Pharmaceuticals, Inc. | Methods for the treatment of addiction |
JP2005511639A (ja) | 2001-11-30 | 2005-04-28 | ニューロサーチ、アクティーゼルスカブ | 虚血性疾患の治療用ドパミン再取り込み阻害活性を有するトロパン誘導体 |
US7459464B2 (en) | 2002-05-30 | 2008-12-02 | Neurosearch A/S | Triple monoamine reuptake inhibitors for the treatment of chronic pain |
EP1560813B1 (en) | 2002-11-01 | 2010-03-17 | NeuroSearch A/S | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
AU2003302609B9 (en) | 2002-12-02 | 2008-05-15 | Xenome Ltd | Novel chi-conotoxin peptides (-I) |
EP2412719A1 (en) | 2002-12-02 | 2012-02-01 | Xenome Ltd | Chi-conotoxin peptides |
CN100551924C (zh) * | 2003-02-12 | 2009-10-21 | 神经研究公司 | 8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
DE602004024033D1 (de) | 2003-02-12 | 2009-12-24 | Neurosearch As | 8-azabicycloä3.2.1üoctanderivate und ihre verwendung als monoamine-neurotransmitter-reuptake inhibitoren |
CN100372850C (zh) * | 2003-02-12 | 2008-03-05 | 神经研究公司 | 新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
CA2515732A1 (en) | 2003-02-12 | 2004-08-26 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CN100368409C (zh) | 2003-06-24 | 2008-02-13 | 神经研究公司 | 8-氮杂双环[3.2.1]辛烷衍生物及其用于制备单胺神经递质再摄取抑制剂的用途 |
AR045141A1 (es) * | 2003-07-31 | 2005-10-19 | Neurosearch As | Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas. |
CA2540834C (en) | 2003-10-03 | 2010-06-22 | Pfizer Inc. | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation |
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CA2554617A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
EP1708706A1 (en) * | 2004-01-22 | 2006-10-11 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist |
DE102004004965B4 (de) * | 2004-01-31 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates |
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US5496953A (en) | 1990-08-09 | 1996-03-05 | Research Triangle Institute | Cocaine receptor binding ligands |
US5128118A (en) * | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US5380848A (en) * | 1990-08-09 | 1995-01-10 | Research Triangle Institute | Cocaine receptor binding ligands |
DK0644775T3 (da) * | 1991-11-15 | 2000-03-06 | Nat Inst Health | Kokainreceptorbindende ligander |
AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
WO1995028401A1 (en) * | 1994-04-19 | 1995-10-26 | Neurosearch A/S | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
GB9626611D0 (en) * | 1996-12-20 | 1997-02-05 | Unilever Plc | Agglomerated silicas |
-
1997
- 1997-02-21 AU AU17940/97A patent/AU720358B2/en not_active Ceased
- 1997-02-21 NZ NZ330886A patent/NZ330886A/xx not_active IP Right Cessation
- 1997-02-21 KR KR10-1998-0706518A patent/KR100446571B1/ko not_active IP Right Cessation
- 1997-02-21 UA UA98073814A patent/UA49872C2/ru unknown
- 1997-02-21 RU RU98117314/04A patent/RU2167876C2/ru active
- 1997-02-21 EP EP01108256A patent/EP1130020A1/en not_active Withdrawn
- 1997-02-21 HU HU9901199A patent/HU228356B1/hu not_active IP Right Cessation
- 1997-02-21 CZ CZ19982520A patent/CZ287007B6/cs not_active IP Right Cessation
- 1997-02-21 PT PT97903355T patent/PT885220E/pt unknown
- 1997-02-21 EP EP97903355A patent/EP0885220B1/en not_active Expired - Lifetime
- 1997-02-21 TR TR1998/01641T patent/TR199801641T2/xx unknown
- 1997-02-21 SG SG9903902A patent/SG99853A1/en unknown
- 1997-02-21 WO PCT/EP1997/000850 patent/WO1997030997A1/en active IP Right Grant
- 1997-02-21 IL IL12514697A patent/IL125146A/en not_active IP Right Cessation
- 1997-02-21 ZA ZA9701525A patent/ZA971525B/xx unknown
- 1997-02-21 PL PL97328503A patent/PL185132B1/pl not_active IP Right Cessation
- 1997-02-21 DE DE69705608T patent/DE69705608T2/de not_active Expired - Lifetime
- 1997-02-21 EE EE9800254A patent/EE04751B1/xx not_active IP Right Cessation
- 1997-02-21 CN CN97192505A patent/CN1077574C/zh not_active Expired - Fee Related
- 1997-02-21 SI SI9730163T patent/SI0885220T1/xx unknown
- 1997-02-21 ES ES97903355T patent/ES2159839T3/es not_active Expired - Lifetime
- 1997-02-21 JP JP52981097A patent/JP3238414B2/ja not_active Expired - Fee Related
- 1997-02-21 BR BR9707636A patent/BR9707636A/pt not_active IP Right Cessation
- 1997-02-21 AT AT97903355T patent/ATE203023T1/de active
- 1997-02-21 US US09/101,524 patent/US6288079B1/en not_active Expired - Lifetime
- 1997-02-21 CA CA002244773A patent/CA2244773C/en not_active Expired - Lifetime
- 1997-02-21 SK SK929-98A patent/SK281813B6/sk not_active IP Right Cessation
- 1997-02-21 DK DK97903355T patent/DK0885220T3/da active
-
1998
- 1998-07-15 BG BG102637A patent/BG63945B1/bg unknown
- 1998-08-17 IS IS4825A patent/IS1824B/is unknown
- 1998-08-21 NO NO19983877A patent/NO318731B1/no not_active IP Right Cessation
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1999
- 1999-09-17 HK HK99104015A patent/HK1018957A1/xx not_active IP Right Cessation
-
2001
- 2001-03-21 US US09/814,413 patent/US6395748B2/en not_active Expired - Fee Related
- 2001-10-08 GR GR20010401690T patent/GR3036829T3/el unknown
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2002
- 2002-03-15 US US10/099,642 patent/US20020128284A1/en not_active Abandoned
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