BG63945B1 - Тропанови производни, тяхното получаване и приложение - Google Patents
Тропанови производни, тяхното получаване и приложение Download PDFInfo
- Publication number
- BG63945B1 BG63945B1 BG102637A BG10263798A BG63945B1 BG 63945 B1 BG63945 B1 BG 63945B1 BG 102637 A BG102637 A BG 102637A BG 10263798 A BG10263798 A BG 10263798A BG 63945 B1 BG63945 B1 BG 63945B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- tropane
- dichlorophenyl
- chlorophenyl
- ethoxymethyl
- normethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK19496 | 1996-02-22 | ||
PCT/EP1997/000850 WO1997030997A1 (en) | 1996-02-22 | 1997-02-21 | Tropane-derivatives, their preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
BG102637A BG102637A (en) | 1999-06-30 |
BG63945B1 true BG63945B1 (bg) | 2003-07-31 |
Family
ID=8090830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102637A BG63945B1 (bg) | 1996-02-22 | 1998-07-15 | Тропанови производни, тяхното получаване и приложение |
Country Status (32)
Country | Link |
---|---|
US (3) | US6288079B1 (ru) |
EP (2) | EP0885220B1 (ru) |
JP (1) | JP3238414B2 (ru) |
KR (1) | KR100446571B1 (ru) |
CN (1) | CN1077574C (ru) |
AT (1) | ATE203023T1 (ru) |
AU (1) | AU720358B2 (ru) |
BG (1) | BG63945B1 (ru) |
BR (1) | BR9707636A (ru) |
CA (1) | CA2244773C (ru) |
CZ (1) | CZ287007B6 (ru) |
DE (1) | DE69705608T2 (ru) |
DK (1) | DK0885220T3 (ru) |
EE (1) | EE04751B1 (ru) |
ES (1) | ES2159839T3 (ru) |
GR (1) | GR3036829T3 (ru) |
HK (1) | HK1018957A1 (ru) |
HU (1) | HU228356B1 (ru) |
IL (1) | IL125146A (ru) |
IS (1) | IS1824B (ru) |
NO (1) | NO318731B1 (ru) |
NZ (1) | NZ330886A (ru) |
PL (1) | PL185132B1 (ru) |
PT (1) | PT885220E (ru) |
RU (1) | RU2167876C2 (ru) |
SG (1) | SG99853A1 (ru) |
SI (1) | SI0885220T1 (ru) |
SK (1) | SK281813B6 (ru) |
TR (1) | TR199801641T2 (ru) |
UA (1) | UA49872C2 (ru) |
WO (1) | WO1997030997A1 (ru) |
ZA (1) | ZA971525B (ru) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2356225T3 (es) * | 1998-09-30 | 2011-04-06 | Nihon Medi-Physics Co., Ltd. | Procedimiento para producir un derivado de ácido tropinona-monocarboxílico ópticamente activo. |
AUPP627498A0 (en) | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
KR20030030817A (ko) * | 2001-10-11 | 2003-04-18 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 세로토닌 운반 억제제 |
AU2002348135A1 (en) * | 2001-10-31 | 2003-05-12 | Recovery Pharmaceuticals, Inc. | Methods for the treatment of addiction |
JP2005511639A (ja) * | 2001-11-30 | 2005-04-28 | ニューロサーチ、アクティーゼルスカブ | 虚血性疾患の治療用ドパミン再取り込み阻害活性を有するトロパン誘導体 |
US7459464B2 (en) | 2002-05-30 | 2008-12-02 | Neurosearch A/S | Triple monoamine reuptake inhibitors for the treatment of chronic pain |
US7560562B2 (en) | 2002-11-01 | 2009-07-14 | Neurosearch A/S | Piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2004050688A1 (en) | 2002-12-02 | 2004-06-17 | Xenome Ltd | NOVEL χ-CONOTOXIN PEPTIDES (-II) |
ATE547424T1 (de) | 2002-12-02 | 2012-03-15 | Xenome Ltd | Chi-conotoxinpeptide mit einer n-terminalen pyroglutaminsäure |
WO2004072075A1 (en) | 2003-02-12 | 2004-08-26 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CN100372850C (zh) * | 2003-02-12 | 2008-03-05 | 神经研究公司 | 新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
CN100551924C (zh) * | 2003-02-12 | 2009-10-21 | 神经研究公司 | 8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
AU2004212166B2 (en) | 2003-02-12 | 2010-07-29 | Neurosearch A/S | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
KR20060030482A (ko) * | 2003-06-24 | 2006-04-10 | 뉴로서치 에이/에스 | 신규한 8-아자-바이사이클로[3.2.1]옥탄 유도체 및모노아민 신경전달물질 재흡수 억제제로서의 이의 용도 |
AR045141A1 (es) * | 2003-07-31 | 2005-10-19 | Neurosearch As | Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas. |
US7309790B2 (en) | 2003-10-03 | 2007-12-18 | Pfizer Inc | Chemical compounds |
JP2007508336A (ja) * | 2003-10-16 | 2007-04-05 | ニューロサーチ、アクティーゼルスカブ | モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物 |
KR20060125805A (ko) * | 2003-11-18 | 2006-12-06 | 베링거 인겔하임 인터내셔날 게엠베하 | 고체 약제학적 제제 형태 |
WO2005070428A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist |
CA2553649A1 (en) | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
AU2005205882A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
DE102004004965B4 (de) * | 2004-01-31 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates |
EP1755602A1 (en) * | 2004-06-04 | 2007-02-28 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation |
EP1761527A1 (en) * | 2004-06-18 | 2007-03-14 | Neurosearch A/S | Novel 9-aza-bicyclo¬3.3.1|nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US7524958B2 (en) | 2004-06-18 | 2009-04-28 | Neurosearch A/S | Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CA2570075A1 (en) | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
RU2382040C2 (ru) * | 2004-09-30 | 2010-02-20 | НьюроСёрч А/С | Новые хромен-2-оновые производные и их применение в качестве ингибиторов обратного захвата моноаминовых нейромедиаторов |
MX2007002384A (es) | 2004-09-30 | 2007-05-11 | Neurosearch As | Nuevos derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina. |
DE602006007550D1 (de) | 2005-02-10 | 2009-08-13 | Neurosearch As | Alkylsubstituierte homopiperazinderivate und deren verwendung als monoamin neurotransmitter wiederaufnahmeinhibitoren |
JP2008534650A (ja) * | 2005-04-04 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | 新規置換ジアザビシクロ誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 |
US20090137625A1 (en) | 2005-04-08 | 2009-05-28 | Dan Peters | Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors |
US7943630B2 (en) * | 2005-06-28 | 2011-05-17 | Neurosearch A/S | 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
ATE481386T1 (de) * | 2005-06-28 | 2010-10-15 | Neurosearch As | Neue 3-aza-spiroä5.5üundec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern |
JP2008546827A (ja) * | 2005-06-28 | 2008-12-25 | ノイロサーチ アクティーゼルスカブ | 新規な3−アザ−スピロ[5.5]ウンデカ−8−エン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用 |
WO2007000465A1 (en) * | 2005-06-28 | 2007-01-04 | Neurosearch A/S | Novel 3-aza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
JP2009500440A (ja) * | 2005-07-12 | 2009-01-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 性欲障害治療用医薬組成物 |
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CA2620418C (en) * | 2005-08-24 | 2014-04-22 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Benztropine compounds and uses thereof |
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EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
TW200804367A (en) * | 2005-11-11 | 2008-01-16 | Neurosearch As | Novel compounds |
WO2007090886A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
TW200800980A (en) | 2006-02-17 | 2008-01-01 | Neurosearch As | Novel compounds |
WO2008028903A2 (en) | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
US7691893B2 (en) * | 2006-09-11 | 2010-04-06 | Glaxo Group Limited | Chemical compounds |
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WO2010132487A1 (en) | 2009-05-12 | 2010-11-18 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
EP2430020B1 (en) | 2009-05-15 | 2013-10-09 | Aniona ApS | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US20120220604A1 (en) | 2009-09-21 | 2012-08-30 | Neurosearch A/S | Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2011092061A1 (en) | 2010-01-29 | 2011-08-04 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2011117289A1 (en) | 2010-03-25 | 2011-09-29 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors |
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EP2625170A1 (en) | 2010-10-07 | 2013-08-14 | Takeda Pharmaceutical Company Limited | 1,4-oxazepane derivatives |
CN108853071A (zh) | 2012-02-16 | 2018-11-23 | 萨尼奥纳有限责任公司 | 用于联合治疗的药物组合物 |
EA033298B1 (ru) | 2015-03-03 | 2019-09-30 | Саниона А/С | Комбинированная лекарственная форма тезофензина и метопролола |
EA026727B1 (ru) * | 2015-09-10 | 2017-05-31 | Замертон Холдингс Лимитед | Соль (1r,2r,3s)-3-(3,4-дихлорфенил)-2-(этоксиметил)-8-метил-8-азабицикло[3.2.1]октана и фталевой кислоты, способ её получения, продукт способа, фармацевтические композиции для лечения и/или профилактики нарушений, связанных с ожирением, их применение и способы лечения и/или профилактики нарушений, связанных с ожирением |
EP3402473A1 (en) | 2016-01-15 | 2018-11-21 | Saniona A/S | Tesofensine and metoprolol for treatment of hypertension |
EA028995B1 (ru) * | 2016-02-25 | 2018-01-31 | Замертон Холдингс Лимитед | Соль тезофензина и оптически активных ацетиламинокислот, их применение для лечения и/или профилактики нарушений, связанных с ожирением |
RU2019109050A (ru) * | 2016-09-07 | 2020-10-08 | Саниона А/С | Композиции тезофензина |
DE102017210141A1 (de) | 2017-06-16 | 2018-12-20 | Henkel Ag & Co. Kgaa | Portion zur Bereitstellung tensidhaltiger Flotten |
WO2020144146A1 (en) | 2019-01-07 | 2020-07-16 | Saniona A/S | Tesofensine for reduction of body weight in prader-willi patients |
MX2022013236A (es) | 2020-04-22 | 2023-01-24 | Saniona As | Tratamiento de la obesidad hipotalamica. |
TWI772928B (zh) * | 2020-10-21 | 2022-08-01 | 行政院原子能委員會核能研究所 | 非放射性標準品β-CFT之製備方法 |
WO2024008808A1 (en) | 2022-07-08 | 2024-01-11 | Initiator Pharma A/S | Compound for treatment of female sexual dysfunction |
CN115572289A (zh) * | 2022-10-24 | 2023-01-06 | 龙曦宁(上海)医药科技有限公司 | 一种特索芬辛的合成方法 |
WO2024089247A1 (en) | 2022-10-28 | 2024-05-02 | Initiator Pharma A/S | Compound for treatment of pain |
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DE69233656D1 (de) * | 1991-11-15 | 2006-10-19 | Res Triangle Inst | Kokain-Rezeptor Bindungsliganden |
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
AU672644B2 (en) | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
AU671163B2 (en) | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
CZ284379B6 (cs) * | 1994-04-19 | 1998-11-11 | Neurosearch A/S | Tropanové deriváty, způsob jejich přípravy a jejich použití |
GB9626611D0 (en) * | 1996-12-20 | 1997-02-05 | Unilever Plc | Agglomerated silicas |
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1997
- 1997-02-21 ZA ZA9701525A patent/ZA971525B/xx unknown
- 1997-02-21 AT AT97903355T patent/ATE203023T1/de active
- 1997-02-21 PL PL97328503A patent/PL185132B1/pl not_active IP Right Cessation
- 1997-02-21 IL IL12514697A patent/IL125146A/en not_active IP Right Cessation
- 1997-02-21 DE DE69705608T patent/DE69705608T2/de not_active Expired - Lifetime
- 1997-02-21 UA UA98073814A patent/UA49872C2/ru unknown
- 1997-02-21 SI SI9730163T patent/SI0885220T1/xx unknown
- 1997-02-21 JP JP52981097A patent/JP3238414B2/ja not_active Expired - Fee Related
- 1997-02-21 CA CA002244773A patent/CA2244773C/en not_active Expired - Lifetime
- 1997-02-21 DK DK97903355T patent/DK0885220T3/da active
- 1997-02-21 NZ NZ330886A patent/NZ330886A/xx not_active IP Right Cessation
- 1997-02-21 PT PT97903355T patent/PT885220E/pt unknown
- 1997-02-21 EP EP97903355A patent/EP0885220B1/en not_active Expired - Lifetime
- 1997-02-21 EE EE9800254A patent/EE04751B1/xx not_active IP Right Cessation
- 1997-02-21 WO PCT/EP1997/000850 patent/WO1997030997A1/en active IP Right Grant
- 1997-02-21 TR TR1998/01641T patent/TR199801641T2/xx unknown
- 1997-02-21 SK SK929-98A patent/SK281813B6/sk not_active IP Right Cessation
- 1997-02-21 US US09/101,524 patent/US6288079B1/en not_active Expired - Lifetime
- 1997-02-21 BR BR9707636A patent/BR9707636A/pt not_active IP Right Cessation
- 1997-02-21 KR KR10-1998-0706518A patent/KR100446571B1/ko not_active IP Right Cessation
- 1997-02-21 RU RU98117314/04A patent/RU2167876C2/ru active
- 1997-02-21 CZ CZ19982520A patent/CZ287007B6/cs not_active IP Right Cessation
- 1997-02-21 HU HU9901199A patent/HU228356B1/hu not_active IP Right Cessation
- 1997-02-21 SG SG9903902A patent/SG99853A1/en unknown
- 1997-02-21 AU AU17940/97A patent/AU720358B2/en not_active Ceased
- 1997-02-21 CN CN97192505A patent/CN1077574C/zh not_active Expired - Fee Related
- 1997-02-21 EP EP01108256A patent/EP1130020A1/en not_active Withdrawn
- 1997-02-21 ES ES97903355T patent/ES2159839T3/es not_active Expired - Lifetime
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1998
- 1998-07-15 BG BG102637A patent/BG63945B1/bg unknown
- 1998-08-17 IS IS4825A patent/IS1824B/is unknown
- 1998-08-21 NO NO19983877A patent/NO318731B1/no not_active IP Right Cessation
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1999
- 1999-09-17 HK HK99104015A patent/HK1018957A1/xx not_active IP Right Cessation
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2001
- 2001-03-21 US US09/814,413 patent/US6395748B2/en not_active Expired - Fee Related
- 2001-10-08 GR GR20010401690T patent/GR3036829T3/el unknown
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2002
- 2002-03-15 US US10/099,642 patent/US20020128284A1/en not_active Abandoned
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