MX2009003183A - Derivados de sulfonilpirazolincarboxamidina como antagonistas de 5-ht6. - Google Patents

Derivados de sulfonilpirazolincarboxamidina como antagonistas de 5-ht6.

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Publication number
MX2009003183A
MX2009003183A MX2009003183A MX2009003183A MX2009003183A MX 2009003183 A MX2009003183 A MX 2009003183A MX 2009003183 A MX2009003183 A MX 2009003183A MX 2009003183 A MX2009003183 A MX 2009003183A MX 2009003183 A MX2009003183 A MX 2009003183A
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MX
Mexico
Prior art keywords
disorders
compounds
disorder
antagonists
disease
Prior art date
Application number
MX2009003183A
Other languages
English (en)
Inventor
Jan Zorgdrager
Cornelis G Kruse
Hiskias G Keizer
Bakker Wouter I Iwema
Van Der Martina A W Neut
Van Arnold Loevezijn
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of MX2009003183A publication Critical patent/MX2009003183A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K9/1605—Excipients; Inactive ingredients
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  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a derivados de sulfonilpirazolincarboxam idina como antagonistas de receptores 5-HT6, a métodos para la preparación de estos compuestos y a nuevos compuestos intermedios útiles para su síntesis; la invención también se refiere a los usos de tales compuestos y composiciones, particularmente su uso en la administración de los mismos a pacientes para lograr un efecto terapéutico en la enfermedad de Parkinson, corea de Huntigton, esquizofrenia, ansiedad, depresión, depresión maníaca, psicosis, epilepsia, trastornos compulsivos obsesivos, trastornos emocionales, migraña, enfermedad de Alzheimer, declinación cognitiva relacionada con la edad, daño cognitivo suave, trastornos del sueño, trastornos alimenticios, anorexia, bulimia, trastornos de comer en exceso, ataques de pánico, acatisia, trastorno de déficit de atención por hiperactividad, trastorno de déficit de atención, supresión del abuso de cocaína, etanol, nicotina o benzodiazepinas, dolor, trastornos asociados con trauma espinal o lesión de la cabeza, hidrocefália, trastorno funcional del intestino, síndrome de intestino irritable, obesidad y diabetes tipo 2; los compuestos tienen la fórmula general (1): (ver fórmula (I)) en donde los símbolos tienen los significados dados en la memoria descriptiva.
MX2009003183A 2006-09-22 2007-09-20 Derivados de sulfonilpirazolincarboxamidina como antagonistas de 5-ht6. MX2009003183A (es)

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EP06121087 2006-09-22
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PCT/EP2007/059944 WO2008034863A2 (en) 2006-09-22 2007-09-20 Sulfonylpyrazoline carboxamidine derivatives as 5-ht6 antagonists

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EP3112334A1 (en) * 2015-06-29 2017-01-04 DPx Fine Chemicals Austria GmbH & CoKG Process for manufacturing 1-cyclopropyl-naphthalenes
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EP4178982A1 (en) 2020-07-13 2023-05-17 Precirix N.V. Antibody fragment against folr1
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WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

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EA200970310A1 (ru) 2009-10-30
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NO20091485L (no) 2009-04-17
HRP20120215T1 (hr) 2012-04-30
JP5225280B2 (ja) 2013-07-03
CY1112418T1 (el) 2015-12-09
SA07280510B1 (ar) 2012-02-07
AU2007298987B2 (en) 2012-10-04
PT2069310E (pt) 2012-02-28
CA2662484C (en) 2015-06-23
ATE537149T1 (de) 2011-12-15
US20140303372A1 (en) 2014-10-09
KR20090060356A (ko) 2009-06-11
MY147263A (en) 2012-11-30
ES2377996T3 (es) 2012-04-04
SI2069310T1 (sl) 2012-02-29
CN101679279B (zh) 2013-11-13
HK1137992A1 (en) 2010-08-13
DK2069310T3 (da) 2012-03-19
TWI428334B (zh) 2014-03-01
EA021543B1 (ru) 2015-07-30
AR062907A1 (es) 2008-12-17
WO2008034863A2 (en) 2008-03-27
KR101433745B1 (ko) 2014-08-25
US20080311179A1 (en) 2008-12-18
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AU2007298987B8 (en) 2012-11-08
AU2007298987A1 (en) 2008-03-27
CA2662484A1 (en) 2008-03-27
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CN101679279A (zh) 2010-03-24
US20100145042A1 (en) 2010-06-10
TW200821299A (en) 2008-05-16
EP2069310B1 (en) 2011-12-14
IL197232A0 (en) 2009-12-24
IL197232A (en) 2015-11-30
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