NO20091485L - Sulfonylpyrazol og sulfonylpyrazolin karboksamidinderivater som 5-HT6 antagonister - Google Patents
Sulfonylpyrazol og sulfonylpyrazolin karboksamidinderivater som 5-HT6 antagonisterInfo
- Publication number
- NO20091485L NO20091485L NO20091485A NO20091485A NO20091485L NO 20091485 L NO20091485 L NO 20091485L NO 20091485 A NO20091485 A NO 20091485A NO 20091485 A NO20091485 A NO 20091485A NO 20091485 L NO20091485 L NO 20091485L
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- disorders
- attention deficit
- disorder
- compounds
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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Abstract
Foreliggende oppfinnelse angår sulfonylpyrazolin karboksamidin derivater som antagonister av 5-HT6 reseptorer, fremgangsmåter for fremstilling av disse forbindelsene og nye intermediater anvendelige for deres syntese. Forbindelsen angår også anvendelsene av slike forbindelser og sammensetninger, særlig deres anvendelse ved administrering av dem til pasienter for å oppnå en terapeutisk effekt ved Parkinson's sykdom, Huntington's chorea, schizofreni, angst, depresjon, manisk depresjon, psykoser, epilepsi, obsessive kompulsive forstyrrelser, humør forstyrrelser, migrene, Alzheimer's sykdom, aldersrelatert kognitiv svekkelse, mild kognitiv svekkelse, søvnforstyrrelser, spiseforstyrrelser, anorexi, bulimi, overspise forstyrrelser, panikkangrep, akathisi, oppmerksomhetssvikt hyperaktivitet forstyrrelse, oppmerksomhetsvikt forstyrrelse, abstinens fra misbruk av kokain, etanol, nikotin eller benzodiazepiner, smerte, forstyrrelser assosiert med ryggtraume eller hodeskade, hydrocephalus, funksjonell tarm forstyrrelse, Irritabel Tarm Syndrom, fedme og type-2 diabetes. Forbindelsene har den generelle formel (1): hvori symbolene har betydningene gitt i beskrivelsen.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84640606P | 2006-09-22 | 2006-09-22 | |
EP06121087 | 2006-09-22 | ||
US90286507P | 2007-02-23 | 2007-02-23 | |
EP07102965 | 2007-02-23 | ||
PCT/EP2007/059944 WO2008034863A2 (en) | 2006-09-22 | 2007-09-20 | Sulfonylpyrazoline carboxamidine derivatives as 5-ht6 antagonists |
Publications (1)
Publication Number | Publication Date |
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NO20091485A NO20091485L (no) | 2006-09-22 | 2009-04-16 | Sulfonylpyrazol og sulfonylpyrazolin karboksamidinderivater som 5-HT6 antagonister |
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US (3) | US7728018B2 (no) |
EP (1) | EP2069310B1 (no) |
JP (1) | JP5225280B2 (no) |
KR (1) | KR101433745B1 (no) |
CN (1) | CN101679279B (no) |
AR (1) | AR062907A1 (no) |
AT (1) | ATE537149T1 (no) |
AU (1) | AU2007298987B8 (no) |
BR (1) | BRPI0716860A2 (no) |
CA (1) | CA2662484C (no) |
CY (1) | CY1112418T1 (no) |
DK (1) | DK2069310T3 (no) |
EA (1) | EA021543B1 (no) |
ES (1) | ES2377996T3 (no) |
HK (1) | HK1137992A1 (no) |
HR (1) | HRP20120215T1 (no) |
IL (1) | IL197232A (no) |
MX (1) | MX2009003183A (no) |
MY (1) | MY147263A (no) |
NO (1) | NO20091485L (no) |
PL (1) | PL2069310T3 (no) |
PT (1) | PT2069310E (no) |
SA (1) | SA07280510B1 (no) |
SI (1) | SI2069310T1 (no) |
TW (1) | TWI428334B (no) |
WO (1) | WO2008034863A2 (no) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US7786144B2 (en) * | 2006-05-31 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Sulphur containing pyrazole derivatives as selective cannabinoid CB1 receptor antagonists |
SA07280510B1 (ar) | 2006-09-22 | 2012-02-07 | سولفاي فارماسوتيكالز بي . في | سلفونيل بيرازول ومشتقات سلفونيل كربوكساميدين كمضادات ht6-5 |
AR070898A1 (es) * | 2008-03-18 | 2010-05-12 | Solvay Pharm Bv | Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6 |
AR079935A1 (es) * | 2010-01-29 | 2012-02-29 | Abbott Healthcare Products Bv | Sintesis de derivados de pirazolin carboxamidina sustituida |
CA2850707C (en) * | 2011-10-03 | 2023-03-21 | The University Of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
FR2999574B1 (fr) * | 2012-12-18 | 2014-12-05 | Isochem Sa | Procede de synthese des hydrazines endocycliques |
SI3027613T1 (sl) | 2013-07-25 | 2018-10-30 | Uniwersytet Jagiellonski | Derivati pirolokvinolina kot 5-HT6 antagonisti, postopek priprave in uporabe le-teh |
EP3109237A1 (en) | 2015-06-22 | 2016-12-28 | AnaMar AB | Novel 5-ht2 antagonists |
EP3112334A1 (en) * | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
WO2019030122A1 (en) * | 2017-08-08 | 2019-02-14 | S H Kelkar And Company Limited | COMPOSITIONS COMPRISING AN ODORIZING MATERIAL |
WO2019180176A1 (en) | 2018-03-21 | 2019-09-26 | Spherium Biomed, S.L. | Composition for the treatment of schizophrenia and/or psychosis |
EP4178982A1 (en) | 2020-07-13 | 2023-05-17 | Precirix N.V. | Antibody fragment against folr1 |
WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
Family Cites Families (8)
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DZ3335A1 (fr) * | 2000-03-23 | 2001-09-27 | Solvay Pharm Bv | Derives de 4,5-dihydro-1h-pyrazole ayant une activite antagoniste de cb1 |
AR034160A1 (es) | 2000-09-30 | 2004-02-04 | Gruenenthal Gmbh | Sulfonilguanidinas, medicamentos que contienen estos compuestos y el uso de sulfonilguanidinas |
JP4313671B2 (ja) * | 2001-09-21 | 2009-08-12 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | Cb1−拮抗活性を有する新規4,5−ジヒドロ−1h−ピラゾール誘導体 |
CA2442245C (en) * | 2001-09-21 | 2010-03-30 | Solvay Pharmaceuticals B.V. | 4,5-dihydro-1h-pyrazole derivatives having potent cb1-antagonistic activity |
BRPI0616995A2 (pt) * | 2005-08-17 | 2011-07-05 | Solvay Pharm Gmbh | composição farmacêutica, e uso de inibidor do canal de potássio kv1.3 na preparação de medicamento |
SA07280510B1 (ar) | 2006-09-22 | 2012-02-07 | سولفاي فارماسوتيكالز بي . في | سلفونيل بيرازول ومشتقات سلفونيل كربوكساميدين كمضادات ht6-5 |
WO2008087123A2 (en) * | 2007-01-16 | 2008-07-24 | Solvay Pharmaceuticals B.V. | Use of 5-ht6 antagonists to prevent relapse into addiction |
US20080171779A1 (en) * | 2007-01-16 | 2008-07-17 | Solvay Pharmaceuticals B.V. | Use of 5-ht6 antagonists to prevent relapse into addiction |
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