ZA966045B - Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1). - Google Patents

Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1).

Info

Publication number
ZA966045B
ZA966045B ZA9606045A ZA966045A ZA966045B ZA 966045 B ZA966045 B ZA 966045B ZA 9606045 A ZA9606045 A ZA 9606045A ZA 966045 A ZA966045 A ZA 966045A ZA 966045 B ZA966045 B ZA 966045B
Authority
ZA
South Africa
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
Prior art date
Application number
ZA9606045A
Other languages
English (en)
Inventor
Ann T Mckenzie
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA966045(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ZA966045B publication Critical patent/ZA966045B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
ZA9606045A 1995-07-17 1996-07-16 Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1). ZA966045B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17

Publications (1)

Publication Number Publication Date
ZA966045B true ZA966045B (en) 1997-02-04

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9606045A ZA966045B (en) 1995-07-17 1996-07-16 Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1).

Country Status (33)

Country Link
US (1) US6121461A (no)
JP (1) JP3296563B2 (no)
KR (1) KR100431039B1 (no)
CN (1) CN1081632C (no)
AT (1) ATE207465T1 (no)
AU (1) AU725368B2 (no)
BG (1) BG63629B1 (no)
BR (1) BR9610567A (no)
CA (1) CA2220458C (no)
CO (1) CO4700442A1 (no)
CZ (1) CZ294109B6 (no)
DK (1) DK0848704T3 (no)
EA (1) EA000505B1 (no)
EE (1) EE03607B1 (no)
ES (1) ES2166456T3 (no)
GE (1) GEP20002028B (no)
HK (1) HK1018053A1 (no)
HR (1) HRP960313B1 (no)
HU (1) HU223598B1 (no)
ID (1) ID16158A (no)
IL (3) IL122162A (no)
MX (1) MX9708857A (no)
MY (1) MY118398A (no)
NO (1) NO309899B1 (no)
NZ (1) NZ312906A (no)
PE (1) PE1798A1 (no)
PL (1) PL192244B1 (no)
RO (1) RO120068B1 (no)
SK (1) SK284201B6 (no)
TW (1) TW401399B (no)
UA (1) UA44796C2 (no)
WO (1) WO1997003958A1 (no)
ZA (1) ZA966045B (no)

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PL193479B1 (pl) 1995-07-17 2007-02-28 Warner Lambert Co Formy krystaliczne hydratu atorwastatyny, kompozycja farmaceutyczna zawierająca formę krystaliczną I hydratu atorwastatyny oraz jej zastosowanie
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IL149087A0 (en) 1999-12-17 2002-11-10 Warner Lambert Res & Dev Ie A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium
ATE320415T1 (de) 1999-12-17 2006-04-15 Pfizer Science & Tech Ltd Verfahren zur herstellung von kristallin atorvastin kalcium
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LT5196B (lt) 2000-11-30 2005-02-25 Teva Pharmaceutical Industries Ltd. Naujos atorvastatino pusiau kalcio kristalinės formos ir jų gavimo būdai, taip pat ir nauji kitų formų gavimo būdai
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US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
CZ2004126A3 (cs) * 2001-07-30 2004-12-15 Dr. Reddy's Laboratories Limited Krystalické formy VI. A VII. vápenaté soli atorvastatinu
US20030114497A1 (en) * 2001-07-31 2003-06-19 Laman Alani Pharmaceutical compositions of amlodipine and atorvastatin
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US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
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CN102424663B (zh) * 2010-12-03 2013-08-14 天津滨江药物研发有限公司 一种阿托伐他汀氨基酸盐及其制备方法
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CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
KR101723783B1 (ko) 2017-02-24 2017-04-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법

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Also Published As

Publication number Publication date
HUP9901687A3 (en) 2000-04-28
ES2166456T3 (es) 2002-04-16
NO980208D0 (no) 1998-01-16
HRP960313B1 (en) 2002-08-31
SK284201B6 (sk) 2004-10-05
KR100431039B1 (ko) 2004-08-25
CN1190957A (zh) 1998-08-19
EE03607B1 (et) 2002-02-15
IL128863A0 (en) 2000-01-31
IL177378A0 (en) 2006-12-10
HUP9901687A2 (hu) 1999-10-28
BG63629B1 (bg) 2002-07-31
AU6484196A (en) 1997-02-18
PL324532A1 (en) 1998-06-08
JPH11509229A (ja) 1999-08-17
PE1798A1 (es) 1998-03-04
WO1997003958A1 (en) 1997-02-06
SK5998A3 (en) 1998-05-06
AU725368B2 (en) 2000-10-12
IL122162A0 (en) 1998-04-05
RO120068B1 (ro) 2005-08-30
CO4700442A1 (es) 1998-12-29
EA000505B1 (ru) 1999-10-28
CZ12398A3 (cs) 1998-06-17
TW401399B (en) 2000-08-11
CA2220458C (en) 2002-09-24
HK1018053A1 (en) 1999-12-10
JP3296563B2 (ja) 2002-07-02
EA199800129A1 (ru) 1998-08-27
US6121461A (en) 2000-09-19
PL192244B1 (pl) 2006-09-29
CZ294109B6 (cs) 2004-10-13
GEP20002028B (en) 2000-04-10
MY118398A (en) 2004-10-30
NO309899B1 (no) 2001-04-17
BR9610567A (pt) 1999-07-06
ID16158A (id) 1997-09-11
CA2220458A1 (en) 1997-02-06
ATE207465T1 (de) 2001-11-15
MX9708857A (es) 1998-03-31
HRP960313A2 (en) 1998-04-30
BG102186A (en) 1998-10-30
CN1081632C (zh) 2002-03-27
IL122162A (en) 1999-07-14
EE9800016A (et) 1998-08-17
NZ312906A (en) 2000-12-22
NO980208L (no) 1998-01-16
UA44796C2 (uk) 2002-03-15
HU223598B1 (hu) 2004-10-28
IL128863A (en) 2006-09-05
DK0848704T3 (da) 2002-02-04
KR19990029044A (ko) 1999-04-15

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