ZA966045B - Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1). - Google Patents

Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1).

Info

Publication number
ZA966045B
ZA966045B ZA9606045A ZA966045A ZA966045B ZA 966045 B ZA966045 B ZA 966045B ZA 9606045 A ZA9606045 A ZA 9606045A ZA 966045 A ZA966045 A ZA 966045A ZA 966045 B ZA966045 B ZA 966045B
Authority
ZA
South Africa
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
Prior art date
Application number
ZA9606045A
Other languages
English (en)
Inventor
Ann T Mckenzie
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA966045(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ZA966045B publication Critical patent/ZA966045B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
ZA9606045A 1995-07-17 1996-07-16 Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1). ZA966045B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17

Publications (1)

Publication Number Publication Date
ZA966045B true ZA966045B (en) 1997-02-04

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9606045A ZA966045B (en) 1995-07-17 1996-07-16 Form III crystalline [R-(R*,R*)]-2-(4-fluorophenyl)-B,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1).

Country Status (33)

Country Link
US (1) US6121461A (fr)
JP (1) JP3296563B2 (fr)
KR (1) KR100431039B1 (fr)
CN (1) CN1081632C (fr)
AT (1) ATE207465T1 (fr)
AU (1) AU725368B2 (fr)
BG (1) BG63629B1 (fr)
BR (1) BR9610567A (fr)
CA (1) CA2220458C (fr)
CO (1) CO4700442A1 (fr)
CZ (1) CZ294109B6 (fr)
DK (1) DK0848704T3 (fr)
EA (1) EA000505B1 (fr)
EE (1) EE03607B1 (fr)
ES (1) ES2166456T3 (fr)
GE (1) GEP20002028B (fr)
HK (1) HK1018053A1 (fr)
HR (1) HRP960313B1 (fr)
HU (1) HU223598B1 (fr)
ID (1) ID16158A (fr)
IL (3) IL122162A (fr)
MX (1) MX9708857A (fr)
MY (1) MY118398A (fr)
NO (1) NO309899B1 (fr)
NZ (1) NZ312906A (fr)
PE (1) PE1798A1 (fr)
PL (1) PL192244B1 (fr)
RO (1) RO120068B1 (fr)
SK (1) SK284201B6 (fr)
TW (1) TW401399B (fr)
UA (1) UA44796C2 (fr)
WO (1) WO1997003958A1 (fr)
ZA (1) ZA966045B (fr)

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US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
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CN1536999B (zh) * 2001-08-03 2012-08-08 西巴特殊化学品控股有限公司 氟伐他汀钠的晶形
US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
CN100406436C (zh) * 2002-02-15 2008-07-30 特瓦制药工业有限公司 阿托韦兹他汀半钙结晶以及制备阿托韦兹他汀半钙形式ix的方法
JP4422488B2 (ja) * 2002-02-19 2010-02-24 テバ ファーマシューティカル インダストリーズ リミティド アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム
BR0215644A (pt) * 2002-03-18 2004-12-21 Biocon Ltd Inibidores de redutase de hmg-coa amorfos do tamanho de partìcula desejado
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
DE60315308T2 (de) 2002-08-06 2007-12-20 Warner-Lambert Company Llc Verfahren zum herstell von 5-(4-fluorphenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxotetrahydropyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrol-3-carbonsäurephenylamid
CA2491051A1 (fr) * 2002-09-03 2004-03-18 Morepen Laboratories Limited Forme vi de calcium d'atorvastatine ou hydrates de cette derniere
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CA2547216A1 (fr) 2005-09-21 2007-03-21 Renuka D. Reddy Procede de recuit de l'atorvastatine amorphe
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KR100878140B1 (ko) * 2007-01-29 2009-01-12 한미약품 주식회사 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물
WO2009007856A2 (fr) * 2007-07-11 2009-01-15 Actavis Group Ptc Ehf Nouveau polymorphe d'atorvastatine calcium et son utilisation pour la préparation d'atorvastatine calcium amorphe
US20110142883A1 (en) * 2007-07-20 2011-06-16 Actavis Group Ptc Ehf Amorphous Coprecipitates of Atorvastatin Pharmaceutically Acceptable Salts
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US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
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CZ201039A3 (cs) 2010-01-19 2011-07-27 Zentiva, K. S Zpusob prumyslové výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) s vysokým specifickým povrchem a jeho použití v lékové forme
KR20120011249A (ko) * 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN103274985B (zh) * 2010-12-03 2016-03-09 上海科州药物研发有限公司 一种阿托伐他汀氨基酸盐
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WO2013004591A1 (fr) 2011-07-01 2013-01-10 Dsm Sinochem Pharmaceuticals Netherlands B.V. Cristaux micronisés d'atorvastatine hémicalcique
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CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
KR101723783B1 (ko) 2017-02-24 2017-04-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법

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Publication number Publication date
HUP9901687A3 (en) 2000-04-28
AU725368B2 (en) 2000-10-12
BG102186A (en) 1998-10-30
CZ294109B6 (cs) 2004-10-13
SK284201B6 (sk) 2004-10-05
HK1018053A1 (en) 1999-12-10
DK0848704T3 (da) 2002-02-04
PL324532A1 (en) 1998-06-08
IL177378A0 (en) 2006-12-10
ES2166456T3 (es) 2002-04-16
CN1081632C (zh) 2002-03-27
PE1798A1 (es) 1998-03-04
BR9610567A (pt) 1999-07-06
PL192244B1 (pl) 2006-09-29
ID16158A (id) 1997-09-11
WO1997003958A1 (fr) 1997-02-06
SK5998A3 (en) 1998-05-06
AU6484196A (en) 1997-02-18
CO4700442A1 (es) 1998-12-29
KR19990029044A (ko) 1999-04-15
EE03607B1 (et) 2002-02-15
HUP9901687A2 (hu) 1999-10-28
JP3296563B2 (ja) 2002-07-02
RO120068B1 (ro) 2005-08-30
UA44796C2 (uk) 2002-03-15
KR100431039B1 (ko) 2004-08-25
BG63629B1 (bg) 2002-07-31
NO980208L (no) 1998-01-16
JPH11509229A (ja) 1999-08-17
EA000505B1 (ru) 1999-10-28
IL128863A (en) 2006-09-05
GEP20002028B (en) 2000-04-10
CA2220458C (fr) 2002-09-24
CN1190957A (zh) 1998-08-19
HU223598B1 (hu) 2004-10-28
NZ312906A (en) 2000-12-22
IL122162A0 (en) 1998-04-05
HRP960313A2 (en) 1998-04-30
US6121461A (en) 2000-09-19
TW401399B (en) 2000-08-11
HRP960313B1 (en) 2002-08-31
IL128863A0 (en) 2000-01-31
EA199800129A1 (ru) 1998-08-27
MY118398A (en) 2004-10-30
IL122162A (en) 1999-07-14
MX9708857A (es) 1998-03-31
CA2220458A1 (fr) 1997-02-06
CZ12398A3 (cs) 1998-06-17
NO309899B1 (no) 2001-04-17
ATE207465T1 (de) 2001-11-15
EE9800016A (et) 1998-08-17
NO980208D0 (no) 1998-01-16

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