ZA200900070B - Hydroxylated and methoxylated cyclopenta [D] pyrimidines as AKT protein kinase inhibitors - Google Patents

Hydroxylated and methoxylated cyclopenta [D] pyrimidines as AKT protein kinase inhibitors

Info

Publication number
ZA200900070B
ZA200900070B ZA200900070A ZA200900070A ZA200900070B ZA 200900070 B ZA200900070 B ZA 200900070B ZA 200900070 A ZA200900070 A ZA 200900070A ZA 200900070 A ZA200900070 A ZA 200900070A ZA 200900070 B ZA200900070 B ZA 200900070B
Authority
ZA
South Africa
Prior art keywords
pyrimidines
hydroxylated
protein kinase
kinase inhibitors
akt protein
Prior art date
Application number
ZA200900070A
Other languages
English (en)
Inventor
Ian S Mitchell
James F Blake
Rui Xu
Nicholas C Kallan
Dengming Xiao
Keith Lee Spencer
Josef R Bencsik
Jun Liang
Brian Safina
Birong Zhang
Christine Chabot
Steven Do
Eli M Wallace
Anna L Banka
Stephen T Schlachter
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200900070(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of ZA200900070B publication Critical patent/ZA200900070B/xx

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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ZA200900070A 2006-07-06 2009-01-05 Hydroxylated and methoxylated cyclopenta [D] pyrimidines as AKT protein kinase inhibitors ZA200900070B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
ZA200900070B true ZA200900070B (en) 2010-03-31

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ID=38686743

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Application Number Title Priority Date Filing Date
ZA200900070A ZA200900070B (en) 2006-07-06 2009-01-05 Hydroxylated and methoxylated cyclopenta [D] pyrimidines as AKT protein kinase inhibitors

Country Status (35)

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EP (4) EP2399909B1 (hr)
JP (4) JP5266216B2 (hr)
KR (5) KR101495408B1 (hr)
CN (2) CN101578273B (hr)
AR (3) AR061842A1 (hr)
AT (1) ATE524447T1 (hr)
AU (1) AU2007269060B2 (hr)
BR (3) BRPI0713923B8 (hr)
CA (2) CA2836316A1 (hr)
CL (1) CL2007001993A1 (hr)
CO (1) CO6150161A2 (hr)
CR (1) CR10600A (hr)
CY (1) CY1112117T1 (hr)
DK (2) DK2402325T3 (hr)
ES (3) ES2554228T3 (hr)
HK (3) HK1126768A1 (hr)
HR (1) HRP20110908T1 (hr)
HU (1) HUE026237T2 (hr)
IL (2) IL196028A (hr)
IN (1) IN2014KN02886A (hr)
MA (1) MA31655B1 (hr)
MX (4) MX366319B (hr)
MY (1) MY147364A (hr)
NO (1) NO342346B1 (hr)
NZ (3) NZ573732A (hr)
PL (2) PL2402325T3 (hr)
PT (1) PT2049501E (hr)
RS (1) RS52212B (hr)
RU (2) RU2478632C2 (hr)
SG (4) SG184706A1 (hr)
SI (2) SI2402325T1 (hr)
TW (2) TW201332994A (hr)
UA (1) UA95641C2 (hr)
WO (1) WO2008006040A1 (hr)
ZA (1) ZA200900070B (hr)

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RU2481336C2 (ru) 2006-07-06 2013-05-10 Эррэй Биофарма Инк. Циклопента(d)пиримидины в качестве ингибиторов протеинкиназ акт
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
DE602007011628D1 (de) * 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
EP2054418B1 (en) * 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
US20110135569A1 (en) 2007-03-20 2011-06-09 Peak Biosciences Inc. Method for therapeutic administration of radionucleosides
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CN103396409B (zh) 2007-07-05 2015-03-11 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
KR20150091196A (ko) 2007-07-05 2015-08-07 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
ES2426092T3 (es) * 2008-01-09 2013-10-21 Array Biopharma, Inc. 5H-Ciclopenta[d]pirimidinas como inhibidores de proteínas cinasas AKT
JP5539225B2 (ja) * 2008-01-09 2014-07-02 アレイ バイオファーマ、インコーポレイテッド Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン
WO2009089459A1 (en) * 2008-01-09 2009-07-16 Array Biopharma Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
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