ZA200802046B - A process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol - Google Patents

A process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol

Info

Publication number
ZA200802046B
ZA200802046B ZA200802046A ZA200802046A ZA200802046B ZA 200802046 B ZA200802046 B ZA 200802046B ZA 200802046 A ZA200802046 A ZA 200802046A ZA 200802046 A ZA200802046 A ZA 200802046A ZA 200802046 B ZA200802046 B ZA 200802046B
Authority
ZA
South Africa
Prior art keywords
florfenicol
intermediates
compounds useful
protected aminodiol
oxazolidine protected
Prior art date
Application number
ZA200802046A
Other languages
English (en)
Inventor
James C Towson
Original Assignee
Schering Plough Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd
Publication of ZA200802046B publication Critical patent/ZA200802046B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200802046A 2005-09-07 2008-03-04 A process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol ZA200802046B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71468505P 2005-09-07 2005-09-07

Publications (1)

Publication Number Publication Date
ZA200802046B true ZA200802046B (en) 2008-12-31

Family

ID=37684114

Family Applications (3)

Application Number Title Priority Date Filing Date
ZA200802046A ZA200802046B (en) 2005-09-07 2008-03-04 A process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol
ZA200802048A ZA200802048B (en) 2005-09-07 2008-03-04 An improved process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol
ZA200802047A ZA200802047B (en) 2005-09-07 2008-03-04 A process for preparing ester oxazolidine compounds and their conversion to Florfenicol

Family Applications After (2)

Application Number Title Priority Date Filing Date
ZA200802048A ZA200802048B (en) 2005-09-07 2008-03-04 An improved process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol
ZA200802047A ZA200802047B (en) 2005-09-07 2008-03-04 A process for preparing ester oxazolidine compounds and their conversion to Florfenicol

Country Status (19)

Country Link
US (3) US7786329B2 (pt)
EP (3) EP1928820B1 (pt)
JP (3) JP5113754B2 (pt)
KR (3) KR101408596B1 (pt)
CN (3) CN101300238A (pt)
AU (3) AU2006287716A1 (pt)
BR (3) BRPI0615565A2 (pt)
CA (3) CA2621987A1 (pt)
EC (3) ECSP088266A (pt)
ES (1) ES2459205T3 (pt)
IL (3) IL189828A0 (pt)
MX (3) MX2008003187A (pt)
NO (3) NO20081685L (pt)
RU (3) RU2008112946A (pt)
SI (1) SI1928820T1 (pt)
TW (3) TW200804253A (pt)
UA (1) UA93212C2 (pt)
WO (3) WO2007030385A2 (pt)
ZA (3) ZA200802046B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200505425A (en) * 2003-05-29 2005-02-16 Schering Plough Ltd Compositions and method for treating infection in cattle and swine
EP1785414A1 (en) * 2005-11-09 2007-05-16 KRKA, tovarna zdravil, d.d., Novo mesto Process for the synthesis of intermediates of chloramphenicol or its analogues
WO2008076256A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
EP2173726A2 (en) * 2007-07-25 2010-04-14 Intervet International B.V. Process for preparing oxazolidine- and oxazolidinone-aminodiols
PE20091171A1 (es) * 2007-12-14 2009-08-03 Schering Plough Ltd Proceso para recuperar florfenicol y analogos de florfenicol
US8314252B2 (en) * 2008-07-30 2012-11-20 Intervet Inc. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
CN101941927B (zh) * 2010-09-28 2012-10-03 湖北美天生物科技有限公司 氟苯尼考中间体(1r,2r)-2-氨基-1–(4-(甲砜基)苯基)-1,3-丙二醇的合成方法
JP2014513116A (ja) 2011-05-02 2014-05-29 ゾエティス・エルエルシー 抗菌剤として有用な新規セファロスポリン
CN103254103A (zh) * 2013-06-05 2013-08-21 南通金利油脂工业有限公司 氟化剂在制备氟苯尼考工艺中的应用
CN103965085B (zh) * 2014-04-17 2016-02-24 上海恒晟药业有限公司 一种取代1,2-氨基醇药物的制备方法
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN111500652B (zh) * 2019-01-30 2024-03-26 苏州引航生物科技有限公司 一种制备氟苯尼考的方法
CN110302163A (zh) * 2019-07-23 2019-10-08 东莞正大康地饲料有限公司 一种氟苯尼考可溶性粉及其制备方法
CN110773207A (zh) * 2019-09-25 2020-02-11 陈红菊 一种在室温且无光条件下可完全分解甲醛的冷触媒材料及其制备方法
CN111423391A (zh) * 2020-03-18 2020-07-17 浙江康牧药业有限公司 一种氟苯尼考中间体的制备方法
CN113402475A (zh) * 2021-06-07 2021-09-17 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002637A (en) * 1973-07-09 1977-01-11 Rohm And Haas Company Oxazolidine, oxazolidine-containing condensation and addition polymers and methods of producing them
EP0678506A3 (en) * 1983-06-02 1996-07-24 Zambon Spa Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
IT1237798B (it) * 1989-10-20 1993-06-17 Zambon Spa Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
WO1994004523A1 (en) * 1992-08-21 1994-03-03 Japan Tobacco Inc. Dioxacycloalkane compound with renin-inhibiting activity
US5663361A (en) * 1996-08-19 1997-09-02 Schering Corporation Process for preparing intermediates to florfenicol
JP2001240571A (ja) * 2000-03-01 2001-09-04 Udagawa Reiko フッ素アルコールの製造方法
CN1649829A (zh) * 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol

Also Published As

Publication number Publication date
JP5113754B2 (ja) 2013-01-09
CA2621971A1 (en) 2007-03-15
EP1928820A2 (en) 2008-06-11
WO2007030405A2 (en) 2007-03-15
JP2009507074A (ja) 2009-02-19
MX2008003186A (es) 2008-03-18
CA2621961A1 (en) 2007-03-15
KR101408596B1 (ko) 2014-06-17
IL189829A0 (en) 2008-11-03
MX2008003187A (es) 2008-03-18
CN101300238A (zh) 2008-11-05
TWI331139B (en) 2010-10-01
NO20081684L (no) 2008-06-05
IL189828A0 (en) 2008-11-03
TW200804253A (en) 2008-01-16
WO2007030386A3 (en) 2007-05-24
US20070055080A1 (en) 2007-03-08
ES2459205T3 (es) 2014-05-08
RU2008112950A (ru) 2009-10-20
WO2007030405A3 (en) 2007-05-18
EP1934190A2 (en) 2008-06-25
UA93212C2 (ru) 2011-01-25
TW200800924A (en) 2008-01-01
CN101300237A (zh) 2008-11-05
US20070055067A1 (en) 2007-03-08
CN101300227A (zh) 2008-11-05
RU2008112952A (ru) 2009-10-20
KR20080049040A (ko) 2008-06-03
BRPI0615565A2 (pt) 2011-05-24
AU2006287716A1 (en) 2007-03-15
AU2006287697A1 (en) 2007-03-15
JP2009507842A (ja) 2009-02-26
NO20081686L (no) 2008-06-05
NO20081685L (no) 2008-06-05
AU2006287696A1 (en) 2007-03-15
ZA200802048B (en) 2008-11-26
EP1934189A2 (en) 2008-06-25
EP1928820B1 (en) 2014-01-29
US7786329B2 (en) 2010-08-31
KR20080041699A (ko) 2008-05-13
BRPI0615767A2 (pt) 2011-05-24
ZA200802047B (en) 2008-12-31
JP2009507075A (ja) 2009-02-19
RU2008112946A (ru) 2009-10-20
US20070055066A1 (en) 2007-03-08
CA2621987A1 (en) 2007-03-15
TW200804254A (en) 2008-01-16
MX2008003188A (es) 2008-03-18
WO2007030386A2 (en) 2007-03-15
WO2007030385A3 (en) 2007-05-24
CN101300227B (zh) 2013-07-03
BRPI0615764A2 (pt) 2011-05-24
ECSP088266A (es) 2008-04-28
WO2007030385A2 (en) 2007-03-15
ECSP088268A (es) 2008-04-28
ECSP088267A (es) 2008-04-28
SI1928820T1 (sl) 2014-08-29
KR20080049039A (ko) 2008-06-03
IL189830A0 (en) 2008-11-03

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