ZA200407944B - Heteroaryl compounds which inhibit leukocyte adhesion mediated by Alpha-4 integrins - Google Patents
Heteroaryl compounds which inhibit leukocyte adhesion mediated by Alpha-4 integrins Download PDFInfo
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- ZA200407944B ZA200407944B ZA200407944A ZA200407944A ZA200407944B ZA 200407944 B ZA200407944 B ZA 200407944B ZA 200407944 A ZA200407944 A ZA 200407944A ZA 200407944 A ZA200407944 A ZA 200407944A ZA 200407944 B ZA200407944 B ZA 200407944B
- Authority
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- South Africa
- Prior art keywords
- diethylamino
- ylamino
- pyrimidin
- dimethylcarbamoyloxyphenyl
- propionic acid
- Prior art date
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38324402P | 2002-05-24 | 2002-05-24 |
Publications (1)
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| ZA200407944B true ZA200407944B (en) | 2006-07-26 |
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| ZA200407944A ZA200407944B (en) | 2002-05-24 | 2004-10-01 | Heteroaryl compounds which inhibit leukocyte adhesion mediated by Alpha-4 integrins |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7335663B2 (de) |
| EP (1) | EP1507533B1 (de) |
| JP (1) | JP4413135B2 (de) |
| CN (1) | CN1311829C (de) |
| AT (1) | ATE464298T1 (de) |
| AU (1) | AU2003237302B8 (de) |
| BR (1) | BR0309619A (de) |
| CA (1) | CA2480756A1 (de) |
| DE (1) | DE60332109D1 (de) |
| EA (1) | EA008180B1 (de) |
| IL (1) | IL164323A (de) |
| MX (1) | MXPA04011657A (de) |
| NO (1) | NO20045276L (de) |
| NZ (1) | NZ535723A (de) |
| TW (1) | TW200307671A (de) |
| WO (1) | WO2003099231A2 (de) |
| ZA (1) | ZA200407944B (de) |
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| DE60043692D1 (de) * | 1999-01-22 | 2010-03-04 | Elan Pharm Inc | Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen |
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| AU2005222074B2 (en) * | 2004-03-10 | 2011-02-17 | Merck Sharp & Dohme Corp. | VLA-4 antagonists |
| NZ588839A (en) * | 2004-07-08 | 2012-09-28 | Elan Pharm Inc | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
| KR20070044054A (ko) * | 2004-08-16 | 2007-04-26 | 머크 앤드 캄파니 인코포레이티드 | Ｖｌａ-4 길항제 |
| CN101273035A (zh) * | 2005-09-29 | 2008-09-24 | 伊兰制药公司 | 抑制由vla-4介导的白细胞粘附的氨基甲酸酯化合物 |
| BRPI0616687A2 (pt) * | 2005-09-29 | 2011-06-28 | Elan Pharm Inc | compostos de pirimidinil amida que inibem a adesão leucocitária mediada por vla-4 |
| JP5135235B2 (ja) * | 2006-02-27 | 2013-02-06 | エラン ファーマシューティカルズ，インコーポレイテッド | Ｖａｌ−４によって媒介される白血球の接着を阻害するピリミジニルスルホンアミド化合物 |
| PL2676967T3 (pl) | 2006-02-28 | 2019-12-31 | Biogen Ma Inc. | Metody leczenia chorób zapalnych i autoimmunologicznych za pomocą natalizumabu |
| CA2641160A1 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| EA016626B1 (ru) | 2006-03-03 | 2012-06-29 | Элан Фамэсьютикэлс, Инк. | Способ лечения натализумабом воспалительного и/или аутоиммунного заболевания (варианты) |
| WO2009075806A1 (en) * | 2007-12-07 | 2009-06-18 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating liquid tumors |
| JP2012525336A (ja) * | 2009-04-27 | 2012-10-22 | エラン ファーマシューティカルズ，インコーポレイテッド | α−４インテグリンのピリジノンアンタゴニスト |
| DK3339865T5 (da) | 2010-01-11 | 2023-03-20 | Biogen Ma Inc | Assay for jc-virus-antistoffer |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| US8343706B2 (en) | 2010-01-25 | 2013-01-01 | International Business Machines Corporation | Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same |
| EP3004334A4 (de) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | Verfahren zur beurteilung eines pml-risikos |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| CN112969700A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的咪唑并吡啶衍生物 |
| JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４β７インテグリンの阻害のための化合物 |
| EP3873897A1 (de) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Verbindungen zur inhibierung von alpha-4-beta-7-integrin |
| CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
| CN111197057B (zh) * | 2018-11-19 | 2024-04-19 | 中国科学院分子细胞科学卓越创新中心 | 调控免疫细胞迁移的组合物和方法 |
| WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
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-
2003
- 2003-05-26 TW TW092114184A patent/TW200307671A/zh unknown
- 2003-05-27 CA CA002480756A patent/CA2480756A1/en not_active Abandoned
- 2003-05-27 AU AU2003237302A patent/AU2003237302B8/en not_active Ceased
- 2003-05-27 US US10/494,788 patent/US7335663B2/en not_active Expired - Fee Related
- 2003-05-27 CN CNB038112582A patent/CN1311829C/zh not_active Expired - Fee Related
- 2003-05-27 EA EA200401561A patent/EA008180B1/ru not_active IP Right Cessation
- 2003-05-27 BR BR0309619-0A patent/BR0309619A/pt not_active IP Right Cessation
- 2003-05-27 US US10/447,208 patent/US7008949B2/en not_active Expired - Fee Related
- 2003-05-27 JP JP2004506758A patent/JP4413135B2/ja not_active Expired - Fee Related
- 2003-05-27 NZ NZ535723A patent/NZ535723A/en unknown
- 2003-05-27 MX MXPA04011657A patent/MXPA04011657A/es active IP Right Grant
- 2003-05-27 DE DE60332109T patent/DE60332109D1/de not_active Expired - Lifetime
- 2003-05-27 WO PCT/US2003/017150 patent/WO2003099231A2/en active IP Right Grant
- 2003-05-27 AT AT03736768T patent/ATE464298T1/de not_active IP Right Cessation
- 2003-05-27 EP EP03736768A patent/EP1507533B1/de not_active Expired - Lifetime
-
2004
- 2004-09-28 IL IL164323A patent/IL164323A/en not_active IP Right Cessation
- 2004-10-01 ZA ZA200407944A patent/ZA200407944B/en unknown
- 2004-12-01 NO NO20045276A patent/NO20045276L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003099231A3 (en) | 2004-01-22 |
| JP4413135B2 (ja) | 2010-02-10 |
| EA200401561A1 (ru) | 2005-06-30 |
| IL164323A0 (en) | 2005-12-18 |
| US7335663B2 (en) | 2008-02-26 |
| MXPA04011657A (es) | 2005-08-18 |
| ATE464298T1 (de) | 2010-04-15 |
| CN1652789A (zh) | 2005-08-10 |
| US7008949B2 (en) | 2006-03-07 |
| EP1507533A2 (de) | 2005-02-23 |
| TW200307671A (en) | 2003-12-16 |
| US20040142954A1 (en) | 2004-07-22 |
| DE60332109D1 (de) | 2010-05-27 |
| AU2003237302B8 (en) | 2008-04-03 |
| IL164323A (en) | 2010-02-17 |
| CN1311829C (zh) | 2007-04-25 |
| WO2003099231A2 (en) | 2003-12-04 |
| AU2003237302A1 (en) | 2003-12-12 |
| JP2005529155A (ja) | 2005-09-29 |
| NZ535723A (en) | 2005-08-26 |
| EP1507533A4 (de) | 2007-05-23 |
| EP1507533B1 (de) | 2010-04-14 |
| EA008180B1 (ru) | 2007-04-27 |
| BR0309619A (pt) | 2005-06-28 |
| NO20045276L (no) | 2004-12-01 |
| CA2480756A1 (en) | 2003-12-04 |
| AU2003237302B2 (en) | 2008-03-06 |
| US20050130999A1 (en) | 2005-06-16 |
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