ZA200406940B - Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane as NMDA, 5HT3, and neuronal nicotinic receptor antagonists. - Google Patents

Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane as NMDA, 5HT3, and neuronal nicotinic receptor antagonists. Download PDF

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Publication number
ZA200406940B
ZA200406940B ZA200406940A ZA200406940A ZA200406940B ZA 200406940 B ZA200406940 B ZA 200406940B ZA 200406940 A ZA200406940 A ZA 200406940A ZA 200406940 A ZA200406940 A ZA 200406940A ZA 200406940 B ZA200406940 B ZA 200406940B
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South Africa
Prior art keywords
disease
nmda
mrz
nicotinic receptor
azatricyclic
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ZA200406940A
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English (en)
Inventor
Christopher Graham Rap Parsons
Wojciech Danysz
Valerjans Kauss
Markus Gold
Markus Henrich
Ivars Kalvinsh
Aigars Jirgensons
Maksims Vanejevs
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Merz Pharma Gmbh & Co Kgaa
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Publication of ZA200406940B publication Critical patent/ZA200406940B/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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ZA200406940A 2002-03-21 2004-08-31 Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane as NMDA, 5HT3, and neuronal nicotinic receptor antagonists. ZA200406940B (en)

Applications Claiming Priority (1)

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US36638602P 2002-03-21 2002-03-21

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ZA200406940B true ZA200406940B (en) 2005-09-22

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ZA200406940A ZA200406940B (en) 2002-03-21 2004-08-31 Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane as NMDA, 5HT3, and neuronal nicotinic receptor antagonists.

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Country Link
US (4) US7022729B2 (https=)
EP (1) EP1485086A1 (https=)
JP (1) JP4262606B2 (https=)
KR (1) KR100741257B1 (https=)
CN (1) CN1638762A (https=)
AR (1) AR039008A1 (https=)
AU (1) AU2003216855B2 (https=)
CA (1) CA2474637A1 (https=)
CO (1) CO5611104A2 (https=)
EA (1) EA007098B1 (https=)
GE (1) GEP20063954B (https=)
IL (1) IL164041A0 (https=)
MX (1) MXPA04007755A (https=)
NO (1) NO20044481L (https=)
PL (1) PL372701A1 (https=)
TW (1) TW200306189A (https=)
UA (1) UA77778C2 (https=)
WO (1) WO2003080046A1 (https=)
ZA (1) ZA200406940B (https=)

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ES2483126T3 (es) 2004-06-17 2014-08-05 Merz Pharma Gmbh & Co. Kgaa Formulaciones de formas de dosificación de neramexano
US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
EP2111858A1 (en) 2008-04-25 2009-10-28 EPFL Ecole Polytechnique Fédérale de Lausanne Novel treatment for alzheimer's disease
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
PE20130775A1 (es) * 2010-05-27 2013-07-21 Targacept Inc Antagonistas no competitivos de receptores nicotinicos
RU2014122338A (ru) * 2011-11-03 2015-12-10 Таргасепт, Инк. Неконкурентные модуляторы никотиновых рецепторов
JP6095122B2 (ja) * 2012-01-25 2017-03-15 国立大学法人東北大学 脳機能改善剤
PE20151727A1 (es) 2013-03-14 2015-12-17 Boehringer Ingelheim Int Acido 2-aza-biciclo[2.2.1]heptano-3-carboxilico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c
KR102510588B1 (ko) 2014-09-12 2023-03-17 베링거 인겔하임 인터내셔날 게엠베하 카텝신 c의 스피로사이클릭 억제제

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EA200401230A1 (ru) 2005-02-24
IL164041A0 (en) 2005-12-18
AU2003216855B2 (en) 2005-08-18
JP4262606B2 (ja) 2009-05-13
US7238703B2 (en) 2007-07-03
AR039008A1 (es) 2005-02-02
KR100741257B1 (ko) 2007-07-19
PL372701A1 (en) 2005-07-25
WO2003080046A1 (en) 2003-10-02
AU2003216855A1 (en) 2003-10-08
US20060019983A1 (en) 2006-01-26
UA77778C2 (en) 2007-01-15
KR20040091005A (ko) 2004-10-27
JP2005525385A (ja) 2005-08-25
US20040034055A1 (en) 2004-02-19
CN1638762A (zh) 2005-07-13
US20060019982A1 (en) 2006-01-26
US20070185151A1 (en) 2007-08-09
CO5611104A2 (es) 2006-02-28
EP1485086A1 (en) 2004-12-15
US7022729B2 (en) 2006-04-04
EA007098B1 (ru) 2006-06-30
TW200306189A (en) 2003-11-16
GEP20063954B (en) 2006-10-25
NO20044481L (no) 2004-10-20
CA2474637A1 (en) 2003-10-02
MXPA04007755A (es) 2004-10-15

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