EA200401230A1 - Азабициклические, азатрициклические и азаспироциклические производные аминоциклогексана в качестве антагонистов рецепторов nmda, 5ht и нейронных никотиновых рецепторов - Google Patents

Азабициклические, азатрициклические и азаспироциклические производные аминоциклогексана в качестве антагонистов рецепторов nmda, 5ht и нейронных никотиновых рецепторов

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Publication number
EA200401230A1
EA200401230A1 EA200401230A EA200401230A EA200401230A1 EA 200401230 A1 EA200401230 A1 EA 200401230A1 EA 200401230 A EA200401230 A EA 200401230A EA 200401230 A EA200401230 A EA 200401230A EA 200401230 A1 EA200401230 A1 EA 200401230A1
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EA
Eurasian Patent Office
Prior art keywords
receptors
disorders
azatricyclic
azabicyclic
antagonists
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EA200401230A
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English (en)
Other versions
EA007098B1 (ru
Inventor
Кристофер Грахам Рафаэль Парсонс
Маркус Хенрих
Войцех Даныш
Ивар Калвиньш
Валерьянс Каусс
Айгарс Йиргенсонс
Маркус Гольд
Максимс Ванейевс
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Мерц Фарма Гмбх Унд Ко. Кгаа
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Application filed by Мерц Фарма Гмбх Унд Ко. Кгаа filed Critical Мерц Фарма Гмбх Унд Ко. Кгаа
Publication of EA200401230A1 publication Critical patent/EA200401230A1/ru
Publication of EA007098B1 publication Critical patent/EA007098B1/ru

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Abstract

Предложены азабициклические, азатрициклические и азаспироциклические производные аминоциклогексанов формулы 1 (N, Y, Z, R, R-Rимеют значения, указанные в формуле изобретения), которые являются системно действующими в качестве антагонистов рецепторов NMDA, 5HT и никотиновых рецепторов, фармацевтические композиции, содержащие их, способ их получения и способ лечения нарушений ЦНС, которые включают нарушения глутаматергической, серотонинергической и никотиновой трансмиссии, и лечения иммуномодуляторных нарушений, а также нарушений, которые можно лечить средствами с антималярийной и антитрипаносомной активностью, антивирусной активностью (против вируса Borna), с действием против вируса (простого герпеса HSV) и активностью против вируса гепатита C.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401230A 2002-03-21 2003-03-21 Азабициклические, азатрициклические и азаспироциклические производные аминоциклогексана в качестве антагонистов рецепторов nmda, 5ht и нейронных никотиновых рецепторов EA007098B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36638602P 2002-03-21 2002-03-21
PCT/GB2003/001236 WO2003080046A1 (en) 2002-03-21 2003-03-21 Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane nmda, 5ht3, and neuronal nicotinic receptor antagoni sts

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EA200401230A1 true EA200401230A1 (ru) 2005-02-24
EA007098B1 EA007098B1 (ru) 2006-06-30

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US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
EP2111858A1 (en) 2008-04-25 2009-10-28 EPFL Ecole Polytechnique Fédérale de Lausanne Novel treatment for alzheimer's disease
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
US8809397B2 (en) 2010-05-27 2014-08-19 Targacept, Inc. Nicotinic receptor non-competitive antagonists
MX2014005216A (es) * 2011-11-03 2014-08-22 Targacept Inc Moduladores no competitivos de receptores nicotinicos.
JP6095122B2 (ja) * 2012-01-25 2017-03-15 国立大学法人東北大学 脳機能改善剤
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DK3191487T3 (da) 2014-09-12 2019-10-28 Boehringer Ingelheim Int Spirocykliske cathepsin-c-inhibitorer

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US7238703B2 (en) 2007-07-03
CA2474637A1 (en) 2003-10-02
EP1485086A1 (en) 2004-12-15
KR20040091005A (ko) 2004-10-27
ZA200406940B (en) 2005-09-22
CO5611104A2 (es) 2006-02-28
EA007098B1 (ru) 2006-06-30
US20040034055A1 (en) 2004-02-19
US20060019983A1 (en) 2006-01-26
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US20060019982A1 (en) 2006-01-26
IL164041A0 (en) 2005-12-18
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AR039008A1 (es) 2005-02-02
NO20044481L (no) 2004-10-20
UA77778C2 (en) 2007-01-15
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CN1638762A (zh) 2005-07-13
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