NO20044481L - Azabisykliske, azatrisykliske og azaspirosykliske derivater av aminosykloheksan-NMDA, -5HT3 og neuronale nikotinreseptorantagonister. - Google Patents

Azabisykliske, azatrisykliske og azaspirosykliske derivater av aminosykloheksan-NMDA, -5HT3 og neuronale nikotinreseptorantagonister.

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Publication number
NO20044481L
NO20044481L NO20044481A NO20044481A NO20044481L NO 20044481 L NO20044481 L NO 20044481L NO 20044481 A NO20044481 A NO 20044481A NO 20044481 A NO20044481 A NO 20044481A NO 20044481 L NO20044481 L NO 20044481L
Authority
NO
Norway
Prior art keywords
azabicyclic
nmda
receptor antagonists
azatrocyclic
nicotine receptor
Prior art date
Application number
NO20044481A
Other languages
English (en)
Inventor
Wojciech Danysz
Markus Gold
Ivars Kalvinsh
Valerjans Kauss
Aigars Jirgensons
Christopher Graham Raphael Parsons
Markus Henrich
Maksims Vanejevs
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of NO20044481L publication Critical patent/NO20044481L/no

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

Azabisykliske, azatrisykliske og azaspirosykliske derivater av aminosykloheksaner med formel I (N, Y, Z, R, R-Rsom definert i kravene) som er systemisk aktive som NMDA-, 5HT- og nikotinreseptor-antagonister, farmasøytiske preparater som omfatter det samme, metode for fremstilling derav, og metode for å behandle CNS-lidelser som omfatter forstyrrelser av glutamaterg, serotoninerg og nikotinerg transmisjon, behandle immunomodulerende lidelser, og antimalaria-, antitrypanosomal, anti-Borna-virus-, anti-HSV- og anti-hepatitt C-virus-aktivitet.
NO20044481A 2002-03-21 2004-10-20 Azabisykliske, azatrisykliske og azaspirosykliske derivater av aminosykloheksan-NMDA, -5HT3 og neuronale nikotinreseptorantagonister. NO20044481L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36638602P 2002-03-21 2002-03-21
PCT/GB2003/001236 WO2003080046A1 (en) 2002-03-21 2003-03-21 Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane nmda, 5ht3, and neuronal nicotinic receptor antagoni sts

Publications (1)

Publication Number Publication Date
NO20044481L true NO20044481L (no) 2004-10-20

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NO20044481A NO20044481L (no) 2002-03-21 2004-10-20 Azabisykliske, azatrisykliske og azaspirosykliske derivater av aminosykloheksan-NMDA, -5HT3 og neuronale nikotinreseptorantagonister.

Country Status (19)

Country Link
US (4) US7022729B2 (no)
EP (1) EP1485086A1 (no)
JP (1) JP4262606B2 (no)
KR (1) KR100741257B1 (no)
CN (1) CN1638762A (no)
AR (1) AR039008A1 (no)
AU (1) AU2003216855B2 (no)
CA (1) CA2474637A1 (no)
CO (1) CO5611104A2 (no)
EA (1) EA007098B1 (no)
GE (1) GEP20063954B (no)
IL (1) IL164041A0 (no)
MX (1) MXPA04007755A (no)
NO (1) NO20044481L (no)
PL (1) PL372701A1 (no)
TW (1) TW200306189A (no)
UA (1) UA77778C2 (no)
WO (1) WO2003080046A1 (no)
ZA (1) ZA200406940B (no)

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US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
EP2111858A1 (en) 2008-04-25 2009-10-28 EPFL Ecole Polytechnique Fédérale de Lausanne Novel treatment for alzheimer's disease
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
MX337106B (es) * 2010-05-27 2016-02-12 Targacept Inc Antagonistas no competitivos de receptores nicotinicos.
BR112014010719A2 (pt) * 2011-11-03 2017-05-02 Targacept Inc moduladores não competitivos de receptor nicotínico
EP2808021B1 (en) * 2012-01-25 2017-08-23 Tohoku University Brain function improving agent
ES2845473T3 (es) 2013-03-14 2021-07-26 Boehringer Ingelheim Int (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C
DK3191487T3 (da) 2014-09-12 2019-10-28 Boehringer Ingelheim Int Spirocykliske cathepsin-c-inhibitorer

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US7238703B2 (en) 2007-07-03
WO2003080046A1 (en) 2003-10-02
KR20040091005A (ko) 2004-10-27
CA2474637A1 (en) 2003-10-02
AU2003216855B2 (en) 2005-08-18
GEP20063954B (en) 2006-10-25
EA007098B1 (ru) 2006-06-30
PL372701A1 (en) 2005-07-25
KR100741257B1 (ko) 2007-07-19
EP1485086A1 (en) 2004-12-15
US20040034055A1 (en) 2004-02-19
ZA200406940B (en) 2005-09-22
US20070185151A1 (en) 2007-08-09
CN1638762A (zh) 2005-07-13
TW200306189A (en) 2003-11-16
JP4262606B2 (ja) 2009-05-13
EA200401230A1 (ru) 2005-02-24
US20060019982A1 (en) 2006-01-26
AR039008A1 (es) 2005-02-02
MXPA04007755A (es) 2004-10-15
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IL164041A0 (en) 2005-12-18
US20060019983A1 (en) 2006-01-26
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