PT1255734E - Derivados de isatina com actividade neurotrofica - Google Patents

Derivados de isatina com actividade neurotrofica

Info

Publication number
PT1255734E
PT1255734E PT01946852T PT01946852T PT1255734E PT 1255734 E PT1255734 E PT 1255734E PT 01946852 T PT01946852 T PT 01946852T PT 01946852 T PT01946852 T PT 01946852T PT 1255734 E PT1255734 E PT 1255734E
Authority
PT
Portugal
Prior art keywords
derivatives
isatin
neurotherapic
activity
isatin derivatives
Prior art date
Application number
PT01946852T
Other languages
English (en)
Inventor
Mette Groenborg
Dan Peters
Arne Moeller
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of PT1255734E publication Critical patent/PT1255734E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT01946852T 2000-01-24 2001-01-23 Derivados de isatina com actividade neurotrofica PT1255734E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200000106 2000-01-24

Publications (1)

Publication Number Publication Date
PT1255734E true PT1255734E (pt) 2006-09-29

Family

ID=8158986

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01946852T PT1255734E (pt) 2000-01-24 2001-01-23 Derivados de isatina com actividade neurotrofica

Country Status (12)

Country Link
US (2) US7282511B2 (pt)
EP (2) EP1255734B1 (pt)
JP (1) JP2003520851A (pt)
CN (1) CN1298704C (pt)
AT (1) ATE330941T1 (pt)
AU (1) AU781067B2 (pt)
CA (1) CA2394292A1 (pt)
DE (1) DE60120925T2 (pt)
DK (1) DK1255734T3 (pt)
ES (1) ES2266214T3 (pt)
PT (1) PT1255734E (pt)
WO (1) WO2001055110A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60041399D1 (de) 1999-05-19 2009-03-05 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
WO2002064139A1 (en) * 2001-02-15 2002-08-22 Neurosearch A/S Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
WO2006047299A2 (en) * 2004-10-22 2006-05-04 University Of Florida Research Foundation, Inc. Organotypic slice cultures and uses thereof
EP1957486A4 (en) 2005-11-23 2009-11-11 Painceptor Pharma Corp COMPOSITIONS AND METHODS FOR MODULATION OF IONIC CHANNELS
WO2007115409A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
HUP0600409A3 (en) * 2006-05-15 2008-05-28 Univ Szegedi Izatin and it's derivatives for use as a medicine
US20090246134A1 (en) * 2007-05-30 2009-10-01 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322833A (en) * 1977-05-09 1982-03-30 Micro Display Systems, Inc. Electronic timepiece having conductive face cover for implementing display function
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
EP0089394A1 (en) * 1982-03-23 1983-09-28 Sterling Drug Inc. 1-H-Indole-2,3-dione derivatives and preparation thereof
IE69677B1 (en) 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
JP2550456B2 (ja) * 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
CA2076948C (en) 1991-08-28 2002-04-16 Frank Watjen Isatineoxime derivatives, their preparation and use
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
JPH06228112A (ja) * 1993-02-05 1994-08-16 Yamanouchi Pharmaceut Co Ltd （１ｈ，４ｈ）キノキサリン誘導体
WO1994026747A1 (en) 1993-05-13 1994-11-24 Neurosearch A/S Ampa antagonists and a method of treatment therewith
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
JPH083159A (ja) * 1994-06-17 1996-01-09 Nippon Kayaku Co Ltd ６−（１−ｈ−イミダゾール−１−イル）−７−ニトロ−２，３−（１ｈ，４ｈ）−キノキサリンジオン塩酸塩の製造方法
AU687255B2 (en) * 1994-09-14 1998-02-19 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
US5801174A (en) * 1994-09-14 1998-09-01 Neurosearch A/S Fused indole and quinoxaline derivatives, their preparation and use
CA2199468C (en) * 1994-09-27 2006-06-06 Jun-Ichi Shishikura 1,2,3,4-tetrahydroquinoxalinedione derivative
DE4436852A1 (de) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
TW448171B (en) * 1996-06-06 2001-08-01 Yamanouchi Pharma Co Ltd Imidazole-substituted quinoxalinedione derivatives
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
DE69922936T2 (de) * 1998-03-31 2005-12-08 Neurosearch A/S Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
JP2002519373A (ja) 1998-07-02 2002-07-02 エーザイ株式会社 製薬組成物及びそれらの使用
EP1002535A1 (en) 1998-10-28 2000-05-24 Hrissanthi Ikonomidou New use of glutamate antagonists for the treatment of cancer
ATE285769T1 (de) * 1998-12-04 2005-01-15 Neurosearch As Verwendung von isatinderivaten als ionenkanalaktivierende mittel
DE60041399D1 (de) * 1999-05-19 2009-03-05 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen

Also Published As

Publication number Publication date
WO2001055110A1 (en) 2001-08-02
ATE330941T1 (de) 2006-07-15
ES2266214T3 (es) 2007-03-01
EP1736468A2 (en) 2006-12-27
DE60120925T2 (de) 2006-11-09
CA2394292A1 (en) 2001-08-02
JP2003520851A (ja) 2003-07-08
EP1255734A1 (en) 2002-11-13
US20060229311A1 (en) 2006-10-12
DE60120925D1 (de) 2006-08-03
AU781067B2 (en) 2005-05-05
US7282511B2 (en) 2007-10-16
AU2831201A (en) 2001-08-07
EP1255734B1 (en) 2006-06-21
US7595336B2 (en) 2009-09-29
US20030040518A1 (en) 2003-02-27
CN1298704C (zh) 2007-02-07
CN1395563A (zh) 2003-02-05
DK1255734T3 (da) 2006-10-09
EP1736468A3 (en) 2007-01-03

Similar Documents

Publication Publication Date Title
ATE380029T1 (de) Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke
DE60216830D1 (de) Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen
ATE355374T1 (de) Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
IL173032A0 (en) Pyridazine derivatives and their use as therapeutic agents
PT816376E (pt) Inibidores de trombina como agentes anticoagulantes
IL173396A0 (en) Piperazine derivatives and their use as therapeutic agents
DE60134453D1 (de) Pharmazeutische Zusammensetzungen zur Behandlung von ZNS und anderen Krankheiten
ATE142877T1 (de) Melatoninderivate zur behandlung von schlafstörungen und zur pre-anästhesie
BR0317020A (pt) Derivados de hidroxietilamina para o tratamento de doença de alzheimer
IS6459A (is) Arýl sambrædd azapólýsýklísk efnasambönd
PT1235826E (pt) Acrilamidas de quinuclidina
ATE524169T1 (de) Therapeutische strategien für die prävention und behandlung der alzeheimer-krankheit
IL104154A0 (en) Saccharin derivatives,their preparation and pharmaceutical compositions containing them
DE69731368D1 (de) Mittel zum schutz von nervenzellen
DE60312736D1 (de) 1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
DE69716810D1 (de) 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one
DE69834500D1 (de) Xanthinderivative zur behandlung von hirnischämie
ATE137965T1 (de) Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege
PT1255734E (pt) Derivados de isatina com actividade neurotrofica
NO20010940D0 (no) TAN-1057 derivater
HUP0100611A2 (hu) Triazin vegyületek, és ilyeneket tartalmazó gyógyszerkészítmények a központi idegrendszer elváltozásainak kezelésére
ATE285773T1 (de) Pharmazeutische zusammensetzungen zur behandlung von neurologischen krankheiten
HUP0103712A2 (hu) Paroxetin sók, eljárás az előállításukra és gyógyászati alkalmazásuk
ATE548048T1 (de) Oncomodulin zur behandlung von neurologishen erkrankungen
PT950053E (pt) Novos derivados de benzoilalquil-1,2,3,6-tetra-hidropiridinas