DK1255734T3 - Hidtil ukendte isatin-derivater - Google Patents

Hidtil ukendte isatin-derivater

Info

Publication number
DK1255734T3
DK1255734T3 DK01946852T DK01946852T DK1255734T3 DK 1255734 T3 DK1255734 T3 DK 1255734T3 DK 01946852 T DK01946852 T DK 01946852T DK 01946852 T DK01946852 T DK 01946852T DK 1255734 T3 DK1255734 T3 DK 1255734T3
Authority
DK
Denmark
Prior art keywords
isatin derivatives
derivatives
new
formula
new isatin
Prior art date
Application number
DK01946852T
Other languages
English (en)
Inventor
Mette Groenborg
Dan Peters
Arne Moeller
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of DK1255734T3 publication Critical patent/DK1255734T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DK01946852T 2000-01-24 2001-01-23 Hidtil ukendte isatin-derivater DK1255734T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000106 2000-01-24
PCT/DK2001/000049 WO2001055110A1 (en) 2000-01-24 2001-01-23 Isatine derivatives with neurotrophic activity

Publications (1)

Publication Number Publication Date
DK1255734T3 true DK1255734T3 (da) 2006-10-09

Family

ID=8158986

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01946852T DK1255734T3 (da) 2000-01-24 2001-01-23 Hidtil ukendte isatin-derivater

Country Status (12)

Country Link
US (2) US7282511B2 (da)
EP (2) EP1736468A3 (da)
JP (1) JP2003520851A (da)
CN (1) CN1298704C (da)
AT (1) ATE330941T1 (da)
AU (1) AU781067B2 (da)
CA (1) CA2394292A1 (da)
DE (1) DE60120925T2 (da)
DK (1) DK1255734T3 (da)
ES (1) ES2266214T3 (da)
PT (1) PT1255734E (da)
WO (1) WO2001055110A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2369746A1 (en) * 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1361878A1 (en) * 2001-02-15 2003-11-19 Neurosearch A/S Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
WO2006047299A2 (en) * 2004-10-22 2006-05-04 University Of Florida Research Foundation, Inc. Organotypic slice cultures and uses thereof
AU2006317545B2 (en) 2005-11-23 2012-04-12 Aros Pharma Aps Compositions and methods for modulating gated ion channels
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
HUP0600409A3 (en) * 2006-05-15 2008-05-28 Univ Szegedi Izatin and it's derivatives for use as a medicine
WO2008144931A1 (en) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322833A (en) * 1977-05-09 1982-03-30 Micro Display Systems, Inc. Electronic timepiece having conductive face cover for implementing display function
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
EP0089394A1 (en) 1982-03-23 1983-09-28 Sterling Drug Inc. 1-H-Indole-2,3-dione derivatives and preparation thereof
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
JP2550456B2 (ja) * 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
MX9204914A (es) 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
JPH06228112A (ja) * 1993-02-05 1994-08-16 Yamanouchi Pharmaceut Co Ltd （１ｈ，４ｈ）キノキサリン誘導体
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
CA2161783C (en) * 1993-05-13 2006-08-15 Frank Watjen Ampa antagonists and a method of treatment therewith
JPH083159A (ja) * 1994-06-17 1996-01-09 Nippon Kayaku Co Ltd ６−（１−ｈ−イミダゾール−１−イル）−７−ニトロ−２，３−（１ｈ，４ｈ）−キノキサリンジオン塩酸塩の製造方法
DE69514532T2 (de) * 1994-09-14 2000-07-06 Neurosearch As Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung
NZ293266A (en) * 1994-09-14 1998-01-26 Neurosearch As Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions
ATE209644T1 (de) * 1994-09-27 2001-12-15 Yamanouchi Pharma Co Ltd 1,2,3,4-tetrahydroquinoxalindion derivate und ihre verwendung als glutamat rezeptor antagonisten
DE4436852A1 (de) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE4439492A1 (de) 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
TW448171B (en) 1996-06-06 2001-08-01 Yamanouchi Pharma Co Ltd Imidazole-substituted quinoxalinedione derivatives
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
NZ507259A (en) * 1998-03-31 2003-07-25 Neurosearch As Indole-2,3-dione-3-oxime derivatives for therapeutic use
EP1100504A2 (en) 1998-07-02 2001-05-23 Eisai Co., Ltd. Pharmaceutical compositions and their uses for treatment of demyelinating disorders
EP1002535A1 (en) * 1998-10-28 2000-05-24 Hrissanthi Ikonomidou New use of glutamate antagonists for the treatment of cancer
JP2002531498A (ja) * 1998-12-04 2002-09-24 ニューロサーチ、アクティーゼルスカブ イオンチャネル活性剤としてのイサチン誘導体の使用方法
CA2369746A1 (en) * 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders

Also Published As

Publication number Publication date
US7282511B2 (en) 2007-10-16
PT1255734E (pt) 2006-09-29
EP1255734A1 (en) 2002-11-13
US7595336B2 (en) 2009-09-29
JP2003520851A (ja) 2003-07-08
CN1395563A (zh) 2003-02-05
EP1255734B1 (en) 2006-06-21
EP1736468A3 (en) 2007-01-03
US20030040518A1 (en) 2003-02-27
CN1298704C (zh) 2007-02-07
DE60120925D1 (de) 2006-08-03
WO2001055110A1 (en) 2001-08-02
DE60120925T2 (de) 2006-11-09
EP1736468A2 (en) 2006-12-27
ES2266214T3 (es) 2007-03-01
US20060229311A1 (en) 2006-10-12
CA2394292A1 (en) 2001-08-02
AU781067B2 (en) 2005-05-05
AU2831201A (en) 2001-08-07
ATE330941T1 (de) 2006-07-15

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