ZA200406937B - Derivatives of 4-(imidazol-5-YL)-2-(4-sulfoanilino) pyrimidine with CDK inhibitory activity. - Google Patents
Derivatives of 4-(imidazol-5-YL)-2-(4-sulfoanilino) pyrimidine with CDK inhibitory activity. Download PDFInfo
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- ZA200406937B ZA200406937B ZA200406937A ZA200406937A ZA200406937B ZA 200406937 B ZA200406937 B ZA 200406937B ZA 200406937 A ZA200406937 A ZA 200406937A ZA 200406937 A ZA200406937 A ZA 200406937A ZA 200406937 B ZA200406937 B ZA 200406937B
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- South Africa
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- compound
- formula
- acceptable salt
- pharmaceutically acceptable
- vivo hydrolysable
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- 108009000000 signalling pathways Proteins 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000005505 thiomorpholino group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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CN (1) | CN1649863A (zh) |
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GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
US7442697B2 (en) | 2002-03-09 | 2008-10-28 | Astrazeneca Ab | 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity |
GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
GB0504753D0 (en) * | 2005-03-08 | 2005-04-13 | Astrazeneca Ab | Chemical compounds |
WO2007015064A1 (en) | 2005-07-30 | 2007-02-08 | Astrazeneca Ab | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders |
US7858807B2 (en) * | 2005-08-23 | 2010-12-28 | Ube Industries, Ltd. | Method for producing 1-substituted-5-acylimidazole compound |
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US8378096B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
JP2009510160A (ja) * | 2005-10-03 | 2009-03-12 | アストラゼネカ・アクチエボラーグ | アルツハイマー病を予防および/または治療するための医薬の製造におけるピリミジン誘導体の使用 |
UY29827A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | 2-amina-pirimidina-4-(2-metil-1-(tetrahidro-2h-piran-4-il)-1-imidazol-5-y1) sustituidas y sus derivados, composiciones farmacéuticas que las contienen, procesos para su preparación y aplicaciones |
TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
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2002
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2003
- 2003-03-06 PL PL03372703A patent/PL372703A1/xx not_active Application Discontinuation
- 2003-03-06 WO PCT/GB2003/000983 patent/WO2003076436A1/en not_active Application Discontinuation
- 2003-03-06 EP EP03709965A patent/EP1487823A1/en not_active Ceased
- 2003-03-06 AU AU2003214394A patent/AU2003214394A1/en not_active Abandoned
- 2003-03-06 MX MXPA04008807A patent/MXPA04008807A/es not_active Application Discontinuation
- 2003-03-06 CN CNA038100053A patent/CN1649863A/zh active Pending
- 2003-03-06 JP JP2003574653A patent/JP3569524B1/ja not_active Expired - Fee Related
- 2003-03-06 RU RU2004130440/04A patent/RU2004130440A/ru not_active Application Discontinuation
- 2003-03-06 US US10/507,081 patent/US7465728B2/en not_active Expired - Fee Related
- 2003-03-06 CA CA002478701A patent/CA2478701A1/en not_active Abandoned
- 2003-03-06 IL IL16391003A patent/IL163910A0/xx unknown
- 2003-03-06 KR KR10-2004-7014055A patent/KR20040091114A/ko not_active Application Discontinuation
- 2003-03-06 BR BR0308212-1A patent/BR0308212A/pt not_active IP Right Cessation
- 2003-03-07 AR ARP030100799A patent/AR039563A1/es not_active Application Discontinuation
- 2003-03-07 TW TW092104931A patent/TW200306838A/zh unknown
- 2003-03-07 UY UY27705A patent/UY27705A1/es not_active Application Discontinuation
- 2003-06-03 UA UA20041008095A patent/UA78292C2/uk unknown
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2004
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Also Published As
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IS7439A (is) | 2004-09-07 |
NO20043851L (no) | 2004-09-14 |
RU2004130440A (ru) | 2005-05-10 |
US20050131000A1 (en) | 2005-06-16 |
KR20040091114A (ko) | 2004-10-27 |
GB0205693D0 (en) | 2002-04-24 |
JP2005519135A (ja) | 2005-06-30 |
JP2004256550A (ja) | 2004-09-16 |
BR0308212A (pt) | 2004-12-21 |
WO2003076436A1 (en) | 2003-09-18 |
JP3569524B1 (ja) | 2004-09-22 |
CN1649863A (zh) | 2005-08-03 |
AU2003214394A1 (en) | 2003-09-22 |
MXPA04008807A (es) | 2004-11-26 |
PL372703A1 (en) | 2005-07-25 |
CA2478701A1 (en) | 2003-09-18 |
US7465728B2 (en) | 2008-12-16 |
IL163910A0 (en) | 2005-12-18 |
TW200306838A (en) | 2003-12-01 |
UY27705A1 (es) | 2003-10-31 |
AR039563A1 (es) | 2005-02-23 |
UA78292C2 (en) | 2007-03-15 |
EP1487823A1 (en) | 2004-12-22 |
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