ZA200307792B - Expression technology for proteins containing a hybrid isotype antibody moioety. - Google Patents

Expression technology for proteins containing a hybrid isotype antibody moioety. Download PDF

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Publication number
ZA200307792B
ZA200307792B ZA200307792A ZA200307792A ZA200307792B ZA 200307792 B ZA200307792 B ZA 200307792B ZA 200307792 A ZA200307792 A ZA 200307792A ZA 200307792 A ZA200307792 A ZA 200307792A ZA 200307792 B ZA200307792 B ZA 200307792B
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ZA
South Africa
Prior art keywords
fusion protein
protein
antibody
domain
hinge
Prior art date
Application number
ZA200307792A
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English (en)
Inventor
Stephen D Gillies
Kin-Ming Lo
Jeffrey Way
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Merck Patent Gmbh
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Publication of ZA200307792B publication Critical patent/ZA200307792B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200307792A 2001-03-07 2003-10-06 Expression technology for proteins containing a hybrid isotype antibody moioety. ZA200307792B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27409601P 2001-03-07 2001-03-07

Publications (1)

Publication Number Publication Date
ZA200307792B true ZA200307792B (en) 2004-07-06

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Family Applications (1)

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ZA200307792A ZA200307792B (en) 2001-03-07 2003-10-06 Expression technology for proteins containing a hybrid isotype antibody moioety.

Country Status (17)

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US (2) US7148321B2 (fr)
EP (1) EP1366067B1 (fr)
JP (1) JP4234438B2 (fr)
KR (2) KR20090010127A (fr)
CN (1) CN1330664C (fr)
AU (1) AU2002248571B2 (fr)
BR (1) BR0207854A (fr)
CA (1) CA2440221C (fr)
DK (1) DK1366067T3 (fr)
ES (1) ES2393733T3 (fr)
HU (1) HUP0303428A2 (fr)
MX (1) MXPA03008031A (fr)
PL (1) PL206701B1 (fr)
PT (1) PT1366067E (fr)
RU (1) RU2003129528A (fr)
WO (1) WO2002072605A2 (fr)
ZA (1) ZA200307792B (fr)

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CA2440221C (fr) 2013-02-05
CN1509293A (zh) 2004-06-30
RU2003129528A (ru) 2005-04-10
HUP0303428A2 (hu) 2004-01-28
DK1366067T3 (da) 2012-10-22
US20060263856A1 (en) 2006-11-23
KR100900176B1 (ko) 2009-06-02
MXPA03008031A (es) 2003-12-04
AU2002248571B2 (en) 2007-01-18
EP1366067A2 (fr) 2003-12-03
KR20030092015A (ko) 2003-12-03
EP1366067B1 (fr) 2012-09-26
PL206701B1 (pl) 2010-09-30
CA2440221A1 (fr) 2002-09-19
WO2002072605A2 (fr) 2002-09-19
PL366981A1 (en) 2005-02-07
BR0207854A (pt) 2004-08-24
ES2393733T3 (es) 2012-12-27
PT1366067E (pt) 2012-11-29
CN1330664C (zh) 2007-08-08
US7148321B2 (en) 2006-12-12
KR20090010127A (ko) 2009-01-28
US8066994B2 (en) 2011-11-29
JP2004525630A (ja) 2004-08-26
US20030044423A1 (en) 2003-03-06
EP1366067A4 (fr) 2005-07-20
JP4234438B2 (ja) 2009-03-04
WO2002072605A3 (fr) 2002-11-14

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