ZA200306721B - Aryl and heteroaryl urea CHK1 inhibitors for use as radiosensitizers and chemosensitizers. - Google Patents

Aryl and heteroaryl urea CHK1 inhibitors for use as radiosensitizers and chemosensitizers. Download PDF

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ZA200306721B
ZA200306721B ZA200306721A ZA200306721A ZA200306721B ZA 200306721 B ZA200306721 B ZA 200306721B ZA 200306721 A ZA200306721 A ZA 200306721A ZA 200306721 A ZA200306721 A ZA 200306721A ZA 200306721 B ZA200306721 B ZA 200306721B
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South Africa
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group
alkyl
aryl
alkylenen
hydro
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ZA200306721A
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English (en)
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Kathleen S Keegan
Edward A Kesicki
John Joseph Gaudino
Adam Wade Cook
Cowen Scott Douglass
Laurence Edward Burgess
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Icos Corp
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Publication of ZA200306721B publication Critical patent/ZA200306721B/en

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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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NO326776B1 (no) 2009-02-16
CN100374425C (zh) 2008-03-12
US20030069284A1 (en) 2003-04-10
US20050245525A1 (en) 2005-11-03
CN1507436A (zh) 2004-06-23
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UA76977C2 (en) 2006-10-16
US7067506B2 (en) 2006-06-27
JP2004523568A (ja) 2004-08-05
US20100105683A1 (en) 2010-04-29
RS52077B (sr) 2012-06-30
IS6935A (is) 2003-08-29
BR0207811A (pt) 2005-02-01
HRP20030688A2 (en) 2005-10-31
MXPA03007920A (es) 2003-12-04

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