PL364564A1 - Arylomocznikowe i heteroarylomocznikowe inhibitory Chk1 przeznaczone do użycia jako sensybilizatoryradioterapeutyczne i sensybilizatory chemioterapeutyczne - Google Patents

Arylomocznikowe i heteroarylomocznikowe inhibitory Chk1 przeznaczone do użycia jako sensybilizatoryradioterapeutyczne i sensybilizatory chemioterapeutyczne

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Publication number
PL364564A1
PL364564A1 PL02364564A PL36456402A PL364564A1 PL 364564 A1 PL364564 A1 PL 364564A1 PL 02364564 A PL02364564 A PL 02364564A PL 36456402 A PL36456402 A PL 36456402A PL 364564 A1 PL364564 A1 PL 364564A1
Authority
PL
Poland
Prior art keywords
aryl
chamosensitizers
radiosensitizers
chk1 inhibitors
heteroaryl
Prior art date
Application number
PL02364564A
Other languages
English (en)
Other versions
PL212707B1 (pl
Inventor
Kathleen S. Keegan
Edward A. Kesicki
John Joseph Gaudino
Adam Wade Cook
Scott Douglas Cowen
Laurence Edward Burgess
Original Assignee
Icos Corporation
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Filing date
Publication date
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of PL364564A1 publication Critical patent/PL364564A1/pl
Publication of PL212707B1 publication Critical patent/PL212707B1/pl

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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US7608618B2 (en) 2009-10-27
ATE511503T1 (de) 2011-06-15
PT1379510E (pt) 2011-07-15
NO326776B1 (no) 2009-02-16
CN100374425C (zh) 2008-03-12
US20030069284A1 (en) 2003-04-10
US20050245525A1 (en) 2005-11-03
CN1507436A (zh) 2004-06-23
KR100861829B1 (ko) 2008-10-07
NZ527787A (en) 2005-12-23
YU69003A (sh) 2006-05-25
IL157563A0 (en) 2004-03-28
DK1379510T3 (da) 2011-08-29
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HK1062438A1 (en) 2004-11-05
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NO20033858L (no) 2003-10-10
ZA200306721B (en) 2004-05-03
HRP20030688B1 (hr) 2013-12-06
JP4222833B2 (ja) 2009-02-12
CA2439709A1 (en) 2002-09-12
EA200300947A1 (ru) 2004-04-29
CA2439709C (en) 2011-05-03
NO20033858D0 (no) 2003-09-01
EP1379510B1 (en) 2011-06-01
WO2002070494A1 (en) 2002-09-12
KR20080046228A (ko) 2008-05-26
EP1379510A1 (en) 2004-01-14
AU2002258451B2 (en) 2006-08-31
UA76977C2 (en) 2006-10-16
US7067506B2 (en) 2006-06-27
JP2004523568A (ja) 2004-08-05
US20100105683A1 (en) 2010-04-29
RS52077B (sr) 2012-06-30
IS6935A (is) 2003-08-29
BR0207811A (pt) 2005-02-01
HRP20030688A2 (en) 2005-10-31
MXPA03007920A (es) 2003-12-04

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