EA200300947A1 - Арил и гетероарил мочевины в качестве ингибиторов chk1 для использования в качестве радиосенсибилизаторов и химиосенсибилизаторов - Google Patents

Арил и гетероарил мочевины в качестве ингибиторов chk1 для использования в качестве радиосенсибилизаторов и химиосенсибилизаторов

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Publication number
EA200300947A1
EA200300947A1 EA200300947A EA200300947A EA200300947A1 EA 200300947 A1 EA200300947 A1 EA 200300947A1 EA 200300947 A EA200300947 A EA 200300947A EA 200300947 A EA200300947 A EA 200300947A EA 200300947 A1 EA200300947 A1 EA 200300947A1
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EA
Eurasian Patent Office
Prior art keywords
sensitivers
aryl
chk1
inhibitors
radio
Prior art date
Application number
EA200300947A
Other languages
English (en)
Other versions
EA014954B1 (ru
Inventor
Джон Джозеф Годино
Эдвард А. Кесицки
Скотт Даглас Кауэн
Лоренс Эдуард Бэрджесс
Original Assignee
Айкос Корпорейшн
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Publication date
Application filed by Айкос Корпорейшн filed Critical Айкос Корпорейшн
Publication of EA200300947A1 publication Critical patent/EA200300947A1/ru
Publication of EA014954B1 publication Critical patent/EA014954B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Настоящее изобретение относится к сильнодействующим и селективным химиосенсибилизирующим агентам, полезным при лечении заболеваний и состояний, относящихся к повреждению ДНК или повреждениям в репликации ДНК. Настоящие соединения являются ингибиторами киназы точки контроля Chk1. Конкретно, арил- и гетероарилзамещенные производные мочевины демонстрируют значительную активность в ингибировании Chk1.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300947A 2001-03-02 2002-03-01 Арил и гетероарил мочевины в качестве ингибиторов chk1 для использования в качестве радиосенсибилизаторов и химиосенсибилизаторов EA014954B1 (ru)

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US20100105683A1 (en) 2010-04-29
IS6935A (is) 2003-08-29
NO20033858L (no) 2003-10-10
YU69003A (sh) 2006-05-25
HRP20030688B1 (hr) 2013-12-06
AU2002258451B2 (en) 2006-08-31
KR100861829B1 (ko) 2008-10-07
US7608618B2 (en) 2009-10-27
NZ527787A (en) 2005-12-23
GEP20053659B (en) 2005-11-10
NO326776B1 (no) 2009-02-16
HK1062438A1 (en) 2004-11-05
DK1379510T3 (da) 2011-08-29
CY1111590T1 (el) 2015-10-07
ATE511503T1 (de) 2011-06-15
US20030069284A1 (en) 2003-04-10
EP1379510A1 (en) 2004-01-14
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PT1379510E (pt) 2011-07-15
ZA200306721B (en) 2004-05-03
CA2439709C (en) 2011-05-03
KR20080046228A (ko) 2008-05-26
NO20033858D0 (no) 2003-09-01
CN1507436A (zh) 2004-06-23
RS52077B (sr) 2012-06-30
CN100374425C (zh) 2008-03-12
JP2004523568A (ja) 2004-08-05
EA014954B1 (ru) 2011-04-29
IL157563A0 (en) 2004-03-28
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