ZA200206077B - Adenosine receptor modulators. - Google Patents

Adenosine receptor modulators. Download PDF

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Publication number
ZA200206077B
ZA200206077B ZA200206077A ZA200206077A ZA200206077B ZA 200206077 B ZA200206077 B ZA 200206077B ZA 200206077 A ZA200206077 A ZA 200206077A ZA 200206077 A ZA200206077 A ZA 200206077A ZA 200206077 B ZA200206077 B ZA 200206077B
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South Africa
Prior art keywords
amino
furan
pyrimidine
carbonitrile
pyridin
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ZA200206077A
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English (en)
Inventor
Edilio Maurizio Borroni
Gavin John Kilpatrick
Gerda Hubert-Trottmann
Roger David Norcross
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Hoffmann La Roche
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Publication of ZA200206077B publication Critical patent/ZA200206077B/en

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Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110075507A1 (en) * 1997-10-24 2011-03-31 Revalesio Corporation Diffuser/emulsifier
US6702949B2 (en) 1997-10-24 2004-03-09 Microdiffusion, Inc. Diffuser/emulsifier for aquaculture applications
AR023052A1 (es) * 1998-09-25 2002-09-04 Mitsuharu Yoshimura Milton Derivados de pirimidona
BR0113148A (pt) * 2000-08-08 2003-07-08 Ortho Mcneil Pharm Inc Composições de 2-piridinamina e métodos relacionados
GB0100620D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
DE10110438A1 (de) * 2001-03-05 2002-09-19 Bayer Ag Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10110747A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung
DE10110754A1 (de) * 2001-03-07 2002-09-19 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115945A1 (de) * 2001-03-30 2002-10-02 Bayer Ag Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115922A1 (de) * 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
US7160899B2 (en) 2001-04-09 2007-01-09 Neurosearch A/S Adenosine A2A receptor antangonists combined with neurotrophic activity compounds in the treatment of Parkinson's disease
US6903109B2 (en) 2001-04-18 2005-06-07 Ortho-Muniel Pharmaceutical, Inc. Arylindenopyridines and related therapeutic and prophylactic methods
US6958328B2 (en) 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods
WO2003037888A1 (fr) * 2001-09-21 2003-05-08 Mitsubishi Pharma Corporation Derives de 3-substitue-4-pyrimidone
JP4368682B2 (ja) * 2001-09-21 2009-11-18 田辺三菱製薬株式会社 3−置換−4−ピリミドン誘導体
TWI330183B (fr) * 2001-10-22 2010-09-11 Eisai R&D Man Co Ltd
CA2473864C (fr) 2002-01-28 2013-06-11 Kyowa Hakko Kogyo Co., Ltd. Composition de traitement des patients souffrant de troubles moteurs
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
US20040127510A1 (en) 2002-04-16 2004-07-01 Heintzelman Geoffrey R. Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
AR040456A1 (es) 2002-06-27 2005-04-06 Bristol Myers Squibb Co Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana
GB0215844D0 (en) 2002-07-09 2002-08-14 Novartis Ag Organic compounds
CA2492342C (fr) * 2002-07-22 2011-03-22 Orchid Chemicals & Pharmaceuticals Ltd. Nouveaux derives bioactifs de la pyrimidine
AU2002950853A0 (en) * 2002-08-19 2002-09-12 Fujisawa Pharmaceutical Co., Ltd. Aminopyrimidine compound and pharmaceutical use thereof
ATE325115T1 (de) 2002-08-19 2006-06-15 Glaxo Group Ltd Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
JP4688498B2 (ja) * 2002-11-04 2011-05-25 バーテックス ファーマシューティカルズ インコーポレイテッド Jakインヒビターとしてのヘテロアリール−ピリミジン誘導体
ZA200505258B (en) * 2002-12-16 2006-09-27 Mitsubishi Pharma Corp 3-Substituted-4-pyrimidone derivatives
UA92450C2 (ru) * 2003-01-14 2010-11-10 Арена Фармасьютикалз, Инк. 1,2,3-тризамещенные арильные и гетероарильные производные как модуляторы метаболизма, профилактика и лечение расстройств, связанных с ним, таких как диабет и гипергликемия
CN102558155A (zh) * 2003-01-14 2012-07-11 阿伦纳药品公司 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
SI1599468T1 (sl) * 2003-01-14 2008-02-29 Arena Pharm Inc 1,2,3-trisubstituirani arilni in heteroarilni derivati kot modulatorji metabolizma ter profilaksa in zdravljenje motenj v zvezi z njim, kot diabetesain hiperglikemije
TWI357408B (en) * 2003-03-26 2012-02-01 Mitsubishi Tanabe Pharma Corp 3-substituted-4-pyrimidone derivatives
EP1615931A1 (fr) 2003-04-09 2006-01-18 Biogen Idec MA Inc. Triazolopyrazines et procedes de preparation et d'utilisation ce celles-ci
EP1615930A2 (fr) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Triazolotriazines et pyrazolotriazines et leurs procedes de fabrication et d'utilisation
ATE418555T1 (de) 2003-04-09 2009-01-15 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
EP1505064A1 (fr) * 2003-08-05 2005-02-09 Bayer HealthCare AG Dérivés de 2-aminopyrimidine
GB0323137D0 (en) * 2003-10-03 2003-11-05 Chang Lisa C W 2,4,6- Trisubstituted pyrimidines and their different uses
GB0323138D0 (en) * 2003-10-03 2003-11-05 Chang Lisa C W Pyrimidines substituted in the 2,4,6 positions and their different uses
DE60327375D1 (de) * 2003-10-03 2009-06-04 Ortho Mcneil Pharm Inc Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten
WO2005037199A2 (fr) 2003-10-10 2005-04-28 Bristol-Myers Squibb Company Derives de pyrazole utilises comme modulateurs du recepteur de cannabinoide
EP1689722A2 (fr) 2003-10-10 2006-08-16 Bayer Pharmaceuticals Corporation Derives de pyrimidine dans le traitement de troubles hyperproliferatifs
US20070099938A1 (en) * 2003-10-24 2007-05-03 Ono Pharmaceutical Co., Ltd. Antistress drug and medical use thereof
CA2543644A1 (fr) * 2003-10-27 2005-05-06 Astellas Pharma Inc. Derives de pyrazine et utilisation pharmaceutique de ce derive
WO2005054239A1 (fr) * 2003-12-05 2005-06-16 Bayer Healthcare Ag Derives de 2-aminopyrimidine
EA010568B1 (ru) * 2003-12-15 2008-10-30 Ньюрокрайн Байосайнсиз Инк. 2,6-бисгетероарил-4-аминопиримидины в качестве антагонистов аденозиновых рецепторов
WO2005060969A1 (fr) * 2003-12-24 2005-07-07 Astrazeneca Ab Pyrimidines a activite tie2 (tek)
RU2006138036A (ru) 2004-03-30 2008-05-10 Чирон Корпорейшн (Us) Производные замещенного тиофена в качестве противораковых средств
JP4794200B2 (ja) * 2004-04-30 2011-10-19 大塚製薬株式会社 4−アミノ−5−シアノピリミジン誘導体
GB0416168D0 (en) * 2004-07-20 2004-08-18 Vernalis Cambridge Ltd Pyrmidothiophene compounds
DE102004042607A1 (de) * 2004-09-03 2006-03-09 Bayer Healthcare Ag Substituierte Phenylaminothiazole und ihre Verwendung
MX2007003318A (es) 2004-09-20 2007-05-18 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
US7767677B2 (en) 2004-09-20 2010-08-03 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
AR051094A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
JP4958785B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体およびステアロイル−CoAデサチュラーゼインヒビターとしてのそれらの使用
CA2581623A1 (fr) 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Composes a base de pyridine, leur procede de preparation et compositions les contenant
WO2006041404A1 (fr) * 2004-10-15 2006-04-20 Astrazeneca Ab Composes amino substitues et utilisation de ces compose
EP1802588A4 (fr) * 2004-10-15 2010-02-17 Astrazeneca Ab Amino-pyrimidones substitues et utilisation de ceux-ci
EP1824828A2 (fr) * 2004-12-03 2007-08-29 Peakdale Molecular Limited Derives de pyridine utiles comme intermediaires pour des produits pharmaceutiques ou agrochimiques
DE602006020864D1 (de) * 2005-04-11 2011-05-05 Almirall Sa 2, 6-di-(hetero-)aryl-4-amido-pyrimidine als adenosin-rezeptor-antagonisten
US20070078135A1 (en) * 2005-04-18 2007-04-05 Neurogen Corporation Substituted heteroaryl CB1 antagonists
WO2007130075A1 (fr) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Derives aminothiazole utilises en tant qu'inhibiteurs de la stearoyle-coa desaturase humaine
ES2270715B1 (es) 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
ES2274712B1 (es) 2005-10-06 2008-03-01 Laboratorios Almirall S.A. Nuevos derivados imidazopiridina.
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
CN101360720A (zh) * 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
WO2007058581A1 (fr) * 2005-11-15 2007-05-24 Astrazeneca Ab Nouveaux derives de 2-aminopyrimidine derivatives et leur utilisation
DE102006008880A1 (de) * 2006-02-27 2007-09-06 Merck Patent Gmbh Aminopyrimidinderivate
EP1989210A2 (fr) * 2006-03-02 2008-11-12 Cv Therapeutics, Inc. Antagonistes du recepteur a2a de l'adenosine
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途
AR061185A1 (es) 2006-05-26 2008-08-13 Chugai Pharmaceutical Co Ltd Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
ATE528292T1 (de) 2006-06-20 2011-10-15 Ishihara Sangyo Kaisha Schädlingsbekämpfungsmittel mit neuem pyridyl- methanamin-derivat oder salz daraus
DE102006042143A1 (de) * 2006-09-08 2008-03-27 Bayer Healthcare Aktiengesellschaft Neue substituierte Bipyridin-Derivate und ihre Verwendung
DE102006044696A1 (de) 2006-09-22 2008-03-27 Bayer Healthcare Ag 3-Cyano-5-thiazaheteroaryl-dihydropyridine und ihre Verwendung
US7985745B2 (en) * 2006-10-02 2011-07-26 Abbott Laboratories Method for pain treatment
US8784897B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of therapeutic treatment of eyes
US8445546B2 (en) 2006-10-25 2013-05-21 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
WO2008052143A2 (fr) 2006-10-25 2008-05-02 Revalesio Corporation Dispositif de mélange et ses fluides de sortie
EP2083876A4 (fr) 2006-10-25 2012-09-19 Revalesio Corp Méthodes de soins et de traitement de plaies
US8597689B2 (en) 2006-10-25 2013-12-03 Revalesio Corporation Methods of wound care and treatment
DE102006056739A1 (de) 2006-12-01 2008-06-05 Bayer Healthcare Ag Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung
DE102006056740A1 (de) * 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung
CN101679371A (zh) * 2006-12-04 2010-03-24 艾美罗股份公司 作为腺苷受体拮抗剂的取代的嘧啶
BRPI0720003A2 (pt) * 2006-12-08 2018-09-18 Hoffmann La Roche pirimidinas substituídas e seu uso como moduladores de jnk
CL2008000467A1 (es) 2007-02-14 2008-08-22 Janssen Pharmaceutica Nv Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma
US20080217501A1 (en) * 2007-02-14 2008-09-11 Chad Jensen Power a-frame
PE20090110A1 (es) 2007-03-01 2009-04-04 Chugai Pharmaceutical Co Ltd Compuestos macrociclicos derivados de amina como agentes inhibidores de hsp90
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
CN101679264A (zh) 2007-03-16 2010-03-24 斯克里普斯研究学院 粘着斑激酶抑制剂
WO2008116185A2 (fr) * 2007-03-21 2008-09-25 Neurocrine Biosciences, Inc. Pyrimidines substituées utilisées comme antagonistes des récepteurs de l'adénosine
EP2173722B1 (fr) * 2007-07-26 2012-08-29 Novartis AG Dérivés de pyrimidines pour le traitement de maladies inflammmatoires et allergiques
DE102007035367A1 (de) 2007-07-27 2009-01-29 Bayer Healthcare Ag Substituierte Aryloxazole und ihre Verwendung
DE102007036076A1 (de) 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
AU2008297876B2 (en) 2007-09-14 2011-07-07 Addex Pharma S.A. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
ATE496906T1 (de) 2007-09-14 2011-02-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyri inyl-2'-one
CA2698929C (fr) * 2007-09-14 2016-01-19 Addex Pharma S.A. 4-phenyle-1h-pyridine-2-ones 1,3-disubstituees
CN101889004B (zh) 2007-10-12 2014-09-10 阿斯利康公司 蛋白激酶抑制剂
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US9745567B2 (en) 2008-04-28 2017-08-29 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US20090263495A1 (en) * 2007-10-25 2009-10-22 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
CA2703648A1 (fr) * 2007-10-25 2009-04-30 Revalesio Corporation Compositions bacteriostatiques ou bacteriocides et procedes
CN101861316B (zh) 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
DE102007061764A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellierte Cyanopyridine und ihre Verwendung
DE102007061763A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte azabicyclische Verbindungen und ihre Verwendung
DE102008008838A1 (de) 2008-02-13 2009-08-20 Bayer Healthcare Ag Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung
EP2274007B1 (fr) * 2008-03-10 2016-12-14 Cornell University Modulation de la perméabilité d'une barrière hématoencéphalique
DE102008013587A1 (de) 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung
CN102076327B (zh) 2008-05-01 2014-04-16 利发利希奥公司 治疗消化功能紊乱的组合物和方法
EP2297104B1 (fr) * 2008-05-29 2013-08-07 Bayer Intellectual Property GmbH Dicyanopyridines substituées par du 2-alcoxy et leur utilisation
TW201010984A (en) * 2008-07-29 2010-03-16 Boehringer Ingelheim Int 5-alkynyl-pyrimidines
CA2735764C (fr) 2008-09-02 2016-06-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Derives de 3-azabicyclo[3.1.0]hexyle comme modulateurs des recepteurs metabotropiques du glutamate
US20100093714A1 (en) * 2008-10-13 2010-04-15 Devraj Chakravarty AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
RS53075B (en) 2009-05-12 2014-04-30 Janssen Pharmaceuticals Inc. 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
CA2760259C (fr) 2009-05-12 2018-05-01 Janssen Pharmaceuticals, Inc. Derives de la 1,2,4-triazolo [4,3-a] pyridine et leur utilisation en tant que modulateurs allosteriques positifs des recepteurs mglur2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
WO2011075616A1 (fr) 2009-12-18 2011-06-23 Temple University - Of The Commonwealth System Of Higher Education Pyrido[2,3-d]pyrimidin-7(8h)-ones substitués et leurs utilisations thérapeuthiques
UY33199A (es) 2010-01-26 2011-08-31 Boehringer Ingelheim Int 5-alquinil-pirimidinas.
AU2011226073B2 (en) 2010-03-10 2015-05-28 Astrazeneca Ab 4-Phenyl pyridine analogues as protein kinase inhibitors.
ES2365960B1 (es) * 2010-03-31 2012-06-04 Palobiofarma, S.L Nuevos antagonistas de los receptores de adenosina.
EA201201527A1 (ru) 2010-05-07 2013-12-30 Ревалезио Корпорейшн Композиции и способы повышения физиологической производительности и времени восстановления
JP5951600B2 (ja) 2010-05-21 2016-07-13 インフィニティー ファーマシューティカルズ, インコーポレイテッド キナーゼ調節のための、化合物、組成物および方法
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US9290485B2 (en) 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
DK2600719T3 (da) * 2010-08-05 2014-12-15 Univ Temple 2-substituerede 8-alkyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-carbonnitriler og anvendelser deraf
CN103347500A (zh) 2010-08-12 2013-10-09 利发利希奥公司 用于治疗tau蛋白病的组合物和方法
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
US10894787B2 (en) 2010-09-22 2021-01-19 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
CA2816957A1 (fr) 2010-11-07 2012-05-10 Targegen, Inc. Compositions et procedes de traitement de la myelofibrose
EP2661435B1 (fr) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. Dérivés 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
EP2643320B1 (fr) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. Dérivés de la 1,2,4-triazolo [4,3-a] pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2
CZ305457B6 (cs) * 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
CN103635472B (zh) 2011-02-28 2018-01-12 阵列生物制药公司 丝氨酸/苏氨酸激酶抑制剂
WO2013020062A1 (fr) 2011-08-04 2013-02-07 Array Biopharma Inc. Composés de quinazoline utiles en tant qu'inhibiteurs de la sérine/thréonine kinase
TW201311663A (zh) 2011-08-29 2013-03-16 Infinity Pharmaceuticals Inc 雜環化合物及其用途
CA2864085C (fr) 2012-02-08 2021-11-23 Sunovion Pharmaceuticals Inc. Composes heteroaryles et procede d'utilisation correspondant
CN106349217B (zh) 2012-03-01 2020-08-28 阵列生物制药公司 丝氨酸/苏氨酸激酶抑制剂
WO2013144191A1 (fr) 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh 2-amino-3-cyanopyridines substituées utilisées comme inhibiteurs de l'échange sodium-calcium et leurs utilisations dans le cas de maladies cardiovasculaires
EP2888247B1 (fr) 2012-08-27 2020-03-25 Array Biopharma, Inc. Inhibiteurs de sérine/thréonine kinase pour le traitement de maladies hyperprolifératives
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
CN103819400B (zh) * 2013-09-16 2016-05-04 江西师范大学 一种多组分反应合成具有不对称结构1.4-二氢吡啶及其衍生物的方法
JP2017504562A (ja) * 2013-12-19 2017-02-09 アーチャー−ダニエルズ−ミッドランド カンパニー フラン−2,5−ジメタノールおよび(テトラヒドロフラン−2,5−ジイル)ジメタノールのスルホネートとその誘導体
CN109999033B (zh) 2014-01-21 2022-12-23 詹森药业有限公司 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途
KR20200126026A (ko) 2014-01-21 2020-11-05 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
KR20230151072A (ko) 2015-01-06 2023-10-31 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 상태의 치료 방법
AU2016220153B2 (en) * 2015-02-17 2020-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
JP6807337B2 (ja) 2015-02-17 2021-01-06 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ ミトコンドリア治療剤としてのフェノチアジン類似体
HUE060476T2 (hu) 2015-06-22 2023-03-28 Arena Pharm Inc (R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra
EP3483142A1 (fr) * 2016-07-05 2019-05-15 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Composé d'acétylène aromatique ou d'éthylène aromatique, produit intermédiaire, procédé de préparation, composition pharmaceutique et leur utilisation
BR112019001439A8 (pt) 2016-07-29 2019-11-12 Pgi Drug Discovery Llc compostos e composições e usos dos mesmos
KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
US11390605B2 (en) 2016-08-25 2022-07-19 Arizona Board Of Regents On Behalf Of Arizona State University Substituted pyrimidine compounds as multifunctional radical quenchers and their uses
CN106632076B (zh) * 2016-09-20 2019-04-30 中国药科大学 4,6-二苯基嘧啶类化合物、其制备方法和医药用途
EP3582772A1 (fr) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Composés et méthodes de traitement de l'angiocholite biliaire primitive
US10172856B2 (en) 2017-04-06 2019-01-08 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives as histamine H4 modulators
JOP20190279A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag الصور البلورية من 5-برومو -2، 6-داي (1h-بيرازول -1-يل) بيريميدين -4- أمين وأملاح جديدة
WO2019028165A1 (fr) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. Composés d'isochromane et leurs utilisations
WO2019072143A1 (fr) * 2017-10-11 2019-04-18 上海迪诺医药科技有限公司 Dérivé de 4-aminopyridine, composition pharmaceutique contenant celui-ci, procédé de préparation associé et utilisation correspondante
EP3733659B1 (fr) 2017-12-29 2023-12-20 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Dérivé de vinyle aromatique ou d'éthyle aromatique, procédé de préparation associé, intermédiaire, composition pharmaceutique et application
CN110240593A (zh) * 2018-03-09 2019-09-17 四川科伦博泰生物医药股份有限公司 取代芳胺化合物及其制备方法和用途
CN113874015B (zh) 2018-12-21 2024-05-24 细胞基因公司 Ripk2的噻吩并吡啶抑制剂
WO2020135195A1 (fr) 2018-12-28 2020-07-02 四川科伦博泰生物医药股份有限公司 Composé aminopyridine, son procédé de préparation et son utilisation
EP3904352A4 (fr) * 2018-12-28 2022-09-07 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Composé aryle substitué, procédé de préparation correspondant et utilisation associée
CN111377873B (zh) * 2018-12-28 2023-03-28 四川科伦博泰生物医药股份有限公司 氨基嘧啶化合物及其制备方法和用途
AU2020236225A1 (en) 2019-03-14 2021-09-16 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
JP2022550394A (ja) * 2019-09-30 2022-12-01 エフ.ホフマン-ラ ロシュ アーゲー B型肝炎ウイルス感染症の処置および予防のための置換ピリミジン
US11986465B1 (en) 2023-11-09 2024-05-21 King Faisal University 2-amino-4-(4-bromophenyl)-6-ethoxypyridine-3,5-dicarbonitrile as an antibacterial compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996228A (en) 1973-12-21 1976-12-07 Societa' Farmaceutici Italia S.P.A. Pyrimidinoaminoethyl ergoline derivatives
GB9125001D0 (en) * 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
JPH08134044A (ja) * 1994-11-09 1996-05-28 Nippon Shoji Kk 新規ピリミジン化合物、中間体及びそれらの製造法
US5514505A (en) * 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
JPH09301958A (ja) * 1996-05-09 1997-11-25 Nippon Shoji Kk 新規ピリミジン化合物及び抗ロタウイルス剤
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
US5952331A (en) * 1996-05-23 1999-09-14 Syntex (Usa) Inc. Aryl pyrimidine derivatives
US5958934A (en) * 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
JPH11158073A (ja) * 1997-09-26 1999-06-15 Takeda Chem Ind Ltd アデノシンa3拮抗剤
CN1297447A (zh) * 1998-02-17 2001-05-30 图拉列克股份有限公司 抗病毒嘧啶衍生物

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