ZA200104656B - Aromatic heterocyclic compounds as antiinflammatory agents. - Google Patents
Aromatic heterocyclic compounds as antiinflammatory agents. Download PDFInfo
- Publication number
- ZA200104656B ZA200104656B ZA200104656A ZA200104656A ZA200104656B ZA 200104656 B ZA200104656 B ZA 200104656B ZA 200104656 A ZA200104656 A ZA 200104656A ZA 200104656 A ZA200104656 A ZA 200104656A ZA 200104656 B ZA200104656 B ZA 200104656B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazol
- urea
- naphthalen
- butyl
- tert
- Prior art date
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- 125000006615 aromatic heterocyclic group Chemical group 0.000 title description 3
- 239000002260 anti-inflammatory agent Substances 0.000 title description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title description 2
- 239000004202 carbamide Substances 0.000 claims description 136
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 93
- 125000000217 alkyl group Chemical group 0.000 claims description 89
- -1 thiomorpholine sulfoxide Chemical class 0.000 claims description 69
- 150000001875 compounds Chemical class 0.000 claims description 43
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
- 125000000623 heterocyclic group Chemical group 0.000 claims description 32
- 125000001624 naphthyl group Chemical group 0.000 claims description 26
- 125000003545 alkoxy group Chemical group 0.000 claims description 24
- 125000005843 halogen group Chemical group 0.000 claims description 21
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- 229910052799 carbon Inorganic materials 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 14
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- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 claims description 2
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- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- 1999-09-12 UA UA2001085812A patent/UA73492C2/uk unknown
- 1999-12-09 EP EP99960668A patent/EP1147104B1/en not_active Expired - Lifetime
- 1999-12-09 IL IL14339499A patent/IL143394A0/xx unknown
- 1999-12-09 CN CN99815702A patent/CN1333767A/zh active Pending
- 1999-12-09 AT AT99960668T patent/ATE549328T1/de active
- 1999-12-09 EE EEP200100376A patent/EE04527B1/xx not_active IP Right Cessation
- 1999-12-09 MX MXPA01005628A patent/MXPA01005628A/es unknown
- 1999-12-09 YU YU39101A patent/YU39101A/sh unknown
- 1999-12-09 CZ CZ20012635A patent/CZ20012635A3/cs unknown
- 1999-12-09 PL PL99351764A patent/PL351764A1/xx unknown
- 1999-12-09 WO PCT/US1999/029165 patent/WO2000043384A1/en not_active Application Discontinuation
- 1999-12-09 RU RU2001122111/04A patent/RU2220142C2/ru not_active IP Right Cessation
- 1999-12-09 JP JP2000594800A patent/JP3793694B2/ja not_active Expired - Fee Related
- 1999-12-09 HU HU0201406A patent/HUP0201406A3/hu unknown
- 1999-12-09 TR TR2001/02072T patent/TR200102072T2/xx unknown
- 1999-12-09 NZ NZ513525A patent/NZ513525A/en unknown
- 1999-12-09 KR KR1020017009100A patent/KR100669839B1/ko not_active IP Right Cessation
- 1999-12-09 SK SK1019-2001A patent/SK10192001A3/sk unknown
- 1999-12-09 AU AU17522/00A patent/AU770581B2/en not_active Ceased
- 1999-12-09 BR BR9916930-4A patent/BR9916930A/pt not_active IP Right Cessation
- 1999-12-09 CA CA2352524A patent/CA2352524C/en not_active Expired - Fee Related
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2000
- 2000-01-17 MY MYPI20000134A patent/MY128063A/en unknown
- 2000-01-17 TW TW089100638A patent/TW546297B/zh not_active IP Right Cessation
- 2000-01-18 US US09/484,638 patent/US6319921B1/en not_active Expired - Lifetime
- 2000-01-18 CO CO00002439A patent/CO5150218A1/es unknown
- 2000-01-18 PE PE2000000034A patent/PE20001399A1/es not_active Application Discontinuation
- 2000-01-19 AR ARP000100242A patent/AR034089A1/es not_active Suspension/Interruption
- 2000-04-18 SA SA00210018A patent/SA00210018B1/ar unknown
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2001
- 2001-05-24 IL IL143394A patent/IL143394A/en not_active IP Right Cessation
- 2001-05-31 US US09/871,559 patent/US6333325B1/en not_active Expired - Lifetime
- 2001-06-07 ZA ZA200104656A patent/ZA200104656B/en unknown
- 2001-06-12 US US09/879,776 patent/US20020058678A1/en not_active Abandoned
- 2001-06-26 US US09/891,579 patent/US6329415B1/en not_active Expired - Lifetime
- 2001-06-26 US US09/891,820 patent/US6506748B2/en not_active Expired - Lifetime
- 2001-06-27 BG BG105653A patent/BG64971B1/bg active Active
- 2001-07-10 HR HR20010516A patent/HRP20010516A2/hr not_active Application Discontinuation
- 2001-07-18 NO NO20013559A patent/NO20013559L/no not_active Application Discontinuation
- 2001-08-02 US US09/920,899 patent/US6372773B1/en not_active Expired - Lifetime
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2002
- 2002-04-24 HK HK02103087.6A patent/HK1041484A1/zh unknown
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