YU13304A - Epitopna vakcina beta-amiloidne-analogne-t-ćelije - Google Patents

Epitopna vakcina beta-amiloidne-analogne-t-ćelije

Info

Publication number
YU13304A
YU13304A YU13304A YUP13304A YU13304A YU 13304 A YU13304 A YU 13304A YU 13304 A YU13304 A YU 13304A YU P13304 A YUP13304 A YU P13304A YU 13304 A YU13304 A YU 13304A
Authority
YU
Yugoslavia
Prior art keywords
methods
amyloid
analogues
app
autologous
Prior art date
Application number
YU13304A
Other languages
English (en)
Inventor
Peter Birk Rasmussen
Martin Roland Jensen
Klaus Gregorius Nielsen
Peter Koefoed
Florence Dal Degan
Original Assignee
Pharmexa A/S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32870659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU13304(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmexa A/S. filed Critical Pharmexa A/S.
Priority to MEP-432/08A priority Critical patent/MEP43208A/xx
Publication of YU13304A publication Critical patent/YU13304A/sh
Publication of RS51699B publication Critical patent/RS51699B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Otkriveni su novi postupci za borbu protiv bolesti koje karakterise nakupljanje amiloida. Postupci se uopsteno oslanjaju na imunizaciju protiv amiloidnog prekursorskog proteina (APP) ili beta amiloida (Aβ). Imunizacija se pozeljno postize primenom analoga autolognog APP ili Aβ, gde su pomenuti analozi sposobni da indukuju proizvodnju antitela protiv autolognih amiloidogenih polipeptida. Posebno pozeljan kao imunogen je autologni Aβ koji je modifikovan uvodenjem jednog ili nekoliko stranih, imunodominantnih i raznorodnih T-celijskih epitopa. Takode su opisani nukleinsko kiselinska vakcinacija protiv APP ili Aβ i vakcinacija upotrebom zivih vakcina, kao i postupci i sredstva korisni za vakcinaciju. Takvi postupci i sredstva obuhvataju postupke za pripremanje analoga i farmaceutskih formulacija, kao i nukleinsko kiselinske fragmente, vektore, transformisane celije, polipeptide i farmaceutske formulacije.
YU13304A 2001-08-20 2002-08-20 Beta-amiloid-analog-t-ćelijski-epitop vakcina RS51699B (sr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-432/08A MEP43208A (en) 2001-08-20 2002-08-20 Beta-amyloid-analogue-t-cell epitop vaccine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200101231 2001-08-20
US33764301P 2001-10-22 2001-10-22
US37302702P 2002-04-16 2002-04-16
DKPA200200558 2002-04-16

Publications (2)

Publication Number Publication Date
YU13304A true YU13304A (sh) 2006-08-17
RS51699B RS51699B (sr) 2011-10-31

Family

ID=32870659

Country Status (30)

Country Link
US (3) US20030157117A1 (sh)
EP (3) EP1685847A1 (sh)
JP (2) JP2004538332A (sh)
KR (3) KR20040044465A (sh)
CN (1) CN101675992B (sh)
AR (1) AR036270A1 (sh)
AT (1) ATE334698T1 (sh)
AU (3) AU2002325199B2 (sh)
BR (1) BR0212047A (sh)
CA (1) CA2457140C (sh)
CO (1) CO5560581A2 (sh)
CY (1) CY1105737T1 (sh)
DE (1) DE60213615T3 (sh)
DK (1) DK1420815T3 (sh)
EA (2) EA007533B1 (sh)
ES (1) ES2269749T5 (sh)
HK (1) HK1064934A1 (sh)
HR (2) HRP20040218A2 (sh)
HU (1) HUP0400669A3 (sh)
IL (2) IL159964A0 (sh)
IS (1) IS7133A (sh)
ME (1) MEP43208A (sh)
MX (1) MXPA04001467A (sh)
MY (1) MY144532A (sh)
NZ (2) NZ547224A (sh)
PL (1) PL215125B1 (sh)
PT (1) PT1420815E (sh)
RS (1) RS51699B (sh)
SI (1) SI1420815T1 (sh)
WO (1) WO2003015812A2 (sh)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287468B6 (sk) * 2000-02-21 2010-10-07 H. Lundbeck A/S Použitie analógu autológneho Aß alebo APP polypeptidu živočícha, analóg, fragment nukleovej kyseliny, vektor, transformovaná bunka, bunková línia a kompozície
KR100879810B1 (ko) * 2000-02-21 2009-01-22 하. 룬드벡 아크티에셀스카브 아밀로이드의 하향-조절을 위한 신규한 방법
US7264810B2 (en) 2001-01-19 2007-09-04 Cytos Biotechnology Ag Molecular antigen array
MY144532A (en) * 2001-08-20 2011-09-30 Lundbeck & Co As H Novel method for down-regulation of amyloid
US20080014194A1 (en) * 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US8506959B2 (en) * 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
WO2008103472A2 (en) * 2007-02-23 2008-08-28 Elan Pharmaceuticals, Inc. Prevention and treatment of synucleinopathic and amyloidogenic disease
US9034337B2 (en) * 2003-10-31 2015-05-19 Prothena Biosciences Limited Treatment and delay of outset of synucleinopathic and amyloidogenic disease
US8697082B2 (en) * 2002-11-01 2014-04-15 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
TW200509968A (en) * 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
KR100546066B1 (ko) * 2003-03-21 2006-01-26 한국생명공학연구원 베타아밀로이드 유전자의 다중 연결체를 발현하는 형질전환 식물 세포 및 이로부터 배양된 식물
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
US7807171B2 (en) 2003-07-25 2010-10-05 Ac Immune Sa Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
WO2005042575A2 (en) * 2003-10-30 2005-05-12 Pharmexa A/S Method for down-regulation of vegf
WO2005047860A2 (en) 2003-11-08 2005-05-26 Elan Pharmaceuticals, Inc. Antibodies to alpha-synuclein
EP1711208A2 (en) * 2004-01-28 2006-10-18 Curix APS Conjugates of amyloid proteins as vaccines for amyloid-related diseases
KR100639397B1 (ko) 2004-03-18 2006-10-26 (주)에스제이바이오메드 항비만용 면역원성 하이브리드 폴리펩타이드 및 이를포함하는 항비만 백신 조성물
GB0424563D0 (en) * 2004-11-05 2004-12-08 Novartis Ag Organic compounds
JP2008540417A (ja) * 2005-05-05 2008-11-20 メルク エンド カムパニー インコーポレーテッド ペプチドコンジュゲート組成物およびアルツハイマー病の予防および治療のための方法
CN101506236B (zh) 2005-11-30 2012-12-12 雅培制药有限公司 抗淀粉样β蛋白的单克隆抗体及其用途
BRPI0619249A2 (pt) 2005-11-30 2011-09-20 Abbott Lab anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
EP1992639A4 (en) * 2006-02-22 2009-08-26 Hayashibara Biochem Lab PEPTIDE VACCINE FOR INDUCING THE PRODUCTION OF AMYLOID ANTI-PEPTIDE ANTIBODIES
US8188046B2 (en) 2006-10-16 2012-05-29 University Of South Florida Amyloid beta peptides and methods of use
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8147833B2 (en) * 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
EP2486928A1 (en) 2007-02-27 2012-08-15 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
US7618944B2 (en) * 2007-03-01 2009-11-17 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
WO2008124646A2 (en) * 2007-04-06 2008-10-16 The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services Use of amyloid proteins as vaccine scaffolds
JP5349297B2 (ja) 2007-04-20 2013-11-20 一般財団法人化学及血清療法研究所 ペプチド免疫応答増強方法
US20110002949A1 (en) * 2008-07-08 2011-01-06 Savage Mary J Vaccine for the treatment of alzheimer's disease
EP2348042B1 (en) * 2008-10-16 2017-07-05 The Chemo-Sero-Therapeutic Research Institute Modified amyloid beta peptide
MX360403B (es) 2010-04-15 2018-10-31 Abbvie Inc Proteinas de union a amiloide beta.
US9289488B2 (en) 2010-08-12 2016-03-22 Ac Immune Sa Vaccine engineering
JP6147665B2 (ja) 2010-08-14 2017-06-14 アッヴィ・インコーポレイテッド アミロイドベータ結合タンパク質
EP2632434A1 (en) 2010-10-26 2013-09-04 AC Immune S.A. Liposome-based construct comprising a peptide modified through hydrophobic moieties
US20120321694A1 (en) * 2010-10-27 2012-12-20 Daniel Larocque Compositions and uses
CA2885924C (en) * 2012-08-21 2022-12-13 Institute For Molecular Medicine, Inc. Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein
US10195257B2 (en) 2013-07-28 2019-02-05 Qantu Therapeutics, Inc. Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response
WO2015036646A1 (es) * 2013-09-13 2015-03-19 Fundación Pública Andaluza Progreso Y Salud Combinaciones de proteínas agregantes y chaperonas moleculares para el tratamiento de proteinopatías o enfermedades conformacionales
WO2015135942A1 (en) * 2014-03-11 2015-09-17 Universite D'aix-Marseille A chimeric peptide that interacts with cell membrane gangliosides
CA2971288A1 (en) * 2015-02-02 2016-08-11 The University Of Birmingham Targeting moiety peptide epitope complexes having a plurality of t-cell epitopes
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
CN104880441B (zh) * 2015-05-14 2017-12-22 上海皓拓生物技术有限公司 β‑分泌酶特异性抑制剂的筛选方法及其筛选系统
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
WO2018078038A1 (en) 2016-10-28 2018-05-03 H. Lundbeck A/S Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders
EP3532053A1 (en) 2016-10-28 2019-09-04 H. Lundbeck A/S Combination treatments comprising administration of imidazopyrazinones
EP3568411B1 (en) * 2017-01-13 2024-03-06 Pietro P. Sanna Methods and compositions for treating hpa hyperactivity
CN108187038B (zh) * 2017-05-25 2020-05-01 成都安特金生物技术有限公司 一种狂犬病结合疫苗
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
HUE057202T2 (hu) 2017-12-14 2022-04-28 H Lundbeck As Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával
US11535611B2 (en) 2017-12-20 2022-12-27 H. Lundbeck A/S Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
CA3095983A1 (en) * 2018-04-10 2019-10-17 Ac Immune Sa Anti-abeta therapeutic vaccines
CN112165956A (zh) * 2018-04-10 2021-01-01 Ac免疫有限公司 抗Aβ治疗性疫苗
EP3952913A4 (en) * 2019-04-12 2023-05-10 The Johns Hopkins University CELLS PRESENTING TOLEROGENIC ARTIFICIAL ANTIGEN
GB202008250D0 (en) * 2020-06-02 2020-07-15 Emergex Vaccines Holding Ltd Diagnosis, prevention and treatment of coronavirus infection
CN115925987A (zh) * 2022-02-28 2023-04-07 安域生物科技(杭州)有限公司 基于β-淀粉样蛋白修饰的抗原多肽及其应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4596792A (en) 1981-09-04 1986-06-24 The Regents Of The University Of California Safe vaccine for hepatitis containing polymerized serum albumin
JPS5938877A (ja) 1982-08-30 1984-03-02 Musashi Eng Kk 紙葉判別方法
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US5223482A (en) 1986-11-17 1993-06-29 Scios Nova Inc. Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
US5278056A (en) 1988-02-05 1994-01-11 The Trustees Of Columbia University In The City Of New York Retroviral packaging cell lines and process of using same
US5192688A (en) 1988-08-15 1993-03-09 Switzer Iii Robert C Histological analysis method
US5753624A (en) 1990-04-27 1998-05-19 Milkhaus Laboratory, Inc. Materials and methods for treatment of plaquing disease
US5200339A (en) 1990-08-17 1993-04-06 Abraham Carmela R Proteases causing abnormal degradation of amyloid β-protein precursor
US5780587A (en) 1990-08-24 1998-07-14 President And Fellows Of Harvard College Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
US5780036A (en) 1991-08-26 1998-07-14 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus
NZ249704A (en) 1992-02-11 1996-11-26 Jackson H M Found Military Med A two carrier immunogenic construct comprising a 70+ kd molecule conjugated to at least 1 t-dependent antigen, preparation, compositions containing the construct
AU678152B2 (en) 1992-03-27 1997-05-22 Whitehead Institute For Biomedical Research Non-infectious HIV particles and uses therefor
US5851787A (en) 1992-04-20 1998-12-22 The General Hospital Corporation Nucleic acid encoding amyloid precursor-like protein and uses thereof
AU4377793A (en) 1992-05-20 1993-12-13 Johns Hopkins University, The Alternative receptor therapy
DK100592D0 (da) 1992-08-10 1992-08-10 Mouritsen & Elsner Aps Metode til kemisk kobling paa faste faser
US5958883A (en) * 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
US5747323A (en) 1992-12-31 1998-05-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Retroviral vectors comprising a VL30-derived psi region
AU707083B2 (en) 1993-08-26 1999-07-01 Bavarian Nordic Inc. Inducing antibody response against self-proteins with the aid of foreign T-cell epitopes
DK96493D0 (da) 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
AU698962B2 (en) * 1993-09-14 1998-11-12 Epimmune, Inc. Alteration of immune response using pan DR-binding peptides
AUPM411994A0 (en) * 1994-02-25 1994-03-24 Deakin Research Limited Epitopes
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
US5573916A (en) 1994-05-19 1996-11-12 Coretech, Inc. Immunogenic constructs comprising b-cell and t-cell epitopes on common carrier
IL115743A0 (en) 1994-10-28 1996-01-19 American Nat Red Cross A mammal with cells containing a transgene and its production
US5589154A (en) * 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
CA2214247C (en) 1995-03-14 2004-02-10 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
IL118578A (en) 1995-06-07 2006-12-31 Connaught Lab Hybrid nucleic acid molecule for expression of lipoproteins
US5874469A (en) 1996-01-05 1999-02-23 Alcon Laboratories, Inc. Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
US5985581A (en) 1996-07-25 1999-11-16 The Mclean Hospital Corporation Use of presenilin-1 for diagnosis of alzheimers disease
AUPO390396A0 (en) 1996-11-29 1996-12-19 Csl Limited Novel promiscuous T helper cell epitopes
PT1005374E (pt) 1997-01-22 2007-07-18 Mgi Pharma Biolog Inc Micropartículas para administração de ácido nucleico
AU1388899A (en) 1997-11-11 1999-05-31 Board Of Regents Of The University Of Oklahoma, The An alzheimer-related, endothelium-derived toxic factor and methods for its use
US6913745B1 (en) * 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US6787523B1 (en) * 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6761888B1 (en) * 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US20040062802A1 (en) 1998-04-02 2004-04-01 Hermelin Victor M. Maximizing effectiveness of substances used to improve health and well being
NO314086B1 (no) * 1998-05-08 2003-01-27 Gemvax As Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til
KR20010072025A (ko) 1998-07-21 2001-07-31 추후제출 활성화 폴리히드록시폴리머에 의한 고체 표면 코팅
IL141588A0 (en) 1998-09-15 2002-03-10 M & E Biotech As Method for down-regulating osteoprotegerin ligand activity
ES2222728T3 (es) * 1998-10-05 2005-02-01 Pharmexa A/S Procedimiento de vacunacion terapeutica.
GB2361948B (en) † 1998-11-06 2003-04-16 Baker Hughes Inc Drilling fluid systems with improved fluid loss properties
AU2495300A (en) 1999-01-07 2000-07-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Lentivirus vector system
CZ303515B6 (cs) 1999-04-19 2012-11-07 Smithkline Beecham Biologicals S. A. Adjuvantní prostredek
US6787637B1 (en) * 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
AR024558A1 (es) 1999-06-01 2002-10-16 Neuralab Ltd Composiciones del peptido a-beta y procesos para producir las mismas
KR20080059676A (ko) 1999-11-29 2008-06-30 뉴로겜 인터내셔널 리미티드 알츠하이머 및 아밀로이드 관련 질병의 예방 및 치료용백신
WO2001042306A2 (en) * 1999-12-08 2001-06-14 Mindset Biopharmaceuticals (Usa), Inc. Chimeric peptides (short b-cell epitope joined to a t-cell epitope) and their use for immunization
KR100879810B1 (ko) 2000-02-21 2009-01-22 하. 룬드벡 아크티에셀스카브 아밀로이드의 하향-조절을 위한 신규한 방법
SK287468B6 (sk) 2000-02-21 2010-10-07 H. Lundbeck A/S Použitie analógu autológneho Aß alebo APP polypeptidu živočícha, analóg, fragment nukleovej kyseliny, vektor, transformovaná bunka, bunková línia a kompozície
GB0004530D0 (en) 2000-02-25 2000-04-19 Univ Nottingham Adjuvants
EP1284998B1 (en) * 2000-05-22 2004-12-29 New York University Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits
WO2002038177A2 (en) 2000-11-10 2002-05-16 Wyeth Holdings Corporation Adjuvant combination formulations
US7097837B2 (en) 2001-02-19 2006-08-29 Pharmexa A/S Synthetic vaccine agents
JP2002273199A (ja) * 2001-03-15 2002-09-24 Idemitsu Petrochem Co Ltd ガス状流体の抜き出し方法
US6906169B2 (en) 2001-05-25 2005-06-14 United Biomedical, Inc. Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide
MY144532A (en) 2001-08-20 2011-09-30 Lundbeck & Co As H Novel method for down-regulation of amyloid
US20030185845A1 (en) 2001-11-16 2003-10-02 Steen Klysner Novel immunogenic mimetics of multimer proteins
WO2003059379A2 (en) 2002-01-17 2003-07-24 Pharmexa A/S Immunogenic carcinoembryonic antigen (cea)
WO2003075951A2 (en) 2002-03-11 2003-09-18 Pharmexa A/S Novel application of vaccination against tnf-alpha
CA2493119A1 (en) 2002-07-17 2004-01-22 Mindset Biopharmaceuticals Usa Inc. Peptides and methods of screening immunogenic peptide vaccines against alzheimer's disease

Also Published As

Publication number Publication date
DE60213615T2 (de) 2007-08-09
KR20090074830A (ko) 2009-07-07
CA2457140C (en) 2014-08-05
PL369099A1 (en) 2005-04-18
ES2269749T3 (es) 2007-04-01
HUP0400669A3 (en) 2011-07-28
JP2009280582A (ja) 2009-12-03
US8871212B2 (en) 2014-10-28
NZ547224A (en) 2008-06-30
IL188506A0 (en) 2008-04-13
US20100047262A1 (en) 2010-02-25
WO2003015812A2 (en) 2003-02-27
KR20100086520A (ko) 2010-07-30
DK1420815T3 (da) 2006-12-04
HUP0400669A2 (hu) 2005-01-28
ATE334698T1 (de) 2006-08-15
EA007533B1 (ru) 2006-10-27
JP5114455B2 (ja) 2013-01-09
BR0212047A (pt) 2004-08-17
MEP43208A (en) 2011-02-10
KR101057488B1 (ko) 2011-08-19
WO2003015812A3 (en) 2004-03-25
RS51699B (sr) 2011-10-31
AU2010212381B2 (en) 2012-01-19
CA2457140A1 (en) 2004-02-27
ES2269749T5 (es) 2017-12-04
CN101675992A (zh) 2010-03-24
EP3299029A1 (en) 2018-03-28
KR20040044465A (ko) 2004-05-28
CO5560581A2 (es) 2005-09-30
MXPA04001467A (es) 2005-02-17
MY144532A (en) 2011-09-30
AU2010212381A1 (en) 2010-09-09
HRP20120283A2 (hr) 2012-06-30
HRP20040218A2 (en) 2004-08-31
US20050163744A1 (en) 2005-07-28
EA200400332A1 (ru) 2004-08-26
SI1420815T1 (sl) 2006-12-31
PL215125B1 (pl) 2013-10-31
CY1105737T1 (el) 2010-12-22
AU2007249087B2 (en) 2010-05-20
AU2002325199B2 (en) 2007-09-20
EP1420815A2 (en) 2004-05-26
EP1685847A1 (en) 2006-08-02
AR036270A1 (es) 2004-08-25
DE60213615T3 (de) 2017-11-23
NZ530940A (en) 2007-11-30
IL188506A (en) 2017-08-31
IL159964A0 (en) 2004-06-20
IS7133A (is) 2004-01-29
HK1064934A1 (en) 2005-02-08
CN101675992B (zh) 2014-05-21
AU2007249087A1 (en) 2008-01-10
EP1420815B1 (en) 2006-08-02
EA200600974A1 (ru) 2006-10-27
DE60213615D1 (de) 2006-09-14
EA011610B1 (ru) 2009-04-28
PT1420815E (pt) 2006-12-29
JP2004538332A (ja) 2004-12-24
US20030157117A1 (en) 2003-08-21
EP1420815B2 (en) 2017-08-09

Similar Documents

Publication Publication Date Title
YU13304A (sh) Epitopna vakcina beta-amiloidne-analogne-t-ćelije
MY131826A (en) Novel method for down-regulation of amyloid
MXPA02007796A (es) Metodo novedoso para la disminucion de cuerpos amiloides.
RU2553345C2 (ru) Применение мимотопов для лечения бетта-амилоидозов
BenMohamed et al. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses
TR200400621T2 (tr) GDF-8 aktivitesinin aşağı doğru düzenlenmesi için bir yöntem.
US20150093431A1 (en) Compositions
ES2701084T3 (es) Compuestos inmunogénicos que comprenden péptido gp41 de VIH acoplado a proteína portadora CRM197
EP2844280A1 (en) Composition
ES2662022T3 (es) Vacunas atenuadas de la gripe porcina y procedimientos de fabricación y uso de las mismas
TW201345927A (zh) 組成物
NO20040431L (no) Ny fremgangsmate for nedregulering av amyloid
JP2023536497A (ja) 免疫原性化合物
MY135691A (en) Method for down-regulation of gdf-8 activity
Hospers et al. Construction of a triple modified p53 containing DNA vaccine to enhance processing and presentation of the p53 antigen
TW201348264A (zh) 組成物
UA85815C2 (uk) Застосуваня імуногену для профілактики або лікування хвороби альцгеймера або інших захворювань, пов'язаних з відкладенням амілоїду
ECSP003580A (es) Metodos nuevos para aumentar la masa muscular mediante la inmunizacion contra el gdf-8