WO2017034014A1 - Composition contenant un peptide de collagène et une céramide et son procédé de production - Google Patents

Composition contenant un peptide de collagène et une céramide et son procédé de production Download PDF

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Publication number
WO2017034014A1
WO2017034014A1 PCT/JP2016/074925 JP2016074925W WO2017034014A1 WO 2017034014 A1 WO2017034014 A1 WO 2017034014A1 JP 2016074925 W JP2016074925 W JP 2016074925W WO 2017034014 A1 WO2017034014 A1 WO 2017034014A1
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Prior art keywords
cyclodextrin
ceramide
raw material
collagen peptide
composition
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PCT/JP2016/074925
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English (en)
Japanese (ja)
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俊明 栃木
明子 ▲高▼田
田中　正浩
一政 大西
浩樹 大原
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株式会社明治
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Priority to CN201680049214.5A priority Critical patent/CN107920580A/zh
Priority to JP2017536485A priority patent/JP6762302B2/ja
Priority to SG11201800826UA priority patent/SG11201800826UA/en
Publication of WO2017034014A1 publication Critical patent/WO2017034014A1/fr
Priority to HK18105591.2A priority patent/HK1246096A1/zh

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
    • A23L29/281—Proteins, e.g. gelatin or collagen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins

Definitions

  • the present invention relates to a composition containing a collagen peptide and ceramide in which browning that occurs during the granulation step is suppressed, and a method for producing the same.
  • Collagen peptides and ceramides are well known as ingredients for foods and drinks that are expected to have a cosmetic effect on the skin (International Publication No. 2008/059927 (Patent Document 1), International Publication No. 2010/125910 (Patents). Document 2) and Japanese Patent Application Laid-Open No. 2008-184428 (Patent Document 3)).
  • Collagen peptides used in foods are obtained from raw materials such as pig skin and fish scales.
  • the ceramide material used for a foodstuff is obtained from plant-derived raw materials, such as rice, wheat, and konjac rice, and animal-derived raw materials, such as egg yolk and milk.
  • the component composition contained in the resulting material will be different.
  • the main component of plant-derived ceramide is glycosylceramide to which glucose is bound, but animal-derived ceramide is rich in sphingomyelin and glycosphingolipids.
  • animal-derived ceramide is rich in sphingomyelin and glycosphingolipids.
  • the composition of proteins, lipids, minerals, etc. contained therein will be different.
  • the form of goods is various, for example, a powder, a tablet, a capsule, a drink, a jelly drink, a gummi etc. are mentioned.
  • a powdered beverage containing a collagen peptide is required to be easily soluble. Since the collagen peptide raw powder has poor sedimentation in water, after granulating the granules containing collagen peptide and granules with good sedimentation in water separately in advance, add an emulsifier while mixing, A method for producing a rapidly soluble granule by preparing a mixed granule coated with an emulsifier is known (International Publication No. 2006/117958 (Patent Document 4)).
  • the inventors of the present invention tried to produce a powdery or granular composition containing collagen peptide and ceramide as essential components, and further containing vitamin C, a fragrance and the like.
  • a raw material having a high content of sphingomyelin as the ceramide a phospholipid material derived from animal raw materials (phospholipid derived from milk, lipid content 85% by weight) whose lipid content in the solid content exceeds 70% by weight. Selected as ceramide raw material.
  • a composition containing a collagen peptide and ceramide is a composition in which the collagen peptide and ceramide are uniformly dispersed, and is generated during the granulation process and during storage in a high temperature zone such as summer. It is an object of the present invention to provide a composition and a method for producing the same, in which the proceeding browning change and undesirable odor are suppressed.
  • the inventors of the present invention examined the combination of ingredients that cause browning. As a result of spraying a mixed solution of raw materials other than collagen peptide on the collagen peptide and fluidized bed granulation, it was found that a particularly unpleasant odor was generated in the test section where the collagen peptide and the ceramide raw material were combined. Furthermore, as a result of repeated investigations by the present inventors, it was found that browning and a specific odor are generated even if the packaging material is filled with only the ceramide raw material before granulation and stored only in a high temperature zone.
  • the present inventors further studied a means for stabilizing the ceramide raw material.
  • a complex in which a ceramide raw material was included with cyclodextrin was very high in storage stability.
  • spraying the complex solution onto the collagen peptide and granulating not only the collagen peptide and ceramide are uniformly dispersed in the composition, but also browning during the production and storage in the high temperature zone. It has been found that both the change and the generation of an unpleasant odor are significantly suppressed.
  • the present invention is based on these findings.
  • the present invention is characterized by the following matters.
  • a composition containing collagen and ceramide characterized by comprising a step of obtaining a mixed solution containing a ceramide raw material and cyclodextrin, and then a step of spraying the mixed solution onto collagen peptide or collagen peptide-containing granules to granulate How to manufacture.
  • the collagen peptide and the ceramide are uniformly dispersed in the composition, and further, the collagen peptide and the browning of the composition generated during the granulation step and the generation of an unpleasant odor are suppressed.
  • a composition containing ceramide and a method for producing the same can be provided.
  • browning and undesired odor that occur during storage in a high temperature zone such as summer can be suppressed.
  • a composition having the above-mentioned good characteristics can be obtained.
  • FIG. 1 shows a differential scanning calorimetry (DSC) chart of samples with different weight ratios of the ceramide raw material and cyclodextrin regarding Test Example 4.
  • the horizontal axis represents temperature (° C.), and the vertical axis represents DSC (differential scanning calorie) ( ⁇ W).
  • FIG. 2 shows an NMR spectrum of samples with different weight ratios of the ceramide raw material and cyclodextrin regarding Test Example 5.
  • the horizontal axis represents chemical shift (ppm), and the vertical axis represents relative intensity.
  • FIG. 3 shows an NMR spectrum of samples having different weight ratios of the ceramide raw material and cyclodextrin with respect to Test Example 5.
  • the “composition containing a collagen peptide and ceramide” contains at least a “ceramide raw material”, “cyclodextrin”, and “collagen peptide” described later.
  • ceramide is a kind of sphingolipid, which has a structure in which sphingosine, a fatty acid and a sugar are combined, and is derived from nature. Examples include those derived from animals extracted from milk, eggs, etc., those derived from plants extracted from wheat, rice, soybeans, konjac koji, corn, etc., and those derived from microorganisms extracted from yeasts. These ceramides can be obtained by a known extraction method. Furthermore, in addition to the known extraction method described above, it can also be obtained through a processing step of coating with an emulsifier or the like. In the present invention, the “ceramide raw material” contains the aforementioned ceramide.
  • ceramide raw material in the present invention those having a lipid content in the solid content of 70% by weight or more are preferable. According to the present invention, a raw material having the lipid content in the solid content of the ceramide raw material of 80% by weight or more, further 85% by weight or more can be used.
  • the ceramide raw material preferably contains “milk-derived phospholipid”.
  • the milk-derived phospholipid is produced by extracting from milk, and contains phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin as main components.
  • phospholipid derived from milk widely refers to phospholipid extracted from milk, but commercially available products can also be used.
  • the ceramide raw material preferably contains sphingomyelin.
  • a ceramide raw material containing 15% by weight or more of sphingomyelin is preferable.
  • Cyclodextrin examples of the cyclodextrin preferably used in the composition of the present invention include ⁇ -cyclodextrin, ⁇ -cyclodextrin, ⁇ -cyclodextrin and the like. More preferred is ⁇ -cyclodextrin or ⁇ -cyclodextrin, and ⁇ -cyclodextrin is particularly preferred. Cyclodextrin is a compound having a three-dimensional structure in which sugar chains are cyclic. The outer side is hydrophilic and the inner side is lipophilic.
  • the “mixed solution” refers to a solution obtained by dissolving at least the ceramide raw material and cyclodextrin in a solvent such as water.
  • a solvent used for the mixed solution water is preferable.
  • the temperature of the solvent is not particularly limited, but may be 40 ° C. or higher, and preferably 40 to 80 ° C. for easy dissolution.
  • the preferred amount of solvent varies with the type of cyclodextrin.
  • the amount of solvent in the case of using ⁇ -cyclodextrin may be 1.5 times or more the weight of the solid content of the components (cyclodextrin, ceramide raw material and optionally added components) in the mixed solution, The weight is preferably 2.5 to 5 times, more preferably about 3 to 4 times.
  • the amount of the solvent may be 5 times or more, preferably 6.5 times or more the solid content of the components in the mixed solution.
  • the amount of the solvent may be 10 times or more, preferably 20 times or more the weight of the solid content of the components in the mixed solution.
  • the weight ratio of the ceramide raw material and cyclodextrin in the mixed solution is preferably 1: 0.5 to 1: 5, more preferably 1: 1 to 1: 2, and particularly preferably 1: 1.5 to 1. : 2.
  • the one where the weight ratio of the cyclodextrin in a liquid mixture is high shows the tendency for browning and generation
  • the higher the weight ratio of cyclodextrin in the mixture the higher the fluidity of the finally obtained composition.
  • the weight ratio of cyclodextrin in the mixed solution is high, the amount of the solvent (water) necessary for spraying as a binder solution having an appropriate viscosity increases.
  • the upper limit of the weight ratio of cyclodextrin in the mixed solution is preferably in the above-described range.
  • the mixed solution may contain other components as long as the effects of the present invention are not impaired.
  • binders glycol arabic, pullulan, guar gum, starch, etc.
  • cores diextrin, starch, crystalline cellulose, carbohydrate raw materials, etc.
  • antioxidants catechins, vitamins, rosemary extract, bayberry extract, etc.
  • emulsifiers brighteners, fragrances and the like.
  • Collagen peptide is produced by extracting from skin, bones, ligaments, tendons, cartilage, etc. produced as by-products when processing livestock such as cattle and pigs and fish.
  • the “collagen peptide” is obtained by degrading the collagen or gelatin extracted as described above by an enzyme, chemical treatment or the like.
  • the origin of the collagen peptide can be selected as appropriate, but is preferably derived from fish.
  • the molecular weight of collagen contained in the collagen peptide can be appropriately selected.
  • the low molecular weight collagen component may be highly reactive, it can be contained in the composition of the present invention without browning during the granulation step.
  • a collagen peptide having an average molecular weight of 1800 to 5000 can be suitably used as the collagen peptide.
  • a collagen peptide-containing granule can be obtained by spraying the above-described collagen peptide with a binder liquid containing a separately prepared binder (preferably gum arabic) and granulating it.
  • a binder liquid containing a separately prepared binder (preferably gum arabic) and granulating it.
  • Other components can be added to the binder liquid as long as the effects of the present invention are not impaired.
  • examples of other components include carbohydrate raw materials, lactic acid bacteria powder, amino acid powder, vitamin powder, fragrance, emulsifier, crystalline cellulose, colorant, sweetener, acidulant, lubricant, and the like.
  • the granulation method include fluidized bed granulation, extrusion granulation, compression granulation, spray drying and the like, and fluidized bed granulation is particularly preferable.
  • Collagen peptide-containing granules include those obtained through a drying step or a cooling step optionally after the above-described granulation step.
  • composition of the present invention is obtained by spraying the above-described collagen peptide or collagen peptide-containing granule by spraying a mixed liquid containing a ceramide raw material and cyclodextrin.
  • the composition of the present invention is characterized in that a ceramide raw material encapsulated in cyclodextrin adheres to a collagen peptide or a collagen peptide-containing granule.
  • the ceramide raw material included in the cyclodextrin adheres to the collagen peptide or the collagen peptide-containing granule, and a coating layer is formed from the ceramide raw material included in the cyclodextrin.
  • the coating layer includes a case where the collagen peptide or the collagen peptide-containing granule is entirely or partially coated. Therefore, it can also be said that the composition by this invention has a coating layer by the ceramide raw material included by the cyclodextrin on all or one part on collagen peptide or a collagen peptide containing granule.
  • the composition of the present invention includes a step of obtaining a mixed solution containing a ceramide raw material and cyclodextrin, and then a step of spraying the mixed solution onto collagen peptide or collagen peptide-containing granules to granulate. It can be manufactured by a method.
  • the composition of the present invention is manufactured by further blending a binder (for example, gum arabic) in a mixed solution containing a ceramide raw material and cyclodextrin, and spraying and granulating the collagen peptide or collagen peptide-containing granule.
  • a binder for example, gum arabic
  • spraying and granulating the collagen peptide or collagen peptide-containing granule can do.
  • the granulation method include fluidized bed granulation, extrusion granulation, compression granulation, spray drying and the like, and fluidized bed granulation is particularly preferable.
  • the composition of the present invention includes those obtained optionally through a drying step and a cooling step after the granulation step.
  • composition of the present invention there is no particular limitation on the weight ratio of the aforementioned collagen peptide, ceramide raw material, and cyclodextrin.
  • the composition of the present invention can be applied uniformly even if the amount of ceramide is small relative to the collagen peptide, even if the amount of collagen peptide is small relative to the ceramide, and the amount of collagen peptide and ceramide is almost the same. A dispersed one is obtained.
  • binder such as gum arabic
  • carbohydrate raw material glucosamine, N-acetylglucosamine, hyaluronic acid, chondroitin sulfate, coenzyme Q10, whey fermentation product, plant extract, lactic acid bacteria powder, amino acid powder, vitamin powder, sweetener , Fragrances, emulsifiers, lubricants, brighteners and the like.
  • the above-mentioned components are appropriately selected before, during the granulation step, after the granulation step, before the step of granulating the collagen peptide or collagen peptide-containing granule by spraying a mixed solution containing a ceramide raw material and cyclodextrin. Can be added.
  • composition of the present invention can also be obtained through a tableting process or a compression process in addition to the granule mixing process described above.
  • a well-known means can be employ
  • the property of the “composition” of the present invention is a mixed granule, a mixed granule containing an added powder component, a tablet obtained by tableting the granule, or a compression obtained by compression molding the granule. It has a molded body.
  • the composition of the present invention can be used as it is as a powdered beverage, a tablet or the like because the browning change and the generation of odor during storage in a granulation step and a high temperature zone are suppressed.
  • the composition of the present invention can be used as a raw material for other forms of products such as gummi, jelly beverage, and packaged beverage.
  • the composition of the present invention has good flowability and is difficult to dust, and therefore has excellent handling properties at the time of production.
  • Comparative Example 1 Composition granulated by spraying ceramide raw material directly on collagen peptide [base powder]
  • Collagen peptide (collagen peptide made from Nitta gelatin, molecular weight about 3000): 150 parts by weight
  • Sodium ascorbate 10 parts by weight
  • Trehalose fine powder 100 parts by weight
  • Maltodextrin 40 parts by weight
  • Binder liquid 0.5 parts by weight of gum arabic and 10 parts by weight of a ceramide raw material (milk-derived phospholipid, lipid content 85% by weight, manufactured by Fontera Japan) were added to 40 parts by weight of stirred water and dissolved.
  • the base powder was put into a fluidized bed granulator and granulated by spraying the binder liquid while flowing at 85 ° C. After drying the granules obtained by granulation at 100 ° C. for 30 minutes, spraying 2.5 parts by weight of a fragrance and 2.5 parts by weight of an emulsifier while adding and mixing 80 parts by weight of maltodextrin, The composition of Comparative Example 1 was obtained. The obtained composition was granular, and ceramide and collagen peptide were uniformly dispersed.
  • Comparative Example 1 browned during granulation with a fluidized bed granulator and generated an undesirable odor. Furthermore, when the obtained composition was enclosed in an aluminum pouch and stored at 23 ° C., 37 ° C. and 60 ° C. for 1 week, browning proceeded in any storage temperature range, and the unpleasant odor became stronger. It was.
  • Test Example 1 Study on combinations of components that cause browning changes Samples of each test group described in Table 1 were prepared. The same raw material used in Comparative Example 1 was used as the raw material used in this test example. Test group 1-1 was an untreated collagen peptide. Test group 1-2 was prepared by drying 400 parts by weight of collagen peptide at 100 ° C. for 30 minutes. In the test sections 1-3 to 1-8, the base powder raw material is put in a fluidized bed granulator, granulated by spraying a binder liquid while flowing at 85 ° C., and then dried at 100 ° C. for 30 minutes. Prepared.
  • Test Example 2 Composition containing collagen peptides having different molecular weights Collagen peptides having average molecular weights of about 5,000, about 3,000, about 2,000, and about 1,800 (all made by Nitta Gelatin), respectively, as raw materials
  • a composition was prepared as While the base powder (280 parts by weight of the collagen peptide) was added to the fluidized bed granulator and allowed to flow, the binder liquid (30 parts by weight of water and 17 parts by weight of the same ceramide raw material as in Comparative Example 1) was sprayed at 85 ° C. After granulation, it was dried at 100 ° C. for 30 minutes. Each obtained composition was sealed in an aluminum pouch bag and stored at 23 ° C., 40 ° C., and 60 ° C. for 1 week. The scent and color difference were evaluated for each composition after storage. The evaluation results of the color difference are shown in Table 2.
  • Test Example 3 Preservation Test of Ceramide Raw Material
  • a ceramide raw material (milk-derived phospholipid, lipid content 85% by weight, manufactured by Fontera Japan) was enclosed in an aluminum pouch bag and stored at 40 ° C. for 1 week and 60 ° C. for 4 days. Each ceramide raw material after storage was browned and had an unpleasant odor (odor like fishing bait).
  • Example 1 [Base powder] Maltodextrin: 300 parts by weight Collagen peptide (collagen peptide made by Nitta Gelatin, molecular weight about 3000): 370 parts by weight Carbohydrate raw material (trehalose fine powder): 175 parts by weight [binder liquid] 2.0 parts by weight of gum arabic was added to 100 parts by weight of water being stirred and dissolved.
  • the binder liquid was sprayed while the base powder was fluidized at 85 ° C. in a fluidized bed granulator. Subsequently, each of the mixed solutions of Examples 1-1 to 1-5 shown in Table 3 was sprayed, dried at about 100 ° C. for about 10 minutes, and then cooled, whereby each of compositions 1-1 to 1 was cooled. -5 was obtained.
  • the time required for spraying was about 20 minutes for Examples 1-1 to 1-3, about 180 minutes for Example 1-4, and about 70 minutes for Example 1-5.
  • the powdered additional component (sodium ascorbate: 2.4 parts by weight) was mixed with 94.5 parts by weight of each of the obtained compositions 1-1 to 1-3. Subsequently, 1.0 part by weight of a fragrance and 0.6 part by weight of an emulsifier were sprayed onto the mixture to obtain compositions 1-1a to 1-3a.
  • compositions 1-1 to 1-3 were mixed with the following powdery additional components.
  • Maltodextrin 30 parts by weight
  • Sodium ascorbate 1.5 parts by weight
  • 0.8 parts by weight of a fragrance and 0.6 parts by weight of an emulsifier are sprayed onto the mixture to thereby obtain compositions 1-1b to 1- 3b was obtained.
  • compositions described above were those in which ceramide and collagen peptide were uniformly dispersed. In addition, any of the compositions did not cause browning during the production process, and could be produced without producing an undesirable odor.
  • compositions using ⁇ -cyclodextrin 1-1 to 1-3, 1-1a to 1-3a, 1-1b to 1-3b
  • all of the compositions have good dispersibility and sedimentation. Had sex. All of the prepared beverages were cloudy and had a good quality with a faint milky aroma.
  • compositions 1-1a to 1-3a and the compositions 1-1b to 1-3b were sealed in aluminum pouches and stored at 60 ° C. for 4 days and at 40 ° C. or 23 ° C. for 2 months.
  • Compositions 1-4 to 1-5 were similarly stored at 60 ° C. for 4 days and at 40 ° C. or 23 ° C. for 2 weeks. None of the compositions after storage was browned and no undesirable odor was generated.
  • Test Example 4 Analysis of inclusion effect of ceramide raw material with cyclodextrin (1) DSC The thermal behavior of the sample obtained by changing the weight ratio of the ceramide raw material and cyclodextrin was evaluated by differential scanning calorimetry (DSC).
  • ceramide raw materials milk-derived phospholipid, lipid content 85% by weight, manufactured by Fontera Japan
  • ⁇ -CD ⁇ -cyclodextrin
  • a measurement sample having a weight ratio was prepared according to the following procedure.
  • Samples (1) and (10) the raw materials were used for measurement as they were.
  • Samples (2) to (9) were obtained by weighing each raw material so as to have a specific weight ratio, stirring for 10 minutes with a stirrer in addition to about 70 ° C. warm water having a weight of 4 times the solid content.
  • the mixed liquid was spray-dried at a blowing temperature of 100 ° C. with a fluidized bed granulator to obtain each sample.
  • EXSTAR6000 manufactured by Seiko Instruments Inc. was used as a DSC measuring instrument.
  • the measurement weight was 5.0 mg
  • the measurement atmosphere was Air
  • the heating rate was 2 ° C./min.
  • the inclusion ratio of the ceramide raw material (milk-derived phospholipid, lipid content 85% by weight) by cyclodextrin ( ⁇ -CD) indicates that the weight ratio of the ceramide raw material to cyclodextrin is at least 2: 1 (1: 0). .5) to 1: 2 was confirmed. Further, it was considered that all the ceramide raw materials used in the sample were included in the cyclodextrin when the weight ratio of the ceramide raw material to the cyclodextrin was about 1: 1. Furthermore, it was considered that all the ceramide raw materials used for the samples were included in the cyclodextrin when the weight ratio of the ceramide raw material to the cyclodextrin was in the range of 1.03125: 1 to 1: 2.
  • Test Example 5 Analysis of inclusion action of ceramide raw material with cyclodextrin (2) NMR
  • the liquid mixture prepared by changing the weight ratio of the ceramide raw material and cyclodextrin and its dry powder were evaluated by nuclear magnetic resonance analysis.
  • the raw material ceramide raw material milk-derived phospholipid, lipid content 85% by weight, manufactured by Fontera Japan
  • cyclodextrin ⁇ -CD; trade name: CAVAMAX® W8 Food, manufactured by Cyclochem
  • the raw ceramide raw material (same as above) and cyclodextrin (same as above) are mixed with water at a weight ratio of 1: 2 and 0: 1 ( ⁇ -CD single product), respectively, and heated to 70 ° C.
  • the mixture obtained by stirring was freeze-dried and then pulverized to obtain a dry powder.
  • the obtained dry powder was dissolved in heavy water, respectively, and used as each measurement sample in the same manner as described above.
  • the obtained measurement sample was subjected to 1H-NMR nuclear magnetic resonance analysis.
  • the analysis was performed at 25 ° C. using an Avance 500 nuclear magnetic resonance spectrum measuring apparatus (1H resonance frequency 500 MHz) manufactured by Bruker BioSpin Co., Ltd. as an apparatus.
  • the chemical shifts of H3 and H5 in samples having different ratios of milk-derived phospholipid and ⁇ -cyclodextrin were almost the same. This was considered to mean that milk-derived phospholipid was not included in ⁇ -cyclodextrin in the measured mixed solution. That is, the composition containing collagen and ceramide of the present invention forms an inclusion body in the production process of obtaining a mixed solution containing a ceramide raw material (milk-derived phospholipid) and cyclodextrin ( ⁇ -cyclodextrin). Not suggested.
  • a mixed solution containing ⁇ -cyclodextrin and milk-derived phospholipid and a mixed solution containing ⁇ -cyclodextrin and milk-derived phospholipid were also prepared, and in each case, milk-derived phospholipid and cyclodextrin were mixed.
  • the inclusion ability in the solution was actually confirmed. As a result, it was found that the inclusion ability in these cases was extremely weak. From these results, it was considered that the situation regarding the presence or absence of inclusions in the solution was the same for ⁇ -cyclodextrin and ⁇ -cyclodextrin as for ⁇ -cyclodextrin. .

Abstract

La présente invention concerne une composition présentant une configuration dans laquelle une matière brute à base de céramide incorporée dans une cyclodextrine est collée sur un peptide de collagène ou des granules contenant chacun le peptide de collagène. La composition peut être produite par pulvérisation d'une solution contenant une matière brute à base de céramide et de la cyclodextrine sur un peptide de collagène ou des granules contenant chacun le peptide de collagène et ensuite granulation du produit résultant. Selon la présente invention, le collagène et la céramide sont uniformément dispersés dans la composition, l'apparition d'une décoloration brunâtre pendant le procédé de granulation ou le stockage dans des conditions de température élevée peut être évitée, et la formation d'une odeur désagréable peut également être évitée.
PCT/JP2016/074925 2015-08-26 2016-08-26 Composition contenant un peptide de collagène et une céramide et son procédé de production WO2017034014A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201680049214.5A CN107920580A (zh) 2015-08-26 2016-08-26 含有胶原蛋白肽及神经酰胺的组合物及其制造方法
JP2017536485A JP6762302B2 (ja) 2015-08-26 2016-08-26 コラーゲンペプチド及びセラミドを含有する組成物とその製造方法
SG11201800826UA SG11201800826UA (en) 2015-08-26 2016-08-26 Collagen peptide- and ceramide-containing composition and method of producing the same
HK18105591.2A HK1246096A1 (zh) 2015-08-26 2018-04-30 含有膠原蛋白肽及神經醯胺的組合物及其製造方法

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JP2015166707 2015-08-26
JP2015-166707 2015-08-26

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WO2017034014A1 true WO2017034014A1 (fr) 2017-03-02

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