WO2012129495A1 - Opioid receptor ligands and methods of using and making same - Google Patents

Opioid receptor ligands and methods of using and making same Download PDF

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Publication number
WO2012129495A1
WO2012129495A1 PCT/US2012/030327 US2012030327W WO2012129495A1 WO 2012129495 A1 WO2012129495 A1 WO 2012129495A1 US 2012030327 W US2012030327 W US 2012030327W WO 2012129495 A1 WO2012129495 A1 WO 2012129495A1
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WO
WIPO (PCT)
Prior art keywords
ethyl
compound
amine
methyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/030327
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English (en)
French (fr)
Inventor
Dennis Yamashita
Dimitar Gotchev
Philip Pitis
Xiao-Tao Chen
Guodong Liu
Catherine C.K. Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trevena Inc
Original Assignee
Trevena Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46877853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2012129495(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EA201391332A priority Critical patent/EA025456B1/ru
Priority to SI201231000T priority patent/SI2688403T1/sl
Priority to HRP20171021TT priority patent/HRP20171021T1/hr
Priority to EP20217112.0A priority patent/EP3872076A1/en
Priority to EP12760456.9A priority patent/EP2688403B1/en
Priority to ES12760456.9T priority patent/ES2632009T3/es
Priority to RS20170630A priority patent/RS56111B1/sr
Priority to CA2830742A priority patent/CA2830742C/en
Priority to MEP-2017-129A priority patent/ME02754B/me
Priority to KR1020187025108A priority patent/KR101991326B1/ko
Priority to EP17173483.3A priority patent/EP3290415B1/en
Priority to AU2012230761A priority patent/AU2012230761B2/en
Priority to KR1020197016977A priority patent/KR102129247B1/ko
Priority to BR112013024136-5A priority patent/BR112013024136B1/pt
Priority to PL17173483T priority patent/PL3290415T3/pl
Priority to DK12760456.9T priority patent/DK2688403T3/en
Priority to NZ615993A priority patent/NZ615993B2/en
Application filed by Trevena Inc filed Critical Trevena Inc
Priority to LTEP12760456.9T priority patent/LT2688403T/lt
Priority to JP2014501273A priority patent/JP5912169B2/ja
Priority to CN201280021050.7A priority patent/CN103702561B/zh
Priority to SM20170325T priority patent/SMT201700325T1/it
Priority to KR1020137027288A priority patent/KR101991327B1/ko
Publication of WO2012129495A1 publication Critical patent/WO2012129495A1/en
Priority to IL228506A priority patent/IL228506A/en
Anticipated expiration legal-status Critical
Priority to IL243318A priority patent/IL243318B/en
Priority to AU2017200745A priority patent/AU2017200745B2/en
Priority to CY20171100716T priority patent/CY1119057T1/el
Priority to IL272165A priority patent/IL272165B/en
Priority to IL284407A priority patent/IL284407B2/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Definitions

  • This application describes opioid receptor (OR) ligands. It also describes methods of modulating opioid receptor activity using the compositions described herein. Certain compositions described herein act as opioid receptor agonists. Other compositions described herein act as opioid receptor antagonists.
  • Di is an aryl. Examples of the aryl groups are shown above.
  • cabocycle is cyclohexyl, cyclohexenyl or cyclopentyl.
  • reporter genes may be used as described in U.S. Pat. No. 5,436, 128, herein incorporated by reference.
  • the reporter genes can be, e.g. , chloramphenicol acetyltransferase, firefly luciferase, bacterial luciferase, ⁇ - galactosidase and alkaline phosphatase.
  • the protein of interest can be used as an indirect reporter via attachment to a second reporter such as green fluorescent protein (see, e.g., Mistili & Spector, Nature Biotechnology 15:961 964 (1997)).
  • the amount of transcription is then compared to the amount of transcription in either the same cell in the absence of the test compound, or it may be compared with the amount of transcription in a substantially identical cell that lacks the protein of interest.
  • a substantially identical cell may be derived from the same cells from which the recombinant cell was prepared but which had not been modified by introduction of heterologous DNA. Any difference in the amount of transcription indicates that the test compound has in some manner altered the activity of the protein of interest.
  • compositions can be formulated by standard techniques using one or more physiologically acceptable carriers or excipients.
  • the formulations may contain a buffer and/or a preservative.
  • the compounds and their physiologically acceptable salts and solvates can be formulated for administration by any suitable route, including via inhalation, topically, nasally, orally, parenterally ⁇ e.g., intravenously, intraperitoneal ⁇ , intravesically or intrathecal ly) or rectally in a vehicle comprising one or more
  • compositions may include diluents of various buffer content ⁇ e.g., TR.IS or other amines, carbonates, phosphates, amino acids, for example, glycinamide hydrochloride (especially in the physiological pH range), N-glycylglycine, sodium or potassium phosphate (dibasic, tribasic), etc. or TRIS-HCl or acetate), pH and ionic strength; additives such as detergents and solubilizing agents (e.g., surfactants such as Pluronics, Tween 20, Tween 80
  • N-alkyl-N,N-dimethylammonio- 1 -propanesulfonates 3-cholamido- l-propyldimethylammonio-l-propanesulfonate, dodecylphosphocholine, myristoyl lysophosphatidylcholine, hen egg lysolecithin), cationic surfactants (quarternary ammonium bases) (e.g. cetyl-trimethylammonium bromide, cetylpyridinium chloride), non-ionic surfactants,
  • the compounds can also be formulated in rectal compositions, for example, suppositories or retention enemas, for example, containing conventional suppository bases, for example, cocoa butter or other glycerides.
  • the compounds can be formulated as a depot preparation. Such long-acting formulations can be administered by implantation (for example, subcutaneously or intramuscularly) or by intramuscular injection.
  • the compounds can be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/US2012/030327 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same Ceased WO2012129495A1 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
KR1020137027288A KR101991327B1 (ko) 2011-03-23 2012-03-23 오피오이드 수용체 리간드와 그 용도 및 제조방법
PL17173483T PL3290415T3 (pl) 2011-03-23 2012-03-23 Ligandy receptora opioidowego oraz sposoby ich stosowania i wytwarzania
HRP20171021TT HRP20171021T1 (hr) 2011-03-23 2012-03-23 Ligandi opioidnih receptora i metode za njihovu uporabu i izradu
EP20217112.0A EP3872076A1 (en) 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same
EP12760456.9A EP2688403B1 (en) 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same
ES12760456.9T ES2632009T3 (es) 2011-03-23 2012-03-23 Ligandos de receptores de opioides y métodos para utilizar y obtener los mismos
RS20170630A RS56111B1 (sr) 2011-03-23 2012-03-23 Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme
CA2830742A CA2830742C (en) 2011-03-23 2012-03-23 Substituted oxanes as opioid receptor ligands and methods of using and making same
NZ615993A NZ615993B2 (en) 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same
KR1020187025108A KR101991326B1 (ko) 2011-03-23 2012-03-23 오피오이드 수용체 리간드와 그 용도 및 제조방법
EP17173483.3A EP3290415B1 (en) 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same
AU2012230761A AU2012230761B2 (en) 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same
KR1020197016977A KR102129247B1 (ko) 2011-03-23 2012-03-23 오피오이드 수용체 리간드와 그 용도 및 제조방법
BR112013024136-5A BR112013024136B1 (pt) 2011-03-23 2012-03-23 Compostos ligantes de receptor opióide, seu processo de preparação, composições farmacêuticas compreendendo os mesmos e seus usos
DK12760456.9T DK2688403T3 (en) 2011-03-23 2012-03-23 OPIOID RECEPTOR LIGANDS AND METHODS FOR USING AND MANUFACTURING SAME
EA201391332A EA025456B1 (ru) 2011-03-23 2012-03-23 Лиганды опиоидных рецепторов и способы их применения и получения
MEP-2017-129A ME02754B (me) 2011-03-23 2012-03-23 Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme
SI201231000T SI2688403T1 (sl) 2011-03-23 2012-03-23 Ligandi opioidnih receptorjev in metode uporabe in izdelave istega
LTEP12760456.9T LT2688403T (lt) 2011-03-23 2012-03-23 Opioidų receptorių ligandai ir jų panaudojimo bei gamybos būdai
JP2014501273A JP5912169B2 (ja) 2011-03-23 2012-03-23 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
CN201280021050.7A CN103702561B (zh) 2011-03-23 2012-03-23 阿片样物质受体配体以及使用和制备其的方法
SM20170325T SMT201700325T1 (it) 2011-03-23 2012-03-23 Ligandi del recettore degli oppioidi e metodi per l’uso e la produzione dei medesimi
IL228506A IL228506A (en) 2011-03-23 2013-09-17 Opioid receptor ligands and pharmacy preparations containing them
IL243318A IL243318B (en) 2011-03-23 2015-12-27 Opioid receptor ligands and methods for their use and preparation
AU2017200745A AU2017200745B2 (en) 2011-03-23 2017-02-03 Opioid receptor ligands and methods of using and making same
CY20171100716T CY1119057T1 (el) 2011-03-23 2017-07-04 Συνδετες υποδοχεα οπιοειδους και μεθοδοι χρησης και κατασκευης αυτων
IL272165A IL272165B (en) 2011-03-23 2020-01-21 Opioid receptor ligands and methods for their use and preparation
IL284407A IL284407B2 (en) 2011-03-23 2021-06-27 Opioid receptor ligands and methods for their use and preparation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161466809P 2011-03-23 2011-03-23
US61/466,809 2011-03-23
US201261596808P 2012-02-09 2012-02-09
US61/596,808 2012-02-09

Publications (1)

Publication Number Publication Date
WO2012129495A1 true WO2012129495A1 (en) 2012-09-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/030327 Ceased WO2012129495A1 (en) 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same

Country Status (22)

Country Link
US (8) US8835488B2 (enExample)
EP (3) EP3872076A1 (enExample)
JP (6) JP5912169B2 (enExample)
KR (3) KR102129247B1 (enExample)
CN (1) CN103702561B (enExample)
AU (2) AU2012230761B2 (enExample)
CA (1) CA2830742C (enExample)
CY (1) CY1119057T1 (enExample)
DK (2) DK3290415T3 (enExample)
EA (1) EA025456B1 (enExample)
ES (2) ES2857549T3 (enExample)
HR (1) HRP20171021T1 (enExample)
HU (2) HUE032948T2 (enExample)
IL (4) IL228506A (enExample)
LT (1) LT2688403T (enExample)
ME (1) ME02754B (enExample)
PL (2) PL3290415T3 (enExample)
PT (2) PT2688403T (enExample)
RS (1) RS56111B1 (enExample)
SI (1) SI2688403T1 (enExample)
SM (1) SMT201700325T1 (enExample)
WO (1) WO2012129495A1 (enExample)

Cited By (30)

* Cited by examiner, † Cited by third party
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