CN110678453A - 一种氧杂螺环类衍生物的制备方法及其中间体 - Google Patents

一种氧杂螺环类衍生物的制备方法及其中间体 Download PDF

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Publication number
CN110678453A
CN110678453A CN201880035013.9A CN201880035013A CN110678453A CN 110678453 A CN110678453 A CN 110678453A CN 201880035013 A CN201880035013 A CN 201880035013A CN 110678453 A CN110678453 A CN 110678453A
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heteroaryl
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CN110678453B (zh
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李文海
齐维兴
邱振均
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Jiangsu Hengrui Medicine Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

本发明涉及一种氧杂螺环类衍生物的制备方法及其中间体，该方法缩短了反应步骤、提高了反应产率、简单易操控、利于工业扩大生产。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN201880035013.9A 2017-09-28 2018-09-27 一种氧杂螺环类衍生物的制备方法及其中间体 Active CN110678453B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710896555 2017-09-28
CN2017108965552 2017-09-28
PCT/CN2018/107901 WO2019062804A1 (zh) 2017-09-28 2018-09-27 一种氧杂螺环类衍生物的制备方法及其中间体

Publications (2)

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CN110678453A true CN110678453A (zh) 2020-01-10
CN110678453B CN110678453B (zh) 2023-03-10

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CN201880035013.9A Active CN110678453B (zh) 2017-09-28 2018-09-27 一种氧杂螺环类衍生物的制备方法及其中间体

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Country Link
US (1) US11111236B2 (zh)
EP (1) EP3689859A4 (zh)
JP (1) JP2020535177A (zh)
KR (1) KR20200060750A (zh)
CN (1) CN110678453B (zh)
AU (1) AU2018341782A1 (zh)
BR (1) BR112020005858A2 (zh)
CA (1) CA3076395A1 (zh)
MX (1) MX2020003784A (zh)
TW (1) TWI690524B (zh)
WO (1) WO2019062804A1 (zh)
ZA (1) ZA202002138B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024153159A1 (zh) * 2023-01-18 2024-07-25 上海森辉医药有限公司 一种四氢-1-萘胺及其衍生物的制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019205983A1 (zh) * 2018-04-28 2019-10-31 四川科伦博泰生物医药股份有限公司 氧杂螺环类化合物及其制备方法和用途
WO2022143715A1 (zh) * 2020-12-29 2022-07-07 上海海雁医药科技有限公司 氧杂螺环取代的吡咯并吡唑衍生物及其中间体和制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012129495A1 (en) * 2011-03-23 2012-09-27 Trevena, Inc. Opioid receptor ligands and methods of using and making same
WO2017063509A1 (zh) * 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用
CN106588899A (zh) * 2015-10-15 2017-04-26 江苏恒瑞医药股份有限公司 吡啶基取代的6‑氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012129495A1 (en) * 2011-03-23 2012-09-27 Trevena, Inc. Opioid receptor ligands and methods of using and making same
WO2017063509A1 (zh) * 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用
CN106588899A (zh) * 2015-10-15 2017-04-26 江苏恒瑞医药股份有限公司 吡啶基取代的6‑氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024153159A1 (zh) * 2023-01-18 2024-07-25 上海森辉医药有限公司 一种四氢-1-萘胺及其衍生物的制备方法

Also Published As

Publication number Publication date
CN110678453B (zh) 2023-03-10
RU2020113709A3 (zh) 2022-01-25
TWI690524B (zh) 2020-04-11
US11111236B2 (en) 2021-09-07
EP3689859A4 (en) 2021-08-25
EP3689859A1 (en) 2020-08-05
ZA202002138B (en) 2021-05-26
AU2018341782A1 (en) 2020-04-16
CA3076395A1 (en) 2019-04-04
RU2020113709A (ru) 2021-10-18
TW201914997A (zh) 2019-04-16
WO2019062804A1 (zh) 2019-04-04
US20200308151A1 (en) 2020-10-01
BR112020005858A2 (pt) 2020-09-29
JP2020535177A (ja) 2020-12-03
MX2020003784A (es) 2020-08-03
KR20200060750A (ko) 2020-06-01

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