JP5912169B2 - オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 - Google Patents

オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 Download PDF

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JP5912169B2
JP5912169B2 JP2014501273A JP2014501273A JP5912169B2 JP 5912169 B2 JP5912169 B2 JP 5912169B2 JP 2014501273 A JP2014501273 A JP 2014501273A JP 2014501273 A JP2014501273 A JP 2014501273A JP 5912169 B2 JP5912169 B2 JP 5912169B2
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compound
pharmaceutically acceptable
acceptable salt
optionally substituted
alkyl
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JP2014508811A (ja
JP2014508811A5 (enExample
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デニス・ヤマシタ
デミター・ゴッチェフ
フィリップ・ピティス
シャオ−タオ・チェン
グオドーン・リウ
キャサリン・シー．ケー．・ユエン
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Trevena Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/12—Antidiarrhoeals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014501273A 2011-03-23 2012-03-23 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法 Active JP5912169B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161466809P 2011-03-23 2011-03-23
US61/466,809 2011-03-23
US201261596808P 2012-02-09 2012-02-09
US61/596,808 2012-02-09
PCT/US2012/030327 WO2012129495A1 (en) 2011-03-23 2012-03-23 Opioid receptor ligands and methods of using and making same

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JP2016067208A Division JP6243949B2 (ja) 2011-03-23 2016-03-30 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法

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JP2014508811A JP2014508811A (ja) 2014-04-10
JP2014508811A5 JP2014508811A5 (enExample) 2015-05-07
JP5912169B2 true JP5912169B2 (ja) 2016-04-27

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JP2014501273A Active JP5912169B2 (ja) 2011-03-23 2012-03-23 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2016067208A Expired - Fee Related JP6243949B2 (ja) 2011-03-23 2016-03-30 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2017216012A Expired - Fee Related JP6649341B2 (ja) 2011-03-23 2017-11-09 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2020004039A Active JP6923683B2 (ja) 2011-03-23 2020-01-15 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2021122940A Active JP7248750B2 (ja) 2011-03-23 2021-07-28 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2023040218A Pending JP2023075282A (ja) 2011-03-23 2023-03-15 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法

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JP2016067208A Expired - Fee Related JP6243949B2 (ja) 2011-03-23 2016-03-30 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2017216012A Expired - Fee Related JP6649341B2 (ja) 2011-03-23 2017-11-09 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2020004039A Active JP6923683B2 (ja) 2011-03-23 2020-01-15 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2021122940A Active JP7248750B2 (ja) 2011-03-23 2021-07-28 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
JP2023040218A Pending JP2023075282A (ja) 2011-03-23 2023-03-15 オピオイド受容体リガンド並びにそれらの使用方法及び製造方法

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US (8) US8835488B2 (enExample)
EP (3) EP3872076A1 (enExample)
JP (6) JP5912169B2 (enExample)
KR (3) KR102129247B1 (enExample)
CN (1) CN103702561B (enExample)
AU (2) AU2012230761B2 (enExample)
CA (1) CA2830742C (enExample)
CY (1) CY1119057T1 (enExample)
DK (2) DK3290415T3 (enExample)
EA (1) EA025456B1 (enExample)
ES (2) ES2857549T3 (enExample)
HR (1) HRP20171021T1 (enExample)
HU (2) HUE032948T2 (enExample)
IL (4) IL228506A (enExample)
LT (1) LT2688403T (enExample)
ME (1) ME02754B (enExample)
PL (2) PL3290415T3 (enExample)
PT (2) PT2688403T (enExample)
RS (1) RS56111B1 (enExample)
SI (1) SI2688403T1 (enExample)
SM (1) SMT201700325T1 (enExample)
WO (1) WO2012129495A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023075282A (ja) * 2011-03-23 2023-05-30 トレベナ・インコーポレイテッド オピオイド受容体リガンド並びにそれらの使用方法及び製造方法

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CN106588899B (zh) * 2015-10-15 2019-11-15 江苏恒瑞医药股份有限公司 吡啶基取代的6-氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用
HK1251472A1 (zh) * 2015-12-14 2019-02-01 特维娜有限公司 治療痛覺過敏的方法
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KR20180094938A (ko) * 2015-12-17 2018-08-24 트레베나, 인코포레이티드. 오피오이드 수용체 리간드와 시토크롬 p450 억제제의 결합
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TWI682929B (zh) * 2017-04-14 2020-01-21 大陸商江蘇恒瑞醫藥股份有限公司 一種阿片樣物質受體（mor）激動劑的鹽、其富馬酸鹽i晶型及製備方法
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CN109206417B (zh) * 2017-07-04 2023-01-03 四川海思科制药有限公司 阿片受体激动剂及其应用
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