WO2009114046A2 - Acute stroke revascularization/recanalization systems processes and products thereby - Google Patents

Acute stroke revascularization/recanalization systems processes and products thereby Download PDF

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Publication number
WO2009114046A2
WO2009114046A2 PCT/US2008/083185 US2008083185W WO2009114046A2 WO 2009114046 A2 WO2009114046 A2 WO 2009114046A2 US 2008083185 W US2008083185 W US 2008083185W WO 2009114046 A2 WO2009114046 A2 WO 2009114046A2
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WIPO (PCT)
Prior art keywords
revascularization
acute stroke
catheter
improved neurological
medical device
Prior art date
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Ceased
Application number
PCT/US2008/083185
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English (en)
French (fr)
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WO2009114046A3 (en
Inventor
John Fulkerson
David A. Ferrera
Andrew Cragg
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Mindframe LLC
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Mindframe LLC
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Priority to EP08873248A priority Critical patent/EP2217315B1/en
Priority to CA2717790A priority patent/CA2717790A1/en
Priority to JP2010533336A priority patent/JP5504167B2/ja
Priority to AU2008352581A priority patent/AU2008352581B2/en
Priority to ES08873248T priority patent/ES2385631T3/es
Application filed by Mindframe LLC filed Critical Mindframe LLC
Priority to GB0922251A priority patent/GB2463592B/en
Publication of WO2009114046A2 publication Critical patent/WO2009114046A2/en
Publication of WO2009114046A3 publication Critical patent/WO2009114046A3/en
Priority to US12/651,353 priority patent/US20100174309A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320725—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with radially expandable cutting or abrading elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2/013—Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02—Dilators made of swellable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/0084—Material properties low friction
    • A61B2017/00845—Material properties low friction of moving parts with respect to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0059—Additional features; Implant or prostheses properties not otherwise provided for temporary
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1095—Balloon catheters with special features or adapted for special applications with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1097—Balloon catheters with special features or adapted for special applications with perfusion means for enabling blood circulation only while the balloon is in an inflated state, e.g. temporary by-pass within balloon

Definitions

  • the present disclosure relates to minimally invasive and catheter delivered revascularization systems for use in the vasculature, especially those suited for usage above the juncture of the Subclavian Artery and Common Coratid Artery.
  • this disclosure relates to revascularization devices for use in treatment of ischemic stroke, including improved neurological medical devices which are tethered or reconstrainable self-expanding neurological medical devices.
  • acute stroke revascularization/recanalization systems comprising, in combination; catheter systems having guidewires to access and emplace improved neurological medical devices into the cerebral vasculature, the systems including proximal stainless steel pushers with distal nitinol devices.
  • a novel enhanced tethered revascularization device is deliverable through highly constricted and tortuous vessels, entering a zone associated with subject thrombi/emboli, where deployment impacts the embolus, compacting the same into luminal walls which enables perfusion and lysis of the embolus, while the revascularization device itself remains continuous with the delivery system acting as a filter, basket or stand alone revascularization mechanism, depending on the status of the embolus and other therapeutic aspects of the treatment being offered for consideration.
  • the instant system in certain iterations, once deployed the instant system compacts the embolus against the luminal wall, creating a channel for blood flow which may act like a natural lytic agent to lyse or dissolve the embolus.
  • an improved neurological medical device which comprises, in combination, a catheter system effective for delivering a combination radial filter/revascularization device and basket assembly into a desired location in the cerebral vascular system, a self-expanding radial filter/revascularization device and basket assembly detachably tethered to the catheter system which functions in at least three respective modes, wherein the radial filter/revascuiarization device and basket assembly is attached to the catheter and wherein radial filter/revascuiarization device and basket assembly further comprises at least two states per mode, a retracted state and an expanded state; and wherein the radial filter/revascuiarization device and basket assembly may retracted into the retracted state after deployment in an expanded state, in each mode.
  • a process comprising in combination providing a revascularization device tethered to a catheter by emplacing the system into a patient for travel to a desired location in a vessel having an obstruction/lesion and deploying the revascularization device by allowing it to move from a first state to a second state across a lesion which compresses the subject embolus into a luminal wall to which it is adjacent whereby creating a channel for blood flow as a lytic agent, and removing the system which the obstruction/lesion is addressed.
  • lytic agents can be administred via the guidewire lumen, as a feature of the present invention.
  • the U.S. Food and Drug Administration has previously approved a clot retrieval device (The Merci® brand of retriever X4, X5, X6, L4, L5 & L6: Concentric Medical, Mountain View, CA).
  • This clot retriever is successful in restoring blood flow in only approximately 50% of the cases, and multiple passes with this device are often required to achieve successful recanalization.
  • IA thrombolytics administered concomitantly enhance the procedural success of this device but may increase the risk of hemorrhagic transformation of the revascularization infarction.
  • coronary and neuro-stent implantation used for mechanical thrombolysis of recalcitrant occlusions.
  • stent placement with balloon-mounted or self-expanding coronary and neuro-types of stents has been shown to be an independent predictor for recanalization of both intracranial and extra cranial cerebro-vasculature occlusions. This provides some insight into approaches needed to overcome these longstanding issues.
  • self-expanding stents designed specifically for the cerebro- vasculature can be delivered to target areas of intracranial stenosis with a success rate of >95% and an increased safety profile of deliverability because these stents are deployed at significantly lower pressures than balloon-mounted coronary stents.
  • systems using this data have yet to become commercial, available or accepted by most practitioners.
  • self-expanding stents are not mounted on balloons, they are the most trackable of the stents currently available for the intracranial circulation. Unlike clot retrievers, which lose access to the target (occlusion site) every time they are retrieved (and often to necessitate multiple passes), self-expanding stents allow for wire access to the occlusion at all times, increasing the safety profile of the procedure by not requiring repeat maneuvers to gain access to the target site (as in the case for the Merci® brand of clot retriever).
  • Self-expanding stent placement of acute intracranial vessel occlusions may provide a novel means of recanalization after failure of clot retrieval, angioplasty, and/or thrombolytic therapy.
  • the patency rates in this series are encouraging, yet issues remain to be addressed.
  • In-stent stenosis or delayed stenosis may be treated in a delayed fashion on an elective basis, should the patient achieve a functional recovery from the stroke.
  • Recanalization with self-expanding stents may provide flow through the patent artery, and restore flow to the perforators, or, alternatively, they may remain occluded. Restoring flow to the main artery, however, will reduce the stroke burden. What is needed is a solution leveraging positive aspects of stent-based treatment without the negative outcomes which have been associated with traditional stenting.
  • Figure 1 is a perspective view of an embodiment of an acute stroke recanalization system according to embodiments of the present disclosure in a first configuration
  • Figure 2 is a perspective view of an embodiment of an acute stroke recanalization system according to embodiments of the present disclosure tailored for use with the neurovasculature in a second configuration, further illustrating modular aspects of the system as used with tethered or reconstrainable self-expanding neurological medical devices.
  • a poly-modic system can be iterated which impacts, addresses and/or crosses an embolus, radially filters, and either removes the offending embolus or is optionally emplaced to address the same.
  • a paucity of extant systems effective for such combination therapies is noted among the art.
  • the instant system allows for natural lysis, revascularization of the challenged vessels, and importantly radially filters any particulates generated, to obviate the need to be concerned with distal migration of the same, unlike prior systems or applications which include largely "off-label" usages of devices approved only for aneurysms in the brain.
  • the present disclosure relates to revascularization devices used to treat, among other things, ischemic stroke.
  • the revascularization devices of the present disclosure are designed to be used in neuro-type applications, wherein the specifications of the present catheters and revascularization devices may be deployed in the blood vessels of the cerebral vascular system.
  • the revascularization systems and catheters of the present disclosure is deployment in other parts of the body wherein the specifications of the present disclosure may be used in other vessels of the body in a non-invasive manner.
  • a catheter-based revascularization system for revascularization of blood vessels.
  • the revascularization devices of the present disclosure are for revascularization of blood vessels.
  • the catheter-based revascularization system of the present disclosure is deployed into a blood vessel having an embolus, the revascularization device is expanded thereby opening the vessel so that the vessel can resume proper blood flow.
  • deployment of the system of the present disclosure establishes immediate 50% of the diameter of the lumen patency of the vessel being addressed.
  • no system having adequately small profile with flexibility to promote improved access for in-site treatment is known which may be used as a temporary (not implanted) solution.
  • detachment methods comprising mechanical, electrical, hydraulic, chemical, or thermal, and others are within the scope of the instant teachings.
  • the deployed revascularization device radially filters larger embolus particles from traveling downstream, thereby reducing the chances of further complications.
  • the revascularization device is modified to be in a removable state together with filtered detritus, and the catheter-revascularization system is removed from the blood vessels of the patient.
  • intracranial stents as a method for arterial recanalization during cerebral ischemia caused by focal occlusion of an intracranial vessel has been demonstrated to have benefits in some cases.
  • angiographic recanalization of occluded vessels has not been adequately achieved before stent placement, in most cases.
  • Endovascular treatment with stent deployment for ICA dissection with high-grade stenosis or occlusion may be most appropriate when anticoagulation fails to prevent a new ischemic event.
  • the MCA may be patent.
  • Stent assisted endovascular thrombolysis/thrombectormy compared favorably with IV rtPA thrombolysis, underscoring the need for the instant device.
  • catheter-based revascularization system 100 provides a platform for lysing emboli in occluded blood vessels.
  • catheter-based revascularization system 100 generally comprises control end 102 and deployment end 104.
  • control end 102 is a portion of the device that allows a user, such as a surgeon, to control deployment of the device through the blood vessels of a patient.
  • delivery handle 106 and winged apparatus 108 Included as part of control end 102 is delivery handle 106 and winged apparatus 108, in some embodiments.
  • module 113 see Fig. 2 is detachable.
  • shipping lock (not shown) is installed between delivery handle 106 and winged apparatus 108 to prevent deployment and premature extension of revascularization device 124 (see Fig. 2) while not in use. Furthermore, by preventing delivery handle 106 from being advanced towards winged apparatus 108, coatings applied to revascularization device 124 are stored in a configuration whereby they will not rub off or be otherwise damaged while catheter-based revascularization system 100 is not in use.
  • agent delivery device 130 provides a conduit in fluid communication with the lumen of the catheter-based revascularization system 100 enabling users of the system to deliver agents through catheter-revascularization system 100 directly to the location of the embolus.
  • the instant revascularization system delivery device may be made from materials known to artisans, including stainless steel hypotube, stainless steel coil, polymer jackets, and/or radiopaque jackets.
  • luer connector 132 or a functional equivalent provides sterile access to the lumen of catheter-based revascularization system 100 to effect delivery of a chosen agent.
  • revascularization devices of the present invention include embodiments made essentially of nitinol or spring tempered stainless steel. Revascularization devices likewise may be coated or covered with therapeutic substances in pharmacologically effective amounts or lubricious materials. According to embodiments, coatings include namodopene, vasodialators, sirolamus, and paclitaxel. Additionally, at least heparin and other coating materials of pharmaceutical nature may be used.
  • Deployment end 104 of catheter-based revascularization system 100 comprises proximal segment 110 and distal segment 120.
  • Proximal segment 110 houses distal segment 120 and comprises outer catheter 112 that is of a suitable length and diameter for deployment into the blood vessel of the neck, head, and cerebral vasculature.
  • proximal segment 110 is from at least about 100 cm to approximately 115 cm long with an outer diameter of at least about 2.5 French to about 4 French.
  • distal segment 120 comprises inner catheter 122 and revascularization device 124 (as shown here in one embodiment having uniform cells, variable cells likewise being within other embodiments of the present invention), which is connected to inner catheter 122.
  • Inner catheter 122 is made from stainless steel coil, stainless steel wire, or ribbon or laser cut hypotube and is of a suitable length and diameter to move through outer catheter 112 during deployment.
  • inner catheter 122 extends from outer catheter 112 38 cm, thereby giving it a total length of between at least about 143 and 175 cm.
  • the diameter of inner catheter 122 according to the exemplary embodiment is 2.7 French, with an inner diameter of at least about 0.012 to 0.029 inches.
  • the inner diameter of inner catheter 122 may be any suitable diameter provided inner catheter 122 maintains the strength and flexibility to both deploy and retract revascularization device 124.
  • revascularization device 124 is a self-expanding, reconstrictable retractable device tethered to inner catheter 122.
  • Revascularization device 124 may be made from nitinol, spring tempered stainless steel, or equivalents as known and understood by artisans, according to embodiments.
  • Revascularization device 124 may be from at least about 3.5 mm to about 50 mm in its expanded state. In an expanded state, revascularization device 124 is designed to expand in diameter to the luminal wall of blood vessel where it is deployed.
  • revascularization device 124 may be coated or covered with substances imparting lubricous characteristics or therapeutic substances, as desired.
  • the expandable mesh design of revascularization device 124 must by a pattern whereby when revascularization device 124 is retracted, it is able to fully retract into inner catheter 122.
  • the nature of the cell type likewise changes with respect to the embodiment used, and is often determined based upon nature of the clot.
  • Catheter-revascularization system 100 is deployed through a patient's blood vessels. Once the user of catheter-revascularization system 100 determines that the embolus to be addressed is crossed, as known and understood well by artisans, revascularization device 124 is deployed by first positioning outer catheter 112 in a location immediately distal to the embolus.
  • distal catheter 120 is deployed in a location whereby revascularization device 124 expands at the location of the embolus, as illustrated by Fig. 2.
  • the embolus is thereby compressed against the luminal wall of the blood vessel and blood flow is restored.
  • Modular detachable segment 113 is known also, and may be swapped out, as needed, if an Rx system is used.
  • creating a channel for flow ideally includes making a vessel at least about halfway-patent, or 50% of diameter of a vessel being open.
  • the channel created may be a cerebral equivalent of thrombolysis in myocardial infarction TIMf 1, TIMI 2, or TIMI 3.
  • Restoration of blood flow may act as a natural lytic agent and many emboli may begin to dissolve.
  • Revascularization device 124 is designed, according to embodiments, to radially filter larger pieces of the dissolving embolus and prevent them from traveling distal to the device and potentially causing occlusion in another location. Because the revascularization device provides continuous radial pressure at the location of the obstruction, as the embolus dissolves, the blood flow continues to increase.
  • revascularization device 124 is sheathed into outer catheter 112 and removed from the body. According to embodiments, larger pieces of the thrombus may be retracted with revascularization device 124 after being captured in the radial filtering process. According to embodiments, revascularization device 124 may be detachable whereby the revascularization device 124 may detach from catheter-based revascularization system 100 if it is determined that revascularization device 124 should remain in the patient. As discussed above, illustrated in the Figures, and claimed below according to embodiments, catheter-based revascularization system 100 reconstrainable attachment or attachment by tether may be optionally detachable. Revascularization device detachment methods comprise mechanical, electrical hydraulic, chemical, thermal, and those other uses known to artisans.
  • each physical element disclosed should be understood to encompass a disclosure of the action which that physical element facilitates.

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  • Heart & Thoracic Surgery (AREA)
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PCT/US2008/083185 2007-11-12 2008-11-12 Acute stroke revascularization/recanalization systems processes and products thereby Ceased WO2009114046A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB0922251A GB2463592B (en) 2007-11-12 2008-11-12 Acute stroke revascularization/recanalization systems processes and products thereby
CA2717790A CA2717790A1 (en) 2007-11-12 2008-11-12 Acute stroke revascularization/recanalization systems processes and products thereby
JP2010533336A JP5504167B2 (ja) 2007-11-12 2008-11-12 急性脳卒中血管再生／再疎通システム、プロセスおよびそれらによる製品
AU2008352581A AU2008352581B2 (en) 2007-11-12 2008-11-12 Acute stroke revascularization/recanalization systems processes and products thereby
ES08873248T ES2385631T3 (es) 2007-11-12 2008-11-12 Sistemas y procedimientos de revascularización/recanalización de un infarto agudo y productos relacionados con los mismos
EP08873248A EP2217315B1 (en) 2007-11-12 2008-11-12 Acute stroke revascularization/recanalization systems processes and products thereby
US12/651,353 US20100174309A1 (en) 2008-05-19 2009-12-31 Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98738407P 2007-11-12 2007-11-12
US60/987,384 2007-11-12
US12/123,390 2008-05-19
US12/123,390 US9198687B2 (en) 2007-10-17 2008-05-19 Acute stroke revascularization/recanalization systems processes and products thereby

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WO2009114046A2 true WO2009114046A2 (en) 2009-09-17
WO2009114046A3 WO2009114046A3 (en) 2009-12-17

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EP (2) EP2478930A3 (https=)
JP (1) JP5504167B2 (https=)
AU (1) AU2008352581B2 (https=)
CA (1) CA2717790A1 (https=)
ES (1) ES2385631T3 (https=)
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Cited By (16)

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US8679142B2 (en) 2008-02-22 2014-03-25 Covidien Lp Methods and apparatus for flow restoration
WO2014184489A1 (fr) 2013-05-13 2014-11-20 Machi Antonino Dispositif de chirurgie endovasculaire
US8945143B2 (en) 2007-10-17 2015-02-03 Covidien Lp Expandable tip assembly for thrombus management
US9387098B2 (en) 2007-10-17 2016-07-12 Covidien Lp Revascularization devices
WO2018050262A1 (en) 2016-09-19 2018-03-22 Cti Vascular Ag Catheter system for treating vascular and non-vascular diseases
US10130385B2 (en) 2007-06-26 2018-11-20 Roxwood Medical Inc. Method and apparatus for placing a catheter within a vasculature
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EP2217315A2 (en) 2010-08-18
GB201008683D0 (en) 2010-07-07
EP2478930A2 (en) 2012-07-25
JP2011502655A (ja) 2011-01-27
US20100318097A1 (en) 2010-12-16
US20090105737A1 (en) 2009-04-23
CA2717790A1 (en) 2009-09-17
EP2217315B1 (en) 2012-05-16
EP2478930A3 (en) 2012-12-26
US20110190797A1 (en) 2011-08-04
GB2463592A (en) 2010-03-24
AU2008352581A1 (en) 2009-09-17
WO2009114046A3 (en) 2009-12-17
GB2463592B (en) 2010-08-04
JP5504167B2 (ja) 2014-05-28
EP2217315A4 (en) 2010-12-08
ES2385631T3 (es) 2012-07-27
AU2008352581B2 (en) 2013-06-20
GB0922251D0 (en) 2010-02-03
US9198687B2 (en) 2015-12-01
US20100217187A1 (en) 2010-08-26

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