WO2008093829A1 - Ｌ－アミノ酸の製造法 - Google Patents

Ｌ－アミノ酸の製造法 Download PDF

Info

Publication number
WO2008093829A1
WO2008093829A1 PCT/JP2008/051643 JP2008051643W WO2008093829A1 WO 2008093829 A1 WO2008093829 A1 WO 2008093829A1 JP 2008051643 W JP2008051643 W JP 2008051643W WO 2008093829 A1 WO2008093829 A1 WO 2008093829A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
production
culture medium
producing
culturing
Prior art date
Application number
PCT/JP2008/051643
Other languages
English (en)
French (fr)
Inventor
Yoko Asakura
Ippei Inoue
Hisashi Yasueda
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to EP08704352.7A priority Critical patent/EP2128263B1/en
Publication of WO2008093829A1 publication Critical patent/WO2008093829A1/ja
Priority to US12/533,061 priority patent/US8993279B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/63—Vibrio

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Ｌ－アミノ酸生産能を有するビブリオ属細菌を培地中で培養し、該培地中にＬ－アミノ酸を生成蓄積させ、同培地からＬ－アミノ酸を回収することを特徴とする、Ｌ－アミノ酸の製造法。
PCT/JP2008/051643 2007-02-01 2008-02-01 Ｌ－アミノ酸の製造法 WO2008093829A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08704352.7A EP2128263B1 (en) 2007-02-01 2008-02-01 Method for production of l-amino acid
US12/533,061 US8993279B2 (en) 2007-02-01 2009-07-31 Method for production of L-amino acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-022910 2007-02-01
JP2007022910A JP2010088301A (ja) 2007-02-01 2007-02-01 Ｌ−アミノ酸の製造法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/533,061 Continuation US8993279B2 (en) 2007-02-01 2009-07-31 Method for production of L-amino acid

Publications (1)

Publication Number Publication Date
WO2008093829A1 true WO2008093829A1 (ja) 2008-08-07

Family

ID=39674132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051643 WO2008093829A1 (ja) 2007-02-01 2008-02-01 Ｌ－アミノ酸の製造法

Country Status (4)

Country Link
US (1) US8993279B2 (ja)
EP (1) EP2128263B1 (ja)
JP (1) JP2010088301A (ja)
WO (1) WO2008093829A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016301A1 (ja) * 2009-08-03 2011-02-10 味の素株式会社 ビブリオ属細菌を用いたｌ－リジンの製造法
CN118086167A (zh) * 2024-04-28 2024-05-28 天津科技大学 一种生产l-色氨酸的基因工程菌及其构建方法与应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
US20120292022A1 (en) * 2010-11-22 2012-11-22 E. I. Du Pont De Nemours And Company Composition for improving oil recovery including n-lauroyl amino acid-based compounds and microbes
KR101654810B1 (ko) * 2011-04-05 2016-09-07 바이오스트림테크놀러지스(주) 신규미생물 비브리오 스플린디더스 ｂｓｔ３９８ 및 이를 이용한 저분자 히알루론산의 제조방법
CN104195073A (zh) * 2014-08-08 2014-12-10 中国科学院南海海洋研究所 一种通用弧菌电感受态细胞制备及电转化方法
JP2021166470A (ja) * 2018-05-25 2021-10-21 Ｓｐｉｂｅｒ株式会社 ビブリオ属細菌の培地
GB201810016D0 (en) * 2018-06-19 2018-08-01 Univ I Tromsoe Norges Microbial hosts for protein production
CN110205346B (zh) * 2019-07-02 2021-04-06 武汉轻工大学 一种l-丝氨酸的制备方法
US20210355434A1 (en) * 2020-05-14 2021-11-18 EVN Holdings LLC Methods of Producing Cannabinoids
CN112175981B (zh) * 2020-09-07 2024-06-25 中国水产科学研究院南海水产研究所 一种基于无水乙醇或十二烷基磺酸钠刺激的哈维弧菌定点基因敲除的方法

Citations (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4828078B1 (ja) 1969-03-20 1973-08-29
JPS559784A (en) 1978-07-10 1980-01-23 Ajinomoto Co Inc Preparation of l-lysine
JPS568692A (en) 1979-07-03 1981-01-29 Kyowa Hakko Kogyo Co Ltd Preparation of l-lysine by fermentation
JPS566499B1 (ja) 1970-04-14 1981-02-12
JPS5685291A (en) 1979-12-13 1981-07-11 Asahi Chem Ind Co Ltd Microbial preparation of l-tryptophan
JPS5771397A (en) 1980-08-22 1982-05-04 Ajinomoto Co Inc Preparation of l-tryptophan by fermentation method
JPS6062993A (ja) 1983-09-16 1985-04-11 Kyowa Hakko Kogyo Co Ltd Ｌ−セリンの製造法
JPS6087788A (ja) 1983-08-29 1985-05-17 Ajinomoto Co Inc 発酵法によるｌ―アミノ酸の製造法
EP0149911A2 (en) 1984-01-09 1985-07-31 Minnesota Mining And Manufacturing Company Electrical connector locator plate
JPS62244382A (ja) 1986-04-16 1987-10-24 Ajinomoto Co Inc 新規プロモーター及び該プロモーターを用いた遺伝子発現方法
JPS62275696A (ja) 1986-05-24 1987-11-30 Nippon Soda Co Ltd Ｌ−メチオニンの製造法
JPS62289194A (ja) 1986-06-09 1987-12-16 Ajinomoto Co Inc フエニルアラニン又はその誘導体の製造法
JPS63216490A (ja) 1987-03-06 1988-09-08 Sagami Chem Res Center 微生物によるエイコサペンタエン酸含有脂質の製造法
JPH01104190A (ja) 1987-07-17 1989-04-21 Ajinomoto Co Inc チミジンの製造方法
JPH01215280A (ja) 1988-02-23 1989-08-29 Showa Denko Kk 微生物の改良
JPH02458A (ja) 1987-10-12 1990-01-05 Ajinomoto Co Inc 発酵法によるｌ―イソロイシンの製造法
JPH0242988A (ja) 1988-08-03 1990-02-13 Ajinomoto Co Inc 組換えｄｎａ、該組換えｄｎａを有する微生物及び該微生物を用いるｌ−アミノ酸の製造法
JPH02109985A (ja) 1988-02-22 1990-04-23 Eurolysine 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌
WO1990004636A1 (en) 1988-10-25 1990-05-03 Vsesojuzny Nauchno-Issledovatelsky Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov (Vniigenetika) Strain of bacteria escherichia coli, producer of l-threonine
EP0488424A2 (en) 1990-11-30 1992-06-03 Ajinomoto Co., Inc. Recombinant DNA sequences encoding feedback inhibition released enzymes, plasmids comprising the recombinant DNA sequences, transformed microorganisms useful in the production of aromatic amino acids, and a process for preparing aromatic amino acids by fermentation
JPH057491A (ja) 1990-10-15 1993-01-19 Ajinomoto Co Inc 温度感受性プラスミド
JPH05130882A (ja) 1991-11-11 1993-05-28 Kyowa Hakko Kogyo Co Ltd 発酵法によるｌ−イソロイシンの製造法
JPH05304969A (ja) 1992-02-25 1993-11-19 Kyowa Hakko Kogyo Co Ltd 発酵法によるアミノ酸の製造法
WO1994008031A1 (de) 1992-09-28 1994-04-14 Consortium für elektrochemische Industrie GmbH Mikroorganismen für die produktion von tryptophan und verfahren zu ihrer herstellung
JPH06102028B2 (ja) 1985-10-04 1994-12-14 協和醗酵工業株式会社 アミノ酸の製造法
US5378616A (en) 1991-08-07 1995-01-03 Ajinomoto Co., Inc. Mutant Escherichia coli capable of enhanced L-glutamic acid production by fermentation
WO1995006114A1 (fr) 1993-08-24 1995-03-02 Ajinomoto Co., Inc. Allele de phosphenolpyruvate carboxylase, gene de cet allele et procede de production de l'acide amine
WO1995023864A1 (fr) 1994-03-04 1995-09-08 Ajinomoto Co., Inc. Procede de production de l-lysine
JPH0847397A (ja) 1994-05-30 1996-02-20 Ajinomoto Co Inc 発酵法によるｌ−イソロイシンの製造法
WO1996006926A1 (fr) 1994-08-30 1996-03-07 Ajinomoto Co., Inc. Procede pour produire de la l-valine et de la l-leucine
WO1996017930A1 (fr) 1994-12-09 1996-06-13 Ajinomoto Co., Inc. Nouveau gene de decarboxylase de lysine et procede de production de lysine l
WO1996040934A1 (fr) 1995-06-07 1996-12-19 Ajinomoto Co., Inc. Procede de production de l-lysine
EP0763127A1 (en) 1994-06-09 1997-03-19 Purdue Research Foundation Deblocking the common pathway of aromatic amino acid synthesis
WO1997023697A1 (de) 1995-12-23 1997-07-03 Krups Kompaktlogistik Gmbh Automatisches parkhaus
US5661012A (en) 1992-11-10 1997-08-26 Ajinomoto Co., Inc. Method for the production of L-threonine by fermentation, using mutated DNA encoding aspartokinase III
US5763231A (en) 1995-03-30 1998-06-09 Ajinomoto Co., Inc. Process for producing L-leucine
RU2119536C1 (ru) 1997-01-21 1998-09-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм escherichia coli - продуцент l-гистидина
US5830716A (en) 1993-10-28 1998-11-03 Ajinomoto Co., Inc. Increased amounts of substances by modifying a microorganism to increase production of NADPH from NADH
EP0877090A1 (en) 1995-08-30 1998-11-11 Ajinomoto Co., Inc. Process for producing l-amino acids
WO1999018228A2 (de) 1997-10-04 1999-04-15 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen herstellung von aminosäuren der aspartat- und/oder glutamatfamilie und im verfahren einsetzbare mittel
JPH11155571A (ja) 1997-11-25 1999-06-15 Ajinomoto Co Inc Ｌ−システインの製造法
EP0952221A2 (en) 1998-03-18 1999-10-27 Ajinomoto Co., Ltd. L-Glutamic acid-producing bacterium and method for producing L-glutamic acid
EP0955368A2 (en) 1998-03-18 1999-11-10 Ajinomoto Co., Ltd. L-glutamic acid-producing bacterium and method for producing l-glutamic acid
US5998178A (en) 1994-05-30 1999-12-07 Ajinomoto Co., Ltd. L-isoleucine-producing bacterium and method for preparing L-isoleucine through fermentation
WO2000002545A2 (en) 1998-07-09 2000-01-20 Warner-Lambert Company Compositions comprising gaba analogs and a decongestant to relieve sinus headache pain
US6040160A (en) 1993-12-08 2000-03-21 Ajinomoto Co., Inc. Method of producing L-lysine by fermentation
EP0994190A2 (en) 1998-10-13 2000-04-19 Ajinomoto Co., Inc. DNA conferring L-homoserine resistance to bacteria, and its use
EP0999282A2 (en) 1998-10-19 2000-05-10 Ajinomoto Co., Inc. L-glutamic acid producing bacterium and process for producing l-glutamic acid
JP2000157276A (ja) 1998-11-24 2000-06-13 Ajinomoto Co Inc サーマス属細菌のｌ−リジン生合成系遺伝子
EP1013765A1 (en) 1998-12-23 2000-06-28 Ajinomoto Co., Ltd. Gene and method for producing L-amino acids
EP1016710A2 (en) 1998-12-30 2000-07-05 Ajinomoto Co., Inc. Method for producing L-amino acids
WO2000061723A1 (fr) 1999-04-09 2000-10-19 Ajinomoto Co., Inc. Bacteries produisant du l-amino acide et procede de production de l-amino acide
EP1067191A2 (en) 1999-07-09 2001-01-10 Ajinomoto Co., Ltd. DNA coding for mutant isopropylmalate synthase, L-leucine-producing microorganism and method for producing L-leucine
WO2001002542A1 (fr) 1999-07-02 2001-01-11 Ajinomoto Co., Inc. Procede de production d'acide l-amine
EP1070376A1 (de) 1998-04-09 2001-01-24 Siemens Aktiengesellschaft Anordnung und verfahren zur elektrischen energieversorgung einer elektrischen last
EP1092776A1 (en) 1999-10-14 2001-04-18 Ajinomoto Co., Inc. Method for producing L-amino acid by fermentation
US6303383B1 (en) 1999-03-16 2001-10-16 Ajinomoto Co., Inc. Temperature sensitive plasmid for coryneform bacteria
EP1170361A2 (en) 2000-06-28 2002-01-09 Ajinomoto Co., Inc. New mutant N-Acetylglutamate synthase and method for L-Arginine production
WO2002026993A1 (en) 2000-09-28 2002-04-04 Archer-Daniels-Midland Company Escherichia coli strains which over-produce l-threonine and processes for the production of l-threonine by fermentation
WO2003004598A2 (en) 2001-07-06 2003-01-16 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family
WO2003008609A2 (en) 2001-07-18 2003-01-30 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced pykf gene
JP2003135066A (ja) 1999-03-19 2003-05-13 Ajinomoto Co Inc Ｌ−リジンの製造法
JP2003169668A (ja) 2001-09-28 2003-06-17 Ajinomoto Co Inc Ｌ−システイン生産菌及びｌ−システインの製造法
EP1352966A2 (en) 2002-03-27 2003-10-15 Ajinomoto Co., Inc. Method for producing L-amino acid
JP2004024259A (ja) 2002-06-25 2004-01-29 Ajinomoto Co Inc Ｌ−ロイシンの製造方法
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity
WO2005049808A1 (en) 2003-11-21 2005-06-02 Ajinomoto Co., Inc. Method for producing l-amino acid by fermentation
WO2005056776A1 (en) 2003-12-15 2005-06-23 Cj Corp. E.coli mutant containing mutant genes related with tryptophan biosynthesis and production method of tryptophan by using the same
JP2005237379A (ja) 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2005085419A1 (en) 2004-03-04 2005-09-15 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing l-glutamic acid

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3703429A (en) 1968-05-08 1972-11-21 American Filtrona Corp Apparatus for making filter means
JPS4912092A (ja) 1972-05-18 1974-02-02
JPS5819275B2 (ja) 1977-04-09 1983-04-16 協和醗酵工業株式会社 α−メチル−Ｌ−ド−パの製造法
JPS62239997A (ja) 1986-04-14 1987-10-20 Ajinomoto Co Inc Ｌ−３，４−ジヒドロキシフエニルアラニン及びその誘導体の製造法
JP3298135B2 (ja) * 1992-03-04 2002-07-02 味の素株式会社 コリネホルム細菌由来のシュークラーゼ遺伝子
WO1996006180A1 (fr) * 1994-08-19 1996-02-29 Ajinomoto Co., Inc. Procede de production de l-lysine et d'acide l-glutamique par fermentation
JP4088982B2 (ja) 1996-10-15 2008-05-21 味の素株式会社 発酵法によるｌ−アミノ酸の製造法
SE9801852D0 (sv) 1998-05-26 1998-05-26 Sbl Vaccin Ab Method of producing thy A-strains of Vibro cholerae, suck strains and their use
EP0982589A1 (en) 1998-08-26 2000-03-01 Universiteit Gent Method for testing the toxicity of chemical substances using gastropods
DE69941594D1 (de) 1998-09-25 2009-12-10 Ajinomoto Kk Coryneforme bakterien zur herstellung von l-glu
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
JP2001046067A (ja) 1999-08-04 2001-02-20 Ajinomoto Co Inc 好熱性バチルス属細菌由来のｌ−リジン生合成系遺伝子
JP2001120292A (ja) 1999-08-17 2001-05-08 Ajinomoto Co Inc 発酵法によるｌ−アミノ酸の製造法
ATE411378T1 (de) 2000-01-21 2008-10-15 Ajinomoto Kk Verfahren zur herstellung von l-lysin
JP4380029B2 (ja) 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
EP1266966B1 (en) 2001-06-12 2009-04-29 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol assimilating bacterium
US6911332B2 (en) 2002-06-12 2005-06-28 Ajinomoto Co., Inc. Isolated polynucleotides encoding d-arabino-3-hexulose-6-phosphate synthases from Methylophilus methylotrophus
JP4110243B2 (ja) 2002-07-09 2008-07-02 特許技術開発株式会社 Ｎ‐アセチルグルコサミンの製造方法
JP4120364B2 (ja) 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法
JP2004166595A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP2004166592A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP2004166640A (ja) 2002-11-21 2004-06-17 Hokkaido Technology Licence Office Co Ltd 宿主細胞で海洋微生物由来の組換え多糖分解酵素の産生を高めるカルシウム化合物添加培地
DE102004001674B4 (de) 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
US7060475B2 (en) 2003-02-28 2006-06-13 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in intermediates metabolism of central metabolic pathway in methylophilus methylotrophus
US7029893B2 (en) 2003-02-28 2006-04-18 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus
US7026149B2 (en) 2003-02-28 2006-04-11 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in the stress response to environmental changes in Methylophilus methylotrophus
JP2004261150A (ja) 2003-03-04 2004-09-24 Ajinomoto Co Inc 目的物質の製造法
US20070196901A1 (en) 2003-10-31 2007-08-23 Hill Russell T Kahalalide-producing bacteria
US20050148048A1 (en) 2003-11-27 2005-07-07 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
KR100584383B1 (ko) * 2004-01-20 2006-05-26 삼성전자주식회사 광선로가입자장치들의 링크 상태를 관리하기 위한광선로종단장치 및 이를 적용한 기가비트 이더넷 기반의수동 광가입자망
EP1664318B1 (en) 2004-01-30 2009-09-23 Ajinomoto Co., Inc. L-amino acid-producing microorganism and method for producing l-amino acid
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
RU2004137198A (ru) * 2004-12-21 2006-06-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ИНАКТИВИРОВАН ГЕН yafA
JP2009060791A (ja) * 2006-03-30 2009-03-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2009165355A (ja) 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
JP2010263790A (ja) * 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
US8268597B2 (en) 2008-03-03 2012-09-18 Global Bio-Chem Technology Group Company Limited Recombinant microorganism and method for producing L-lysine

Patent Citations (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4828078B1 (ja) 1969-03-20 1973-08-29
JPS566499B1 (ja) 1970-04-14 1981-02-12
JPS559784A (en) 1978-07-10 1980-01-23 Ajinomoto Co Inc Preparation of l-lysine
JPS568692A (en) 1979-07-03 1981-01-29 Kyowa Hakko Kogyo Co Ltd Preparation of l-lysine by fermentation
JPS5685291A (en) 1979-12-13 1981-07-11 Asahi Chem Ind Co Ltd Microbial preparation of l-tryptophan
JPS5771397A (en) 1980-08-22 1982-05-04 Ajinomoto Co Inc Preparation of l-tryptophan by fermentation method
US4371614A (en) 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
JPS6087788A (ja) 1983-08-29 1985-05-17 Ajinomoto Co Inc 発酵法によるｌ―アミノ酸の製造法
JPS6062993A (ja) 1983-09-16 1985-04-11 Kyowa Hakko Kogyo Co Ltd Ｌ−セリンの製造法
EP0149911A2 (en) 1984-01-09 1985-07-31 Minnesota Mining And Manufacturing Company Electrical connector locator plate
JPH06102028B2 (ja) 1985-10-04 1994-12-14 協和醗酵工業株式会社 アミノ酸の製造法
JPS62244382A (ja) 1986-04-16 1987-10-24 Ajinomoto Co Inc 新規プロモーター及び該プロモーターを用いた遺伝子発現方法
JPS62275696A (ja) 1986-05-24 1987-11-30 Nippon Soda Co Ltd Ｌ−メチオニンの製造法
JPS62289194A (ja) 1986-06-09 1987-12-16 Ajinomoto Co Inc フエニルアラニン又はその誘導体の製造法
JPS63216490A (ja) 1987-03-06 1988-09-08 Sagami Chem Res Center 微生物によるエイコサペンタエン酸含有脂質の製造法
JPH01104190A (ja) 1987-07-17 1989-04-21 Ajinomoto Co Inc チミジンの製造方法
JPH02458A (ja) 1987-10-12 1990-01-05 Ajinomoto Co Inc 発酵法によるｌ―イソロイシンの製造法
JPH02109985A (ja) 1988-02-22 1990-04-23 Eurolysine 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌
JPH01215280A (ja) 1988-02-23 1989-08-29 Showa Denko Kk 微生物の改良
JPH0242988A (ja) 1988-08-03 1990-02-13 Ajinomoto Co Inc 組換えｄｎａ、該組換えｄｎａを有する微生物及び該微生物を用いるｌ−アミノ酸の製造法
WO1990004636A1 (en) 1988-10-25 1990-05-03 Vsesojuzny Nauchno-Issledovatelsky Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov (Vniigenetika) Strain of bacteria escherichia coli, producer of l-threonine
JPH057491A (ja) 1990-10-15 1993-01-19 Ajinomoto Co Inc 温度感受性プラスミド
EP0488424A2 (en) 1990-11-30 1992-06-03 Ajinomoto Co., Inc. Recombinant DNA sequences encoding feedback inhibition released enzymes, plasmids comprising the recombinant DNA sequences, transformed microorganisms useful in the production of aromatic amino acids, and a process for preparing aromatic amino acids by fermentation
US5378616A (en) 1991-08-07 1995-01-03 Ajinomoto Co., Inc. Mutant Escherichia coli capable of enhanced L-glutamic acid production by fermentation
JPH05130882A (ja) 1991-11-11 1993-05-28 Kyowa Hakko Kogyo Co Ltd 発酵法によるｌ−イソロイシンの製造法
JPH05304969A (ja) 1992-02-25 1993-11-19 Kyowa Hakko Kogyo Co Ltd 発酵法によるアミノ酸の製造法
WO1994008031A1 (de) 1992-09-28 1994-04-14 Consortium für elektrochemische Industrie GmbH Mikroorganismen für die produktion von tryptophan und verfahren zu ihrer herstellung
US5661012A (en) 1992-11-10 1997-08-26 Ajinomoto Co., Inc. Method for the production of L-threonine by fermentation, using mutated DNA encoding aspartokinase III
WO1995006114A1 (fr) 1993-08-24 1995-03-02 Ajinomoto Co., Inc. Allele de phosphenolpyruvate carboxylase, gene de cet allele et procede de production de l'acide amine
EP0733712B1 (en) 1993-10-28 2001-12-12 Ajinomoto Co., Inc. Process for producing substance
US5830716A (en) 1993-10-28 1998-11-03 Ajinomoto Co., Inc. Increased amounts of substances by modifying a microorganism to increase production of NADPH from NADH
US6040160A (en) 1993-12-08 2000-03-21 Ajinomoto Co., Inc. Method of producing L-lysine by fermentation
WO1995023864A1 (fr) 1994-03-04 1995-09-08 Ajinomoto Co., Inc. Procede de production de l-lysine
JPH0847397A (ja) 1994-05-30 1996-02-20 Ajinomoto Co Inc 発酵法によるｌ−イソロイシンの製造法
US5998178A (en) 1994-05-30 1999-12-07 Ajinomoto Co., Ltd. L-isoleucine-producing bacterium and method for preparing L-isoleucine through fermentation
EP0763127A1 (en) 1994-06-09 1997-03-19 Purdue Research Foundation Deblocking the common pathway of aromatic amino acid synthesis
WO1996006926A1 (fr) 1994-08-30 1996-03-07 Ajinomoto Co., Inc. Procede pour produire de la l-valine et de la l-leucine
WO1996017930A1 (fr) 1994-12-09 1996-06-13 Ajinomoto Co., Inc. Nouveau gene de decarboxylase de lysine et procede de production de lysine l
US5763231A (en) 1995-03-30 1998-06-09 Ajinomoto Co., Inc. Process for producing L-leucine
WO1996040934A1 (fr) 1995-06-07 1996-12-19 Ajinomoto Co., Inc. Procede de production de l-lysine
EP0877090A1 (en) 1995-08-30 1998-11-11 Ajinomoto Co., Inc. Process for producing l-amino acids
EP0877090B1 (en) 1995-08-30 2005-11-23 Ajinomoto Co., Inc. Process for producing l-amino acids
WO1997023697A1 (de) 1995-12-23 1997-07-03 Krups Kompaktlogistik Gmbh Automatisches parkhaus
RU2119536C1 (ru) 1997-01-21 1998-09-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм escherichia coli - продуцент l-гистидина
WO1999018228A2 (de) 1997-10-04 1999-04-15 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen herstellung von aminosäuren der aspartat- und/oder glutamatfamilie und im verfahren einsetzbare mittel
JPH11155571A (ja) 1997-11-25 1999-06-15 Ajinomoto Co Inc Ｌ−システインの製造法
EP0955368A2 (en) 1998-03-18 1999-11-10 Ajinomoto Co., Ltd. L-glutamic acid-producing bacterium and method for producing l-glutamic acid
US6331419B1 (en) 1998-03-18 2001-12-18 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
EP0952221A2 (en) 1998-03-18 1999-10-27 Ajinomoto Co., Ltd. L-Glutamic acid-producing bacterium and method for producing L-glutamic acid
US6197559B1 (en) 1998-03-18 2001-03-06 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
EP1070376A1 (de) 1998-04-09 2001-01-24 Siemens Aktiengesellschaft Anordnung und verfahren zur elektrischen energieversorgung einer elektrischen last
WO2000002545A2 (en) 1998-07-09 2000-01-20 Warner-Lambert Company Compositions comprising gaba analogs and a decongestant to relieve sinus headache pain
EP0994190A2 (en) 1998-10-13 2000-04-19 Ajinomoto Co., Inc. DNA conferring L-homoserine resistance to bacteria, and its use
EP0999282A2 (en) 1998-10-19 2000-05-10 Ajinomoto Co., Inc. L-glutamic acid producing bacterium and process for producing l-glutamic acid
JP2000157276A (ja) 1998-11-24 2000-06-13 Ajinomoto Co Inc サーマス属細菌のｌ−リジン生合成系遺伝子
EP1013765A1 (en) 1998-12-23 2000-06-28 Ajinomoto Co., Ltd. Gene and method for producing L-amino acids
EP1016710A2 (en) 1998-12-30 2000-07-05 Ajinomoto Co., Inc. Method for producing L-amino acids
US6303383B1 (en) 1999-03-16 2001-10-16 Ajinomoto Co., Inc. Temperature sensitive plasmid for coryneform bacteria
JP2003135066A (ja) 1999-03-19 2003-05-13 Ajinomoto Co Inc Ｌ−リジンの製造法
WO2000061723A1 (fr) 1999-04-09 2000-10-19 Ajinomoto Co., Inc. Bacteries produisant du l-amino acide et procede de production de l-amino acide
WO2001002542A1 (fr) 1999-07-02 2001-01-11 Ajinomoto Co., Inc. Procede de production d'acide l-amine
EP1067191A2 (en) 1999-07-09 2001-01-10 Ajinomoto Co., Ltd. DNA coding for mutant isopropylmalate synthase, L-leucine-producing microorganism and method for producing L-leucine
EP1092776A1 (en) 1999-10-14 2001-04-18 Ajinomoto Co., Inc. Method for producing L-amino acid by fermentation
EP1170361A2 (en) 2000-06-28 2002-01-09 Ajinomoto Co., Inc. New mutant N-Acetylglutamate synthase and method for L-Arginine production
WO2002026993A1 (en) 2000-09-28 2002-04-04 Archer-Daniels-Midland Company Escherichia coli strains which over-produce l-threonine and processes for the production of l-threonine by fermentation
WO2003004598A2 (en) 2001-07-06 2003-01-16 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family
WO2003004664A2 (en) 2001-07-06 2003-01-16 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family with enhanced fba expression
WO2003008611A2 (en) 2001-07-18 2003-01-30 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced talb gene
WO2003008609A2 (en) 2001-07-18 2003-01-30 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced pykf gene
JP2003169668A (ja) 2001-09-28 2003-06-17 Ajinomoto Co Inc Ｌ−システイン生産菌及びｌ−システインの製造法
EP1352966A2 (en) 2002-03-27 2003-10-15 Ajinomoto Co., Inc. Method for producing L-amino acid
JP2004024259A (ja) 2002-06-25 2004-01-29 Ajinomoto Co Inc Ｌ−ロイシンの製造方法
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity
WO2005049808A1 (en) 2003-11-21 2005-06-02 Ajinomoto Co., Inc. Method for producing l-amino acid by fermentation
WO2005056776A1 (en) 2003-12-15 2005-06-23 Cj Corp. E.coli mutant containing mutant genes related with tryptophan biosynthesis and production method of tryptophan by using the same
JP2005237379A (ja) 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2005085419A1 (en) 2004-03-04 2005-09-15 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing l-glutamic acid

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
"Amino Acid Fermentation", 30 May 1986, JAPAN SCIENTIFIC SOCIETIES PRESS, pages: 77 - 100
CANADIAN JOURNAL OF MICROBIOLOGY, vol. 43, no. 197, 1997
CHO, E.H.; GUMPORT, R.L; GARDNER, J.F., J. BACTERIOL., vol. 184, 2002, pages 5200 - 5203
DATABASE GENPEPT [online] 1 March 2004 (2004-03-01), "Aspartokinase (Aspartate kinase)", XP008110563, Database accession no. (Q87L96) *
DATABASE GENPEPT [online] 1 March 2004 (2004-03-01), "Aspartokinase (Aspartate kinase)", XP008110565, Database accession no. (Q87LR4) *
DATABASE GENPEPT [online] 1 March 2004 (2004-03-01), "Aspartokinase 1/homoserine dehydrogenase, threonine-sensitive", XP008110564, Database accession no. (Q87SD0) *
DATABASE GENPEPT [online] 1 March 2004 (2004-03-01), "Putative aspartokinase", XP008110567, Database accession no. (Q87NZ9) *
DATABASE GENPEPT [online] 28 November 2006 (2006-11-28), "Bifunctional aspartate kinase 2/homoserine dehydrogenase 2", XP008110566, Database accession no. (Q1V6F6) *
DATSENKO, K.A; WANNER, B.L., PROC. NATL. ACAD. SCI. USA., vol. 97, 2000, pages 6640 - 6645
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, 1997, pages 8611 - 8617
LYNN, S. P. ET AL., J. MOL. BIOL., vol. 194, 1987, pages 59 - 69
LYSC, CASSAN, M. ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 1052
MACIAN, M.C. ET AL., SYST. APPL. MICROBIOL., vol. 23, 2000, pages 373 - 375
METHODS ENZYMOL., vol. 183, 1990, pages 63
MIYAJIMA, R ET AL., THE JOURNAL OF BIOCHEMISTRY, vol. 63, no. 2, 1968, pages 139 - 148
PAYNE, W.J., J. BACTERIOLOGY, vol. 76, 1958, pages 301
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
RES. MICROBIOL., vol. 154, 2003, pages 123 - 135
SAMBROOK, J.; FRITSCH, E. F.; MANIATIS, T.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP2128263A4 *
THOMPSON, F.L. ET AL., MICROBIOL. MOL. BIOL. REV., vol. 23, 2004, pages 403 - 43

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016301A1 (ja) * 2009-08-03 2011-02-10 味の素株式会社 ビブリオ属細菌を用いたｌ－リジンの製造法
CN102471791A (zh) * 2009-08-03 2012-05-23 味之素株式会社 使用弧菌属细菌产生l-赖氨酸的方法
EP2463377A1 (en) * 2009-08-03 2012-06-13 Ajinomoto Co., Inc. Process for production of l-lysine using bacterium belonging to genus vibrio
EP2463377A4 (en) * 2009-08-03 2013-01-23 Ajinomoto Kk PROCESS FOR THE PRODUCTION OF L-LYSINE USING A BACTERIUM OF THE GENUS VIBRIO
CN118086167A (zh) * 2024-04-28 2024-05-28 天津科技大学 一种生产l-色氨酸的基因工程菌及其构建方法与应用

Also Published As

Publication number Publication date
US8993279B2 (en) 2015-03-31
EP2128263B1 (en) 2014-10-15
JP2010088301A (ja) 2010-04-22
US20100028958A1 (en) 2010-02-04
EP2128263A1 (en) 2009-12-02
EP2128263A4 (en) 2010-04-28

Similar Documents

Publication Publication Date Title
WO2008093829A1 (ja) Ｌ－アミノ酸の製造法
WO2008133161A1 (ja) カルボキシル基を有する酸性物質の製造法
WO2005073390A3 (en) L-amino acid-producing microorganism and method for producing l-amino acid
WO2008090770A1 (ja) Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法
WO2010093262A8 (en) Alcohol production process
MY141807A (en) L-glutamine acid-producing microorganism and a method for producing l-glutamic acid
PL2235194T3 (pl) Sposób fermentacyjnego wytwarzania 1,5- diaminopentanu
EP2017332A4 (en) MICROORGANISM CAPABLE OF PRODUCING AMINOACID L AND PROCESS FOR PRODUCING AMINOACID L
EP2749652A3 (en) A method for producing a target substance by fermentation
WO2008126667A3 (en) Method for producing lactic acid
MX2011004049A (es) Produccion de etanol en microorganismos.
WO2008102861A1 (ja) Ｌ－アミノ酸の製造法
WO2007116955A3 (en) Method for producing l-amino acid
WO2006070944A3 (en) L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
WO2011036213A3 (en) Fermentation process for producing glycolic acid
WO2008153180A1 (ja) 脂肪組織由来細胞から肝小葉様細胞塊を得る方法
WO2011003034A3 (en) Biological methods for preparing adipic acid
WO2009049274A8 (en) Microorganism engineered to produce isopropanol
WO2008072761A3 (en) Method for producing an l-amino acid
MX2009007114A (es) Produccion de enzima en un medio de cultivo que comprende glicerol crudo.
EP2011861A8 (en) Bacterium capable of producing purine substance, and process for production of purine substance
WO2009028338A1 (ja) 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法
WO2010101855A3 (en) Microbial derived isoprene and methods for making the same
WO2011115439A3 (ko) 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법
WO2012125688A3 (en) Microbial syntheses of aldehydes and corresponding alcohols

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08704352

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008704352

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP