WO2008078448A1 - 塩基性アミノ酸塩酸塩結晶の取得方法 - Google Patents

塩基性アミノ酸塩酸塩結晶の取得方法 Download PDF

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Publication number
WO2008078448A1
WO2008078448A1 PCT/JP2007/070555 JP2007070555W WO2008078448A1 WO 2008078448 A1 WO2008078448 A1 WO 2008078448A1 JP 2007070555 W JP2007070555 W JP 2007070555W WO 2008078448 A1 WO2008078448 A1 WO 2008078448A1
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WIPO (PCT)
Prior art keywords
basic
amino acid
crystals
sulfate
basic amino
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PCT/JP2007/070555
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English (en)
French (fr)
Inventor
Mitsuhiro Kishino
Toshimichi Kamei
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Ajinomoto Co., Inc.
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Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to CN2007800458215A priority Critical patent/CN101558164B/zh
Priority to EP07830289.0A priority patent/EP2096176B1/en
Priority to JP2008550983A priority patent/JPWO2008078448A1/ja
Priority to KR1020097014763A priority patent/KR101046905B1/ko
Priority to CA2672714A priority patent/CA2672714C/en
Priority to MX2009006932A priority patent/MX2009006932A/es
Publication of WO2008078448A1 publication Critical patent/WO2008078448A1/ja
Priority to US12/491,341 priority patent/US8372606B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明は、硫酸イオンを含有する塩基性アミノ酸発酵液からの、製品収量及び品質が従来技術におけるとほぼ同等であって、しかもより簡便な塩基性アミノ酸塩酸塩の分離取得方法を提供することを目的とする。本発明は、硫酸イオンを含有する塩基性アミノ酸発酵液または塩基性アミノ酸産生微生物の生菌体を触媒とする酵素反応液から塩基性アミノ酸の塩酸塩結晶を取得する方法であって、（１）硫酸イオンを含有する塩基性アミノ酸発酵液または酵素反応液に、カルシウム、カリウム、マグネシウムおよびバリウムからなる群より選択される金属の塩化物を添加して該硫酸イオンを該金属の硫酸塩結晶として析出させ、（２）該塩基性アミノ酸溶液から該金属の硫酸塩結晶を除去し、（３）該金属の硫酸塩結晶を除去した塩基性アミノ酸溶液を、該金属の硫酸塩の飽和溶解度以下に維持しつつ冷却して塩基性アミノ酸をその塩酸塩結晶として析出させ、（４）該塩基性アミノ酸結晶を分離し採取すること、を特徴とする方法を提供する。
PCT/JP2007/070555 2006-12-25 2007-10-22 塩基性アミノ酸塩酸塩結晶の取得方法 WO2008078448A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN2007800458215A CN101558164B (zh) 2006-12-25 2007-10-22 碱性氨基酸盐酸盐结晶的取得方法
EP07830289.0A EP2096176B1 (en) 2006-12-25 2007-10-22 Method of obtaining crystal of hydrochloride of basic amino acid
JP2008550983A JPWO2008078448A1 (ja) 2006-12-25 2007-10-22 塩基性アミノ酸塩酸塩結晶の取得方法
KR1020097014763A KR101046905B1 (ko) 2006-12-25 2007-10-22 염기성 아미노산 염산염 결정의 수득 방법
CA2672714A CA2672714C (en) 2006-12-25 2007-10-22 Method for obtaining crystals of a basic amino acid hydrochloride
MX2009006932A MX2009006932A (es) 2006-12-25 2007-10-22 Metodo para obtener cristales de un clorhidrato de aminoacido basico.
US12/491,341 US8372606B2 (en) 2006-12-25 2009-06-25 Methods for obtaining crystals of a basic amino acid hydrochloride

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-347650 2006-12-25
JP2006347650 2006-12-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/491,341 Continuation US8372606B2 (en) 2006-12-25 2009-06-25 Methods for obtaining crystals of a basic amino acid hydrochloride

Publications (1)

Publication Number Publication Date
WO2008078448A1 true WO2008078448A1 (ja) 2008-07-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/070555 WO2008078448A1 (ja) 2006-12-25 2007-10-22 塩基性アミノ酸塩酸塩結晶の取得方法

Country Status (10)

Country Link
US (1) US8372606B2 (ja)
EP (1) EP2096176B1 (ja)
JP (1) JPWO2008078448A1 (ja)
KR (1) KR101046905B1 (ja)
CN (1) CN101558164B (ja)
BR (1) BRPI0703692B1 (ja)
CA (1) CA2672714C (ja)
MX (1) MX2009006932A (ja)
RU (1) RU2460799C2 (ja)
WO (1) WO2008078448A1 (ja)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009088049A1 (ja) 2008-01-10 2009-07-16 Ajinomoto Co., Inc. 発酵法による目的物質の製造法
WO2010084995A2 (en) 2009-01-23 2010-07-29 Ajinomoto Co.,Inc. A method for producing an l-amino acid
WO2011016301A1 (ja) 2009-08-03 2011-02-10 味の素株式会社 ビブリオ属細菌を用いたｌ－リジンの製造法
WO2011024555A1 (ja) 2009-08-28 2011-03-03 味の素株式会社 Ｌ－アミノ酸の製造法
WO2011055710A1 (ja) 2009-11-06 2011-05-12 味の素株式会社 Ｌ－アミノ酸の製造法
EP2345667A2 (en) 2010-01-15 2011-07-20 Ajinomoto Co., Inc. A method for producing an L-amino acid using a bacterium of the enterobacteriaceae family
WO2011096554A1 (ja) 2010-02-08 2011-08-11 味の素株式会社 変異型ｒｐｓＡ遺伝子及びＬ－アミノ酸の製造法
WO2012077739A1 (ja) 2010-12-10 2012-06-14 味の素株式会社 Ｌ－アミノ酸の製造法
WO2012137689A1 (ja) 2011-04-01 2012-10-11 味の素株式会社 Ｌ－システインの製造法
WO2012144472A1 (ja) 2011-04-18 2012-10-26 味の素株式会社 Ｌ－システインの製造法
WO2013069634A1 (ja) 2011-11-11 2013-05-16 味の素株式会社 発酵法による目的物質の製造法
WO2014185430A1 (ja) 2013-05-13 2014-11-20 味の素株式会社 Ｌ－アミノ酸の製造法
EP3165608A1 (en) 2015-10-30 2017-05-10 Ajinomoto Co., Inc. Method for producing l-amino acid of glutamate family
EP3385389A1 (en) 2017-04-03 2018-10-10 Ajinomoto Co., Inc. Method for producing l-amino acid from fructose
JP2021515551A (ja) * 2018-03-05 2021-06-24 アレボ・アクチボラゲットＡｒｅｖｏ Ａｂ 塩基性アミノ酸の分離
WO2022092018A1 (ja) 2020-10-28 2022-05-05 味の素株式会社 Ｌ－アミノ酸の製造法
WO2023013655A1 (ja) 2021-08-02 2023-02-09 味の素株式会社 食品の風味を改善する方法
EP4345166A2 (en) 2022-09-30 2024-04-03 Ajinomoto Co., Inc. Method for producing l-amino acid

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Publication number Priority date Publication date Assignee Title
CN104892437A (zh) * 2015-05-15 2015-09-09 南通荣泰生物科技有限公司 一种l-盐酸赖氨酸的生产工艺
CN105175275B (zh) * 2015-07-01 2017-03-01 山东民强生物科技股份有限公司 一种l‑鸟氨酸的分离纯化方法
CN107963650A (zh) * 2017-12-15 2018-04-27 湖南师范大学 一种氨基酸络合物合成工艺中的母液处理方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4827476A (ja) * 1971-08-11 1973-04-11
EP0534865A1 (fr) 1991-07-26 1993-03-31 Eurolysine Procédé de séparation de la lysine sous la forme d'une solution aqueuse et utilisation de cette solution pour l'alimentation animale
WO1995014002A1 (en) * 1993-11-19 1995-05-26 Aeci Limited Recovery of an amino acid
WO1995023864A1 (fr) 1994-03-04 1995-09-08 Ajinomoto Co., Inc. Procede de production de l-lysine
WO1996017930A1 (fr) 1994-12-09 1996-06-13 Ajinomoto Co., Inc. Nouveau gene de decarboxylase de lysine et procede de production de lysine l
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5434835B2 (ja) * 1972-10-09 1979-10-29
JPS565099A (en) * 1979-06-25 1981-01-20 Ajinomoto Co Inc Production of l-histidine through fermentation process and microorganism used therefor
JPS5618596A (en) 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
DE3242501C1 (de) * 1982-11-18 1984-03-29 Degussa Ag, 6000 Frankfurt Verwendung von waessrigen L-Lysin-Loesungen zur Supplementierung von Futtermitteln mit L-Lysin
DE3345898A1 (de) * 1983-12-20 1985-07-04 Bayer Ag, 5090 Leverkusen Verfahren zur entfernung von sulfat aus elektrolysesole
SU1518948A1 (ru) * 1985-04-15 1995-04-20 Всесоюзный научно-исследовательский институт химии и технологии лекарственных средств Способ получения d, l-лизина-основания
US4835309A (en) * 1988-04-14 1989-05-30 Eastman Kodak Company Ion exchange recovery of L-lysine
RU2003677C1 (ru) 1992-03-30 1993-11-30 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм бактерий ESCHERICHIA COLI - продуцент L-гистидина
DE4217203C2 (de) * 1992-05-23 1995-09-21 Degussa Verfahren zum Abtrennen von Aminosäuren aus wäßrigen Lösungen
US5756761A (en) * 1995-01-24 1998-05-26 Archer Daniels Midland Company Process for drying hydrophobic amino acids with improved process for increased bulk density
EP0768374B1 (en) * 1995-10-13 2003-01-29 Ajinomoto Co., Inc. Method of removing cells from fermentation broth
EP0770676A3 (en) 1995-10-23 1999-05-19 Ajinomoto Co., Ltd. Method for treating fermentation broth
RU2119536C1 (ru) 1997-01-21 1998-09-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм escherichia coli - продуцент l-гистидина
CA2255130A1 (en) * 1997-12-16 1999-06-16 Archer Daniels Midland Company Process for making granular l-lysine feed supplement
JP4294123B2 (ja) * 1998-07-03 2009-07-08 協和発酵バイオ株式会社 ホスホリボシルピロリン酸を経由して生合成される代謝産物の製造法
US6110342A (en) 1998-07-21 2000-08-29 Archer Daniels Midland Company Process for production of amino acid hydrochloride and caustic via electrodialysis water splitting
RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
JP2000256290A (ja) * 1999-03-11 2000-09-19 Ajinomoto Co Inc 安定化リジン水溶液
AU3674500A (en) * 1999-04-09 2000-11-14 Ajinomoto Co., Inc. L-amino acid-producing bacteria and process for producing l-amino acid
CN1236690C (zh) * 1999-06-23 2006-01-18 德古萨股份公司 含有赖氨酸的含水动物饲料添加剂及其生产方法
JP2001046067A (ja) * 1999-08-04 2001-02-20 Ajinomoto Co Inc 好熱性バチルス属細菌由来のｌ−リジン生合成系遺伝子
CA2319283A1 (en) * 1999-09-20 2001-03-20 Kuniki Kino Method for producing l-amino acids by fermentation
EP1106602B1 (en) 1999-12-09 2008-08-27 Archer-Daniels-Midland Company Simulated moving bed chromatographic purification of amino acids
EP1752543A1 (en) 2000-01-20 2007-02-14 Archer-Daniels-Midland Company Process for making a variety of l-lysine feed supplements
WO2001072689A2 (en) * 2000-03-29 2001-10-04 Archer-Daniels-Midland Company Method for separating a basic amino acid from fermentation broth
JP4682454B2 (ja) 2000-06-28 2011-05-11 味の素株式会社 新規変異型ｎ−アセチルグルタミン酸合成酵素及びｌ−アルギニンの製造法
RU2215783C2 (ru) 2001-05-15 2003-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото - Генетика" МУТАНТНАЯ N-АЦЕТИЛГЛУТАМАТ СИНТАЗА (ВАРИАНТЫ), ФРАГМЕНТ ДНК, ШТАММ БАКТЕРИИ Escherichia coli - ПРОДУЦЕНТ АРГИНИНА (ВАРИАНТЫ) И СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА
RU2208640C2 (ru) 2000-07-06 2003-07-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА, ШТАММ Escherichia coli - ПРОДУЦЕНТ L-АРГИНИНА
RU2207371C2 (ru) * 2000-09-26 2003-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот семейства l-глутаминовой кислоты, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты)
IT1320794B1 (it) * 2000-08-08 2003-12-10 Filozoo Aventis S R L Procedimento e sistema per fornire aminoacidi naturosimili ochemioderivati in forma liquida ad animali ruminanti allevati.
JP4273643B2 (ja) * 2000-08-08 2009-06-03 味の素株式会社 好気性培養における培養装置及び消泡制御方法
JP4362959B2 (ja) * 2000-08-24 2009-11-11 味の素株式会社 塩基性アミノ酸の製造方法
JP2002284749A (ja) * 2001-03-23 2002-10-03 Ajinomoto Co Inc 塩基性アミノ酸溶液の製造方法
DE60232120D1 (de) * 2001-06-12 2009-06-10 Ajinomoto Kk Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien
JP2003219807A (ja) * 2002-01-25 2003-08-05 Ajinomoto Co Inc Ｌ−リジンを主成分とする造粒乾燥物
BRPI0307959B1 (pt) * 2002-02-27 2018-04-03 Archer-Daniels-Midland Company Suplementos alimentares para aumentar o nível de aminoácido no plasma de animais ruminantes
JP4120364B2 (ja) * 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法
JP2004166592A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP2004166595A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
WO2004050664A1 (en) * 2002-12-05 2004-06-17 Md Bioalpha Co., Ltd. Method for preparation of amino acid chelate
DE102004001674B4 (de) * 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
US7029893B2 (en) * 2003-02-28 2006-04-18 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus
PL1813677T3 (pl) 2004-10-07 2019-05-31 Ajinomoto Kk Enzymatyczny sposób wytwarzania zasadowych aminokwasów
JP4827476B2 (ja) 2005-09-22 2011-11-30 三洋電機株式会社 パック電池
JP5155149B2 (ja) * 2006-03-15 2013-02-27 協和発酵バイオ株式会社 アミノ酸の精製方法
JP2009165355A (ja) * 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4827476A (ja) * 1971-08-11 1973-04-11
EP0534865A1 (fr) 1991-07-26 1993-03-31 Eurolysine Procédé de séparation de la lysine sous la forme d'une solution aqueuse et utilisation de cette solution pour l'alimentation animale
WO1995014002A1 (en) * 1993-11-19 1995-05-26 Aeci Limited Recovery of an amino acid
WO1995023864A1 (fr) 1994-03-04 1995-09-08 Ajinomoto Co., Inc. Procede de production de l-lysine
WO1996017930A1 (fr) 1994-12-09 1996-06-13 Ajinomoto Co., Inc. Nouveau gene de decarboxylase de lysine et procede de production de lysine l
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2096176A4 *

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* Cited by examiner, † Cited by third party
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EP2749652A2 (en) 2008-01-10 2014-07-02 Ajinomoto Co., Inc. A method for producing a target substance by fermentation
WO2009088049A1 (ja) 2008-01-10 2009-07-16 Ajinomoto Co., Inc. 発酵法による目的物質の製造法
WO2010084995A2 (en) 2009-01-23 2010-07-29 Ajinomoto Co.,Inc. A method for producing an l-amino acid
WO2011016301A1 (ja) 2009-08-03 2011-02-10 味の素株式会社 ビブリオ属細菌を用いたｌ－リジンの製造法
WO2011024555A1 (ja) 2009-08-28 2011-03-03 味の素株式会社 Ｌ－アミノ酸の製造法
WO2011055710A1 (ja) 2009-11-06 2011-05-12 味の素株式会社 Ｌ－アミノ酸の製造法
EP2345667A2 (en) 2010-01-15 2011-07-20 Ajinomoto Co., Inc. A method for producing an L-amino acid using a bacterium of the enterobacteriaceae family
WO2011096554A1 (ja) 2010-02-08 2011-08-11 味の素株式会社 変異型ｒｐｓＡ遺伝子及びＬ－アミノ酸の製造法
WO2012077739A1 (ja) 2010-12-10 2012-06-14 味の素株式会社 Ｌ－アミノ酸の製造法
WO2012137689A1 (ja) 2011-04-01 2012-10-11 味の素株式会社 Ｌ－システインの製造法
WO2012144472A1 (ja) 2011-04-18 2012-10-26 味の素株式会社 Ｌ－システインの製造法
WO2013069634A1 (ja) 2011-11-11 2013-05-16 味の素株式会社 発酵法による目的物質の製造法
WO2014185430A1 (ja) 2013-05-13 2014-11-20 味の素株式会社 Ｌ－アミノ酸の製造法
EP3165608A1 (en) 2015-10-30 2017-05-10 Ajinomoto Co., Inc. Method for producing l-amino acid of glutamate family
EP3385389A1 (en) 2017-04-03 2018-10-10 Ajinomoto Co., Inc. Method for producing l-amino acid from fructose
JP2021515551A (ja) * 2018-03-05 2021-06-24 アレボ・アクチボラゲットＡｒｅｖｏ Ａｂ 塩基性アミノ酸の分離
JP7503496B2 (ja) 2018-03-05 2024-06-20 アレボ・アクチボラゲット 塩基性アミノ酸の分離
WO2022092018A1 (ja) 2020-10-28 2022-05-05 味の素株式会社 Ｌ－アミノ酸の製造法
WO2023013655A1 (ja) 2021-08-02 2023-02-09 味の素株式会社 食品の風味を改善する方法
EP4345166A2 (en) 2022-09-30 2024-04-03 Ajinomoto Co., Inc. Method for producing l-amino acid

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KR20090100406A (ko) 2009-09-23
MX2009006932A (es) 2009-07-06
CA2672714C (en) 2016-04-26
US8372606B2 (en) 2013-02-12
RU2460799C2 (ru) 2012-09-10
BRPI0703692B1 (pt) 2016-12-27
EP2096176A4 (en) 2012-12-26
EP2096176B1 (en) 2017-04-12
KR101046905B1 (ko) 2011-07-07
EP2096176A1 (en) 2009-09-02
CA2672714A1 (en) 2008-07-03
CN101558164A (zh) 2009-10-14
BRPI0703692A (pt) 2008-08-19
CN101558164B (zh) 2012-05-09
JPWO2008078448A1 (ja) 2010-04-15
US20090291477A1 (en) 2009-11-26

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