BRPI0703692A - método para se obter os cristais de um hidrocloreto de aminoácido básico de um caldo de fermentação de aminoácido básico ou na solução de reação enzimática - Google Patents

método para se obter os cristais de um hidrocloreto de aminoácido básico de um caldo de fermentação de aminoácido básico ou na solução de reação enzimática

Info

Publication number
BRPI0703692A
BRPI0703692A BRPI0703692-2A BRPI0703692A BRPI0703692A BR PI0703692 A BRPI0703692 A BR PI0703692A BR PI0703692 A BRPI0703692 A BR PI0703692A BR PI0703692 A BRPI0703692 A BR PI0703692A
Authority
BR
Brazil
Prior art keywords
amino acid
basic amino
crystals
reaction solution
fermentation broth
Prior art date
Application number
BRPI0703692-2A
Other languages
English (en)
Inventor
Mitsuhiro Kishino
Toshimichi Kamei
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BRPI0703692A publication Critical patent/BRPI0703692A/pt
Publication of BRPI0703692B1 publication Critical patent/BRPI0703692B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"MéTODO PARA SE OBTER OS CRISTAIS DE UM HIDROCLORETO DE AMINOáCIDO BáSICO DE UM CALDO DE FERMENTAçãO DE AMINOáCIDO BáSICO OU NA SOLUçãO DE REAçãO ENZIMáTICA". é um objeto da presente invenção prover um método para separar e obter um hidrocloreto de aminoácido básico de um caldo de fermentação de aminoácido básico ou na solução de reação enzimática, cuja reação enzimática tenha sido catalisada por células viáveis de um micróbio produtor de aminoácido básico, cada um contendo íons de sulfato, pela qual o método produz o produto, e as qualidades são quase as mesmas e são garantidas mais facilmente em comparação com a técnica convencional, método este que compreende as etapas de: (1) adicionar o cloreto de um metal selecionado do grupo consistindo em cálcio, potássio, magnésio e bário, ao caldo de fermentação de aminoácido básico, ou à solução de reação enzimática que contenha os tons de sulfato, para precipitar os tons de sulfato como cristais do sulfato de metal resultante, (2) remover os cristais de sulfato de metal da solução de aminoácido básico, (3) esfriar o caldo de fermentação de aminoácido básico ou a solução de reação enzimática, em que os cristais de sulfato de metal são removidos, enquanto se mantém a concentração do sulfato de metal abaixo da sua concentração saturada para precipitar o aminoácido básico como seus cristais de hidrocloreto, e (4) separar os cristais de hidrocloreto de aminoácido básico para coletá-los.
BRPI0703692A 2006-12-25 2007-09-20 método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores BRPI0703692B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006347650 2006-12-25

Publications (2)

Publication Number Publication Date
BRPI0703692A true BRPI0703692A (pt) 2008-08-19
BRPI0703692B1 BRPI0703692B1 (pt) 2016-12-27

Family

ID=39562242

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0703692A BRPI0703692B1 (pt) 2006-12-25 2007-09-20 método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores

Country Status (10)

Country Link
US (1) US8372606B2 (pt)
EP (1) EP2096176B1 (pt)
JP (1) JPWO2008078448A1 (pt)
KR (1) KR101046905B1 (pt)
CN (1) CN101558164B (pt)
BR (1) BRPI0703692B1 (pt)
CA (1) CA2672714C (pt)
MX (1) MX2009006932A (pt)
RU (1) RU2460799C2 (pt)
WO (1) WO2008078448A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
WO2010084995A2 (en) 2009-01-23 2010-07-29 Ajinomoto Co.,Inc. A method for producing an l-amino acid
JP2012196144A (ja) 2009-08-03 2012-10-18 Ajinomoto Co Inc ビブリオ属細菌を用いたｌ−リジンの製造法
JP2012223092A (ja) 2009-08-28 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2013013329A (ja) 2009-11-06 2013-01-24 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2460793C2 (ru) 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae
JP2013074795A (ja) 2010-02-08 2013-04-25 Ajinomoto Co Inc 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
BR112013023465B1 (pt) 2011-04-01 2020-10-27 Ajinomoto Co., Inc método para produzir l-cisteína
JP2014131487A (ja) 2011-04-18 2014-07-17 Ajinomoto Co Inc Ｌ−システインの製造法
CN103930557A (zh) 2011-11-11 2014-07-16 味之素株式会社 利用发酵法制造目标物质的方法
BR112015007916B1 (pt) 2013-05-13 2023-04-04 Ajinomoto Co., Inc Método para produzir l-aminoácido
CN104892437A (zh) * 2015-05-15 2015-09-09 南通荣泰生物科技有限公司 一种l-盐酸赖氨酸的生产工艺
CN105175275B (zh) * 2015-07-01 2017-03-01 山东民强生物科技股份有限公司 一种l‑鸟氨酸的分离纯化方法
JP6623690B2 (ja) 2015-10-30 2019-12-25 味の素株式会社 グルタミン酸系ｌ−アミノ酸の製造法
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
CN107963650A (zh) * 2017-12-15 2018-04-27 湖南师范大学 一种氨基酸络合物合成工艺中的母液处理方法
SE543703C2 (en) * 2018-03-05 2021-06-15 Arevo Ab Separation of basic amino acids
WO2022092018A1 (ja) 2020-10-28 2022-05-05 味の素株式会社 Ｌ－アミノ酸の製造法
WO2023013655A1 (ja) 2021-08-02 2023-02-09 味の素株式会社 食品の風味を改善する方法
US20240117393A1 (en) 2022-09-30 2024-04-11 Ajinomoto Co., Inc. Method for producing l-amino acid

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4827476A (pt) 1971-08-11 1973-04-11
JPS5434835B2 (pt) * 1972-10-09 1979-10-29
JPS565099A (en) 1979-06-25 1981-01-20 Ajinomoto Co Inc Production of l-histidine through fermentation process and microorganism used therefor
JPS5618596A (en) 1979-07-23 1981-02-21 Ajinomoto Co Inc Production of l-lysine through fermentation process
DE3242501C1 (de) * 1982-11-18 1984-03-29 Degussa Ag, 6000 Frankfurt Verwendung von waessrigen L-Lysin-Loesungen zur Supplementierung von Futtermitteln mit L-Lysin
DE3345898A1 (de) * 1983-12-20 1985-07-04 Bayer Ag, 5090 Leverkusen Verfahren zur entfernung von sulfat aus elektrolysesole
SU1518948A1 (ru) * 1985-04-15 1995-04-20 Всесоюзный научно-исследовательский институт химии и технологии лекарственных средств Способ получения d, l-лизина-основания
US4835309A (en) * 1988-04-14 1989-05-30 Eastman Kodak Company Ion exchange recovery of L-lysine
FR2679569B1 (fr) 1991-07-26 1995-05-19 Eurolysine Procede de separation de la lysine sous la forme de solutions aqueuses et utilisation de ces solutions pour l'alimentation animale.
RU2003677C1 (ru) 1992-03-30 1993-11-30 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм бактерий ESCHERICHIA COLI - продуцент L-гистидина
DE4217203C2 (de) * 1992-05-23 1995-09-21 Degussa Verfahren zum Abtrennen von Aminosäuren aus wäßrigen Lösungen
ZA949059B (en) 1993-11-19 1995-07-19 Aeci Ltd Recovery of an amino acid
CN1117152C (zh) 1994-03-04 2003-08-06 味之素株式会社 生产l－赖氨酸的方法
HU223706B1 (hu) 1994-12-09 2004-12-28 Ajinomoto Co., Inc. Új lizin dekarboxiláz gén és eljárás L-lizin termelésére
US5756761A (en) * 1995-01-24 1998-05-26 Archer Daniels Midland Company Process for drying hydrophobic amino acids with improved process for increased bulk density
DE69625981T2 (de) * 1995-10-13 2004-01-22 Ajinomoto Co., Inc. Verfahren zum Entfernen von Zellen aus Fermentationsbrühe
EP0770676A3 (en) 1995-10-23 1999-05-19 Ajinomoto Co., Ltd. Method for treating fermentation broth
RU2119536C1 (ru) 1997-01-21 1998-09-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм escherichia coli - продуцент l-гистидина
CA2255130A1 (en) * 1997-12-16 1999-06-16 Archer Daniels Midland Company Process for making granular l-lysine feed supplement
JP4294123B2 (ja) * 1998-07-03 2009-07-08 協和発酵バイオ株式会社 ホスホリボシルピロリン酸を経由して生合成される代謝産物の製造法
US6110342A (en) 1998-07-21 2000-08-29 Archer Daniels Midland Company Process for production of amino acid hydrochloride and caustic via electrodialysis water splitting
RU2175351C2 (ru) * 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
JP2000256290A (ja) * 1999-03-11 2000-09-19 Ajinomoto Co Inc 安定化リジン水溶液
CN1690191A (zh) * 1999-04-09 2005-11-02 味之素株式会社 L－氨基酸生产菌以及用于生产l－氨基酸的方法
CN1236690C (zh) 1999-06-23 2006-01-18 德古萨股份公司 含有赖氨酸的含水动物饲料添加剂及其生产方法
JP2001046067A (ja) * 1999-08-04 2001-02-20 Ajinomoto Co Inc 好熱性バチルス属細菌由来のｌ−リジン生合成系遺伝子
CA2319283A1 (en) * 1999-09-20 2001-03-20 Kuniki Kino Method for producing l-amino acids by fermentation
DE69939429D1 (de) 1999-12-09 2008-10-09 Archer Daniels Midland Co Reinigung von Aminosäuren durch chromatographische simulierte Wanderbetttrennung
EP1752543A1 (en) 2000-01-20 2007-02-14 Archer-Daniels-Midland Company Process for making a variety of l-lysine feed supplements
AU2001240151B2 (en) * 2000-03-29 2005-06-02 Archer-Daniels-Midland Company Method for separating a basic amino acid from fermentation broth
JP4682454B2 (ja) * 2000-06-28 2011-05-11 味の素株式会社 新規変異型ｎ−アセチルグルタミン酸合成酵素及びｌ−アルギニンの製造法
RU2215783C2 (ru) 2001-05-15 2003-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото - Генетика" МУТАНТНАЯ N-АЦЕТИЛГЛУТАМАТ СИНТАЗА (ВАРИАНТЫ), ФРАГМЕНТ ДНК, ШТАММ БАКТЕРИИ Escherichia coli - ПРОДУЦЕНТ АРГИНИНА (ВАРИАНТЫ) И СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА
RU2208640C2 (ru) 2000-07-06 2003-07-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА, ШТАММ Escherichia coli - ПРОДУЦЕНТ L-АРГИНИНА
RU2207371C2 (ru) * 2000-09-26 2003-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислот семейства l-глутаминовой кислоты, штамм бактерии escherichia coli - продуцент l-аминокислоты (варианты)
JP4273643B2 (ja) * 2000-08-08 2009-06-03 味の素株式会社 好気性培養における培養装置及び消泡制御方法
IT1320794B1 (it) * 2000-08-08 2003-12-10 Filozoo Aventis S R L Procedimento e sistema per fornire aminoacidi naturosimili ochemioderivati in forma liquida ad animali ruminanti allevati.
JP4362959B2 (ja) * 2000-08-24 2009-11-11 味の素株式会社 塩基性アミノ酸の製造方法
JP2002284749A (ja) * 2001-03-23 2002-10-03 Ajinomoto Co Inc 塩基性アミノ酸溶液の製造方法
EP1266966B1 (en) * 2001-06-12 2009-04-29 Ajinomoto Co., Inc. Method for producing L-lysine or L-arginine by using methanol assimilating bacterium
JP2003219807A (ja) * 2002-01-25 2003-08-05 Ajinomoto Co Inc Ｌ−リジンを主成分とする造粒乾燥物
EP1478243B1 (en) * 2002-02-27 2010-06-23 Archer-Daniels-Midland Company Feed supplement for increasing the plasma amino acid level of ruminant livestock and method of administration
JP2004166595A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP2004166592A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP4120364B2 (ja) * 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法
AU2003302660A1 (en) * 2002-12-05 2004-06-23 Md Bioalpha Co., Ltd. Method for preparation of amino acid chelate
DE102004001674B4 (de) * 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
US7029893B2 (en) * 2003-02-28 2006-04-18 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus
EP1651758B1 (en) 2003-07-29 2008-05-28 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attenuated malic enzyme activity
EP1813677B1 (en) 2004-10-07 2019-02-06 Ajinomoto Co., Inc. Enzymatic process for producing basic amino acids
JP4827476B2 (ja) 2005-09-22 2011-11-30 三洋電機株式会社 パック電池
WO2007105790A1 (ja) * 2006-03-15 2007-09-20 Kyowa Hakko Kogyo Co., Ltd. アミノ酸の精製方法
JP2009165355A (ja) * 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法

Also Published As

Publication number Publication date
MX2009006932A (es) 2009-07-06
KR101046905B1 (ko) 2011-07-07
CN101558164B (zh) 2012-05-09
KR20090100406A (ko) 2009-09-23
US8372606B2 (en) 2013-02-12
WO2008078448A1 (ja) 2008-07-03
RU2009124135A (ru) 2010-12-27
BRPI0703692B1 (pt) 2016-12-27
RU2460799C2 (ru) 2012-09-10
CA2672714C (en) 2016-04-26
JPWO2008078448A1 (ja) 2010-04-15
CN101558164A (zh) 2009-10-14
CA2672714A1 (en) 2008-07-03
US20090291477A1 (en) 2009-11-26
EP2096176B1 (en) 2017-04-12
EP2096176A1 (en) 2009-09-02
EP2096176A4 (en) 2012-12-26

Similar Documents

Publication Publication Date Title
BRPI0703692A (pt) método para se obter os cristais de um hidrocloreto de aminoácido básico de um caldo de fermentação de aminoácido básico ou na solução de reação enzimática
BRPI0512167A (pt) processo para a preparação de ácido lático ou lactato a partir de um meio que compreende lactato de magnésio
BR112013033082A2 (pt) método para detectar a presença de bactérias produtoras de carbapenemase em uma amostra
BR0311175A (pt) Processo e sistema de reagente com complexo de enzima-coenzima não regenerável
BRPI0514694A (pt) produção de proteìna de fusão tnfr-ig
BR112013005819A8 (pt) mistura agrícola compreendendo uma fonte de sulfato e silicato de cálcio e processo de formação da mesma
IL190501A0 (en) Multicomponent nucleic acid enzymes and methods for their use
UA105296C2 (ru) Определение и подсчет микроорганизмов
HK1133223A1 (en) Process for scrubbing ammonia from acid gases comprising ammonia and hydrogen sulfide
Gauss et al. Chemical and enzymatic methodologies for the synthesis of enantiomerically pure glyceraldehyde 3-phosphates
Tirumalai et al. The peptidyl transferase center: a window to the past
Sagami et al. Purification and properties of geranylgeranyl-diphosphate synthase from bovine brain.
BRPI0511500A (pt) processo para a preparação de um composto de amÈnio quaternário, uso de uma solução de hidróxido de tetrametilamÈnio de alta pureza, e solução aquosa de hidróxido de tetrametilamÈnio de alta pureza
WO2006082252A3 (en) Method for the enzymatic production of alpha-ketobutyrate
BRPI0412063A (pt) um método para produzir ácido orgánico
BR112014012061A2 (pt) Método para detectar a presença de bactérias de produção de beta-lactamase de espectro expandido em uma amostra
SG155863A1 (en) Composition for cell permeabilization comprising nog, hmp, rubidium chloride and/or lithium chloride for detecting living cells on a membrane
WO2011143575A3 (en) smFRET WITH MEMBRANE PROTEINS
BRPI0509263A (pt) processo para purificar mesotriona
BR0009180A (pt) Processo microbiológico para a preparação de pravastatin
BR112012007968A2 (pt) método para produzir ácido alifático dicarboxílico
ATE321039T1 (de) Verfahren zur herstellung von losartan und losartan-kaliumsalz
Tsueng et al. A low-sodium-salt formulation for the fermentation of salinosporamides by Salinispora tropica strain NPS21184
BRPI0409866A (pt) processo para a preparação de (4-hidroxi-6-oxo-tetrahidropiran-2-il) acetonitrila e seus derivados
AU2003233834A1 (en) Process for treating residue of organic material

Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/09/2007, OBSERVADAS AS CONDICOES LEGAIS.