WO2001074834A1 - O-aryl glucoside sglt2 inhibitors and method - Google Patents

O-aryl glucoside sglt2 inhibitors and method Download PDF

Info

Publication number
WO2001074834A1
WO2001074834A1 PCT/US2001/010092 US0110092W WO0174834A1 WO 2001074834 A1 WO2001074834 A1 WO 2001074834A1 US 0110092 W US0110092 W US 0110092W WO 0174834 A1 WO0174834 A1 WO 0174834A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
inhibitor
alkyl
compounds
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/010092
Other languages
English (en)
French (fr)
Inventor
William N. Washburn
Philip M. Sher
Gang Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22712264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001074834(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to HU0301513A priority Critical patent/HUP0301513A3/hu
Priority to IL15147301A priority patent/IL151473A0/xx
Priority to PL01365176A priority patent/PL365176A1/xx
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to AU2001249598A priority patent/AU2001249598B2/en
Priority to KR1020027012976A priority patent/KR100798203B1/ko
Priority to HK03101354.5A priority patent/HK1049168B/en
Priority to NZ520822A priority patent/NZ520822A/en
Priority to BR0109326-6A priority patent/BR0109326A/pt
Priority to JP2001572523A priority patent/JP4986202B2/ja
Priority to MXPA02009522A priority patent/MXPA02009522A/es
Priority to DE60117012T priority patent/DE60117012T2/de
Priority to AU4959801A priority patent/AU4959801A/xx
Priority to CA002404373A priority patent/CA2404373A1/en
Priority to EP01922840A priority patent/EP1268502B1/en
Publication of WO2001074834A1 publication Critical patent/WO2001074834A1/en
Priority to NO20024642A priority patent/NO20024642L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Definitions

  • SGLT2 As the major renal sodium-dependent transporter of glucose and suggest that the glucosuria locus that has been mapped encodes an SGLT2 regulator. Inhibition of SGLT2 would be predicted to reduce plasma glucose levels via enhanced glucose excretion in diabetic patients.
  • EP 684254-Al appears to encompass derivatives of structure B disclosed in JP 09188625A.
  • A is 0(CH 2 ) m , S, NH(CH 2 ) m , or (CH 2 ) n where n is 0-3 and m is 0-2, and a pharmaceutically acceptable salt thereof, all stereoisomers thereof, and all prodrug esters thereof.
  • the compounds of formula I of the invention as defined above also include the following provisos that
  • a method for treating diabetes and related diseases as defined above and hereinafter wherein a therapeutically effective amount of a combination of a compound of structure I of the invention and one, two or more of other types antidiabetic agents and/or one, two or more other types of therapeutic agents is administered to a human patient in need of treatment.
  • Syndrome X also known as Metabolic Syndrome
  • A is CH 2 or 0 or S, More preferred are compounds of formula IA where A is CH 2 ;
  • Suitable alkylene, alkenylene or alkynylene groups (CH 2 ) m , (CH 2 ) n or (CH 2 ) P (where p can be 1 to 8, preferably 1 to 5, which includes alkylene, alkenylene or alkynylene groups as defined herein) , may optionally include 1, 2, or 3 substituents which include alkyl, alkenyl, halogen, cyano, hydroxy, alkoxy, amino, thioalkyl, keto, C 3 -C 6 cycloalkyl, alkylcarbonylamino or alkylcarbonyloxy.
  • cycloheteroalkyl refers to a 5-, 6- or 7-membered saturated or partially unsaturated ring which includes 1 to 2 hetero atoms such as nitrogen, oxygen and/or sulfur, linked through a carbon atom or a heteroatom, where possible, optionally via the linker (CH 2 ) P (where p is 1, 2 or 3) , such as
  • the compounds of structure I may form a pharmaceutically acceptable salt such as alkali metal salts such as lithium, sodium or potassium, alkaline earth metal salts such as calcium or magnesium as well as zinc or aluminum and other cations such as ammonium, choline, diethanolamine, lysine (D or L) , ethylenediamine, t-butylamine, t-octylamine, tris- (hydroxymethyl) aminomethane (TRIS) , N-methyl glucosamine (NMG) , triethanolamine and dehydroabietylamine.
  • alkali metal salts such as lithium, sodium or potassium
  • alkaline earth metal salts such as calcium or magnesium
  • other cations such as ammonium, choline, diethanolamine, lysine (D or L) , ethylenediamine, t-butylamine, t-octylamine, tris- (hydroxymethyl) aminomethane (TRIS) , N-methyl glucosamine
  • the other type of antidiabetic agent which may be optionally employed in combination with the SGLT2 inhibitor of formula I may be 1,2,3 or more antidiabetic agents or antihyperglycemic agents including insulin secretagogues or insulin sensitizers, or other antidiabetic agents preferably having a mechanism of action different from SGLT2 inhibition and may include biguanides, sulfonyl ureas, glucosidase inhibitors, PPAR ⁇ agonists, such as thiazolidinediones, aP2 inhibitors, PPAR ⁇ / ⁇ dual agonists, dipeptidyl peptidase IV (DP4) inhibitors, and/or meglitinides, as well as insulin, and/or glucagon-like peptide-1 (GLP-1) .
  • biguanides such as thiazolidinediones, aP2 inhibitors, PPAR ⁇ / ⁇ dual agonists, dipeptidyl peptidase IV (
  • the compounds of structure I will be employed in a weight ratio to the sulfonyl urea in the range from about 0.01:1 to about 100:1, preferably from about 0.2:1 to about 10:1.
  • the oral antidiabetic agent may also be a glucosidase inhibitor such as acarbose (disclosed in U.S. Patent No. 4,904,769) or miglitol (disclosed in U.S. Patent No. 4,6.39,436), which may be administered in the same or in a separate oral dosage forms .
  • the compounds of structure I may be employed in combination with a PPAR ⁇ agonist such as a thiazolidinedione oral anti-diabetic agent or other insulin sensitizers (which has an insulin sensitivity effect in NIDDM patients) such as troglitazone (Warner- Lambert's Rezulin ® , disclosed in U.S. Patent No. 4,572,912), rosiglitazone (SKB) , pioglitazone (Takeda) , Mitsubishi's MCC-555 (disclosed in U.S. Patent No.
  • a PPAR ⁇ agonist such as a thiazolidinedione oral anti-diabetic agent or other insulin sensitizers (which has an insulin sensitivity effect in NIDDM patients) such as troglitazone (Warner- Lambert's Rezulin ® , disclosed in U.S. Patent No. 4,572,912), rosiglitazone (SKB) , pioglitazone (
  • a preferred oral dosage form such as tablets or capsules will contain the squalene synthetase inhibitor in an amount of from about 10 to about 500 mg, preferably from about 25 to about 200 mg.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/US2001/010092 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method Ceased WO2001074834A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
EP01922840A EP1268502B1 (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method
BR0109326-6A BR0109326A (pt) 2000-03-30 2001-03-29 Inibidores de sglt2 de glucosìdio de o-arila e método
PL01365176A PL365176A1 (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method
MXPA02009522A MXPA02009522A (es) 2000-03-30 2001-03-29 O-aril-glucosidos como inhibidores de sglt2 y metodo.
AU2001249598A AU2001249598B2 (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method
KR1020027012976A KR100798203B1 (ko) 2000-03-30 2001-03-29 Ｏ-아릴 글루코시드 ｓｇｌｔ2 억제제 및 방법
HK03101354.5A HK1049168B (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method
NZ520822A NZ520822A (en) 2000-03-30 2001-03-29 O-aryl glucoside SGLT2 inhibitors and method
JP2001572523A JP4986202B2 (ja) 2000-03-30 2001-03-29 Ｏ−アリールグルコシドｓｇｌｔ２抑制剤および方法
HU0301513A HUP0301513A3 (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method
IL15147301A IL151473A0 (en) 2000-03-30 2001-03-29 O-aryl glucoside derivatives and pharmaceutical compositons containing the same
DE60117012T DE60117012T2 (de) 2000-03-30 2001-03-29 O-aryl glucosid sglt2 inhibitoren und verfahren
AU4959801A AU4959801A (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method
CA002404373A CA2404373A1 (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method
NO20024642A NO20024642L (no) 2000-03-30 2002-09-27 O-aryl glukosid SGLT2 inhibitorer og fremgangsmÕte

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19309400P 2000-03-30 2000-03-30
US60/193,094 2000-03-30

Publications (1)

Publication Number Publication Date
WO2001074834A1 true WO2001074834A1 (en) 2001-10-11

Family

ID=22712264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010092 Ceased WO2001074834A1 (en) 2000-03-30 2001-03-29 O-aryl glucoside sglt2 inhibitors and method

Country Status (20)

Country Link
US (1) US6683056B2 (enExample)
EP (1) EP1268502B1 (enExample)
JP (1) JP4986202B2 (enExample)
KR (1) KR100798203B1 (enExample)
CN (1) CN1275977C (enExample)
AT (1) ATE316976T1 (enExample)
AU (2) AU4959801A (enExample)
BR (1) BR0109326A (enExample)
CA (1) CA2404373A1 (enExample)
DE (1) DE60117012T2 (enExample)
ES (1) ES2258079T3 (enExample)
HU (1) HUP0301513A3 (enExample)
IL (1) IL151473A0 (enExample)
MX (1) MXPA02009522A (enExample)
NO (1) NO20024642L (enExample)
NZ (1) NZ520822A (enExample)
PL (1) PL365176A1 (enExample)
RU (1) RU2269540C2 (enExample)
WO (1) WO2001074834A1 (enExample)
ZA (1) ZA200207030B (enExample)

Cited By (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044192A1 (en) * 2000-11-30 2002-06-06 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
WO2002064606A1 (fr) * 2001-02-14 2002-08-22 Kissei Pharmaceutical Co., Ltd. Derives glucopyranosyloxybenzylbenzene et leur utilisation medicale
WO2002080936A1 (en) * 2001-04-04 2002-10-17 Ortho Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and ppar modulators
WO2002080935A1 (en) * 2001-04-04 2002-10-17 Ortho Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
WO2003011880A1 (fr) * 2001-07-31 2003-02-13 Kissei Pharmaceutical Co., Ltd. Derive de glucopyranosyloxybenzylbenzene, composition medicinale contenant ce derive, usage medicinal de cette composition et produit intermediaire pour produire cette composition
EP1270584A4 (en) * 2000-03-17 2003-04-09 Kissei Pharmaceutical GLUCOPYRANOSYLOXYBENZYLBENZENE DERIVATIVES, MEDICINAL PREPARATIONS CONTAINING THEM AND INTERMEDIATES FOR THE PREPARATION OF SUCH DERIVATIVES
WO2003080635A1 (en) * 2002-03-22 2003-10-02 Kissei Pharmaceutical Co., Ltd. Crystals of glucopyranosyloxybenzyl benzene derivative
WO2004014931A1 (ja) * 2002-08-09 2004-02-19 Taisho Pharmaceutical Co., Ltd. アリール５−チオ−β−Ｄ−グルコピラノシド誘導体及びそれを含有する糖尿病治療薬
WO2004058790A1 (ja) * 2002-12-25 2004-07-15 Kissei Pharmaceutical Co., Ltd. 含窒素複素環誘導体、それを含有する医薬組成物およびその医薬用途
JP2004196788A (ja) * 2002-12-04 2004-07-15 Kissei Pharmaceut Co Ltd ベンジルフェノール誘導体、それを含有する医薬組成物およびその医薬用途
WO2004087727A1 (ja) * 2003-03-31 2004-10-14 Kissei Pharmaceutical Co., Ltd. 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
US6872706B2 (en) 2000-09-29 2005-03-29 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same
JP2005082506A (ja) * 2003-09-05 2005-03-31 Kao Corp イソプロピルメチルフェノール配糖体
JP2006510643A (ja) * 2002-12-12 2006-03-30 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新しい芳香族フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用
JP2006510644A (ja) * 2002-12-12 2006-03-30 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新しい複素環フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用
WO2005063785A3 (de) * 2003-12-22 2006-04-13 Boehringer Ingelheim Int Glucopyranosyloxy-substituierte aromaten, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
WO2006058597A1 (de) * 2004-12-03 2006-06-08 Merck Patent Gmbh Tetrahydropyranderivate als antidiabetika
US7084124B2 (en) 2003-08-01 2006-08-01 Janssen Pharmaceutica, N.V. Substituted indazole-O-glucosides
US7094764B2 (en) 2003-08-01 2006-08-22 Janssen Pharmaceutica N.V. Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides
US7094763B2 (en) 2003-08-01 2006-08-22 Janssen Pharaceutica, N.V. Substituted fused heterocyclic C-glycosides
JP2006232825A (ja) * 2005-01-31 2006-09-07 Tanabe Seiyaku Co Ltd 医薬組成物
US7129220B2 (en) 2003-08-01 2006-10-31 Janssen Pharmaceutica N.V Substituted indole-O-glucosides
WO2007025943A3 (en) * 2005-08-30 2007-05-10 Boehringer Ingelheim Int Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
JP2007518682A (ja) * 2003-08-01 2007-07-12 田辺製薬株式会社 新規化合物
WO2007128761A2 (de) 2006-05-04 2007-11-15 Boehringer Ingelheim International Gmbh Verwendungen von dpp iv inhibitoren
WO2007147478A1 (de) 2006-06-23 2007-12-27 Merck Patent Gmbh 3 -amino- imidazo [1, 2-a] pyridinderivate als sglt inhibitoren
JPWO2005085237A1 (ja) * 2004-03-04 2008-01-17 キッセイ薬品工業株式会社 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
JPWO2005095429A1 (ja) * 2004-03-31 2008-02-21 キッセイ薬品工業株式会社 フェノール誘導体、それを含有する医薬組成物及びその医薬用途
US7371732B2 (en) 2003-12-22 2008-05-13 Boehringer Ingelheim International Gmbh Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture
WO2008070692A2 (en) 2006-12-06 2008-06-12 Smithkline Beecham Corporation Bicyclic compounds and use as antidiabetics
DE102007008420A1 (de) 2007-02-21 2008-08-28 Merck Patent Gmbh Benzimidazolderivate
US7439232B2 (en) * 2003-04-01 2008-10-21 Taisho Pharmaceutical Co., Ltd. Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
DE102007048716A1 (de) 2007-10-11 2009-04-23 Merck Patent Gmbh Imidazo[1,2-a]pyrimidinderivate
US7579449B2 (en) 2004-03-16 2009-08-25 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
DE102008017590A1 (de) 2008-04-07 2009-10-08 Merck Patent Gmbh Glucopyranosidderivate
FR2929615A1 (fr) * 2008-04-02 2009-10-09 Tfchem Sarl Composes c-aryl glycosides pour le traitement du diabete et de l'obesite.
US7662790B2 (en) 2005-04-15 2010-02-16 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US7666845B2 (en) 2006-12-04 2010-02-23 Janssen Pharmaceutica N.V. Compounds having inhibitory activity against sodium-dependent glucose transporter
US7687469B2 (en) 2004-12-16 2010-03-30 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US7713938B2 (en) 2005-05-03 2010-05-11 Boehringer Ingelheim International Gmbh Crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US7723309B2 (en) 2005-05-03 2010-05-25 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US7745414B2 (en) 2006-02-15 2010-06-29 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
US7767651B2 (en) 2005-01-28 2010-08-03 Chugai Seiyaku Kabushiki Kaisha Spiroketal derivatives and use thereof as diabetic medicine
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
US7772378B2 (en) 2005-02-23 2010-08-10 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US7776830B2 (en) 2006-05-03 2010-08-17 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
US7838499B2 (en) 2007-08-23 2010-11-23 Theracos, Inc. Benzylbenzene derivatives and methods of use
US7847074B2 (en) 2005-09-15 2010-12-07 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof
US7851617B2 (en) 2006-07-27 2010-12-14 Mitsubishi Tanabe Pharma Corporation Indole derivatives
US7851602B2 (en) 2005-07-27 2010-12-14 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
WO2011048112A1 (en) 2009-10-20 2011-04-28 Novartis Ag Glycoside derivatives and uses thereof
WO2011048148A2 (en) 2009-10-20 2011-04-28 Novartis Ag Glycoside derivative and uses thereof
US7935674B2 (en) 2005-01-31 2011-05-03 Mitsubishi Tanabe Pharma Corporation Indole derivatives
US7943582B2 (en) 2006-12-04 2011-05-17 Mitsubishi Tanabe Pharma Corporation Crystalline form of 1-(β-D-glucopyransoyl)-4-methyl-3-[5-(4-fluorophenyl)-2- thienylmethyl]benzene hemihydrate
US7943788B2 (en) 2003-08-01 2011-05-17 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
US7943748B2 (en) 2004-07-27 2011-05-17 Chugai Seiyaku Kabushiki Kaisha Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8048897B2 (en) 2004-07-26 2011-11-01 Chugai Seiyaku Kabushiki Kaisha Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
WO2012025857A1 (en) 2010-08-23 2012-03-01 Hetero Research Foundation Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors
US8129434B2 (en) 2007-12-13 2012-03-06 Theracos, Inc. Benzylphenyl cyclohexane derivatives and methods of use
US8283454B2 (en) 2008-08-22 2012-10-09 Theracos, Inc. Processes for the preparation of SGLT2 inhibitors
WO2012140597A1 (en) 2011-04-14 2012-10-18 Novartis Ag Glycoside derivatives and their uses for the treatment of diabetes
WO2012140596A1 (en) 2011-04-14 2012-10-18 Novartis Ag Glycoside derivatives and uses thereof
JP2012207037A (ja) * 2002-05-20 2012-10-25 Bristol Myers Squibb Co Ｃ−アリールグルコシドｓｇｌｔ２インヒビターおよび方法
US8507450B2 (en) 2005-09-08 2013-08-13 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments
US8551957B2 (en) 2007-08-16 2013-10-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivate
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
US8802842B2 (en) 2009-09-30 2014-08-12 Boehringer Ingelheim International Gmbh Method for the preparation of a crystalline form
EP2774619A1 (de) 2013-03-04 2014-09-10 BioActive Food GmbH Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
US8853385B2 (en) 2008-01-17 2014-10-07 Mitsubishi Tanabe Pharma Corporation Combination therapy comprising SGLT inhibitors and DPP4 inhibitors
US8987323B2 (en) 2010-06-12 2015-03-24 Theracos, Inc. Crystalline form of benzylbenzene SGLT2 inhibitor
US9024009B2 (en) 2007-09-10 2015-05-05 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US9024010B2 (en) 2009-09-30 2015-05-05 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US9061060B2 (en) 2008-07-15 2015-06-23 Theracos Inc. Deuterated benzylbenzene derivatives and methods of use
US9174971B2 (en) 2009-10-14 2015-11-03 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
EP2944311A1 (de) 2014-05-16 2015-11-18 BioActive Food GmbH Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
US9192617B2 (en) 2012-03-20 2015-11-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9464043B2 (en) 2013-10-12 2016-10-11 Theracos Sub, Llc Preparation of hydroxy-benzylbenzene derivatives
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US9949998B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9949997B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US20180185291A1 (en) 2011-03-07 2018-07-05 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
US10406172B2 (en) 2009-02-13 2019-09-10 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US10544135B2 (en) 2011-04-13 2020-01-28 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
US10610489B2 (en) 2009-10-02 2020-04-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof
US10617668B2 (en) 2010-05-11 2020-04-14 Janssen Pharmaceutica Nv Pharmaceutical formulations
US11207337B2 (en) 2015-09-15 2021-12-28 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
US11576894B2 (en) 2009-07-08 2023-02-14 Janssen Pharmaceutica Nv Combination therapy for the treatment of diabetes
EP3485890B1 (en) 2014-01-23 2023-05-10 Boehringer Ingelheim Vetmedica GmbH Sglt2 inhibitors for treatment of metabolic disorders in canine animals
US11666590B2 (en) 2013-04-18 2023-06-06 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2024033288A1 (en) * 2022-08-12 2024-02-15 Société des Produits Nestlé S.A. Salicin derivatives as inhibitors of sglt2
US12263153B2 (en) 2016-11-10 2025-04-01 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US12433906B2 (en) 2013-04-05 2025-10-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2317302C2 (ru) 2000-12-28 2008-02-20 Киссеи Фармасьютикал Ко., Лтд. Производные глюкопиранозилоксипиразола и их применение в лекарственных средствах
KR100882179B1 (ko) * 2001-06-20 2009-02-06 깃세이 야쿠힌 고교 가부시키가이샤 함질소 복소환 유도체, 그것을 함유하는 의약 조성물, 그의약 용도 및 그 제조 중간체
US7956041B2 (en) * 2002-04-26 2011-06-07 Ajinomoto Co., Inc. Prophylactic and therapeutic agent of diabetes mellitus
CA2494179C (en) * 2002-08-08 2012-04-24 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
EP1516665A1 (en) 2003-09-18 2005-03-23 Sony International (Europe) GmbH A method of immobilizing and stretching a nucleic acid on a substrate
WO2005095373A1 (ja) * 2004-03-31 2005-10-13 Kissei Pharmaceutical Co., Ltd. ナフタレン誘導体、それを含有する医薬組成物およびその医薬用途
WO2005095372A1 (ja) * 2004-03-31 2005-10-13 Kissei Pharmaceutical Co., Ltd. ナフタレン誘導体、それを含有する医薬組成物及びその医薬用途
US20050261292A1 (en) * 2004-05-19 2005-11-24 Solvay Pharmaceuticals Gmbh Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions
JP5046370B2 (ja) * 2004-09-29 2012-10-10 キッセイ薬品工業株式会社 １−（β−Ｄ−グリコピラノシル）−３−置換含窒素ヘテロ環化合物、それを含有する医薬組成物及びその医薬用途
AR053329A1 (es) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
UY29694A1 (es) * 2005-07-28 2007-02-28 Boehringer Ingelheim Int Metodos para prevenir y tratar trastornos metabolicos y nuevos derivados de pirazol-o-glucosido
TWI370818B (en) * 2006-04-05 2012-08-21 Astellas Pharma Inc Cocrystal of c-glycoside derivative and l-proline
EP1854806A1 (en) * 2006-05-02 2007-11-14 MPG Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thioglycosides as pharmaceutically active agents
JP5067644B2 (ja) * 2006-05-19 2012-11-07 大正製薬株式会社 Ｃ−フェニルグリシト−ル化合物
US7803778B2 (en) * 2006-05-23 2010-09-28 Theracos, Inc. Glucose transport inhibitors and methods of use
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
TW200817424A (en) * 2006-08-04 2008-04-16 Daiichi Sankyo Co Ltd Benzylphenyl glucopyranoside derivatives
TWI499414B (zh) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
US7795228B2 (en) * 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
WO2008109591A1 (en) * 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
AU2008232419B2 (en) 2007-04-02 2013-06-20 Theracos, Inc. Benzylic glycoside derivatives and methods of use
UA107175C2 (uk) * 2007-07-26 2014-12-10 Спосіб і сполука, призначені для одержання інгібіторів контранспортера натрій-глюкози 2 типу, варіанти
US8252751B2 (en) * 2007-11-30 2012-08-28 Novartis Ag Organic compounds
WO2009096503A1 (ja) * 2008-01-31 2009-08-06 Daiichi Sankyo Company, Limited ベンジルフェニルグルコピラノシド誘導体
US8791077B2 (en) 2008-05-22 2014-07-29 Astrazeneca Ab Method for treating hyperuricemia employing an SGLT2 inhibitor and composition containing same
WO2010023594A1 (en) * 2008-08-28 2010-03-04 Pfizer Inc. Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
CN101445527B (zh) * 2008-12-25 2011-09-14 天津药物研究院 五元芳杂环甲苯基葡萄糖苷、其制备方法和用途
JP5658751B2 (ja) 2009-07-10 2015-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ １−（β−Ｄ−グルコピラノシル）−４−メチル−３−［５−（４−フルオロフェニル）−２−チエニルメチル］ベンゼンのための結晶化方法
EA021983B1 (ru) 2009-11-02 2015-10-30 Пфайзер Инк. Производные диоксабицикло[3.2.1]октан-2,3,4-триола
WO2011070592A2 (en) 2009-12-09 2011-06-16 Panacea Biotec Ltd. Novel sugar derivatives
KR101466838B1 (ko) 2010-06-18 2014-11-28 주식회사 녹십자 Sglt2 억제제로서의 티아졸 유도체 및 이를 포함하는 약학 조성물
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
ES2655443T7 (es) 2011-12-22 2021-03-22 Glycomimetics Inc Compuestos antagonistas de E-selectina
LT2928476T (lt) 2012-12-07 2018-05-25 Glycomimetics, Inc. Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai
CN103127513A (zh) * 2013-03-11 2013-06-05 乔文龙 一种治疗糖尿病及并发症的α-糖苷酶抑制剂和羟甲基戊二酰辅酶A还原酶抑制剂组合物
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
ES2969245T3 (es) 2013-03-14 2024-05-17 Msd Int Gmbh Formas cristalinas y métodos para preparar inhibidores de SGLT2
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
CN105001213B (zh) * 2014-04-14 2020-08-28 上海迪诺医药科技有限公司 C-芳基糖苷衍生物、其药物组合物、制备方法及应用
ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
CN104478967A (zh) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 含腈基苯噻唑基的o-半乳糖苷衍生物、其制备方法和用途
CN104497068A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一种含三氟甲氧基苯s-葡萄糖苷结构的化合物及其用途
CN104497073A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 含丙烯腈和烷氧苯基o-葡萄糖苷结构的衍生物和用途
CN104497074A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一种含丙烯腈基和硝基苯o-葡萄糖苷结构化合物及用途
CN104497072A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 含丙烯腈和卤代苯o-葡萄糖苷结构衍生物、其制备方法和用途
CN104497069A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一类胺基苯基s-葡萄糖苷衍生物、其制备方法和用途
CN104478961A (zh) * 2015-01-15 2015-04-01 佛山市赛维斯医药科技有限公司 含丙烯腈和胺基苯o-葡萄糖苷结构衍生物、其制备方法和用途
CN104497071A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一种含丙烯腈基和腈基苯o-葡萄糖苷结构化合物及用途
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
KR20240046288A (ko) 2016-10-07 2024-04-08 글리코미메틱스, 인크. 매우 강력한 다량체성 e-셀렉틴 길항물질
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
BR112020018184A2 (pt) 2018-03-05 2021-02-02 Glycomimetics, Inc. usos de compostos
US11495339B2 (en) * 2018-06-14 2022-11-08 Astrazeneca Uk Limited Methods for lowering blood sugar with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition
MA53175A (fr) 2018-07-19 2021-05-26 Astrazeneca Ab Méthodes de traitement de hfpef au moyen de dapagliflozine et compositions comprenant celle-ci
CN109456370A (zh) * 2018-12-24 2019-03-12 重庆理工大学 一种钠-葡萄糖协同转运蛋白2抑制剂及其应用
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
CN113801179B (zh) * 2020-06-11 2025-10-31 华东理工大学 一类β-半乳糖苷酶荧光探针、制备方法及其应用
PT4188389T (pt) 2020-07-27 2025-10-07 Astrazeneca Ab Dapagliflozina para utilização em métodos de tratamento de doença renal crónica
EP4315350A1 (en) 2021-04-01 2024-02-07 AstraZeneca UK Limited Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition
CN113980071B (zh) * 2021-11-26 2023-08-22 重庆大学 红景天苷衍生物及其应用
EP4469038A1 (en) 2022-01-26 2024-12-04 Astrazeneca AB Dapagliflozin for use in the treatment of prediabetes or reducing the risk of developing type 2 diabetes
CN114933619B (zh) * 2022-05-18 2024-03-01 上海科利生物医药有限公司 一类硫代糖苷列净类似物及其制备方法和应用
WO2025125513A1 (en) 2023-12-15 2025-06-19 AstraZeneca Ireland Limited Sglt2 inhibitors and baxdrostat for treating chronic kidney disease and hypertension

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0598359A1 (en) * 1992-11-12 1994-05-25 Tanabe Seiyaku Co., Ltd. Hypoglycemic dihydrochalcone derivatives
WO1999031036A2 (en) * 1997-12-12 1999-06-24 Ciba Specialty Chemicals Holding Inc. O-derivatives of halogenated diphenyl ether compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61233621A (ja) * 1985-04-10 1986-10-17 Agency Of Ind Science & Technol 肥満細胞脱顆粒抑制剤
EP0524439A1 (en) * 1991-07-24 1993-01-27 F.Hoffmann-La Roche & Co. Aktiengesellschaft Novel cyclohexane and tetrahydropyran derivatives and antifungal compositions containing these derivatives
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5830873A (en) 1994-05-11 1998-11-03 Tanabe Seiyaku Co., Ltd. Propiophenone derivative and a process for preparing the same
JP2814950B2 (ja) 1994-05-11 1998-10-27 田辺製薬株式会社 血糖降下剤
FI974618L (fi) 1995-06-29 1997-12-23 Texas Biotechnology Corp Kahden- ja kolmenarvoiset pienimolekyyliset selektiininestäjät
JP3034192B2 (ja) 1995-11-07 2000-04-17 田辺製薬株式会社 プロピオフェノン誘導体およびその製法
JP3059088B2 (ja) 1995-11-07 2000-07-04 田辺製薬株式会社 プロピオフェノン誘導体およびその製法
JP3006513B2 (ja) 1995-11-07 2000-02-07 田辺製薬株式会社 医薬組成物
JP3065235B2 (ja) 1995-11-07 2000-07-17 田辺製薬株式会社 プロピオフェノン誘導体およびその製法
DE19615576A1 (de) * 1996-04-19 1997-10-23 Beiersdorf Ag Verfahren zur Herstellung von Mono- und/oder Diglucosiden des Glabridins und deren Verwendung als antiirritativer Wirkstoff in kosmetischen und topischen dermatologischen Zubereitungen
PT850948E (pt) 1996-12-26 2002-08-30 Tanabe Seiyaku Co Derivados propiofenona e processo para a preparacao dos mesmos
WO1998031697A1 (en) 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
JPH10245391A (ja) 1997-03-03 1998-09-14 Dainippon Ink & Chem Inc ７−グリコシロキシベンゾピラン誘導体を有効成分とする糖尿病治療剤
US6486299B1 (en) 1998-09-28 2002-11-26 Curagen Corporation Genes and proteins predictive and therapeutic for stroke, hypertension, diabetes and obesity
US6069238A (en) 1998-09-30 2000-05-30 Eli Lilly And Company Spirocyclic C-glycosides
BR0109323A (pt) * 2000-03-17 2002-12-24 Kissei Pharmaceutical Derivados de gluco piranosiloxi benzil benzeno, composições medicinais contendo os mesmos e intermediários para a preparação dos derivados

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0598359A1 (en) * 1992-11-12 1994-05-25 Tanabe Seiyaku Co., Ltd. Hypoglycemic dihydrochalcone derivatives
WO1999031036A2 (en) * 1997-12-12 1999-06-24 Ciba Specialty Chemicals Holding Inc. O-derivatives of halogenated diphenyl ether compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
T.H. BEMBRY, G. POWELL: "The synthesis of phenolic glycosides", J. AM. CHEM. SOC., vol. 64, 1942, pages 2419 - 2420, XP002174938 *

Cited By (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7465712B2 (en) 2000-03-17 2008-12-16 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
EP1270584A4 (en) * 2000-03-17 2003-04-09 Kissei Pharmaceutical GLUCOPYRANOSYLOXYBENZYLBENZENE DERIVATIVES, MEDICINAL PREPARATIONS CONTAINING THEM AND INTERMEDIATES FOR THE PREPARATION OF SUCH DERIVATIVES
US7045665B2 (en) 2000-03-17 2006-05-16 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
US6872706B2 (en) 2000-09-29 2005-03-29 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same
EP1329456A4 (en) * 2000-09-29 2005-03-30 Kissei Pharmaceutical GLUCOPYRANOSYLOXYBENZYLBENZEN DERIVATIVES AND MEDICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US7129381B2 (en) 2000-11-30 2006-10-31 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
US7053060B2 (en) 2000-11-30 2006-05-30 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
WO2002044192A1 (en) * 2000-11-30 2002-06-06 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
WO2002064606A1 (fr) * 2001-02-14 2002-08-22 Kissei Pharmaceutical Co., Ltd. Derives glucopyranosyloxybenzylbenzene et leur utilisation medicale
US7541341B2 (en) 2001-02-14 2009-06-02 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
US8183213B2 (en) 2001-04-04 2012-05-22 Ortho Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators
WO2002080936A1 (en) * 2001-04-04 2002-10-17 Ortho Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and ppar modulators
US6838442B2 (en) 2001-04-04 2005-01-04 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators
CN100384430C (zh) * 2001-04-04 2008-04-30 奥索-麦克尼尔药品公司 含有葡萄糖重吸收抑制剂和维生素a类-x受体调节剂的联合治疗
WO2002080935A1 (en) * 2001-04-04 2002-10-17 Ortho Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
EP2065044A1 (en) * 2001-04-04 2009-06-03 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators
US8278268B2 (en) 2001-04-04 2012-10-02 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators
WO2003011880A1 (fr) * 2001-07-31 2003-02-13 Kissei Pharmaceutical Co., Ltd. Derive de glucopyranosyloxybenzylbenzene, composition medicinale contenant ce derive, usage medicinal de cette composition et produit intermediaire pour produire cette composition
KR100945455B1 (ko) * 2002-03-22 2010-03-05 깃세이 야쿠힌 고교 가부시키가이샤 글루코피라노실옥시벤질 벤젠 유도체의 결정
WO2003080635A1 (en) * 2002-03-22 2003-10-02 Kissei Pharmaceutical Co., Ltd. Crystals of glucopyranosyloxybenzyl benzene derivative
US7371730B2 (en) 2002-03-22 2008-05-13 Kissei Pharmaceutical Co., Ltd. Crystals of glucopyranosyloxybenzyl benzene derivative
CN1307190C (zh) * 2002-03-22 2007-03-28 橘生药品工业株式会社 吡喃葡糖基氧代苄基苯衍生物的晶体
JP2012207037A (ja) * 2002-05-20 2012-10-25 Bristol Myers Squibb Co Ｃ−アリールグルコシドｓｇｌｔ２インヒビターおよび方法
CN1312165C (zh) * 2002-08-09 2007-04-25 大正制药株式会社 芳基5－硫代－β－D－吡喃葡糖苷衍生物以及含有其的糖尿病治疗药
WO2004014931A1 (ja) * 2002-08-09 2004-02-19 Taisho Pharmaceutical Co., Ltd. アリール５−チオ−β−Ｄ−グルコピラノシド誘導体及びそれを含有する糖尿病治療薬
WO2004014930A1 (ja) * 2002-08-09 2004-02-19 Taisho Pharmaceutical Co., Ltd. 選択的なアリール５−チオ−β−Ｄ−アルドヘキソピラノシドの製造法
US7250522B2 (en) 2002-08-09 2007-07-31 Taisho Pharmaceutical Co., Ltd. Method for selective preparation of aryl 5-thio-β-D-aldohexopyranosides
RU2322449C2 (ru) * 2002-08-09 2008-04-20 Тайсо Фармасьютикал Ко., Лтд. ПРОИЗВОДНЫЕ АРИЛ 5-ТИО-β-D-ГЛЮКОПИРАНОЗИДА И ТЕРАПЕВТИЧЕСКИЕ СРЕДСТВА ПРИ ДИАБЕТЕ, СОДЕРЖАЩИЕ ИХ
US7414072B2 (en) 2002-08-09 2008-08-19 Taisho Pharmaceutical Co., Ltd. Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
JP2004196788A (ja) * 2002-12-04 2004-07-15 Kissei Pharmaceut Co Ltd ベンジルフェノール誘導体、それを含有する医薬組成物およびその医薬用途
JP2006510643A (ja) * 2002-12-12 2006-03-30 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新しい芳香族フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用
RU2340622C2 (ru) * 2002-12-12 2008-12-10 Санофи-Авентис Дойчланд Гмбх Новые ароматические фторгликозидные производные, содержащие эти соединения лекарственные средства, и их применение
US7288528B2 (en) 2002-12-12 2007-10-30 Sanofi-Aventis Deutschland Gmbh Aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
JP2006510644A (ja) * 2002-12-12 2006-03-30 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新しい複素環フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用
WO2004058790A1 (ja) * 2002-12-25 2004-07-15 Kissei Pharmaceutical Co., Ltd. 含窒素複素環誘導体、それを含有する医薬組成物およびその医薬用途
JP4679155B2 (ja) * 2002-12-25 2011-04-27 キッセイ薬品工業株式会社 含窒素複素環誘導体、それを含有する医薬組成物およびその医薬用途
JPWO2004058790A1 (ja) * 2002-12-25 2006-04-27 キッセイ薬品工業株式会社 含窒素複素環誘導体、それを含有する医薬組成物およびその医薬用途
US7655633B2 (en) 2002-12-25 2010-02-02 Kissei Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof
JPWO2004087727A1 (ja) * 2003-03-31 2006-06-29 キッセイ薬品工業株式会社 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
WO2004087727A1 (ja) * 2003-03-31 2004-10-14 Kissei Pharmaceutical Co., Ltd. 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
JP4753716B2 (ja) * 2003-03-31 2011-08-24 キッセイ薬品工業株式会社 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
US7439232B2 (en) * 2003-04-01 2008-10-21 Taisho Pharmaceutical Co., Ltd. Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
US7094764B2 (en) 2003-08-01 2006-08-22 Janssen Pharmaceutica N.V. Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides
US8202984B2 (en) 2003-08-01 2012-06-19 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
JP2007518682A (ja) * 2003-08-01 2007-07-12 田辺製薬株式会社 新規化合物
US7943788B2 (en) 2003-08-01 2011-05-17 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
CN103214471B (zh) * 2003-08-01 2018-02-06 田边三菱制药株式会社 具有钠依赖型葡萄糖转运体抑制活性的化合物的制备方法
CN104109155A (zh) * 2003-08-01 2014-10-22 田边三菱制药株式会社 新颖化合物
US7820630B2 (en) 2003-08-01 2010-10-26 Janssen Pharmaceutica Nv Substituted indole-O-glucosides
US7816331B2 (en) 2003-08-01 2010-10-19 Janssen Pharmaceutica Nv Substituted indazole-O-glucosides
US7129220B2 (en) 2003-08-01 2006-10-31 Janssen Pharmaceutica N.V Substituted indole-O-glucosides
US7482330B2 (en) 2003-08-01 2009-01-27 Janssen Pharmaceutica N.V. Substituted fused heterocyclic C-glycosides
US7511021B2 (en) 2003-08-01 2009-03-31 Janssen Pharmaceutica N.V. Substituted indazole-O-glucosides
US7511020B2 (en) 2003-08-01 2009-03-31 Janssen Pharmaceutica N.V. Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides
US7816328B2 (en) 2003-08-01 2010-10-19 Janssen Pharmaceutica Nv Substituted fused heterocyclic C-glycosides
US7521430B2 (en) 2003-08-01 2009-04-21 Mitsubishi Tanabe Pharma Corporation N-glucoside compounds having an inhibitory activity against sodium-dependent glucose transporter
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
CN103819465A (zh) * 2003-08-01 2014-05-28 田边三菱制药株式会社 新颖化合物
US7816330B2 (en) 2003-08-01 2010-10-19 Janssen Pharmaceutica Nv Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides
US7094763B2 (en) 2003-08-01 2006-08-22 Janssen Pharaceutica, N.V. Substituted fused heterocyclic C-glycosides
US7084124B2 (en) 2003-08-01 2006-08-01 Janssen Pharmaceutica, N.V. Substituted indazole-O-glucosides
US8222219B2 (en) 2003-08-01 2012-07-17 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
CN103214471A (zh) * 2003-08-01 2013-07-24 田边三菱制药株式会社 新颖化合物
US7511022B2 (en) 2003-08-01 2009-03-31 Janssen Pharmaceutica N.V. Substituted indole-O-glucosides
JP2005082506A (ja) * 2003-09-05 2005-03-31 Kao Corp イソプロピルメチルフェノール配糖体
JP2007515441A (ja) * 2003-12-22 2007-06-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシロキシ置換芳香族化合物、前記化合物を含む医薬、それらの使用及びそれらの製造方法
WO2005063785A3 (de) * 2003-12-22 2006-04-13 Boehringer Ingelheim Int Glucopyranosyloxy-substituierte aromaten, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
US7371732B2 (en) 2003-12-22 2008-05-13 Boehringer Ingelheim International Gmbh Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture
JPWO2005085237A1 (ja) * 2004-03-04 2008-01-17 キッセイ薬品工業株式会社 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
US7579449B2 (en) 2004-03-16 2009-08-25 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
JPWO2005095429A1 (ja) * 2004-03-31 2008-02-21 キッセイ薬品工業株式会社 フェノール誘導体、それを含有する医薬組成物及びその医薬用途
US8048897B2 (en) 2004-07-26 2011-11-01 Chugai Seiyaku Kabushiki Kaisha Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
US7943748B2 (en) 2004-07-27 2011-05-17 Chugai Seiyaku Kabushiki Kaisha Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
WO2006058597A1 (de) * 2004-12-03 2006-06-08 Merck Patent Gmbh Tetrahydropyranderivate als antidiabetika
US7687469B2 (en) 2004-12-16 2010-03-30 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US7767651B2 (en) 2005-01-28 2010-08-03 Chugai Seiyaku Kabushiki Kaisha Spiroketal derivatives and use thereof as diabetic medicine
JP2006232825A (ja) * 2005-01-31 2006-09-07 Tanabe Seiyaku Co Ltd 医薬組成物
US7935674B2 (en) 2005-01-31 2011-05-03 Mitsubishi Tanabe Pharma Corporation Indole derivatives
US7772378B2 (en) 2005-02-23 2010-08-10 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US7662790B2 (en) 2005-04-15 2010-02-16 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US7713938B2 (en) 2005-05-03 2010-05-11 Boehringer Ingelheim International Gmbh Crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US7723309B2 (en) 2005-05-03 2010-05-25 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US10442795B2 (en) 2005-05-10 2019-10-15 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
US9127034B2 (en) 2005-05-10 2015-09-08 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivates and intermediates therein
US7851602B2 (en) 2005-07-27 2010-12-14 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
WO2007025943A3 (en) * 2005-08-30 2007-05-10 Boehringer Ingelheim Int Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US7683160B2 (en) 2005-08-30 2010-03-23 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
US8507450B2 (en) 2005-09-08 2013-08-13 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments
US7847074B2 (en) 2005-09-15 2010-12-07 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof
US7745414B2 (en) 2006-02-15 2010-06-29 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
US8557782B2 (en) 2006-05-03 2013-10-15 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
US7776830B2 (en) 2006-05-03 2010-08-17 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
WO2007128761A2 (de) 2006-05-04 2007-11-15 Boehringer Ingelheim International Gmbh Verwendungen von dpp iv inhibitoren
EP2351568A2 (de) 2006-05-04 2011-08-03 Boehringer Ingelheim International GmbH Verwendungen von dpp iv Inhibitoren
EP2397142A2 (de) 2006-05-04 2011-12-21 Boehringer Ingelheim International GmbH Verwendungen von DPP IV Inhibitoren
WO2007147478A1 (de) 2006-06-23 2007-12-27 Merck Patent Gmbh 3 -amino- imidazo [1, 2-a] pyridinderivate als sglt inhibitoren
US7851617B2 (en) 2006-07-27 2010-12-14 Mitsubishi Tanabe Pharma Corporation Indole derivatives
US8513202B2 (en) 2006-12-04 2013-08-20 Mitsubishi Tanabe Pharma Corporation Crystalline form of 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene hemihydrate
US7666845B2 (en) 2006-12-04 2010-02-23 Janssen Pharmaceutica N.V. Compounds having inhibitory activity against sodium-dependent glucose transporter
US7943582B2 (en) 2006-12-04 2011-05-17 Mitsubishi Tanabe Pharma Corporation Crystalline form of 1-(β-D-glucopyransoyl)-4-methyl-3-[5-(4-fluorophenyl)-2- thienylmethyl]benzene hemihydrate
WO2008070692A2 (en) 2006-12-06 2008-06-12 Smithkline Beecham Corporation Bicyclic compounds and use as antidiabetics
EP2325182A1 (en) 2006-12-06 2011-05-25 Glaxosmithkline LLC Bicyclic compounds and use as antidiabetics
DE102007008420A1 (de) 2007-02-21 2008-08-28 Merck Patent Gmbh Benzimidazolderivate
US8551957B2 (en) 2007-08-16 2013-10-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivate
US7838499B2 (en) 2007-08-23 2010-11-23 Theracos, Inc. Benzylbenzene derivatives and methods of use
US8106021B2 (en) 2007-08-23 2012-01-31 Theracos, Inc. Benzylbenzene derivatives and methods of use
US8802637B2 (en) 2007-08-23 2014-08-12 Theracos, Inc. Benzylbenzene derivatives and methods of use
US8575321B2 (en) 2007-08-23 2013-11-05 Theracos, Inc. Benzylbenzene derivatives and methods of use
US9024009B2 (en) 2007-09-10 2015-05-05 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
WO2009049731A1 (de) 2007-10-11 2009-04-23 Merck Patent Gmbh Imidazo [ 1, 2 -a] pyrimidinderivate zur behandlung von erkrankungen wie diabetes
DE102007048716A1 (de) 2007-10-11 2009-04-23 Merck Patent Gmbh Imidazo[1,2-a]pyrimidinderivate
US8129434B2 (en) 2007-12-13 2012-03-06 Theracos, Inc. Benzylphenyl cyclohexane derivatives and methods of use
US8853385B2 (en) 2008-01-17 2014-10-07 Mitsubishi Tanabe Pharma Corporation Combination therapy comprising SGLT inhibitors and DPP4 inhibitors
WO2009121939A3 (en) * 2008-04-02 2010-11-11 Tfchem C-aryl glycoside compounds for the treatment of diabetes and obesity
US8486897B2 (en) 2008-04-02 2013-07-16 Tfchem C-aryl glycoside compounds for the treatment of diabetes and obesity
FR2929615A1 (fr) * 2008-04-02 2009-10-09 Tfchem Sarl Composes c-aryl glycosides pour le traitement du diabete et de l'obesite.
WO2009124638A1 (de) 2008-04-07 2009-10-15 Merck Patent Gmbh Glucopyranosidderivate
DE102008017590A1 (de) 2008-04-07 2009-10-08 Merck Patent Gmbh Glucopyranosidderivate
US9061060B2 (en) 2008-07-15 2015-06-23 Theracos Inc. Deuterated benzylbenzene derivatives and methods of use
US9006403B2 (en) 2008-08-22 2015-04-14 Theracos, Inc. Processes for the preparation of SGLT2 inhibitors
US8283454B2 (en) 2008-08-22 2012-10-09 Theracos, Inc. Processes for the preparation of SGLT2 inhibitors
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US10406172B2 (en) 2009-02-13 2019-09-10 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US12115179B2 (en) 2009-02-13 2024-10-15 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11576894B2 (en) 2009-07-08 2023-02-14 Janssen Pharmaceutica Nv Combination therapy for the treatment of diabetes
US8802842B2 (en) 2009-09-30 2014-08-12 Boehringer Ingelheim International Gmbh Method for the preparation of a crystalline form
US9873714B2 (en) 2009-09-30 2018-01-23 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
US9024010B2 (en) 2009-09-30 2015-05-05 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
US10610489B2 (en) 2009-10-02 2020-04-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof
US9174971B2 (en) 2009-10-14 2015-11-03 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
WO2011048148A2 (en) 2009-10-20 2011-04-28 Novartis Ag Glycoside derivative and uses thereof
WO2011048112A1 (en) 2009-10-20 2011-04-28 Novartis Ag Glycoside derivatives and uses thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US10617668B2 (en) 2010-05-11 2020-04-14 Janssen Pharmaceutica Nv Pharmaceutical formulations
US10533032B2 (en) 2010-06-12 2020-01-14 Theracos Sub, Llc Crystalline form of benzylbenzene SGLT2 inhibitor
US8987323B2 (en) 2010-06-12 2015-03-24 Theracos, Inc. Crystalline form of benzylbenzene SGLT2 inhibitor
US9834573B2 (en) 2010-06-12 2017-12-05 Theracos Sub, Llc Crystalline form of benzylbenzene SGLT2 inhibitor
US10981942B2 (en) 2010-06-12 2021-04-20 Theracos Sub, Llc Crystalline form of benzylbenzene SGLT2 inhibitor
WO2012025857A1 (en) 2010-08-23 2012-03-01 Hetero Research Foundation Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors
US10596120B2 (en) 2011-03-07 2020-03-24 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
US11564886B2 (en) 2011-03-07 2023-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
US20180185291A1 (en) 2011-03-07 2018-07-05 Boehringer Ingelheim International Gmbh Pharmaceutical compositions
US10544135B2 (en) 2011-04-13 2020-01-28 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
WO2012140596A1 (en) 2011-04-14 2012-10-18 Novartis Ag Glycoside derivatives and uses thereof
WO2012140597A1 (en) 2011-04-14 2012-10-18 Novartis Ag Glycoside derivatives and their uses for the treatment of diabetes
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US9192617B2 (en) 2012-03-20 2015-11-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9725478B2 (en) 2012-04-10 2017-08-08 Theracos Sub, Llc Process for the preparation of benzylbenzene SGLT2 inhibitors
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
EP2774619A1 (de) 2013-03-04 2014-09-10 BioActive Food GmbH Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
US9949998B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US10258637B2 (en) 2013-04-05 2019-04-16 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US12433906B2 (en) 2013-04-05 2025-10-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9949997B2 (en) 2013-04-05 2018-04-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11090323B2 (en) 2013-04-05 2021-08-17 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11918596B2 (en) 2013-04-05 2024-03-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11833166B2 (en) 2013-04-05 2023-12-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11666590B2 (en) 2013-04-18 2023-06-06 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US12427162B2 (en) 2013-04-18 2025-09-30 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US9464043B2 (en) 2013-10-12 2016-10-11 Theracos Sub, Llc Preparation of hydroxy-benzylbenzene derivatives
US10093616B2 (en) 2013-10-12 2018-10-09 Theracos Sub, Llc Preparation of hydroxy-benzylbenzene derivatives
EP3485890B1 (en) 2014-01-23 2023-05-10 Boehringer Ingelheim Vetmedica GmbH Sglt2 inhibitors for treatment of metabolic disorders in canine animals
WO2015173383A1 (de) 2014-05-16 2015-11-19 Bioactive Food Gmbh Kombination von biologisch aktiven substanzen zur behandlung von hyperglykämischen erkrankungen
EP2944311A1 (de) 2014-05-16 2015-11-18 BioActive Food GmbH Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen
US11207337B2 (en) 2015-09-15 2021-12-28 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
US12263153B2 (en) 2016-11-10 2025-04-01 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2024033288A1 (en) * 2022-08-12 2024-02-15 Société des Produits Nestlé S.A. Salicin derivatives as inhibitors of sglt2

Also Published As

Publication number Publication date
EP1268502A1 (en) 2003-01-02
JP4986202B2 (ja) 2012-07-25
CA2404373A1 (en) 2001-10-11
AU2001249598B2 (en) 2006-09-07
US20020111315A1 (en) 2002-08-15
DE60117012T2 (de) 2006-08-31
NO20024642D0 (no) 2002-09-27
JP2004500416A (ja) 2004-01-08
NZ520822A (en) 2005-03-24
AU4959801A (en) 2001-10-15
RU2269540C2 (ru) 2006-02-10
KR20030007488A (ko) 2003-01-23
ATE316976T1 (de) 2006-02-15
HUP0301513A3 (en) 2007-05-29
ZA200207030B (en) 2003-12-02
EP1268502B1 (en) 2006-02-01
HUP0301513A2 (hu) 2003-09-29
US6683056B2 (en) 2004-01-27
CN1437608A (zh) 2003-08-20
CN1275977C (zh) 2006-09-20
ES2258079T3 (es) 2006-08-16
IL151473A0 (en) 2003-04-10
NO20024642L (no) 2002-11-21
BR0109326A (pt) 2004-03-30
HK1049168A1 (en) 2003-05-02
PL365176A1 (en) 2004-12-27
KR100798203B1 (ko) 2008-01-24
DE60117012D1 (de) 2006-04-13
MXPA02009522A (es) 2003-05-14

Similar Documents

Publication Publication Date Title
EP1268502B1 (en) O-aryl glucoside sglt2 inhibitors and method
US6555519B2 (en) O-glucosylated benzamide SGLT2 inhibitors and method
US6414126B1 (en) C-aryl glucoside SGLT2 inhibitors and method
US6936590B2 (en) C-aryl glucoside SGLT2 inhibitors and method
AU2001249598A1 (en) O-aryl glucoside sglt2 inhibitors and method
US6515117B2 (en) C-aryl glucoside SGLT2 inhibitors and method
US20030087843A1 (en) O-pyrazole glucoside SGLT2 inhibitors and method of use
HK1049168B (en) O-aryl glucoside sglt2 inhibitors and method

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 520822

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 151473

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2001922840

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2002/07030

Country of ref document: ZA

Ref document number: 200207030

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2002/01246/MU

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2001 572523

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PV2002-3233

Country of ref document: CZ

Ref document number: 2404373

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/009522

Country of ref document: MX

Ref document number: 2001249598

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1020027012976

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 01807538X

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 2002 2002126586

Country of ref document: RU

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: PV2002-3233

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 2001922840

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020027012976

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 520822

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 520822

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 2001922840

Country of ref document: EP