|
US30985A
(en)
|
|
1860-12-18 |
|
Thomas l |
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US4968607A
(en)
|
1987-11-25 |
1990-11-06 |
Immunex Corporation |
Interleukin-1 receptors
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1990005183A1
(en)
|
1988-10-31 |
1990-05-17 |
Immunex Corporation |
Interleukin-4 receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AU651596B2
(en)
|
1990-06-05 |
1994-07-28 |
Immunex Corporation |
Type II interleukin-1 receptors
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
JPH06508035A
(ja)
|
1991-06-14 |
1994-09-14 |
ディーエヌエックス コーポレーション |
トランスジェニックブタにおけるヒトヘモグロビンの生産
|
|
DE69224906T2
(de)
|
1991-07-08 |
1998-10-29 |
Univ Massachusetts |
Thermotropes flüssig-kristallines segment-blockcopolymer
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
NZ255101A
(en)
|
1992-07-24 |
1997-08-22 |
Cell Genesys Inc |
A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US6878687B1
(en)
|
1997-03-07 |
2005-04-12 |
Human Genome Sciences, Inc. |
Protein HMAAD57
|
|
WO1998039446A2
(en)
|
1997-03-07 |
1998-09-11 |
Human Genome Sciences, Inc. |
70 human secreted proteins
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
CA2331386A1
(en)
|
1998-06-26 |
2000-01-06 |
Incyte Pharmaceuticals, Inc. |
Human signal peptide-containing proteins
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US6833268B1
(en)
|
1999-06-10 |
2004-12-21 |
Abgenix, Inc. |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
|
|
AUPQ873300A0
(en)
|
2000-07-12 |
2000-08-03 |
Medvet Science Pty. Ltd. |
A binding motif of a receptor (2)
|
|
CN101289511A
(zh)
|
2000-04-11 |
2008-10-22 |
杰南技术公司 |
多价抗体及其应用
|
|
US7858094B2
(en)
|
2000-12-08 |
2010-12-28 |
Geneprint Corporation |
TREM-1 splice variant for use in modifying immune responses
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
CA2342376C
(en)
|
2001-03-20 |
2013-11-12 |
Marco Colonna |
A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8981061B2
(en)
|
2001-03-20 |
2015-03-17 |
Novo Nordisk A/S |
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
|
|
US8231878B2
(en)
|
2001-03-20 |
2012-07-31 |
Cosmo Research & Development S.P.A. |
Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
CA2454587C
(en)
|
2001-07-25 |
2012-11-13 |
Protein Design Labs, Inc. |
Stable lyophilized pharmaceutical formulation of igg antibodies
|
|
CA2462883A1
(en)
|
2001-10-12 |
2003-04-17 |
Schering Corporation |
Use of bispecific antibodies to regulate immune responses
|
|
US20060263770A1
(en)
|
2002-03-22 |
2006-11-23 |
Marco Colonna |
Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
|
EP1508340A4
(en)
|
2002-05-24 |
2009-07-01 |
Takeda Pharmaceutical |
MEANS FOR IMPROVING INSULIN RESISTANCE
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
GB0401730D0
(en)
|
2004-01-27 |
2004-03-03 |
Bioxell Spa |
Diagnosis method
|
|
CN1961002B
(zh)
|
2004-05-27 |
2011-05-18 |
克鲁塞尔荷兰公司 |
能中和狂犬病病毒的结合分子及其应用
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
US8101345B1
(en)
|
2005-03-25 |
2012-01-24 |
Isis Pharmaceuticals, Inc. |
Proinflammatory nucleic acids
|
|
KR20060135280A
(ko)
|
2005-06-24 |
2006-12-29 |
전남대학교산학협력단 |
선천성 면역에 관여하는 트렘-2의 클로닝
|
|
AU2006265113A1
(en)
|
2005-07-01 |
2007-01-11 |
The Johns Hopkins University |
Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
|
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
|
KR101516823B1
(ko)
|
2006-03-17 |
2015-05-07 |
바이오겐 아이덱 엠에이 인코포레이티드 |
안정화된 폴리펩티드 조성물
|
|
DE202006007499U1
(de)
|
2006-05-11 |
2007-01-11 |
Osaka University |
Verwendung einer Zusammensetzung, die Plexin-A1-DAP12-Interaktion inhibiert, zur Behandlung von Entzündungs-, Autoimmun- oder Knochenresorptionserkrankungen
|
|
WO2007146968A2
(en)
|
2006-06-12 |
2007-12-21 |
Trubion Pharmaceuticals, Inc. |
Single-chain multivalent binding proteins with effector function
|
|
CA2551163A1
(en)
|
2006-07-17 |
2008-01-17 |
Boehringer Ingelheim International Gmbh |
Methods for treating inflammatory, autoimmune or bone resorption diseases
|
|
US7553936B2
(en)
|
2006-12-04 |
2009-06-30 |
The United States of America as represented by Secretary Department of Health and Human Services |
Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions
|
|
US20080247955A1
(en)
|
2007-01-16 |
2008-10-09 |
Jun Kuai |
Inflammation treatment, detection and monitoring via TREM-1
|
|
IN2009DN05758A
(https=)
|
2007-03-12 |
2015-07-24 |
Esbatech Ag |
|
|
US8793074B2
(en)
|
2007-06-21 |
2014-07-29 |
Saint Louis University |
Sequence covariance networks, methods and uses therefor
|
|
US20090074780A1
(en)
|
2007-06-25 |
2009-03-19 |
David Urech |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
|
GR1007327B
(el)
|
2007-08-08 |
2011-06-27 |
Ευαγγελος Γιαμαρελλος-Μπουρμπουλης |
Ο διαλυτος υποδοχεας ενεργοποιησης των μυελοκυτταρων (strem-1) ως δεικτης αποτελεσματικοτητας της θεραπειας του πεπτικου ελκους
|
|
MX2010002683A
(es)
|
2007-09-14 |
2010-03-26 |
Amgen Inc |
Poblaciones de anticuerpos homogeneos.
|
|
TW200918553A
(en)
*
|
2007-09-18 |
2009-05-01 |
Amgen Inc |
Human GM-CSF antigen binding proteins
|
|
ES2563027T3
(es)
|
2008-01-07 |
2016-03-10 |
Amgen Inc. |
Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática
|
|
KR100960684B1
(ko)
|
2008-02-22 |
2010-05-31 |
전남대학교산학협력단 |
Ga733-2 발현 억제제로서의 trem-2 유전자, 및 이를포함하는 형질전환 동물 및 이의 사용방법
|
|
WO2010045479A1
(en)
|
2008-10-15 |
2010-04-22 |
The Board Of Trustees Of The University Of Illinois |
Phospholipid micellar and liposomal compositions and uses thereof
|
|
CA2759978C
(en)
|
2009-04-28 |
2020-06-02 |
Life & Brain Gmbh |
Method for obtaining human microglial precursor cells from pluripotent stem cells
|
|
WO2010132370A2
(en)
|
2009-05-11 |
2010-11-18 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Soluble tlt-1 for the treatment and diagnosis of sepsis
|
|
AU2010270979B2
(en)
|
2009-06-22 |
2015-04-23 |
Medimmune, Llc |
Engineered Fc regions for site-specific conjugation
|
|
US8513185B2
(en)
|
2009-10-13 |
2013-08-20 |
Alexander B. Sigalov |
Inhibition of TREM receptor signaling with peptide variants
|
|
CN102038698A
(zh)
|
2009-10-14 |
2011-05-04 |
山东绿叶天然药物研究开发有限公司 |
莫诺苷的新用途
|
|
JO3244B1
(ar)
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
|
CA2780221A1
(en)
*
|
2009-11-04 |
2011-05-12 |
Fabrus Llc |
Methods for affinity maturation-based antibody optimization
|
|
CN102127168A
(zh)
|
2010-01-19 |
2011-07-20 |
中国人民解放军第二军医大学 |
一种髓样细胞表达激发受体-1的重组融合蛋白及其应用
|
|
KR20110086460A
(ko)
|
2010-01-22 |
2011-07-28 |
한국교원대학교산학협력단 |
수용성 수용체 라이브러리 및 이를 이용한 사이토카인 발현 조절 유전자의 스크리닝 방법
|
|
HUE050815T2
(hu)
|
2010-04-08 |
2021-01-28 |
Inst Nat Sante Rech Med |
A trem-szerû 1. transzkriptumból (tlt-1) származó gátló peptidek és azok felhasználása
|
|
SG185107A1
(en)
|
2010-04-30 |
2012-12-28 |
Alexion Pharma Inc |
Antibodies having reduced immunogenicity in a human
|
|
WO2012016333A1
(en)
|
2010-08-06 |
2012-02-09 |
University Health Network |
Biomarkers for malaria
|
|
US20130130354A1
(en)
|
2010-09-28 |
2013-05-23 |
CTI Salud S.A. |
Novel genes and uses thereof, expression profile of colon, gastric and pancreatic cancer
|
|
WO2012088302A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
|
WO2012088290A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
|
US20140038285A1
(en)
*
|
2011-03-11 |
2014-02-06 |
Amgen Inc. |
Method of correlated mutational analysis to improve therapeutic antibodies
|
|
KR20120112973A
(ko)
|
2011-04-04 |
2012-10-12 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 예방 또는 치료용 조성물
|
|
US20130058947A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc |
Novel Modulators and Methods of Use
|
|
CN107266577B
(zh)
|
2011-10-11 |
2022-09-13 |
弗·哈夫曼-拉罗切有限公司 |
双特异性抗体的改进的组装
|
|
CN104094119A
(zh)
|
2011-10-21 |
2014-10-08 |
斯特姆詹尼克斯公司 |
用于胞内传递生物活性分子的官能化纳米粒子
|
|
CA2854233C
(en)
|
2011-11-04 |
2020-05-12 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
CA2854806A1
(en)
|
2011-11-07 |
2013-05-16 |
Medimmune, Llc |
Multispecific and multivalent binding proteins and uses thereof
|
|
JP2015502397A
(ja)
|
2011-12-23 |
2015-01-22 |
ファイザー・インク |
部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
|
|
TWI450727B
(zh)
|
2011-12-29 |
2014-09-01 |
財團法人工業技術研究院 |
抗人類輸鐵蛋白受體的單域抗體與其應用
|
|
CN102517287B
(zh)
|
2012-01-10 |
2013-09-11 |
广西大学 |
抑制水牛TREM1基因表达的shRNA、慢病毒表达载体及其构建方法和应用
|
|
KR20130114951A
(ko)
|
2012-04-10 |
2013-10-21 |
한양대학교 산학협력단 |
폴리감마글루탐산을 포함하는 Th17 매개성 질환 예방 또는 치료용 조성물
|
|
DK2892920T3
(da)
|
2012-09-07 |
2020-06-08 |
Inst Nat Sante Rech Med |
Hæmmende peptider afledt af udløsningsreceptor udtrykt på myeloide celler-1 (trem-1) trem-lignende transskript 1 (tlt-1) og anvendelser deraf
|
|
CA2886433C
(en)
|
2012-10-04 |
2022-01-04 |
Dana-Farber Cancer Institute, Inc. |
Human monoclonal anti-pd-l1 antibodies and methods of use
|
|
CA2887825A1
(en)
|
2012-10-23 |
2014-05-01 |
The Board Of Regents Of The University Of Texas System |
Engineered igg fc domains
|
|
WO2014074942A1
(en)
|
2012-11-08 |
2014-05-15 |
Illumina, Inc. |
Risk variants of alzheimer's disease
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
US9066928B1
(en)
|
2012-12-04 |
2015-06-30 |
University Of Kentucky Research Foundation |
Method, composition, and kit useful for treatment of alzheimer's disease
|
|
US9580486B2
(en)
|
2013-03-14 |
2017-02-28 |
Amgen Inc. |
Interleukin-2 muteins for the expansion of T-regulatory cells
|
|
WO2014189973A2
(en)
|
2013-05-20 |
2014-11-27 |
Genentech, Inc. |
Anti-transferrin receptor antibodies and methods of use
|
|
KR20150010326A
(ko)
|
2013-07-19 |
2015-01-28 |
전남대학교산학협력단 |
비만 및 제 2형 당뇨 또는 지방간의 예방 또는 치료용 바이아릴아마이드를 포함한 유도체 화합물
|
|
CA2825821A1
(en)
|
2013-08-28 |
2015-02-28 |
Chiesi Farmaceutici S.P.A. |
1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis
|
|
KR101402921B1
(ko)
|
2013-08-28 |
2014-06-02 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 치료를 위한 레스베라톨 유도체의 이용
|
|
WO2015037000A1
(en)
|
2013-09-11 |
2015-03-19 |
Compugen Ltd |
Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
|
|
CN103555829B
(zh)
|
2013-10-12 |
2015-10-21 |
厦门人瑞生物医药科技有限公司 |
一种检测trem2基因r47h突变的探针、试剂盒和方法
|
|
WO2015103594A1
(en)
|
2014-01-06 |
2015-07-09 |
Children's Medical Center Corporation |
Biomarkers for dementia and dementia related neurological disorders
|
|
EP3099717B1
(en)
|
2014-01-31 |
2019-03-27 |
Novartis AG |
Antibody molecules to tim-3 and uses thereof
|
|
CN103866041A
(zh)
|
2014-04-04 |
2014-06-18 |
厦门大学 |
帕金森病和脑白质疏松症的突变检测试剂盒及其检测方法
|
|
LT3129406T
(lt)
|
2014-04-11 |
2019-04-10 |
Medimmune, Llc |
Konjuguoti junginiai, apimantys inžineriniu būdu sukonstruotus cisteino antikūnus
|
|
CN105218669A
(zh)
|
2014-06-10 |
2016-01-06 |
河北翰林生物科技有限公司 |
制备抗人r47h-trem2突变体的人单克隆抗体的方法
|
|
WO2016004389A2
(en)
|
2014-07-03 |
2016-01-07 |
Abbvie Inc. |
Monovalent binding proteins
|
|
EP3172232B1
(en)
|
2014-07-17 |
2023-12-27 |
Novo Nordisk A/S |
Site directed mutagenesis of trem-1 antibodies for decreasing viscosity.
|
|
EP3177322A4
(en)
|
2014-08-08 |
2018-07-18 |
Alector LLC |
Anti-trem2 antibodies and methods of use thereof
|
|
KR101756417B1
(ko)
|
2014-08-21 |
2017-07-10 |
한국유나이티드제약 주식회사 |
금제제를 포함하는 간 섬유화 또는 간 경화의 예방 또는 치료용 약학적 조성물
|
|
CA2961950A1
(en)
|
2014-09-28 |
2016-03-31 |
The Regents Of The University Of California |
Modulation of stimulatory and non-stimulatory myeloid cells
|
|
WO2016064895A1
(en)
|
2014-10-20 |
2016-04-28 |
The Brigham And Women's Hospital, Inc. |
Targeting apolipoprotein e (apoe) in neurologic disease
|
|
US10081792B2
(en)
|
2014-12-31 |
2018-09-25 |
Wisconsin Alumni Research Foundation |
Derivation of human microglia from pluripotent stem cells
|
|
EP3283508B1
(en)
|
2015-04-17 |
2021-03-17 |
Alpine Immune Sciences, Inc. |
Immunomodulatory proteins with tunable affinities
|
|
WO2016187339A1
(en)
|
2015-05-18 |
2016-11-24 |
Synaptec Development Llc |
GALANTAMINE CLEARANCE OF AMYLOIDß
|
|
JP7497953B2
(ja)
|
2015-06-12 |
2024-06-11 |
アレクトル エルエルシー |
抗cd33抗体及びその使用方法
|
|
JP7376977B2
(ja)
|
2015-06-12 |
2023-11-09 |
アレクトル エルエルシー |
抗cd33抗体及びその使用方法
|
|
US10765679B2
(en)
|
2015-07-04 |
2020-09-08 |
Emory University |
Use of TREM-1 inhibitors for treatment, elimination and eradication of HIV-1 infection
|
|
WO2017011342A1
(en)
|
2015-07-10 |
2017-01-19 |
Abbvie Inc. |
Igm-or-ige-modified binding proteins and uses thereof
|
|
WO2017019846A1
(en)
|
2015-07-30 |
2017-02-02 |
Macrogenics, Inc. |
Pd-1-binding molecules and methods use thereof
|
|
CA2996059A1
(en)
|
2015-08-28 |
2017-03-09 |
Alector Llc |
Anti-siglec-7 antibodies and methods of use thereof
|
|
WO2017058866A1
(en)
|
2015-09-28 |
2017-04-06 |
Precision Immune, Inc. |
Anti-trem2 antibodies and uses thereof
|
|
AU2016334051B2
(en)
|
2015-10-06 |
2023-10-26 |
Alector Llc |
Anti-TREM2 antibodies and methods of use thereof
|
|
CA3003458A1
(en)
|
2015-10-29 |
2017-05-04 |
Alector Llc |
Anti-siglec-9 antibodies and methods of use thereof
|
|
US20170218058A1
(en)
|
2016-01-28 |
2017-08-03 |
Alector, LLC |
Anti-apoe4 antigen-binding proteins and methods of use thereof
|
|
WO2017139638A1
(en)
|
2016-02-11 |
2017-08-17 |
The Johns Hopkins University |
Compositions and methods for neuralgenesis
|
|
US11066456B2
(en)
|
2016-02-25 |
2021-07-20 |
Washington University |
Compositions comprising TREM2 and methods of use thereof
|
|
WO2017152102A2
(en)
|
2016-03-04 |
2017-09-08 |
Alector Llc |
Anti-trem1 antibodies and methods of use thereof
|
|
US10875919B2
(en)
|
2016-04-26 |
2020-12-29 |
Alector Llc |
Chimeric receptors and methods of use thereof
|
|
EP3452101A2
(en)
|
2016-05-04 |
2019-03-13 |
CureVac AG |
Rna encoding a therapeutic protein
|
|
EP3463575B1
(en)
|
2016-06-01 |
2025-03-26 |
The University of Virginia Patent Foundation |
Methods and compositions for modulating lymphatic vessels in the central nervous system
|
|
EP3487886A2
(en)
|
2016-07-22 |
2019-05-29 |
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) |
Trem2 cleavage modulators and uses thereof
|
|
CN106244682B
(zh)
|
2016-07-29 |
2019-11-26 |
中山大学 |
Trem-2基因在鉴别猪对蓝耳病毒易感性中的应用
|
|
CN106636330B
(zh)
|
2016-09-21 |
2017-12-15 |
郁金泰 |
阿尔茨海默病的诊断和治疗药物
|
|
AU2017342555A1
(en)
|
2016-10-14 |
2019-05-30 |
Children's Medical Center Corporation |
Compositions and methods for treating diseases and disorders of the central nervous system
|
|
CN118027200A
(zh)
|
2016-12-09 |
2024-05-14 |
艾利妥 |
抗SIRPα抗体及其使用方法
|
|
WO2018119018A1
(en)
|
2016-12-23 |
2018-06-28 |
Genervon Biopharmaceuticals, LLC |
Methods of using gm6 in diagnosing and treating alzheimer's disease
|
|
US20190343882A1
(en)
|
2017-01-12 |
2019-11-14 |
Duke University |
Compositions and Methods for the Treatment of Demyelinating Conditions
|
|
US20190367623A1
(en)
|
2017-01-17 |
2019-12-05 |
Yeda Research And Development Co. Ltd. |
Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells
|
|
WO2018136598A1
(en)
|
2017-01-18 |
2018-07-26 |
Evelo Biosciences, Inc. |
Methods of treating cancer
|
|
WO2018140831A2
(en)
|
2017-01-27 |
2018-08-02 |
Silverback Therapeutics, Inc. |
Tumor targeting conjugates and methods of use thereof
|
|
US10143187B2
(en)
|
2017-02-17 |
2018-12-04 |
Denali Therapeutics Inc. |
Transferrin receptor transgenic models
|
|
US20210293794A1
(en)
|
2017-02-24 |
2021-09-23 |
University Of Hawii Cancer Center |
Metabolic biomarkers for the identification and characterization of alzheimers disease
|
|
EP4272551A3
(en)
|
2017-02-28 |
2024-03-06 |
The Regents of the University of California |
Differentiation and use of human microglia-like cells from pluripotent stem cells and hematopoietic progenitors
|
|
CN110891417B
(zh)
|
2017-03-21 |
2023-05-23 |
杰克逊实验室 |
表达人APOE4和小鼠Trem2 p.R47H的遗传修饰小鼠及其使用方法
|
|
KR101936249B1
(ko)
|
2017-04-04 |
2019-01-08 |
경희대학교 산학협력단 |
쿠마타케닌을 포함하는 암의 예방, 개선 또는 치료용 조성물
|
|
JOP20190248A1
(ar)
|
2017-04-21 |
2019-10-20 |
Amgen Inc |
بروتينات ربط مولد ضد trem2 واستخداماته
|
|
US20180318379A1
(en)
|
2017-05-01 |
2018-11-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of triggering receptor expressed on myeloid cells 1 (trem1) to treat central nervous system disorders
|
|
WO2018213316A1
(en)
|
2017-05-16 |
2018-11-22 |
Alector Llc |
Anti-siglec-5 antibodies and methods of use thereof
|
|
IL270864B2
(en)
|
2017-05-24 |
2025-01-01 |
Nanosomix Inc |
Identification of biomarkers on vesicles for diagnosis and prognosis of diseases and disorders
|
|
US11149094B2
(en)
|
2017-06-05 |
2021-10-19 |
Janssen Biotech, Inc. |
Engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations
|
|
EP3645050A4
(en)
|
2017-06-25 |
2021-08-11 |
Systimmune, Inc. |
Multi-specific antibodies and methods of making and using thereof
|
|
CN109206503A
(zh)
|
2017-07-07 |
2019-01-15 |
厦门大学 |
一种蛋白用于制备防治阿尔茨海默病药物的用途
|
|
US20190008812A1
(en)
|
2017-07-07 |
2019-01-10 |
Washington University |
Methods for treating microglial dysfunction
|
|
WO2019016784A1
(en)
|
2017-07-21 |
2019-01-24 |
Universidade De Coimbra |
ANTI-NUCLEOLIN ANTIBODIES
|
|
KR20200032722A
(ko)
|
2017-07-27 |
2020-03-26 |
노파르티스 아게 |
부분절단효소 내성 trem2 변이체
|
|
BR112019022752A2
(pt)
|
2017-08-03 |
2020-05-19 |
Alector Llc |
anticorpos anti-trem2 e métodos de uso dos mesmos
|
|
KR102733407B1
(ko)
|
2017-08-03 |
2024-11-21 |
알렉터 엘엘씨 |
항-cd33 항체 및 이의 이용 방법
|
|
WO2019032624A1
(en)
|
2017-08-08 |
2019-02-14 |
Pionyr Immunotherapeutics, Inc. |
COMPOSITIONS AND METHODS FOR DEACTIVATING TREM1-EXPRESSING MESHLOID CELLS
|
|
WO2019055841A1
(en)
|
2017-09-14 |
2019-03-21 |
Denali Therapeutics Inc. |
ANTI-TREM2 ANTIBODIES AND METHODS OF USE
|
|
US12276670B2
(en)
|
2017-09-29 |
2025-04-15 |
The General Hospital Corporation |
Methods for identifying and treating adrenomyeloneuropathy (AMN)
|
|
US11364303B2
(en)
|
2017-09-29 |
2022-06-21 |
Pfizer Inc. |
Cysteine engineered antibody drug conjugates
|
|
KR102709597B1
(ko)
|
2017-10-03 |
2024-09-26 |
프리베일 테라퓨틱스, 인크. |
리소좀 장애를 위한 유전자 요법
|
|
WO2019079529A1
(en)
|
2017-10-17 |
2019-04-25 |
The Translational Genomics Research Institute |
TREM2 AGONISTS FOR STIMULATING MICROGLIA AND IDENTIFICATION METHODS
|
|
US10597462B1
(en)
|
2017-11-08 |
2020-03-24 |
University Of Puerto Rico |
Anti-TLT-1 antibody and uses thereof
|
|
WO2019095064A1
(en)
|
2017-11-15 |
2019-05-23 |
UNIVERSITé LAVAL |
Use of srsf3 agents for the treatment and/or prevention of neurological conditions, cancer, bacterial infections or viral infections
|
|
CN109837330A
(zh)
|
2017-11-28 |
2019-06-04 |
上海中优精准医疗科技股份有限公司 |
一种检测trem2基因多态性的探针及方法
|
|
US11470827B2
(en)
|
2017-12-12 |
2022-10-18 |
Alector Llc |
Transgenic mice expressing human TREM proteins and methods of use thereof
|
|
WO2019118513A1
(en)
|
2017-12-12 |
2019-06-20 |
Pionyr Immunotherapeutics, Inc. |
Anti-trem2 antibodies and related methods
|
|
CN111971301B
(zh)
|
2018-01-31 |
2025-01-07 |
艾莱克特有限责任公司 |
抗ms4a4a抗体及其使用方法
|
|
CA3091047A1
(en)
|
2018-02-14 |
2019-08-22 |
Yale University |
Compositions for modulation of a trem or treml protein and methods of use
|
|
NL2020520B1
(en)
|
2018-03-02 |
2019-09-12 |
Labo Bio Medical Invest B V |
Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
|
|
US12201619B2
(en)
|
2018-03-22 |
2025-01-21 |
Nsc Therapeutics Gmbh |
Compounds and methods for use in the treatment of microglia-mediated disorders
|
|
EP3774902A1
(en)
|
2018-04-02 |
2021-02-17 |
Bristol-Myers Squibb Company |
Anti-trem-1 antibodies and uses thereof
|
|
CA3096545A1
(en)
|
2018-04-09 |
2019-10-17 |
The General Hospital Corporation |
Combination therapies for the treatment of amyotropic lateral sclerosis and related disorders
|
|
EP3802602A1
(en)
|
2018-05-25 |
2021-04-14 |
Alector LLC |
Anti-sirpa antibodies and methods of use thereof
|
|
MX2020013172A
(es)
|
2018-06-08 |
2021-03-29 |
Alector Llc |
Anticuerpos anti-siglec-7 y sus metodos de uso.
|
|
CN108752482B
(zh)
|
2018-06-12 |
2019-04-30 |
南京卡提医学科技有限公司 |
携带截短或未截短的髓样细胞触发性受体信号结构的嵌合抗原受体及其应用
|
|
WO2019246483A1
(en)
|
2018-06-21 |
2019-12-26 |
The Jackson Laboratory |
Genetically modified mouse models of alzheimer's disease
|
|
CN112384532B
(zh)
|
2018-06-29 |
2025-01-10 |
艾利妥 |
抗SIRP-β1抗体及其使用方法
|
|
US11278575B2
(en)
|
2018-07-12 |
2022-03-22 |
Duke University |
Compositions and methods for the treatment of demyelinating conditions
|
|
US12174192B2
(en)
|
2018-07-12 |
2024-12-24 |
Corvus Pharmaceuticals, Inc. |
Methods for detecting and treating cancers having adenosine pathway activation
|
|
WO2020018461A1
(en)
|
2018-07-16 |
2020-01-23 |
The University Of Virginia Patent Foundation |
Compositions and methods of diagnosis and treatment for neurological diseases
|
|
CN109112214A
(zh)
|
2018-07-27 |
2019-01-01 |
复旦大学附属中山医院 |
模式识别受体trem2在肝癌预后和治疗中的应用
|
|
JP7535495B2
(ja)
|
2018-07-27 |
2024-08-16 |
アレクトル エルエルシー |
抗Siglec-5抗体及びその使用方法
|
|
MX2021002299A
(es)
|
2018-08-31 |
2021-04-28 |
Alector Llc |
Anticuerpos de anti-cd33 y metodos para usarlos.
|
|
CA3111217A1
(en)
|
2018-09-05 |
2020-03-12 |
The General Hospital Corporation |
Methods of treating cytokine release syndrome
|
|
EP3849598A4
(en)
|
2018-09-11 |
2022-07-06 |
Washington University |
Anti-trem-2 agonist antibodies
|
|
US20210315816A1
(en)
|
2018-09-12 |
2021-10-14 |
Board Of Regents Of The University Of Nebraska |
Antimicrobial compositions and methods
|
|
KR102831552B1
(ko)
|
2018-09-28 |
2025-07-08 |
이노트렘 |
항염 요법에 반응할 수 있는 대상체를 식별하기 위한 가용성 trem-1 수준의 용도
|
|
UY38407A
(es)
|
2018-10-15 |
2020-05-29 |
Novartis Ag |
Anticuerpos estabilizadores de trem2
|
|
KR102096282B1
(ko)
|
2018-10-15 |
2020-04-02 |
재단법인대구경북과학기술원 |
재조합 베큘로바이러스를 이용한 인간 trem2 세포막 단백질의 효율적인 정제방법
|
|
KR102156165B1
(ko)
|
2018-10-29 |
2020-09-15 |
재단법인대구경북과학기술원 |
인간 trem2 세포막 단백질에 대한 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도
|
|
CN111135185A
(zh)
|
2018-11-02 |
2020-05-12 |
杭州星鳌生物科技有限公司 |
天然免疫激活通过调控髓系细胞触发受体trem2抑制大脑神经慢性炎症
|
|
US12466892B2
(en)
|
2018-11-08 |
2025-11-11 |
The Regents Of The University Of California |
Systems and methods for targeting cancer cells
|
|
CN113302206A
(zh)
|
2018-11-26 |
2021-08-24 |
戴纳立制药公司 |
治疗脂质代谢失调的方法
|
|
US12351629B2
(en)
|
2018-12-10 |
2025-07-08 |
Mor Research Applications Ltd. |
TREM2 antibodies and uses thereof
|
|
AR117453A1
(es)
|
2018-12-20 |
2021-08-04 |
Genentech Inc |
Fc de anticuerpos modificados y métodos para utilizarlas
|
|
CN113543808A
(zh)
|
2019-01-04 |
2021-10-22 |
特瑞奥制药公司 |
多特异性蛋白质分子及其用途
|
|
CN109646668B
(zh)
|
2019-01-04 |
2019-10-18 |
厦门大学 |
一种多肽用于制备防治阿尔茨海默病药物的用途
|
|
WO2020150214A1
(en)
|
2019-01-14 |
2020-07-23 |
University Of Virginia Patent Foundation |
Use of integrin inhibitors for treatment or prevention of a neurological immunity disorder and/or nervous system injury
|
|
US20220104468A1
(en)
|
2019-01-22 |
2022-04-07 |
St. Jude Children's Research Hospital |
Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
|
|
WO2020154348A1
(en)
|
2019-01-23 |
2020-07-30 |
The Regents Of The University Of California |
Human genomic construct reporter cells and mouse models to screen therapeutics against microglia-expressed disease associated genes
|
|
EP3917967A4
(en)
|
2019-02-01 |
2023-02-08 |
Seattle Children's Hospital (DBA Seattle Children's Research Institute) |
Microenvironment sensors to regulate engineered gene expression
|
|
MA54873A
(fr)
|
2019-02-01 |
2021-12-08 |
Avrobio Inc |
Compositions et méthodes pour le traitement de troubles neurocognitifs
|
|
MA54880A
(fr)
|
2019-02-01 |
2021-12-08 |
Avrobio Inc |
Compositions et procédés de traitement de troubles neurocognitifs
|
|
PH12021552002A1
(en)
|
2019-02-20 |
2022-09-19 |
Denali Therapeutics Inc |
Anti-trem2 antibodies and methods of use thereof
|
|
WO2020194317A1
(en)
|
2019-03-28 |
2020-10-01 |
Yeda Research And Development Co. Ltd. |
Method of treating lipid-related disorders
|
|
CN110320368A
(zh)
|
2019-05-30 |
2019-10-11 |
广州医科大学附属第一医院(广州呼吸中心) |
基于trem2的诊断试剂盒及其在帕金森病诊断产品上的应用
|
|
CN110241208A
(zh)
|
2019-08-02 |
2019-09-17 |
辽宁中医药大学 |
Trem2作为早期诊断冠心病的分子标志物的应用
|
|
CN110511240B
(zh)
|
2019-08-27 |
2022-03-08 |
南京医科大学 |
一种髓细胞触发受体2的内源性配体及其应用
|
|
CN110882262A
(zh)
|
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