MX2019010941A - Receptores de antigeno y usos de los mismos. - Google Patents
Receptores de antigeno y usos de los mismos.Info
- Publication number
- MX2019010941A MX2019010941A MX2019010941A MX2019010941A MX2019010941A MX 2019010941 A MX2019010941 A MX 2019010941A MX 2019010941 A MX2019010941 A MX 2019010941A MX 2019010941 A MX2019010941 A MX 2019010941A MX 2019010941 A MX2019010941 A MX 2019010941A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen receptors
- treatment
- antigen
- diseases
- receptors
- Prior art date
Links
- 102000006306 Antigen Receptors Human genes 0.000 title abstract 4
- 108010083359 Antigen Receptors Proteins 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
- A61K2239/30—Mixture of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención generalmente abarca el tratamiento de enfermedades al dirigir células que expresan un antígeno en la superficie celular. En particular, la invención se refiere a receptores de antígeno recombinante y usos de los mismos. Las células T diseñadas para expresar tales receptores de antígeno son útiles en el tratamiento de enfermedades caracterizadas por la expresión de uno o más antígenos unidos por los receptores de antígeno.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2017/056086 WO2018166589A1 (en) | 2017-03-15 | 2017-03-15 | Antigen receptors and uses thereof |
PCT/EP2018/056399 WO2018167151A1 (en) | 2017-03-15 | 2018-03-14 | Antigen receptors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019010941A true MX2019010941A (es) | 2019-12-19 |
Family
ID=58360981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010941A MX2019010941A (es) | 2017-03-15 | 2018-03-14 | Receptores de antigeno y usos de los mismos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US11702631B2 (es) |
EP (1) | EP3596113B1 (es) |
JP (1) | JP7073417B2 (es) |
KR (1) | KR102396925B1 (es) |
CN (1) | CN110621693B (es) |
AU (1) | AU2018234068B2 (es) |
BR (1) | BR112019018705A2 (es) |
CA (1) | CA3054253A1 (es) |
ES (1) | ES2886189T3 (es) |
IL (1) | IL269213B2 (es) |
MX (1) | MX2019010941A (es) |
NZ (1) | NZ756383A (es) |
SG (1) | SG11201907715YA (es) |
WO (2) | WO2018166589A1 (es) |
ZA (1) | ZA201905441B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023078431A1 (zh) * | 2021-11-05 | 2023-05-11 | 清华大学 | 一种特异性结合间皮素的合成t细胞受体抗原受体及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409577A (en) | 1966-07-06 | 1968-11-05 | Owens Corning Fiberglass Corp | Method of detackifying tacky resins |
US6534633B1 (en) * | 1998-10-21 | 2003-03-18 | Altor Bioscience Corporation | Polyspecific binding molecules and uses thereof |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
CA2690825C (en) * | 2007-05-11 | 2019-02-12 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
EP2502934B1 (en) * | 2011-03-24 | 2018-01-17 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds |
WO2016180467A1 (en) | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination |
EP3770168A1 (en) | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
WO2017059900A1 (en) * | 2015-10-07 | 2017-04-13 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
-
2017
- 2017-03-15 WO PCT/EP2017/056086 patent/WO2018166589A1/en active Application Filing
-
2018
- 2018-03-14 US US16/493,618 patent/US11702631B2/en active Active
- 2018-03-14 CA CA3054253A patent/CA3054253A1/en active Pending
- 2018-03-14 BR BR112019018705A patent/BR112019018705A2/pt unknown
- 2018-03-14 KR KR1020197030007A patent/KR102396925B1/ko active IP Right Grant
- 2018-03-14 MX MX2019010941A patent/MX2019010941A/es unknown
- 2018-03-14 NZ NZ756383A patent/NZ756383A/en unknown
- 2018-03-14 JP JP2019571780A patent/JP7073417B2/ja active Active
- 2018-03-14 IL IL269213A patent/IL269213B2/en unknown
- 2018-03-14 WO PCT/EP2018/056399 patent/WO2018167151A1/en active Application Filing
- 2018-03-14 CN CN201880031971.9A patent/CN110621693B/zh active Active
- 2018-03-14 ES ES18710059T patent/ES2886189T3/es active Active
- 2018-03-14 SG SG11201907715YA patent/SG11201907715YA/en unknown
- 2018-03-14 EP EP18710059.9A patent/EP3596113B1/en active Active
- 2018-03-14 AU AU2018234068A patent/AU2018234068B2/en active Active
-
2019
- 2019-08-16 ZA ZA2019/05441A patent/ZA201905441B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2018166589A1 (en) | 2018-09-20 |
IL269213A (en) | 2019-11-28 |
WO2018167151A1 (en) | 2018-09-20 |
AU2018234068A1 (en) | 2019-09-05 |
IL269213B2 (en) | 2023-11-01 |
ZA201905441B (en) | 2020-11-25 |
SG11201907715YA (en) | 2019-09-27 |
CN110621693B (zh) | 2024-01-12 |
RU2019125594A3 (es) | 2021-06-09 |
KR102396925B1 (ko) | 2022-05-13 |
JP2020509783A (ja) | 2020-04-02 |
EP3596113B1 (en) | 2021-08-04 |
US20200063101A1 (en) | 2020-02-27 |
AU2018234068B2 (en) | 2021-10-21 |
RU2019125594A (ru) | 2021-04-15 |
JP7073417B2 (ja) | 2022-05-23 |
KR20190128683A (ko) | 2019-11-18 |
ES2886189T3 (es) | 2021-12-16 |
CN110621693A (zh) | 2019-12-27 |
IL269213B1 (en) | 2023-07-01 |
BR112019018705A2 (pt) | 2020-04-07 |
EP3596113A1 (en) | 2020-01-22 |
NZ756383A (en) | 2023-03-31 |
US11702631B2 (en) | 2023-07-18 |
CA3054253A1 (en) | 2018-09-20 |
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