UY33969A - Inhibidores tricíclicos fusionados dobles de las cdk 4/6 y de la flt3 - Google Patents
Inhibidores tricíclicos fusionados dobles de las cdk 4/6 y de la flt3Info
- Publication number
- UY33969A UY33969A UY0001033969A UY33969A UY33969A UY 33969 A UY33969 A UY 33969A UY 0001033969 A UY0001033969 A UY 0001033969A UY 33969 A UY33969 A UY 33969A UY 33969 A UY33969 A UY 33969A
- Authority
- UY
- Uruguay
- Prior art keywords
- fusioned
- flt3
- cdk
- double
- tricyclic inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos de fórmula I, que son inhibidores útiles de la CDK4, de la CDK6 y de la FLT3. Estos compuestos sirven para tratar el cáncer y otros estados de enfermedad diversos. Los compuestos de fórmula I tienen la estructura que se representa a continuación: donde R1 es un grupo de fórmula IA, de fórmula IB, de fórmula IC o de fórmula ID y las definiciones de las variables restantes son como se indica en la presente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161466841P | 2011-03-23 | 2011-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY33969A true UY33969A (es) | 2012-10-31 |
Family
ID=45926933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001033969A UY33969A (es) | 2011-03-23 | 2012-03-23 | Inhibidores tricíclicos fusionados dobles de las cdk 4/6 y de la flt3 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8623885B2 (es) |
| EP (2) | EP2688887B1 (es) |
| JP (1) | JP5647374B2 (es) |
| KR (2) | KR20160035613A (es) |
| CN (1) | CN103703000B (es) |
| AR (1) | AR085544A1 (es) |
| AU (1) | AU2012230896B9 (es) |
| CA (1) | CA2830516C (es) |
| DK (2) | DK2937349T3 (es) |
| ES (2) | ES2620521T3 (es) |
| HK (2) | HK1191014A1 (es) |
| JO (1) | JO3073B1 (es) |
| MX (1) | MX2013010871A (es) |
| MY (1) | MY161199A (es) |
| PT (2) | PT2688887E (es) |
| SG (1) | SG193580A1 (es) |
| TW (1) | TWI438204B (es) |
| UY (1) | UY33969A (es) |
| WO (1) | WO2012129344A1 (es) |
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