UY33210A - DERIVADOS DE PIRAZOLO-[5, 1b]-OXAZOL COMO ANTAGONISTAS DE LOS RECEPTORES DE CRF-1 - Google Patents

DERIVADOS DE PIRAZOLO-[5, 1b]-OXAZOL COMO ANTAGONISTAS DE LOS RECEPTORES DE CRF-1

Info

Publication number
UY33210A
UY33210A UY0001033210A UY33210A UY33210A UY 33210 A UY33210 A UY 33210A UY 0001033210 A UY0001033210 A UY 0001033210A UY 33210 A UY33210 A UY 33210A UY 33210 A UY33210 A UY 33210A
Authority
UY
Uruguay
Prior art keywords
antagonists
derivatives
pirazolo
crf
oxazol
Prior art date
Application number
UY0001033210A
Other languages
English (en)
Inventor
Nicholas James Devereux
Mckenna Jeffrey
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY33210A publication Critical patent/UY33210A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
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  • Gynecology & Obstetrics (AREA)
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  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
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Abstract

Se describen derivados de 4-difluoro-metoxi-fenil-pirazolo-[5.1- b]-oxazol útiles como antagonistas de los receptores del factor de liberación de co rticotropina (CRF1).
UY0001033210A 2010-02-01 2011-01-31 DERIVADOS DE PIRAZOLO-[5, 1b]-OXAZOL COMO ANTAGONISTAS DE LOS RECEPTORES DE CRF-1 UY33210A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30023110P 2010-02-01 2010-02-01

Publications (1)

Publication Number Publication Date
UY33210A true UY33210A (es) 2011-08-31

Family

ID=43641912

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033210A UY33210A (es) 2010-02-01 2011-01-31 DERIVADOS DE PIRAZOLO-[5, 1b]-OXAZOL COMO ANTAGONISTAS DE LOS RECEPTORES DE CRF-1

Country Status (8)

Country Link
US (2) US20120295942A1 (es)
EP (1) EP2531510B1 (es)
JP (1) JP2013518085A (es)
CN (1) CN102762572A (es)
AR (1) AR080055A1 (es)
TW (1) TW201130853A (es)
UY (1) UY33210A (es)
WO (1) WO2011092290A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210064407A (ko) 2014-01-21 2021-06-02 뉴로크린 바이오사이언시즈 인코퍼레이티드 선천성 부신 과형성 치료를 위한 ｃｒｆ1 수용체 길항제
EP3661500A1 (en) 2017-07-31 2020-06-10 Novartis AG Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use

Family Cites Families (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4023A (en) * 1845-05-01 Hijbst
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
GB9802251D0 (en) 1998-02-03 1998-04-01 Ciba Geigy Ag Organic compounds
CN1187048C (zh) 1998-10-02 2005-02-02 诺瓦提斯公司 mGLuR拮抗剂用于治疗疼痛和焦虑
US6525203B1 (en) 1999-03-12 2003-02-25 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
ATE267830T1 (de) * 1999-08-27 2004-06-15 Abbott Lab Als cox-hemmer verwendbare sulfonylphenylpyrazol- verbindungen
GB0028702D0 (en) 2000-11-24 2001-01-10 Novartis Ag Organic compounds
WO2002058704A1 (en) 2001-01-26 2002-08-01 Bristol-Myers Squibb Company Imidazolyl derivatives as corticotropin releasing factor inhibitors
HUP0303623A2 (hu) 2001-03-26 2004-03-01 Novartis Ag. Kondenzált piridinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyászati készítmények vanilloid receptor antagonistaként fájdalom kezelésére
DK1379224T4 (da) 2001-03-29 2013-12-02 Synergy Pharmaceuticals Inc Guanylat-cyklase-receptoragonister til behandling af vævsbetændelse og karcinogenese
JP3894035B2 (ja) 2001-07-04 2007-03-14 東レ株式会社 炭素繊維強化基材、それからなるプリフォームおよび複合材料
TW200306839A (en) 2002-02-06 2003-12-01 Novartis Ag Quinazolinone derivatives and their use as CB agonists
US6696468B2 (en) 2002-05-16 2004-02-24 Dainippon Pharmaceutical Co., Ltd. (s)-4-amino-5-chloro-2-methoxy-n-[1-[1-(2-tetrahydrofuryl-carbonyl)-4-piperidinylmethyl]-4-piperidinyl]benzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
SE0201940D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
DOP2003000703A (es) 2002-09-20 2004-03-31 Pfizer Compuestos de imidazopiradina como agonistas del receptor 5-ht4
GB0223730D0 (en) 2002-10-11 2002-11-20 Novartis Ag Organic compounds
PE20040844A1 (es) 2002-11-26 2004-12-30 Novartis Ag Acidos fenilaceticos y derivados como inhibidores de la cox-2
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0302876D0 (en) 2003-02-07 2003-03-12 Novartis Ag Organic compounds
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
JP2004277319A (ja) 2003-03-14 2004-10-07 Dainippon Pharmaceut Co Ltd １−（４−ピペリジニルメチル）ピペリジニルアミド誘導体およびそれを含有する医薬組成物
JP2004277318A (ja) 2003-03-14 2004-10-07 Dainippon Pharmaceut Co Ltd １−（１−置換カルボニル−４−ピペリジニルメチル）ピペリジン誘導体およびそれを含有する医薬組成物
JP2007501866A (ja) 2003-06-13 2007-02-01 マイクロバイア インコーポレイテッド 胃腸疾患の治療のための方法および組成物
US7491695B2 (en) 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
EP1505064A1 (en) 2003-08-05 2005-02-09 Bayer HealthCare AG 2-Aminopyrimidine derivatives
EP1656354B1 (en) 2003-08-12 2007-09-26 F.Hoffmann-La Roche Ag Tetrahydroquinazoline derivatives as cfr antagonists
EP1656145A1 (en) 2003-08-12 2006-05-17 F. Hoffmann-La Roche Ag Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists
EP1664010A1 (en) 2003-08-29 2006-06-07 Vernalis (R&D) Limited Sulfonamides antagonising n-type calcium channels
AP2184A (en) 2003-09-03 2010-12-02 Pfizer Benzimidazolone compounds having 5-HT4 receptor agonistic activity.
AU2004274403A1 (en) 2003-09-03 2005-03-31 Aventis Pharmaceuticals Inc. 5-aryl-Pyrazolo(4,3-d)pyrimidines, pyridines, and pyrazines and related compounds
JP2005082508A (ja) 2003-09-05 2005-03-31 Dainippon Pharmaceut Co Ltd ２−アルコキシ−６−アミノ−５−ハロゲノ−ｎ−（１−置換−４−ピペリジニル）ピリジン−３−カルボキサミド誘導体およびそれを含有する医薬組成物
EP1680424A2 (en) 2003-09-05 2006-07-19 Neurogen Corporation Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands
KR20060072142A (ko) 2003-09-09 2006-06-27 오노 야꾸힝 고교 가부시키가이샤 Ｃｒｆ 길항제 및 이환식 복소환 화합물
GB0322612D0 (en) 2003-09-26 2003-10-29 Novartis Ag Organic compounds
JP2007507514A (ja) 2003-09-30 2007-03-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キノキサリン化合物
JP2005104896A (ja) 2003-09-30 2005-04-21 Dainippon Pharmaceut Co Ltd ２−アルコキシ−６−アミノ−５−ハロゲノピリジン−３−カルボキサミド誘導体およびそれを含有する医薬組成物
EP1673348B1 (en) 2003-09-30 2009-04-01 Janssen Pharmaceutica N.V. Benzoimidazole compounds
JP2007510645A (ja) 2003-10-31 2007-04-26 アストラゼネカ アクチボラグ アルキン類ｉ
JP4842829B2 (ja) 2003-10-31 2011-12-21 武田薬品工業株式会社 含窒素縮合複素環化合物
NZ547044A (en) 2003-11-10 2010-05-28 Merck Sharp & Dohme Substituted triazoles as sodium channel blockers
US7208596B2 (en) 2003-11-25 2007-04-24 Bristol-Myers Squibb Pharma Company Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
WO2005054239A1 (en) 2003-12-05 2005-06-16 Bayer Healthcare Ag 2-aminopyrimidine derivatives
US7211568B2 (en) 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
RU2006118021A (ru) 2003-12-19 2007-12-10 АстраЗнека АБ (SE) Замещенные пиридин-2-ил-тетразолы (варианты), фармацевтическая композиция, лекарственное средство, способ лечения расстройств с их использованием, способ ингибирования активации метаботропных глютаматных рецепторов -5 и способ получения пиридилпроизводных
JP2005206590A (ja) 2003-12-25 2005-08-04 Mitsubishi Pharma Corp ナトリウムチャネルサイト２選択的阻害剤
WO2005068461A1 (en) 2004-01-07 2005-07-28 Aryx Therapeutics Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
TW200530181A (en) 2004-01-13 2005-09-16 Bristol Myers Squibb Co Heterocyclic compounds useful as growth hormone secretagogues
EP1713797B1 (en) 2004-01-29 2008-03-05 Pfizer, Inc. 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-ht4 receptor agonistic activity
WO2005077345A1 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
WO2005077373A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US20070197549A1 (en) 2004-02-18 2007-08-23 Astrazeneca Ab Tetrazole compounds and their use as metabotropic glutamate receptor antagonists
DK1716152T3 (da) 2004-02-18 2008-11-03 Astrazeneca Ab Kondenserade heterocykliske forbindelser og deres anvendelse som metabotrope receptorantagonister til behandling af gastrointentinde lidelser
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
AU2005214376A1 (en) 2004-02-18 2005-09-01 Astrazeneca Ab Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists
JP2007523181A (ja) 2004-02-18 2007-08-16 アストラゼネカ アクチボラグ ポリヘテロ環式化合物、および、代謝型グルタミン酸受容体アンタゴニストとしてのそれらの使用
BRPI0507501A (pt) 2004-02-18 2007-06-26 Astrazeneca Ab composto, composição farmacêutica, uso do composto, método para o tratamento de distúrbios mediados por mglur5, e, método para inibir a ativação de receptores de mglur5
TW200538108A (en) 2004-02-19 2005-12-01 Astrazeneca Ab Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
TW200538180A (en) 2004-02-20 2005-12-01 Astrazeneca Ab New compounds
WO2005092882A1 (en) 2004-03-01 2005-10-06 Pfizer Japan, Inc. 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
US7087749B2 (en) 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
US7253200B2 (en) 2004-03-25 2007-08-07 Janssen Pharmaceutica, N.V. Imidazole compounds
AU2005231332A1 (en) 2004-03-29 2005-10-20 Merck & Co., Inc. Biaryl substituted pyrazinones as sodium channel blockers
EP1789409A4 (en) 2004-04-02 2010-09-08 Elixir Pharmaceuticals Inc SULPHONAMIDES AND ITS USES
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
EP1734820A4 (en) 2004-04-16 2008-01-23 Neurogen Corp Imidazopyrrazine, imidazopyridine, and imidazo-pyrimidine as CRF1 receptor ligands
GB0412768D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
PE20060526A1 (es) 2004-06-15 2006-07-13 Schering Corp Compuestos triciclicos como antagonistas de mglur1
WO2005123718A2 (en) 2004-06-15 2005-12-29 Pfizer Japan Inc. Benzimidazolone carboxylic acid derivatives
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
US20060035939A1 (en) 2004-07-14 2006-02-16 Japan Tobacco Inc. 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
RU2392278C2 (ru) 2004-07-15 2010-06-20 Джапан Тобакко Инк. Конденсированное производное бензамида и ингибитор активности подтипа 1 рецептора ваниллоида (vr1)
US20080039430A1 (en) 2004-07-19 2008-02-14 Ali Ouaissi Pharmaceutical Compositions For The Treatment Of Leishmaniasis
PE20060574A1 (es) 2004-07-28 2006-06-24 Glaxo Group Ltd Derivados de arilpiperazina sulfonamida como agonistas de los receptores de secretagogos de la hormona del crecimiento (ghs)
ITMI20041566A1 (it) 2004-07-30 2004-10-30 Indena Spa "trpv1 agonisti, formulazioni che li contengono e loro usi"
WO2006016218A1 (en) 2004-08-03 2006-02-16 Pfizer Japan Inc. Aryl or heteroaryl carbonyl derivatives derivatives useful as vanilloid receptor 1 (vr1) antagonists
WO2006023757A2 (en) 2004-08-19 2006-03-02 University Of Virginia Patent Foundation Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents
AU2005284904A1 (en) 2004-09-13 2006-03-23 Amgen Inc. Vanilloid receptor ligands and their use in treatments
GB0420424D0 (en) 2004-09-14 2004-10-20 Ionix Pharmaceuticals Ltd Therapeutic compounds
US20060063792A1 (en) 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
SE0402284D0 (sv) 2004-09-21 2004-09-21 Astrazeneca Ab New heterocyclic amides
MX2007003398A (es) 2004-09-27 2007-05-21 Elixir Pharmaceuticals Inc Sulfonamidas y sus usos.
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
JP5635727B2 (ja) 2004-10-07 2014-12-03 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法
EP1799661A1 (en) 2004-10-08 2007-06-27 AstraZeneca AB New hydroxymethylbenzothiazoles amides
US8143425B2 (en) 2004-10-12 2012-03-27 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
EP1802605A1 (en) 2004-10-15 2007-07-04 Amgen, Inc Imidazole derivatives as vanilloid receptor ligands
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
DE602005014375D1 (de) 2004-10-19 2009-06-18 Neurocrine Biosciences Inc Crf-rezeptor-antagonisten und zugehörige verfahren
US7314933B2 (en) 2004-10-22 2008-01-01 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
ATE431824T1 (de) 2004-11-05 2009-06-15 Theravance Inc Chinolinon-carboxamid-verbindungen
DE602005016446D1 (de) 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
CA2586316A1 (en) 2004-11-11 2006-05-18 Argenta Discovery Ltd. Pyrimidine compounds as histamine modulators
KR101250824B1 (ko) 2004-11-24 2013-04-05 아보트 러보러터리즈 바닐로이드 수용체 아형 1(ｖｒ1) 수용체를 억제하는크로마닐우레아 화합물 및 이의 용도
US20060111416A1 (en) 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
WO2006058338A2 (en) 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
US7875627B2 (en) 2004-12-07 2011-01-25 Abbott Laboratories Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof
US20060128710A1 (en) 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
US7615570B2 (en) 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
SE0403118D0 (sv) 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 2
SE0403117D0 (sv) 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 1
CN101080406A (zh) 2004-12-22 2007-11-28 施万制药 吲唑－甲酰胺化合物
SE0403171D0 (sv) 2004-12-23 2004-12-23 Astrazeneca Ab New compounds
EP1836203A2 (en) 2005-01-14 2007-09-26 Neurogen Corporation Heteroaryl substituted quinolin-4-ylamine analogues
CN101137653B (zh) 2005-01-14 2012-05-09 弗·哈夫曼-拉罗切有限公司 作为mglur5拮抗剂的噻唑-4-甲酰胺衍生物
US7429608B2 (en) 2005-01-20 2008-09-30 Amgen Inc. Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments
WO2006089311A1 (en) 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP2008530225A (ja) 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
GB0503646D0 (en) 2005-02-22 2005-03-30 Novartis Ag Organic compounds
KR101355064B1 (ko) 2005-03-03 2014-01-24 얀센 파마슈티카 엔.브이. 치환된 옥사-디아자-스피로-[5.5]-운데카논 유도체 및뉴로키닌 길항제로서의 이의 용도
ATE443056T1 (de) 2005-03-10 2009-10-15 Pfizer Substituierte n-sulfonylaminophenylethyl-2- phenoxyacetamidverbindungen
US20060211710A1 (en) 2005-03-17 2006-09-21 Pfizer Inc Substituted aryl 1,4-pyrazine derivatives
GB0506147D0 (en) 2005-03-24 2005-05-04 Merck Sharp & Dohme Therapeutic agents
AU2006226775A1 (en) 2005-03-24 2006-09-28 Janssen Pharmaceutica, N.V. Biaryl derived amide modulators of vanilloid VR1 receptor
WO2006105117A2 (en) 2005-03-28 2006-10-05 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
TWI377206B (en) 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
US20060235036A1 (en) 2005-04-15 2006-10-19 Doherty Elizabeth M Vanilloid receptor ligands and their use in treatments
GB0508318D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
WO2006116563A1 (en) 2005-04-25 2006-11-02 Amgen Inc. Vanilloid receptor ligands and their use in treatments
GB0508314D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0509573D0 (en) 2005-05-11 2005-06-15 Merck Sharp & Dohme Therapeutic compounds
JP2009536608A (ja) 2005-05-11 2009-10-15 メルク シャープ エンド ドーム リミテッド バニロイド−１受容体（ｖｒ１）の機能を調節する２，３−置換縮合二環式ピリミジン４−（３ｈ）−オン
JP4862042B2 (ja) 2005-05-11 2012-01-25 アボット・ラボラトリーズ バニロイド受容体サブタイプ１（ｖｒ１）のアンタゴニスト及びその使用
AU2006247487A1 (en) 2005-05-12 2006-11-23 Amgen Inc. Antipyretic agents against VR1-antagonist-induced increases in body temperature
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0510142D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
GB0510141D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
DE102005023588A1 (de) 2005-05-18 2006-11-23 Grünenthal GmbH Salze substituierter Allophansäureester und deren Verwendung in Arzneimitteln
GB0510140D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B2
MX2007014444A (es) 2005-05-18 2008-04-21 Addex Pharmaceuticals Sa Derivados de oxadiazol sustituido como moduladores aloestericos positivos de los receptores de glutamato metabotropicos.
DE102005038947A1 (de) 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
DE102005044813A1 (de) 2005-05-19 2007-10-04 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005044814A1 (de) 2005-05-19 2006-11-23 Grünenthal GmbH Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005023784A1 (de) 2005-05-19 2006-11-30 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005024012A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Verwendung von 2,5-disubstituierten Thiazol-4-on-Derivaten in Arzneimitteln
US7582611B2 (en) 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
MY147756A (en) 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
DE602006019595D1 (de) 2005-06-07 2011-02-24 Theravance Inc Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors
CA2611493A1 (en) 2005-06-10 2006-12-21 Elixir Pharmaceuticals, Inc. Sulfonamide compounds and uses thereof
AU2006259891A1 (en) 2005-06-23 2006-12-28 Albireo Ab New azetidine derivatives as neurokinin receptor antagonists for the treatment of gastrointestinal diseases
WO2006137791A1 (en) 2005-06-23 2006-12-28 Astrazeneca Ab New azetidine derivatives as neurokinin receptor antagonists for the treatment of gastrointestinal diseases
CA2612893A1 (en) 2005-07-05 2007-01-11 Aryx Therapeutics, Inc. Stereoisomeric pyridyl and pyridonyl compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US20090170872A1 (en) 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use
JP2009501199A (ja) 2005-07-12 2009-01-15 グラクソ グループ リミテッド Ｇｐｒ３８アゴニストとしてのピペラジンヘテロアリール誘導体
RU2416612C9 (ru) 2005-07-22 2012-03-27 Ипсен Фарма С.А.С. Стимуляторы секреции гормона роста
US7906532B2 (en) 2005-07-22 2011-03-15 Pfizer Inc. Indazole derivatives
PT1907374E (pt) 2005-07-26 2012-11-05 Glaxo Group Ltd Derivados de benzilpiperazina úteis para o tratamento de doenças gastrointestinais
EP1757290A1 (en) 2005-08-16 2007-02-28 Zentaris GmbH Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
US20090253634A1 (en) 2005-08-19 2009-10-08 Microbia, Inc. Methods and Compositions for the Treatment of Gastrointestinal Disorders
WO2007023242A1 (en) 2005-08-24 2007-03-01 Merz Pharma Gmbh & Co. Kgaa Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
EP1943247A1 (en) 2005-08-25 2008-07-16 Merz Pharma GmbH & Co.KGaA Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
JP2009507855A (ja) 2005-09-08 2009-02-26 スミスクライン・ビーチャム・コーポレイション 非環式１，４−ジアミンおよびその使用
BRPI0615880A2 (pt) 2005-09-13 2011-05-31 Palau Pharma Sa compostos derivados de 2-aminopirimidina como moduladores da atividade de receptor da histamina h4, uso dos mesmos e composição farmacêutica
AR056087A1 (es) 2005-09-29 2007-09-19 Astrazeneca Ab Derivados de azetidina como antagonistas de receptores de neuroquina nk
AR057828A1 (es) 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
AR058807A1 (es) 2005-09-29 2008-02-27 Astrazeneca Ab 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5
HUP0500921A2 (en) 2005-10-05 2007-07-30 Richter Gedeon Nyrt Tetrazole derivatives, process for their preparation and their use
HUP0500920A2 (en) 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
AP2008004432A0 (en) 2005-10-07 2008-04-30 Glenmark Pharmaceuticals Sa Substituted benzofused derivatives and their use as vanilloid receptor ligands
US20070088073A1 (en) 2005-10-19 2007-04-19 Allergan, Inc. Method for treating pain
CN103382176A (zh) 2005-10-19 2013-11-06 格吕伦塔尔有限公司 新颖的辣椒素受体配体和它们用于生产药物的用途
US7902251B2 (en) 2005-10-19 2011-03-08 Allergan, Inc. Method for treating pain
US7538110B2 (en) 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
AR056729A1 (es) 2005-10-28 2007-10-17 Glaxo Group Ltd Compuesto de benzofurano carboxamida, composicion farmaceutica que lo comprende su uso para preparar un medicamento y procesos para su preparcion
JP2009513659A (ja) 2005-10-28 2009-04-02 アボット・ラボラトリーズ Ｔｒｐｖ１受容体を阻害するインダゾール誘導体
JP2007122605A (ja) 2005-10-31 2007-05-17 Fujitsu Ltd インピーダンス回路、電源装置
US20070105920A1 (en) 2005-11-08 2007-05-10 Akzo Nobel N.V. 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives
GB0525661D0 (en) 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
NL2000323C2 (nl) 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine-derivaten.
EP1829879A1 (en) 2006-02-10 2007-09-05 Cellzome (UK) Ltd. Amino pyrimidine compounds for the treatment of inflammatory disorders
WO2007090854A1 (en) 2006-02-10 2007-08-16 Cellzome (Uk) Ltd. Azetidine amino pyrimidine compounds for the treatment of inflammatory disorders
WO2007090853A1 (en) 2006-02-10 2007-08-16 Cellzome (Uk) Ltd. Enantiomers of amino pyrimidine compounds for the treatment of inflammatory disorders
GB0603550D0 (en) 2006-02-22 2006-04-05 Glaxo Group Ltd Novel compounds
US20090192083A1 (en) 2006-02-24 2009-07-30 Currie Mark G Methods and compositions for the treatment of gastrointestinal disorders
US20090305993A1 (en) 2006-02-24 2009-12-10 Ironwood Pharmaceuticals, Inc. Methods and composition for the treatment of gastrointestinal disorders
US8597562B2 (en) 2006-03-30 2013-12-03 GM Global Technology Operations LLC Composite products and methods of making the same
AU2007235577B2 (en) 2006-03-31 2011-09-15 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyridines as modulators of the histamine H4 receptor
EA016264B1 (ru) 2006-03-31 2012-03-30 Янссен Фармацевтика Н.В. Бензоимидазол-2-илпиримидины и пиразины в качестве модуляторов рецептора гистамина н
US7713978B2 (en) 2006-03-31 2010-05-11 Nigel Paul King Compounds
WO2007117401A2 (en) 2006-04-07 2007-10-18 Janssen Pharmaceutica N.V. Indoles and benzoimidazoles as modulators of the histamine h4 receptor
WO2007118852A1 (en) 2006-04-13 2007-10-25 Glaxo Group Limited Aryl and heteroaryl sulphonamides as growth hormone secretagogue receptor agonists
US20090170845A1 (en) * 2006-04-13 2009-07-02 Aegera Therapeutics Inc. USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN
DE602007006019D1 (de) 2006-06-28 2010-06-02 Glaxo Group Ltd Für die behandlung von durch den gpr38-rezeptor vermittelten krankheiten geeignete piperazinylderivate
US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
ES2604943T3 (es) 2007-02-09 2017-03-10 Ocera Therapeutics, Inc. Moduladores macrocíclicos del receptor de la grelina y procedimientos de uso de los mismos
EP2195313B1 (en) 2007-08-27 2014-04-02 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
EP2185553B1 (en) 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ATE502939T1 (de) 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
WO2009144632A1 (en) * 2008-05-30 2009-12-03 Pfizer Limited Novel compounds
US7994203B2 (en) * 2008-08-06 2011-08-09 Novartis Ag Organic compounds
WO2011043387A1 (ja) * 2009-10-08 2011-04-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロオキサゾール化合物

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