UY24499A1 - Nuevos derivados de 2-(3h)-oxazolona - Google Patents
Nuevos derivados de 2-(3h)-oxazolonaInfo
- Publication number
- UY24499A1 UY24499A1 UY24499A UY24499A UY24499A1 UY 24499 A1 UY24499 A1 UY 24499A1 UY 24499 A UY24499 A UY 24499A UY 24499 A UY24499 A UY 24499A UY 24499 A1 UY24499 A1 UY 24499A1
- Authority
- UY
- Uruguay
- Prior art keywords
- oxazolone
- group
- alkyl
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de 2-(3H)-oxazolona de fórmula (I) (figura 1) en donde: R1 es un grupo alquilo o NR4R5, en donde R4 y R5 son cada uno independientemente H o un grupo alquilo o bencilo; R2 es un grupo naftilo, tetrahidronaftilo, o un grupo fenilo no sustituido o fenilo sustituido, siendo los substituyentes seleccionados de 1 a 3 átomos de halógeno o grupos alquilo, hidroxi, alcoxi, o trifluorometilo; y R3 es H o un grupo alquilo. Ejemplo no limitante: 3-(4-fluorofenil)-4-(4-metilsulfonilfenil)-2-(3H)-oxazolona. Además se describe una composición farmacéutica que comprende, como ingrediente activo al compuesto de fórmula l, y un excipiente o diluyente farmacéuticamente aceptable. El uso del compuesto en la fabricación de un medicamento para el tratamiento del dolor, fiebre o inflamación, para inhibir la contracción del músculo liso inducida por protanoides, o para la prevención del cáncer colorectal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009600685A ES2125161B1 (es) | 1996-03-21 | 1996-03-21 | Nuevos derivados de 2-(3h)-oxazolona. |
Publications (1)
Publication Number | Publication Date |
---|---|
UY24499A1 true UY24499A1 (es) | 1997-04-02 |
Family
ID=8294266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24499A UY24499A1 (es) | 1996-03-21 | 1997-03-21 | Nuevos derivados de 2-(3h)-oxazolona |
Country Status (30)
Country | Link |
---|---|
US (1) | US6869968B1 (es) |
EP (1) | EP0888316B1 (es) |
JP (1) | JP3810091B2 (es) |
KR (1) | KR100496395B1 (es) |
CN (1) | CN1110488C (es) |
AR (1) | AR006340A1 (es) |
AT (1) | ATE197294T1 (es) |
AU (1) | AU713811B2 (es) |
BR (1) | BR9708141A (es) |
CA (1) | CA2249420A1 (es) |
CO (1) | CO4780046A1 (es) |
CZ (1) | CZ294963B6 (es) |
DE (1) | DE69703437T2 (es) |
DK (1) | DK0888316T3 (es) |
ES (2) | ES2125161B1 (es) |
GR (1) | GR3035096T3 (es) |
HK (1) | HK1015371A1 (es) |
ID (1) | ID16778A (es) |
IL (1) | IL126206A (es) |
NO (1) | NO311761B1 (es) |
NZ (1) | NZ331901A (es) |
PE (1) | PE42898A1 (es) |
PL (1) | PL188722B1 (es) |
PT (1) | PT888316E (es) |
RU (1) | RU2194043C2 (es) |
TW (1) | TW426674B (es) |
UA (1) | UA52645C2 (es) |
UY (1) | UY24499A1 (es) |
WO (1) | WO1997034882A1 (es) |
ZA (1) | ZA972203B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
ES2131015B1 (es) * | 1997-09-12 | 2000-03-01 | Almirall Prodesfarma Sa | Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas. |
ES2168895A1 (es) * | 1999-03-26 | 2002-06-16 | Almirall Prodesfarma Sa | Derivados de 2-fenilpiran-4-ona. |
ES2154561B1 (es) * | 1998-09-25 | 2001-12-01 | Almirall Prodesfarma Sa | Derivados de 2-fenilpiran-4-ona. |
WO2001045703A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
EP1539679A4 (en) | 2002-06-28 | 2007-07-04 | Nitromed Inc | OXIM- AND / OR HYDRAZO-CONTAINING, NITROSED AND / OR NITROSYLATED CYCLOOXIGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND USE METHODS |
ES2215474B1 (es) | 2002-12-24 | 2005-12-16 | J. URIACH & CIA S.A. | Nuevos derivados de fosforamida. |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
EP1534305B9 (en) | 2003-05-07 | 2007-03-07 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
CN1309717C (zh) * | 2003-06-03 | 2007-04-11 | 李小虎 | 4-芳基-5h-噻吩-2-酮衍生物、其制法和用途 |
CA2676413A1 (en) * | 2007-01-19 | 2008-07-31 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4866182A (en) | 1988-02-18 | 1989-09-12 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic alkanoyl and aroyl oxazolones |
US5380738A (en) * | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
DE4435547A1 (de) | 1994-10-05 | 1996-04-11 | Bayer Ag | Sulfonylaminocarbonyltriazolinone mit über Sauerstoff und Schwefel gebundenen Substituenten |
JP2636819B2 (ja) | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
-
1996
- 1996-03-21 ES ES009600685A patent/ES2125161B1/es not_active Expired - Lifetime
-
1997
- 1997-03-13 ZA ZA9702203A patent/ZA972203B/xx unknown
- 1997-03-19 CZ CZ19982979A patent/CZ294963B6/cs not_active IP Right Cessation
- 1997-03-19 WO PCT/EP1997/001386 patent/WO1997034882A1/en active IP Right Grant
- 1997-03-19 IL IL12620697A patent/IL126206A/en not_active IP Right Cessation
- 1997-03-19 UA UA98094878A patent/UA52645C2/uk unknown
- 1997-03-19 DE DE69703437T patent/DE69703437T2/de not_active Expired - Fee Related
- 1997-03-19 PT PT97915396T patent/PT888316E/pt unknown
- 1997-03-19 PL PL97328915A patent/PL188722B1/pl not_active IP Right Cessation
- 1997-03-19 EP EP97915396A patent/EP0888316B1/en not_active Expired - Lifetime
- 1997-03-19 ES ES97915396T patent/ES2151254T3/es not_active Expired - Lifetime
- 1997-03-19 RU RU98119076/04A patent/RU2194043C2/ru not_active IP Right Cessation
- 1997-03-19 KR KR10-1998-0707459A patent/KR100496395B1/ko not_active IP Right Cessation
- 1997-03-19 AT AT97915396T patent/ATE197294T1/de not_active IP Right Cessation
- 1997-03-19 DK DK97915396T patent/DK0888316T3/da active
- 1997-03-19 BR BR9708141A patent/BR9708141A/pt active Search and Examination
- 1997-03-19 NZ NZ331901A patent/NZ331901A/en unknown
- 1997-03-19 AU AU22893/97A patent/AU713811B2/en not_active Ceased
- 1997-03-19 CN CN97194660A patent/CN1110488C/zh not_active Expired - Fee Related
- 1997-03-19 JP JP53315697A patent/JP3810091B2/ja not_active Expired - Fee Related
- 1997-03-19 CA CA002249420A patent/CA2249420A1/en not_active Abandoned
- 1997-03-19 TW TW086103412A patent/TW426674B/zh not_active IP Right Cessation
- 1997-03-20 CO CO97015097A patent/CO4780046A1/es unknown
- 1997-03-20 ID IDP970904A patent/ID16778A/id unknown
- 1997-03-21 UY UY24499A patent/UY24499A1/es not_active IP Right Cessation
- 1997-03-21 PE PE1997000228A patent/PE42898A1/es not_active Application Discontinuation
- 1997-03-21 AR ARP970101133A patent/AR006340A1/es not_active Application Discontinuation
-
1998
- 1998-09-17 NO NO19984325A patent/NO311761B1/no unknown
- 1998-09-21 US US09/158,966 patent/US6869968B1/en not_active Expired - Fee Related
-
1999
- 1999-02-08 HK HK99100521A patent/HK1015371A1/xx not_active IP Right Cessation
-
2000
- 2000-12-18 GR GR20000402784T patent/GR3035096T3/el not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
VENC | Patent expired |
Effective date: 20170321 |