PE42898A1 - Nuevos derivados de 2-(3h)-oxazolona - Google Patents

Nuevos derivados de 2-(3h)-oxazolona

Info

Publication number
PE42898A1
PE42898A1 PE1997000228A PE00022897A PE42898A1 PE 42898 A1 PE42898 A1 PE 42898A1 PE 1997000228 A PE1997000228 A PE 1997000228A PE 00022897 A PE00022897 A PE 00022897A PE 42898 A1 PE42898 A1 PE 42898A1
Authority
PE
Peru
Prior art keywords
formula
alkyl
compounds
refer
hydrogen
Prior art date
Application number
PE1997000228A
Other languages
English (en)
Inventor
Duran Carles Puig
Noguera Ferran Pujol
Forner Dolors Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8294266&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE42898(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of PE42898A1 publication Critical patent/PE42898A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES DE PREFERENCIA METILO O NR4R5, EN DONDE R4 Y R5 SON HIDROGENO, ALQUILO O BENCILO; R2 ES 2-NAFTILO, FENILO OPCIONALMENTE SUSTITUIDO CON 1; 2 o 3 ATOMOS DE Cl o F, O ES ALQUILO HIDROXILO, ALCOXI O CF3; R3, R4 Y R5 SON DE PREFERENCIA HIDROGENO. TAMBIEN SE REFIEREN A LOS PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I), DOS DE LOS CUALES COMPRENDEN: (A) HACER REACCIONAR UN CARBAMATO DE FORMULA (V) EN DONDE R1a ES ALQUILO O NR4aR5a, EN DONDE R4a Y R5a ES ALQUILO O BENCILO, CON ACIDO ACETICO ANHIDRO; O (B) HACER REACCIONAR EL COMPUESTO DE FORMULA (I) EN DONDE R1 ES Cl, CON R4-NH-R5. LOS COMPUESTOS OBTENIDOS ACTUAN COMO INHIBIDORES SELECTIVOS DE LA CICLOOXIGENASA-2 (COX-2), SIENDO UTILES EN EL TRATAMIENTO DE LA INFLAMACION, DEL DOLOR, DE LA FIEBRE Y DEL ASMA, O PARA LA PREVENCION DEL CANCER COLORRECTAL
PE1997000228A 1996-03-21 1997-03-21 Nuevos derivados de 2-(3h)-oxazolona PE42898A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009600685A ES2125161B1 (es) 1996-03-21 1996-03-21 Nuevos derivados de 2-(3h)-oxazolona.

Publications (1)

Publication Number Publication Date
PE42898A1 true PE42898A1 (es) 1998-08-12

Family

ID=8294266

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000228A PE42898A1 (es) 1996-03-21 1997-03-21 Nuevos derivados de 2-(3h)-oxazolona

Country Status (30)

Country Link
US (1) US6869968B1 (es)
EP (1) EP0888316B1 (es)
JP (1) JP3810091B2 (es)
KR (1) KR100496395B1 (es)
CN (1) CN1110488C (es)
AR (1) AR006340A1 (es)
AT (1) ATE197294T1 (es)
AU (1) AU713811B2 (es)
BR (1) BR9708141A (es)
CA (1) CA2249420A1 (es)
CO (1) CO4780046A1 (es)
CZ (1) CZ294963B6 (es)
DE (1) DE69703437T2 (es)
DK (1) DK0888316T3 (es)
ES (2) ES2125161B1 (es)
GR (1) GR3035096T3 (es)
HK (1) HK1015371A1 (es)
ID (1) ID16778A (es)
IL (1) IL126206A (es)
NO (1) NO311761B1 (es)
NZ (1) NZ331901A (es)
PE (1) PE42898A1 (es)
PL (1) PL188722B1 (es)
PT (1) PT888316E (es)
RU (1) RU2194043C2 (es)
TW (1) TW426674B (es)
UA (1) UA52645C2 (es)
UY (1) UY24499A1 (es)
WO (1) WO1997034882A1 (es)
ZA (1) ZA972203B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125161B1 (es) 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
FR2753449B1 (fr) * 1996-09-13 1998-12-04 Union Pharma Scient Appl Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique
ES2131015B1 (es) * 1997-09-12 2000-03-01 Almirall Prodesfarma Sa Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.
ES2168895A1 (es) * 1999-03-26 2002-06-16 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
ES2154561B1 (es) * 1998-09-25 2001-12-01 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
EP1246621A4 (en) 1999-12-23 2004-11-24 Nitromed Inc NITROSED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS FOR THEIR USE
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
WO2004002420A2 (en) 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
ES2215474B1 (es) 2002-12-24 2005-12-16 J. URIACH & CIA S.A. Nuevos derivados de fosforamida.
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
AU2004237439B2 (en) 2003-05-07 2009-09-10 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
CN1309717C (zh) * 2003-06-03 2007-04-11 李小虎 4－芳基－5h－噻吩－2－酮衍生物、其制法和用途
CN101626787A (zh) * 2007-01-19 2010-01-13 马林克罗特公司 诊断的和治疗的环氧合酶-2结合配体
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866182A (en) 1988-02-18 1989-09-12 Merrell Dow Pharmaceuticals Inc. Cardiotonic alkanoyl and aroyl oxazolones
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
DE4435547A1 (de) 1994-10-05 1996-04-11 Bayer Ag Sulfonylaminocarbonyltriazolinone mit über Sauerstoff und Schwefel gebundenen Substituenten
JP2636819B2 (ja) 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
ES2125161B1 (es) 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
FR2753449B1 (fr) * 1996-09-13 1998-12-04 Union Pharma Scient Appl Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique

Also Published As

Publication number Publication date
UY24499A1 (es) 1997-04-02
MX9701944A (es) 1998-06-30
EP0888316B1 (en) 2000-11-02
AR006340A1 (es) 1999-08-25
ID16778A (id) 1997-11-13
NZ331901A (en) 1999-10-28
KR100496395B1 (ko) 2005-09-27
US6869968B1 (en) 2005-03-22
PL188722B1 (pl) 2005-04-29
CN1110488C (zh) 2003-06-04
AU2289397A (en) 1997-10-10
JP3810091B2 (ja) 2006-08-16
DK0888316T3 (da) 2000-11-27
ATE197294T1 (de) 2000-11-15
NO311761B1 (no) 2002-01-21
PL328915A1 (en) 1999-03-01
IL126206A (en) 2001-06-14
CN1218459A (zh) 1999-06-02
HK1015371A1 (en) 1999-10-15
NO984325L (no) 1998-11-23
WO1997034882A1 (en) 1997-09-25
CZ294963B6 (cs) 2005-04-13
CA2249420A1 (en) 1997-09-25
JP2000506876A (ja) 2000-06-06
ES2151254T3 (es) 2000-12-16
KR20000064727A (ko) 2000-11-06
ZA972203B (en) 1997-09-25
NO984325D0 (no) 1998-09-17
PT888316E (pt) 2001-02-28
CO4780046A1 (es) 1999-05-26
AU713811B2 (en) 1999-12-09
DE69703437T2 (de) 2001-03-08
EP0888316A1 (en) 1999-01-07
IL126206A0 (en) 1999-05-09
UA52645C2 (uk) 2003-01-15
ES2125161B1 (es) 1999-11-16
ES2125161A1 (es) 1999-02-16
RU2194043C2 (ru) 2002-12-10
GR3035096T3 (en) 2001-03-30
CZ297998A3 (cs) 1999-02-17
BR9708141A (pt) 1999-07-27
TW426674B (en) 2001-03-21
DE69703437D1 (de) 2000-12-07

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed