ES2151254T3 - Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2. - Google Patents
Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2.Info
- Publication number
- ES2151254T3 ES2151254T3 ES97915396T ES97915396T ES2151254T3 ES 2151254 T3 ES2151254 T3 ES 2151254T3 ES 97915396 T ES97915396 T ES 97915396T ES 97915396 T ES97915396 T ES 97915396T ES 2151254 T3 ES2151254 T3 ES 2151254T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- cox
- inhibitors
- oxazolone derivatives
- oxazolone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A UN COMPUESTO DE 2 - (3H) - OXAZOLONA DE FORMULA (I), DONDE R 1 ES UN GRUPO ALQUILO O NR SUP,4 R 5 , DONDE R 4 Y R 5 , CADA UNO INDEPENDIENTEMENTE, SON HIDROGENO O UN GRUPO ALQUILO O BENCILO; R 2 ES UN GRUPO NAFTILO, TETRAHIDRONAFTILO, FENILO SIN SUSTITUIR O FENILO SUSTITUIDO POR ENTRE 1 Y 3 ATOMOS DE HALOGENO O POR GRUPOS ALQUILO, HIDROXILO, ALCOXI O TRIFLUOROMETILO; Y R 3 ES HIDROGENO O UN GRUPO ALQUILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009600685A ES2125161B1 (es) | 1996-03-21 | 1996-03-21 | Nuevos derivados de 2-(3h)-oxazolona. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2151254T3 true ES2151254T3 (es) | 2000-12-16 |
Family
ID=8294266
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009600685A Expired - Lifetime ES2125161B1 (es) | 1996-03-21 | 1996-03-21 | Nuevos derivados de 2-(3h)-oxazolona. |
ES97915396T Expired - Lifetime ES2151254T3 (es) | 1996-03-21 | 1997-03-19 | Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009600685A Expired - Lifetime ES2125161B1 (es) | 1996-03-21 | 1996-03-21 | Nuevos derivados de 2-(3h)-oxazolona. |
Country Status (30)
Country | Link |
---|---|
US (1) | US6869968B1 (es) |
EP (1) | EP0888316B1 (es) |
JP (1) | JP3810091B2 (es) |
KR (1) | KR100496395B1 (es) |
CN (1) | CN1110488C (es) |
AR (1) | AR006340A1 (es) |
AT (1) | ATE197294T1 (es) |
AU (1) | AU713811B2 (es) |
BR (1) | BR9708141A (es) |
CA (1) | CA2249420A1 (es) |
CO (1) | CO4780046A1 (es) |
CZ (1) | CZ294963B6 (es) |
DE (1) | DE69703437T2 (es) |
DK (1) | DK0888316T3 (es) |
ES (2) | ES2125161B1 (es) |
GR (1) | GR3035096T3 (es) |
HK (1) | HK1015371A1 (es) |
ID (1) | ID16778A (es) |
IL (1) | IL126206A (es) |
NO (1) | NO311761B1 (es) |
NZ (1) | NZ331901A (es) |
PE (1) | PE42898A1 (es) |
PL (1) | PL188722B1 (es) |
PT (1) | PT888316E (es) |
RU (1) | RU2194043C2 (es) |
TW (1) | TW426674B (es) |
UA (1) | UA52645C2 (es) |
UY (1) | UY24499A1 (es) |
WO (1) | WO1997034882A1 (es) |
ZA (1) | ZA972203B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
ES2131015B1 (es) * | 1997-09-12 | 2000-03-01 | Almirall Prodesfarma Sa | Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas. |
ES2168895A1 (es) * | 1999-03-26 | 2002-06-16 | Almirall Prodesfarma Sa | Derivados de 2-fenilpiran-4-ona. |
ES2154561B1 (es) * | 1998-09-25 | 2001-12-01 | Almirall Prodesfarma Sa | Derivados de 2-fenilpiran-4-ona. |
EP1246621A4 (en) | 1999-12-23 | 2004-11-24 | Nitromed Inc | NITROSED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS FOR THEIR USE |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
WO2004002420A2 (en) | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
ES2215474B1 (es) | 2002-12-24 | 2005-12-16 | J. URIACH & CIA S.A. | Nuevos derivados de fosforamida. |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
AU2004237439B2 (en) | 2003-05-07 | 2009-09-10 | Osteologix A/S | Treating cartilage/bone conditions with water-soluble strontium salts |
CN1309717C (zh) * | 2003-06-03 | 2007-04-11 | 李小虎 | 4-芳基-5h-噻吩-2-酮衍生物、其制法和用途 |
CN101626787A (zh) * | 2007-01-19 | 2010-01-13 | 马林克罗特公司 | 诊断的和治疗的环氧合酶-2结合配体 |
WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4866182A (en) | 1988-02-18 | 1989-09-12 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic alkanoyl and aroyl oxazolones |
US5380738A (en) * | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
DE4435547A1 (de) | 1994-10-05 | 1996-04-11 | Bayer Ag | Sulfonylaminocarbonyltriazolinone mit über Sauerstoff und Schwefel gebundenen Substituenten |
JP2636819B2 (ja) | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
-
1996
- 1996-03-21 ES ES009600685A patent/ES2125161B1/es not_active Expired - Lifetime
-
1997
- 1997-03-13 ZA ZA9702203A patent/ZA972203B/xx unknown
- 1997-03-19 AU AU22893/97A patent/AU713811B2/en not_active Ceased
- 1997-03-19 CN CN97194660A patent/CN1110488C/zh not_active Expired - Fee Related
- 1997-03-19 AT AT97915396T patent/ATE197294T1/de not_active IP Right Cessation
- 1997-03-19 JP JP53315697A patent/JP3810091B2/ja not_active Expired - Fee Related
- 1997-03-19 WO PCT/EP1997/001386 patent/WO1997034882A1/en active IP Right Grant
- 1997-03-19 PT PT97915396T patent/PT888316E/pt unknown
- 1997-03-19 DE DE69703437T patent/DE69703437T2/de not_active Expired - Fee Related
- 1997-03-19 KR KR10-1998-0707459A patent/KR100496395B1/ko not_active IP Right Cessation
- 1997-03-19 UA UA98094878A patent/UA52645C2/uk unknown
- 1997-03-19 ES ES97915396T patent/ES2151254T3/es not_active Expired - Lifetime
- 1997-03-19 CA CA002249420A patent/CA2249420A1/en not_active Abandoned
- 1997-03-19 TW TW086103412A patent/TW426674B/zh not_active IP Right Cessation
- 1997-03-19 NZ NZ331901A patent/NZ331901A/en unknown
- 1997-03-19 RU RU98119076/04A patent/RU2194043C2/ru not_active IP Right Cessation
- 1997-03-19 EP EP97915396A patent/EP0888316B1/en not_active Expired - Lifetime
- 1997-03-19 DK DK97915396T patent/DK0888316T3/da active
- 1997-03-19 BR BR9708141A patent/BR9708141A/pt active Search and Examination
- 1997-03-19 PL PL97328915A patent/PL188722B1/pl not_active IP Right Cessation
- 1997-03-19 IL IL12620697A patent/IL126206A/en not_active IP Right Cessation
- 1997-03-19 CZ CZ19982979A patent/CZ294963B6/cs not_active IP Right Cessation
- 1997-03-20 CO CO97015097A patent/CO4780046A1/es unknown
- 1997-03-20 ID IDP970904A patent/ID16778A/id unknown
- 1997-03-21 PE PE1997000228A patent/PE42898A1/es not_active Application Discontinuation
- 1997-03-21 AR ARP970101133A patent/AR006340A1/es not_active Application Discontinuation
- 1997-03-21 UY UY24499A patent/UY24499A1/es not_active IP Right Cessation
-
1998
- 1998-09-17 NO NO19984325A patent/NO311761B1/no unknown
- 1998-09-21 US US09/158,966 patent/US6869968B1/en not_active Expired - Fee Related
-
1999
- 1999-02-08 HK HK99100521A patent/HK1015371A1/xx not_active IP Right Cessation
-
2000
- 2000-12-18 GR GR20000402784T patent/GR3035096T3/el not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2151254T3 (es) | Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2. | |
AR240909A2 (es) | Derivados de 2-(2'-alquilbenzoil) -1,3-ciclohexanodiona, composicion que los comprende y procedimiento para prepararlo" | |
NO902954D0 (no) | Fremgangsmaate for fremstilling av substituerte kinazolinoner som angitensin ii-antagonister. | |
ES2155995T3 (es) | Compuestos de 4-fenilpiperidina. | |
DE69709938T2 (de) | N-benzylpiperidin- und tetrahydropyridin-derivate | |
ATE126509T1 (de) | Disäuren von diarylstyrylchinolin. | |
NO871861D0 (no) | Fremgangsmaate for fremstilling av nye dopamin beta-hydroxylase inhibitorer. | |
ES2055424T3 (es) | Derivados de n-fenilbenzamida con actividad anti-ulcera y anti-alergia y un metodo para su preparacion. | |
AR241531A1 (es) | Un procedimiento para la preparacion derivados de 2-indolinona, y sus sales farmaceuticamente aceptables. | |
ES2060818T3 (es) | Derivados de indol, benzofurano y benzotiofeno sustituidos como inhibidores de la 5-lipooxigenasa. | |
ZA876345B (en) | Phenolic corrosion inhibitors for coating materials | |
KR860005794A (ko) | 이미다졸 유도체의 제조방법 | |
ES2037708T3 (es) | Un procedimiento para preparar un derivado de bencimidazol. | |
ES8503678A1 (es) | Proceso para producir un ester de benzoilpiperazina. | |
ES496451A0 (es) | Un procedimiento para la produccion de derivados de 1,2,3,4,5,6-hexahidro-6-fenil-azepino (4,5,b) indol. | |
AR246162A1 (es) | Composicion antimicrobiana | |
FI905957A (fi) | Foerfarande foer framstaellning av substituerade cyklohexener, som verkar pao det centrala nervsystemet. | |
ATE30429T1 (de) | Acylamino-oxo- oder hydroxy-substituiertealkylamino thiazine und thiazepine. | |
ES2037011T3 (es) | Procedimiento para la preparacion de nuevos derivados de benzofuran-2-il-imidazol. | |
DK184085A (da) | Heterocycliske aminoforbindelser | |
DK248788A (da) | Bicycliske sulfonamidderivater samt fremgangsmaade til fremstilling deraf | |
TR200001080T2 (tr) | 2 ile ikame edilmiş 1,2-Benisotiyazol türevleri ve bunların serrotonın antagonistleri | |
AR017097A1 (es) | Compuestos de 2-(3h)-oxazolona, utiles como inhibidores selectivos de cox-2; procedimiento para preparar dichos compuestos y composiciones farmaceuticasformuladas con dichos compuestos | |
FI871187A (fi) | Kromogena ftalider, deras framstaellning och anvaendning. | |
AR006139A1 (es) | Glutarimida, procedimientos para su preparación y su utilización. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 888316 Country of ref document: ES |