ES2125161A1 - Nuevos derivados de 2-(3h)-oxazolona. - Google Patents
Nuevos derivados de 2-(3h)-oxazolona.Info
- Publication number
- ES2125161A1 ES2125161A1 ES09600685A ES9600685A ES2125161A1 ES 2125161 A1 ES2125161 A1 ES 2125161A1 ES 09600685 A ES09600685 A ES 09600685A ES 9600685 A ES9600685 A ES 9600685A ES 2125161 A1 ES2125161 A1 ES 2125161A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- cox
- inhibitors
- group
- oxazolone derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Nuevos derivados de 2 -(3H-oxazolona de fórmula (I): en donde: R{sup,1 es un grupo alquilo o -NR{sup,4 R{sup,5 en donde R{sup,4 y R{sup,5 son cada uno independientemente hidrógeno o un grupo alquilo o bencilo; R{sup,2 es un grupo naftilo, tetrahidronaftilo, o un grupo fenilo no substituido o fenilo substituido, siendo los substituyentes seleccionados de 1 a 3 átomos de halógeno o grupos alquilo, hidroxi, alcoxi o trifluorometilo; y R{sup,3 es hidrógeno o un grupo alquilo.
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009600685A ES2125161B1 (es) | 1996-03-21 | 1996-03-21 | Nuevos derivados de 2-(3h)-oxazolona. |
ZA9702203A ZA972203B (en) | 1996-03-21 | 1997-03-13 | New 2-(3H)-oxazolone derivatives. |
MXPA/A/1997/001944A MXPA97001944A (es) | 1996-03-21 | 1997-03-14 | Nuevos derivados de 2-(3h)-oxazolona |
RU98119076/04A RU2194043C2 (ru) | 1996-03-21 | 1997-03-19 | Производные 2-(3h)-оксазолона, способы его получения, фармацевтическая композиция на его основе и способ ингибирования активности сох-2 |
CZ19982979A CZ294963B6 (cs) | 1996-03-21 | 1997-03-19 | 2-(3H)-Oxazolonové deriváty, způsob jejich přípravy, farmaceutické kompozice a jejich použití |
NZ331901A NZ331901A (en) | 1996-03-21 | 1997-03-19 | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
IL12620697A IL126206A (en) | 1996-03-21 | 1997-03-19 | History 2 - (3H) - Oxazolone and their use as COX-2 enzyme inhibitors, processes for their preparation and pharmaceutical preparations containing them |
AT97915396T ATE197294T1 (de) | 1996-03-21 | 1997-03-19 | 2-(3h)-oxazolone-derivate und ihre verwendung als cox-2 inhibitoren |
PCT/EP1997/001386 WO1997034882A1 (en) | 1996-03-21 | 1997-03-19 | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
PL97328915A PL188722B1 (pl) | 1996-03-21 | 1997-03-19 | Nowe związki 2-(3H)-oksazolonu, sposób ich wytwarzania, środek farmaceutyczny zawierający te związki i zastosowanie nowych związków jako inhibitorów COX-2 |
JP53315697A JP3810091B2 (ja) | 1996-03-21 | 1997-03-19 | 2―(3h)―オキサゾロン誘導体およびcox―2阻害剤としてのそれらの使用 |
PT97915396T PT888316E (pt) | 1996-03-21 | 1997-03-19 | Derivados de 2-(3h)-oxazolona e sua utilizacao como inibidores de cox-2 |
DE69703437T DE69703437T2 (de) | 1996-03-21 | 1997-03-19 | 2-(3h)-oxazolone-derivate und ihre verwendung als cox-2 inhibitoren |
ES97915396T ES2151254T3 (es) | 1996-03-21 | 1997-03-19 | Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2. |
TW086103412A TW426674B (en) | 1996-03-21 | 1997-03-19 | New 2-(3H)-oxazolone derivatives |
KR10-1998-0707459A KR100496395B1 (ko) | 1996-03-21 | 1997-03-19 | 2-(3h)-옥사졸론유도체및그것의cox-2억제제로서의사용 |
AU22893/97A AU713811B2 (en) | 1996-03-21 | 1997-03-19 | 2-(3H)-oxazolone derivatives and their use as COX-2 inhibitors |
EP97915396A EP0888316B1 (en) | 1996-03-21 | 1997-03-19 | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
DK97915396T DK0888316T3 (da) | 1996-03-21 | 1997-03-19 | 2-(3H)-oxazolonderivater og deres anvendelse som cox-2 inhibitorer |
UA98094878A UA52645C2 (uk) | 1996-03-21 | 1997-03-19 | Похідні 2-(3н)-оксазолону як інгібітори, спосіб їх отримання та фармацевтична композиція, що їх містить |
BR9708141A BR9708141A (pt) | 1996-03-21 | 1997-03-19 | Composto processo sua preparação uso de composto e composição famracêutica |
CN97194660A CN1110488C (zh) | 1996-03-21 | 1997-03-19 | 2-(3h)-噁唑酮衍生物及其作为cox-2抑制剂的应用 |
CA002249420A CA2249420A1 (en) | 1996-03-21 | 1997-03-19 | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
CO97015097A CO4780046A1 (es) | 1996-03-21 | 1997-03-20 | Nuevos derivados de 2-(3h)-oxazolona |
IDP970904A ID16778A (id) | 1996-03-21 | 1997-03-20 | Turunan 2-(3h)-okasazolon baru |
PE1997000228A PE42898A1 (es) | 1996-03-21 | 1997-03-21 | Nuevos derivados de 2-(3h)-oxazolona |
UY24499A UY24499A1 (es) | 1996-03-21 | 1997-03-21 | Nuevos derivados de 2-(3h)-oxazolona |
ARP970101133A AR006340A1 (es) | 1996-03-21 | 1997-03-21 | Derivados de 2-(3h)-oxazolona, proceso para prepararlos, composiciones farmaceuticas que los incluyan y uso de dichos derivados para tratamientosmedicinales. |
NO19984325A NO311761B1 (no) | 1996-03-21 | 1998-09-17 | 2-(3H)-Oksazolonderivater og deres anvendelse |
US09/158,966 US6869968B1 (en) | 1996-03-21 | 1998-09-21 | 2-(3H)-oxazolone derivatives and their use as COX-2 inhibitors |
HK99100521A HK1015371A1 (en) | 1996-03-21 | 1999-02-08 | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
GR20000402784T GR3035096T3 (en) | 1996-03-21 | 2000-12-18 | 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009600685A ES2125161B1 (es) | 1996-03-21 | 1996-03-21 | Nuevos derivados de 2-(3h)-oxazolona. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2125161A1 true ES2125161A1 (es) | 1999-02-16 |
ES2125161B1 ES2125161B1 (es) | 1999-11-16 |
Family
ID=8294266
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009600685A Expired - Lifetime ES2125161B1 (es) | 1996-03-21 | 1996-03-21 | Nuevos derivados de 2-(3h)-oxazolona. |
ES97915396T Expired - Lifetime ES2151254T3 (es) | 1996-03-21 | 1997-03-19 | Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97915396T Expired - Lifetime ES2151254T3 (es) | 1996-03-21 | 1997-03-19 | Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2. |
Country Status (30)
Country | Link |
---|---|
US (1) | US6869968B1 (es) |
EP (1) | EP0888316B1 (es) |
JP (1) | JP3810091B2 (es) |
KR (1) | KR100496395B1 (es) |
CN (1) | CN1110488C (es) |
AR (1) | AR006340A1 (es) |
AT (1) | ATE197294T1 (es) |
AU (1) | AU713811B2 (es) |
BR (1) | BR9708141A (es) |
CA (1) | CA2249420A1 (es) |
CO (1) | CO4780046A1 (es) |
CZ (1) | CZ294963B6 (es) |
DE (1) | DE69703437T2 (es) |
DK (1) | DK0888316T3 (es) |
ES (2) | ES2125161B1 (es) |
GR (1) | GR3035096T3 (es) |
HK (1) | HK1015371A1 (es) |
ID (1) | ID16778A (es) |
IL (1) | IL126206A (es) |
NO (1) | NO311761B1 (es) |
NZ (1) | NZ331901A (es) |
PE (1) | PE42898A1 (es) |
PL (1) | PL188722B1 (es) |
PT (1) | PT888316E (es) |
RU (1) | RU2194043C2 (es) |
TW (1) | TW426674B (es) |
UA (1) | UA52645C2 (es) |
UY (1) | UY24499A1 (es) |
WO (1) | WO1997034882A1 (es) |
ZA (1) | ZA972203B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
ES2131015B1 (es) * | 1997-09-12 | 2000-03-01 | Almirall Prodesfarma Sa | Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas. |
ES2168895A1 (es) * | 1999-03-26 | 2002-06-16 | Almirall Prodesfarma Sa | Derivados de 2-fenilpiran-4-ona. |
ES2154561B1 (es) * | 1998-09-25 | 2001-12-01 | Almirall Prodesfarma Sa | Derivados de 2-fenilpiran-4-ona. |
WO2001045703A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
EP1539679A4 (en) | 2002-06-28 | 2007-07-04 | Nitromed Inc | OXIM- AND / OR HYDRAZO-CONTAINING, NITROSED AND / OR NITROSYLATED CYCLOOXIGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND USE METHODS |
ES2215474B1 (es) | 2002-12-24 | 2005-12-16 | J. URIACH & CIA S.A. | Nuevos derivados de fosforamida. |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
EP1534305B9 (en) | 2003-05-07 | 2007-03-07 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
CN1309717C (zh) * | 2003-06-03 | 2007-04-11 | 李小虎 | 4-芳基-5h-噻吩-2-酮衍生物、其制法和用途 |
CA2676413A1 (en) * | 2007-01-19 | 2008-07-31 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994027980A1 (en) * | 1993-05-21 | 1994-12-08 | G.D. Searle & Co. | Substituted oxazolyl compounds for the treatment of inflammation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4866182A (en) | 1988-02-18 | 1989-09-12 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic alkanoyl and aroyl oxazolones |
DE4435547A1 (de) | 1994-10-05 | 1996-04-11 | Bayer Ag | Sulfonylaminocarbonyltriazolinone mit über Sauerstoff und Schwefel gebundenen Substituenten |
JP2636819B2 (ja) | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
-
1996
- 1996-03-21 ES ES009600685A patent/ES2125161B1/es not_active Expired - Lifetime
-
1997
- 1997-03-13 ZA ZA9702203A patent/ZA972203B/xx unknown
- 1997-03-19 CZ CZ19982979A patent/CZ294963B6/cs not_active IP Right Cessation
- 1997-03-19 WO PCT/EP1997/001386 patent/WO1997034882A1/en active IP Right Grant
- 1997-03-19 IL IL12620697A patent/IL126206A/en not_active IP Right Cessation
- 1997-03-19 UA UA98094878A patent/UA52645C2/uk unknown
- 1997-03-19 DE DE69703437T patent/DE69703437T2/de not_active Expired - Fee Related
- 1997-03-19 PT PT97915396T patent/PT888316E/pt unknown
- 1997-03-19 PL PL97328915A patent/PL188722B1/pl not_active IP Right Cessation
- 1997-03-19 EP EP97915396A patent/EP0888316B1/en not_active Expired - Lifetime
- 1997-03-19 ES ES97915396T patent/ES2151254T3/es not_active Expired - Lifetime
- 1997-03-19 RU RU98119076/04A patent/RU2194043C2/ru not_active IP Right Cessation
- 1997-03-19 KR KR10-1998-0707459A patent/KR100496395B1/ko not_active IP Right Cessation
- 1997-03-19 AT AT97915396T patent/ATE197294T1/de not_active IP Right Cessation
- 1997-03-19 DK DK97915396T patent/DK0888316T3/da active
- 1997-03-19 BR BR9708141A patent/BR9708141A/pt active Search and Examination
- 1997-03-19 NZ NZ331901A patent/NZ331901A/en unknown
- 1997-03-19 AU AU22893/97A patent/AU713811B2/en not_active Ceased
- 1997-03-19 CN CN97194660A patent/CN1110488C/zh not_active Expired - Fee Related
- 1997-03-19 JP JP53315697A patent/JP3810091B2/ja not_active Expired - Fee Related
- 1997-03-19 CA CA002249420A patent/CA2249420A1/en not_active Abandoned
- 1997-03-19 TW TW086103412A patent/TW426674B/zh not_active IP Right Cessation
- 1997-03-20 CO CO97015097A patent/CO4780046A1/es unknown
- 1997-03-20 ID IDP970904A patent/ID16778A/id unknown
- 1997-03-21 UY UY24499A patent/UY24499A1/es not_active IP Right Cessation
- 1997-03-21 PE PE1997000228A patent/PE42898A1/es not_active Application Discontinuation
- 1997-03-21 AR ARP970101133A patent/AR006340A1/es not_active Application Discontinuation
-
1998
- 1998-09-17 NO NO19984325A patent/NO311761B1/no unknown
- 1998-09-21 US US09/158,966 patent/US6869968B1/en not_active Expired - Fee Related
-
1999
- 1999-02-08 HK HK99100521A patent/HK1015371A1/xx not_active IP Right Cessation
-
2000
- 2000-12-18 GR GR20000402784T patent/GR3035096T3/el not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994027980A1 (en) * | 1993-05-21 | 1994-12-08 | G.D. Searle & Co. | Substituted oxazolyl compounds for the treatment of inflammation |
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Legal Events
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PC2A | Transfer of patent | ||
EC2A | Search report published |
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