ES2125161A1 - Nuevos derivados de 2-(3h)-oxazolona. - Google Patents

Nuevos derivados de 2-(3h)-oxazolona.

Info

Publication number
ES2125161A1
ES2125161A1 ES09600685A ES9600685A ES2125161A1 ES 2125161 A1 ES2125161 A1 ES 2125161A1 ES 09600685 A ES09600685 A ES 09600685A ES 9600685 A ES9600685 A ES 9600685A ES 2125161 A1 ES2125161 A1 ES 2125161A1
Authority
ES
Spain
Prior art keywords
alkyl
cox
inhibitors
group
oxazolone derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09600685A
Other languages
English (en)
Other versions
ES2125161B1 (es
Inventor
Duran Carles Puig
Noguera Ferran Pujol
Forner Dolors Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Grupo Farmaceutico Almirall SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8294266&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2125161(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grupo Farmaceutico Almirall SA filed Critical Grupo Farmaceutico Almirall SA
Priority to ES009600685A priority Critical patent/ES2125161B1/es
Priority to ZA9702203A priority patent/ZA972203B/xx
Priority to MXPA/A/1997/001944A priority patent/MXPA97001944A/es
Priority to DE69703437T priority patent/DE69703437T2/de
Priority to ES97915396T priority patent/ES2151254T3/es
Priority to RU98119076/04A priority patent/RU2194043C2/ru
Priority to JP53315697A priority patent/JP3810091B2/ja
Priority to CZ19982979A priority patent/CZ294963B6/cs
Priority to AT97915396T priority patent/ATE197294T1/de
Priority to DK97915396T priority patent/DK0888316T3/da
Priority to KR10-1998-0707459A priority patent/KR100496395B1/ko
Priority to CA002249420A priority patent/CA2249420A1/en
Priority to BR9708141A priority patent/BR9708141A/pt
Priority to CN97194660A priority patent/CN1110488C/zh
Priority to PCT/EP1997/001386 priority patent/WO1997034882A1/en
Priority to PL97328915A priority patent/PL188722B1/pl
Priority to UA98094878A priority patent/UA52645C2/uk
Priority to EP97915396A priority patent/EP0888316B1/en
Priority to TW086103412A priority patent/TW426674B/zh
Priority to IL12620697A priority patent/IL126206A/en
Priority to AU22893/97A priority patent/AU713811B2/en
Priority to PT97915396T priority patent/PT888316E/pt
Priority to NZ331901A priority patent/NZ331901A/en
Priority to IDP970904A priority patent/ID16778A/id
Priority to CO97015097A priority patent/CO4780046A1/es
Priority to UY24499A priority patent/UY24499A1/es
Priority to ARP970101133A priority patent/AR006340A1/es
Priority to PE1997000228A priority patent/PE42898A1/es
Priority to NO19984325A priority patent/NO311761B1/no
Priority to US09/158,966 priority patent/US6869968B1/en
Priority to HK99100521A priority patent/HK1015371A1/xx
Publication of ES2125161A1 publication Critical patent/ES2125161A1/es
Publication of ES2125161B1 publication Critical patent/ES2125161B1/es
Application granted granted Critical
Priority to GR20000402784T priority patent/GR3035096T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevos derivados de 2 -(3H-oxazolona de fórmula (I): en donde: R{sup,1 es un grupo alquilo o -NR{sup,4 R{sup,5 en donde R{sup,4 y R{sup,5 son cada uno independientemente hidrógeno o un grupo alquilo o bencilo; R{sup,2 es un grupo naftilo, tetrahidronaftilo, o un grupo fenilo no substituido o fenilo substituido, siendo los substituyentes seleccionados de 1 a 3 átomos de halógeno o grupos alquilo, hidroxi, alcoxi o trifluorometilo; y R{sup,3 es hidrógeno o un grupo alquilo.
ES009600685A 1996-03-21 1996-03-21 Nuevos derivados de 2-(3h)-oxazolona. Expired - Lifetime ES2125161B1 (es)

Priority Applications (32)

Application Number Priority Date Filing Date Title
ES009600685A ES2125161B1 (es) 1996-03-21 1996-03-21 Nuevos derivados de 2-(3h)-oxazolona.
ZA9702203A ZA972203B (en) 1996-03-21 1997-03-13 New 2-(3H)-oxazolone derivatives.
MXPA/A/1997/001944A MXPA97001944A (es) 1996-03-21 1997-03-14 Nuevos derivados de 2-(3h)-oxazolona
UA98094878A UA52645C2 (uk) 1996-03-21 1997-03-19 Похідні 2-(3н)-оксазолону як інгібітори, спосіб їх отримання та фармацевтична композиція, що їх містить
AU22893/97A AU713811B2 (en) 1996-03-21 1997-03-19 2-(3H)-oxazolone derivatives and their use as COX-2 inhibitors
RU98119076/04A RU2194043C2 (ru) 1996-03-21 1997-03-19 Производные 2-(3h)-оксазолона, способы его получения, фармацевтическая композиция на его основе и способ ингибирования активности сох-2
JP53315697A JP3810091B2 (ja) 1996-03-21 1997-03-19 ２―（３ｈ）―オキサゾロン誘導体およびｃｏｘ―２阻害剤としてのそれらの使用
CZ19982979A CZ294963B6 (cs) 1996-03-21 1997-03-19 2-(3H)-Oxazolonové deriváty, způsob jejich přípravy, farmaceutické kompozice a jejich použití
AT97915396T ATE197294T1 (de) 1996-03-21 1997-03-19 2-(3h)-oxazolone-derivate und ihre verwendung als cox-2 inhibitoren
DK97915396T DK0888316T3 (da) 1996-03-21 1997-03-19 2-(3H)-oxazolonderivater og deres anvendelse som cox-2 inhibitorer
KR10-1998-0707459A KR100496395B1 (ko) 1996-03-21 1997-03-19 2-(3h)-옥사졸론유도체및그것의cox-2억제제로서의사용
CA002249420A CA2249420A1 (en) 1996-03-21 1997-03-19 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors
BR9708141A BR9708141A (pt) 1996-03-21 1997-03-19 Composto processo sua preparação uso de composto e composição famracêutica
CN97194660A CN1110488C (zh) 1996-03-21 1997-03-19 2－(3h)－噁唑酮衍生物及其作为cox－2抑制剂的应用
PCT/EP1997/001386 WO1997034882A1 (en) 1996-03-21 1997-03-19 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors
PL97328915A PL188722B1 (pl) 1996-03-21 1997-03-19 Nowe związki 2-(3H)-oksazolonu, sposób ich wytwarzania, środek farmaceutyczny zawierający te związki i zastosowanie nowych związków jako inhibitorów COX-2
DE69703437T DE69703437T2 (de) 1996-03-21 1997-03-19 2-(3h)-oxazolone-derivate und ihre verwendung als cox-2 inhibitoren
EP97915396A EP0888316B1 (en) 1996-03-21 1997-03-19 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors
TW086103412A TW426674B (en) 1996-03-21 1997-03-19 New 2-(3H)-oxazolone derivatives
IL12620697A IL126206A (en) 1996-03-21 1997-03-19 History 2 - (3H) - Oxazolone and their use as COX-2 enzyme inhibitors, processes for their preparation and pharmaceutical preparations containing them
ES97915396T ES2151254T3 (es) 1996-03-21 1997-03-19 Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2.
PT97915396T PT888316E (pt) 1996-03-21 1997-03-19 Derivados de 2-(3h)-oxazolona e sua utilizacao como inibidores de cox-2
NZ331901A NZ331901A (en) 1996-03-21 1997-03-19 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors
IDP970904A ID16778A (id) 1996-03-21 1997-03-20 Turunan 2-(3h)-okasazolon baru
CO97015097A CO4780046A1 (es) 1996-03-21 1997-03-20 Nuevos derivados de 2-(3h)-oxazolona
UY24499A UY24499A1 (es) 1996-03-21 1997-03-21 Nuevos derivados de 2-(3h)-oxazolona
ARP970101133A AR006340A1 (es) 1996-03-21 1997-03-21 Derivados de 2-(3h)-oxazolona, proceso para prepararlos, composiciones farmaceuticas que los incluyan y uso de dichos derivados para tratamientosmedicinales.
PE1997000228A PE42898A1 (es) 1996-03-21 1997-03-21 Nuevos derivados de 2-(3h)-oxazolona
NO19984325A NO311761B1 (no) 1996-03-21 1998-09-17 2-(3H)-Oksazolonderivater og deres anvendelse
US09/158,966 US6869968B1 (en) 1996-03-21 1998-09-21 2-(3H)-oxazolone derivatives and their use as COX-2 inhibitors
HK99100521A HK1015371A1 (en) 1996-03-21 1999-02-08 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors
GR20000402784T GR3035096T3 (en) 1996-03-21 2000-12-18 2-(3h)-oxazolone derivatives and their use as cox-2 inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009600685A ES2125161B1 (es) 1996-03-21 1996-03-21 Nuevos derivados de 2-(3h)-oxazolona.

Publications (2)

Publication Number Publication Date
ES2125161A1 true ES2125161A1 (es) 1999-02-16
ES2125161B1 ES2125161B1 (es) 1999-11-16

Family

ID=8294266

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009600685A Expired - Lifetime ES2125161B1 (es) 1996-03-21 1996-03-21 Nuevos derivados de 2-(3h)-oxazolona.
ES97915396T Expired - Lifetime ES2151254T3 (es) 1996-03-21 1997-03-19 Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97915396T Expired - Lifetime ES2151254T3 (es) 1996-03-21 1997-03-19 Derivados de 2-(3h)-oxazolona y su uso como inhibidores de cox-2.

Country Status (30)

Country Link
US (1) US6869968B1 (es)
EP (1) EP0888316B1 (es)
JP (1) JP3810091B2 (es)
KR (1) KR100496395B1 (es)
CN (1) CN1110488C (es)
AR (1) AR006340A1 (es)
AT (1) ATE197294T1 (es)
AU (1) AU713811B2 (es)
BR (1) BR9708141A (es)
CA (1) CA2249420A1 (es)
CO (1) CO4780046A1 (es)
CZ (1) CZ294963B6 (es)
DE (1) DE69703437T2 (es)
DK (1) DK0888316T3 (es)
ES (2) ES2125161B1 (es)
GR (1) GR3035096T3 (es)
HK (1) HK1015371A1 (es)
ID (1) ID16778A (es)
IL (1) IL126206A (es)
NO (1) NO311761B1 (es)
NZ (1) NZ331901A (es)
PE (1) PE42898A1 (es)
PL (1) PL188722B1 (es)
PT (1) PT888316E (es)
RU (1) RU2194043C2 (es)
TW (1) TW426674B (es)
UA (1) UA52645C2 (es)
UY (1) UY24499A1 (es)
WO (1) WO1997034882A1 (es)
ZA (1) ZA972203B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125161B1 (es) 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
FR2753449B1 (fr) * 1996-09-13 1998-12-04 Union Pharma Scient Appl Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique
ES2131015B1 (es) * 1997-09-12 2000-03-01 Almirall Prodesfarma Sa Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.
ES2168895A1 (es) * 1999-03-26 2002-06-16 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
ES2154561B1 (es) * 1998-09-25 2001-12-01 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
IL150368A0 (en) 1999-12-23 2002-12-01 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
WO2004002420A2 (en) 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
ES2215474B1 (es) 2002-12-24 2005-12-16 J. URIACH & CIA S.A. Nuevos derivados de fosforamida.
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
PL1534305T3 (pl) 2003-05-07 2007-03-30 Osteologix As Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
CN1309717C (zh) * 2003-06-03 2007-04-11 李小虎 4－芳基－5h－噻吩－2－酮衍生物、其制法和用途
EP2114461A2 (en) * 2007-01-19 2009-11-11 Mallinckrodt Inc. Diagnostic and therapeutic cyclooxygenase-2 binding ligands
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027980A1 (en) * 1993-05-21 1994-12-08 G.D. Searle & Co. Substituted oxazolyl compounds for the treatment of inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866182A (en) 1988-02-18 1989-09-12 Merrell Dow Pharmaceuticals Inc. Cardiotonic alkanoyl and aroyl oxazolones
DE4435547A1 (de) 1994-10-05 1996-04-11 Bayer Ag Sulfonylaminocarbonyltriazolinone mit über Sauerstoff und Schwefel gebundenen Substituenten
JP2636819B2 (ja) 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
ES2125161B1 (es) 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
FR2753449B1 (fr) * 1996-09-13 1998-12-04 Union Pharma Scient Appl Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027980A1 (en) * 1993-05-21 1994-12-08 G.D. Searle & Co. Substituted oxazolyl compounds for the treatment of inflammation

Also Published As

Publication number Publication date
ZA972203B (en) 1997-09-25
DE69703437T2 (de) 2001-03-08
AR006340A1 (es) 1999-08-25
US6869968B1 (en) 2005-03-22
KR20000064727A (ko) 2000-11-06
DE69703437D1 (de) 2000-12-07
EP0888316B1 (en) 2000-11-02
PL328915A1 (en) 1999-03-01
CN1110488C (zh) 2003-06-04
GR3035096T3 (en) 2001-03-30
CZ294963B6 (cs) 2005-04-13
UA52645C2 (uk) 2003-01-15
CZ297998A3 (cs) 1999-02-17
ID16778A (id) 1997-11-13
ES2125161B1 (es) 1999-11-16
AU713811B2 (en) 1999-12-09
ATE197294T1 (de) 2000-11-15
TW426674B (en) 2001-03-21
PL188722B1 (pl) 2005-04-29
RU2194043C2 (ru) 2002-12-10
PE42898A1 (es) 1998-08-12
NO311761B1 (no) 2002-01-21
JP2000506876A (ja) 2000-06-06
AU2289397A (en) 1997-10-10
NO984325L (no) 1998-11-23
HK1015371A1 (en) 1999-10-15
CN1218459A (zh) 1999-06-02
KR100496395B1 (ko) 2005-09-27
MX9701944A (es) 1998-06-30
IL126206A0 (en) 1999-05-09
UY24499A1 (es) 1997-04-02
JP3810091B2 (ja) 2006-08-16
NO984325D0 (no) 1998-09-17
IL126206A (en) 2001-06-14
EP0888316A1 (en) 1999-01-07
CO4780046A1 (es) 1999-05-26
NZ331901A (en) 1999-10-28
DK0888316T3 (da) 2000-11-27
WO1997034882A1 (en) 1997-09-25
PT888316E (pt) 2001-02-28
ES2151254T3 (es) 2000-12-16
CA2249420A1 (en) 1997-09-25
BR9708141A (pt) 1999-07-27

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