US20040018192A1 - Integrin expression inhibitors - Google Patents

Integrin expression inhibitors Download PDF

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Publication number
US20040018192A1
US20040018192A1 US10/181,562 US18156202A US2004018192A1 US 20040018192 A1 US20040018192 A1 US 20040018192A1 US 18156202 A US18156202 A US 18156202A US 2004018192 A1 US2004018192 A1 US 2004018192A1
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compound
ring
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US10/181,562
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English (en)
Inventor
Toshiaki Wakabayashi
Yasuhiro Funahashi
Naoko Hata
Taro Semba
Yuji Yamamoto
Toru Haneda
Takashi Owa
Akihiko Tsuruoka
Junichi Kamata
Tadashi Okabe
Keiko Takahashi
Kazumasa Nara
Shinichi Hamaoka
Norihiro Ueda
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Eisai Co Ltd
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Eisai Co Ltd
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Assigned to EISAI CO., LTD. reassignment EISAI CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FUNAHASHI, YASUHIRO, HATA, NAOKO, SEMBA, TARO, WAKABAYASHI, TOSHIAKI
Publication of US20040018192A1 publication Critical patent/US20040018192A1/en
Priority to US11/097,218 priority Critical patent/US7834049B2/en
Priority to US12/797,806 priority patent/US20100267754A1/en
Abandoned legal-status Critical Current

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
US10/181,562 2000-02-03 2001-02-01 Integrin expression inhibitors Abandoned US20040018192A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/097,218 US7834049B2 (en) 2000-02-03 2005-04-04 Integrin expression inhibitor
US12/797,806 US20100267754A1 (en) 2000-02-03 2010-06-10 Integrin expression inhibitor

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000-26080 2000-02-03
JP2000026080 2000-02-03
JP2000-402084 2000-12-28
JP2000402084 2000-12-28
PCT/JP2001/000713 WO2001056607A1 (fr) 2000-02-03 2001-02-01 Inhibiteurs de l'expression de l'integrine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/097,218 Continuation US7834049B2 (en) 2000-02-03 2005-04-04 Integrin expression inhibitor

Publications (1)

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US20040018192A1 true US20040018192A1 (en) 2004-01-29

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US10/181,562 Abandoned US20040018192A1 (en) 2000-02-03 2001-02-01 Integrin expression inhibitors
US11/097,218 Expired - Fee Related US7834049B2 (en) 2000-02-03 2005-04-04 Integrin expression inhibitor
US12/797,806 Abandoned US20100267754A1 (en) 2000-02-03 2010-06-10 Integrin expression inhibitor

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Application Number Title Priority Date Filing Date
US11/097,218 Expired - Fee Related US7834049B2 (en) 2000-02-03 2005-04-04 Integrin expression inhibitor
US12/797,806 Abandoned US20100267754A1 (en) 2000-02-03 2010-06-10 Integrin expression inhibitor

Country Status (16)

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US (3) US20040018192A1 (ko)
EP (1) EP1258252B1 (ko)
JP (1) JP4039856B2 (ko)
KR (1) KR100767000B1 (ko)
CN (1) CN100356979C (ko)
AT (1) ATE464892T1 (ko)
AU (1) AU781506B2 (ko)
CA (1) CA2399001C (ko)
DE (1) DE60141889D1 (ko)
ES (1) ES2341843T3 (ko)
HU (1) HUP0300544A3 (ko)
MX (1) MXPA02007249A (ko)
NO (1) NO329158B1 (ko)
NZ (1) NZ520299A (ko)
RU (1) RU2240826C2 (ko)
WO (1) WO2001056607A1 (ko)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026867A3 (en) * 2002-09-19 2004-08-05 Schering Corp Imidazopyridines as cyclin dependent kinase inhibitors
WO2005052122A2 (en) * 2003-11-22 2005-06-09 Sloan-Kettering Institute For Cancer Research METHODS FOR CONTROLLING PATHOLOGICAL ANGIOGENESIS BY INHIBITION OF α6β4 INTEGRIN
WO2005094391A2 (en) 2004-04-02 2005-10-13 The Regents Of The University Of California METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH αVβ5 INTEGRIN
US20070082941A1 (en) * 2003-09-10 2007-04-12 Eisai Co., Ltd. Crystalline sulfonamide-containing indole compound and process for preparing the same
US20090143353A1 (en) * 2005-08-17 2009-06-04 Daiichi Sankyo Company, Limited Antifungal bicyclic hetero ring compounds
WO2011011775A1 (en) 2009-07-24 2011-01-27 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with avb5 integrin
WO2016087593A1 (en) * 2014-12-05 2016-06-09 Syngenta Participations Ag Novel fungicidal quinolinylamidines
WO2018112215A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
WO2019246455A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
WO2020106704A2 (en) 2018-11-19 2020-05-28 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
WO2022173805A1 (en) * 2021-02-09 2022-08-18 Triana Biomedicines, Inc. Amide and ether substituted n-(1h-indol-7-yl)benzenesulfonamides and uses thereof
EP4252629A2 (en) 2016-12-07 2023-10-04 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000247949A (ja) 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
CA2395772C (en) 1999-12-28 2010-09-28 Eisai Co., Ltd. Sulfonamide-containing heterocyclic compounds
CN101025419A (zh) * 2001-02-21 2007-08-29 卫材R&D管理有限公司 测定通过抑制整联蛋白表达所介导的血管生成抑制剂的作用的方法
WO2002070478A1 (en) * 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
EP1430894A4 (en) * 2001-09-05 2007-12-12 Eisai R&D Man Co Ltd LYMPHOCYTE ACTIVATION INHIBITOR AND REMEDY FOR AUTOIMMUNE DISEASE
WO2003074045A1 (fr) * 2002-03-05 2003-09-12 Eisai Co., Ltd. Agent antitumoral comprenant une combinaison d'un compose heterocyclique contenant un sulfamide et d'un inhibiteur d'angiogenese
EP2402309A1 (en) 2002-05-24 2012-01-04 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
GB0215650D0 (en) * 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
NZ538595A (en) * 2002-09-19 2006-04-28 Schering Corp Pyrazolopyridines as cyclin dependent kinase (CDK) inhibitors useful in treating diseases such as cancer, leukemia, fibrosarcoma and glioma
US6939885B2 (en) 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
WO2005090297A1 (en) * 2004-03-19 2005-09-29 Biotie Therapies Corporation Sulphonamide derivatives
EP1873144B1 (en) * 2005-04-20 2014-07-23 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
CA2607670A1 (en) * 2005-05-10 2006-11-16 Vertex Pharmaceuticals Incorporated Bicyclic derivatives as modulators of ion channels
EP1910297B1 (en) 2005-07-11 2016-05-25 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
US20070135499A1 (en) * 2005-07-11 2007-06-14 Aerie Pharmaceuticals, Inc. Hydrazide compounds
FI20055498A0 (fi) * 2005-09-16 2005-09-16 Biotie Therapies Corp Sulfonamidijohdannaisia
FI20055496A0 (fi) * 2005-09-16 2005-09-16 Biotie Therapies Corp Kollageenireseptorien alfa-l-domeeniin sitoutuvat modulaattorit
WO2008036540A2 (en) 2006-09-20 2008-03-27 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US7943728B2 (en) * 2006-12-26 2011-05-17 National Cheng Kung University Disintegrin variants and their use in treating osteoporosis-induced bone loss and angiogenesis-related diseases
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8436038B2 (en) * 2007-08-17 2013-05-07 Lg Life Sciences Ltd. Indole and indazole compounds as an inhibitor of cellular necrosis
JP2011016723A (ja) * 2007-11-02 2011-01-27 Katayama Kagaku Kogyo Kk 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3354643B1 (en) 2009-05-01 2020-10-28 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
EP2487175A1 (en) 2009-10-06 2012-08-15 Kyowa Hakko Kirin Co., Ltd. Pharmaceutical product containing aromatic heterocyclic compound
TWI410408B (zh) * 2010-03-16 2013-10-01 Purzer Pharmaceutical Co Ltd 苯磺醯胺衍生物及其醫藥組合物
CN102199148A (zh) * 2010-03-25 2011-09-28 瑞安大药厂股份有限公司 苯磺酰胺衍生物及其医药组合物
FR2984316B1 (fr) * 2011-12-16 2017-08-11 Oreal Coupleur de structure 7-amino-indole, composition tinctoriale en comprenant, procedes et utilisations.
US9458147B2 (en) * 2012-02-22 2016-10-04 Sanford-Burnham Medical Research Institute Sulfonamide compounds and uses as TNAP inhibitors
US20140275160A1 (en) 2013-03-15 2014-09-18 Aerie Pharmaceuticals, Inc. Combination therapy
CN104163798A (zh) * 2014-07-29 2014-11-26 苏州康润医药有限公司 3-氨基-8-三氟甲基喹啉的合成方法
CN104098498A (zh) * 2014-07-30 2014-10-15 天津市斯芬克司药物研发有限公司 一种吲唑类化合物及其制备方法
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
WO2017086941A1 (en) 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
MX2019002396A (es) 2016-08-31 2019-07-08 Aerie Pharmaceuticals Inc Composiciones oftalmicas.
CA3057872A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CA3083228A1 (en) * 2017-12-14 2019-06-20 Dana-Farber Cancer Institute, Inc. Small molecule degraders that recruit dcaft15
SG11202004260YA (en) 2017-12-15 2020-06-29 Bayer Animal Health Gmbh Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives
WO2019147783A1 (en) 2018-01-25 2019-08-01 Dana-Farber Cancer Institute, Inc. Sulfonamide derivatives for protein degradation
WO2020056345A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CA3114240C (en) 2018-10-30 2023-09-05 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
BR112021007213A2 (pt) 2018-10-30 2021-08-10 Gilead Sciences, Inc. derivados de quinolina como inibidores de integrina alfa4beta7
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
AU2020329207B2 (en) 2019-08-14 2024-02-29 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
JP2024506322A (ja) * 2021-02-09 2024-02-13 セルジーン コーポレーション 蠕虫感染及び疾患の治療のためのスルホンアミド及びその使用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721246A (en) * 1993-09-10 1998-02-24 Eisai Co., Ltd. Heterobicyclic sulfonamide and sulfonic ester derivatives
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
US5773646A (en) * 1996-03-29 1998-06-30 G. D. Searle & Co. Meta-substituted phenylene derivatives
US5843906A (en) * 1996-03-29 1998-12-01 G. D. Searle & Co. Meta-substituted phenylene sulphonamide derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
KR0174752B1 (ko) 1993-09-10 1999-02-01 나이토 하루오 이환식 헤테로환 함유 술폰아미드 유도체 및 그 제조방법
US5574018A (en) 1994-07-29 1996-11-12 Amgen Inc. Conjugates of vitamin B12 and proteins
JP3690831B2 (ja) * 1995-02-27 2005-08-31 エーザイ株式会社 インドール含有スルホンアミド誘導体
ES2158537T3 (es) * 1996-03-29 2001-09-01 Searle & Co Derivados de acidos ciclopropilalcanoicos.
CA2250690A1 (en) * 1996-03-29 1997-10-09 G.D. Searle & Co. Cinnamic acid derivatives and their use as integrin antagonists
DE69710319T2 (de) * 1996-03-29 2002-08-14 Searle & Co Para-substituierte phenylpropansäure derivate als integrin-antagonisten
WO1998040077A1 (en) * 1997-03-11 1998-09-17 Allergan Sales, Inc. Anti-angiogenic agents
WO1998044797A1 (en) * 1997-04-07 1998-10-15 Merck & Co., Inc. A method of treating cancer
US6482849B1 (en) * 1997-06-23 2002-11-19 Tanabe Seiyaku Co., Ltd. Inhibitors of α4β1 mediated cell adhesion
US6197794B1 (en) * 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
EP1054871A2 (en) * 1998-04-01 2000-11-29 Du Pont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
SK15592000A3 (sk) * 1998-04-16 2001-12-03 Texas Biotechnology Corporation N,n-disubstituované amidy, ktoré inhibujú viazanie integrínov na ich receptory
GB9826174D0 (en) * 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
AU2713600A (en) * 1998-12-23 2000-07-31 G.D. Searle & Co. Use of a matrix metalloproteinase inhibitor and an integrin antagonist in the treatment of neoplasia
US6291503B1 (en) * 1999-01-15 2001-09-18 Bayer Aktiengesellschaft β-phenylalanine derivatives as integrin antagonists
JP2000247949A (ja) * 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721246A (en) * 1993-09-10 1998-02-24 Eisai Co., Ltd. Heterobicyclic sulfonamide and sulfonic ester derivatives
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
US5773646A (en) * 1996-03-29 1998-06-30 G. D. Searle & Co. Meta-substituted phenylene derivatives
US5843906A (en) * 1996-03-29 1998-12-01 G. D. Searle & Co. Meta-substituted phenylene sulphonamide derivatives

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026867A3 (en) * 2002-09-19 2004-08-05 Schering Corp Imidazopyridines as cyclin dependent kinase inhibitors
US6992080B2 (en) 2002-09-19 2006-01-31 Schering Corporation Imidazopyridines as cyclin dependent kinase inhibitors
US20060030555A1 (en) * 2002-09-19 2006-02-09 Schering Corporation Novel imidazopyridines as cyclin dependent kinase inhibitors
US7452902B2 (en) 2002-09-19 2008-11-18 Schering Corporation Imidazopyridines as cyclin dependent kinase inhibitors
US20090247768A1 (en) * 2003-09-10 2009-10-01 Keiko Takahashi Crystalline sulfonamide-containing indole compound and process for preparing the same
US20070082941A1 (en) * 2003-09-10 2007-04-12 Eisai Co., Ltd. Crystalline sulfonamide-containing indole compound and process for preparing the same
US7754894B2 (en) * 2003-09-10 2010-07-13 Eisai R&D Management Co., Ltd. Crystalline sulfonamide-containing indole compound and process for preparing the same
WO2005052122A2 (en) * 2003-11-22 2005-06-09 Sloan-Kettering Institute For Cancer Research METHODS FOR CONTROLLING PATHOLOGICAL ANGIOGENESIS BY INHIBITION OF α6β4 INTEGRIN
WO2005052122A3 (en) * 2003-11-22 2005-08-18 Sloan Kettering Inst Cancer METHODS FOR CONTROLLING PATHOLOGICAL ANGIOGENESIS BY INHIBITION OF α6β4 INTEGRIN
US20070104716A1 (en) * 2003-11-22 2007-05-10 Sloan-Kettering Institute For Cancer Research Methods for controlling pathological angiogenesis by inhibition of a6b4 integrin
US7815908B2 (en) 2004-04-02 2010-10-19 Regents Of The University Of California Methods and compositions for treating and preventing disease associated with αVβ5 integrin
EP2394662A2 (en) 2004-04-02 2011-12-14 The Regents of The University of California Methods and compositions for treating and preventing disease associated with AlphavBeta5 intergrin
WO2005094391A2 (en) 2004-04-02 2005-10-13 The Regents Of The University Of California METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH αVβ5 INTEGRIN
US20090280118A1 (en) * 2004-04-02 2009-11-12 The Regents Of The University Of California METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH alphaVbeta5 INTEGRIN
US7737166B2 (en) 2005-08-17 2010-06-15 Daiichi Sankyo Company, Limited Antifungal bicyclic hetero ring compounds
US20090143353A1 (en) * 2005-08-17 2009-06-04 Daiichi Sankyo Company, Limited Antifungal bicyclic hetero ring compounds
US10087252B2 (en) 2009-07-24 2018-10-02 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with αvβ5 integrin
WO2011011775A1 (en) 2009-07-24 2011-01-27 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with avb5 integrin
WO2016087593A1 (en) * 2014-12-05 2016-06-09 Syngenta Participations Ag Novel fungicidal quinolinylamidines
EP4252629A2 (en) 2016-12-07 2023-10-04 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018112215A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
EP4233902A2 (en) 2016-12-14 2023-08-30 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
WO2019246455A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
WO2020106757A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
WO2020106750A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
WO2020106754A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
WO2020106704A2 (en) 2018-11-19 2020-05-28 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
EP4309722A2 (en) 2019-12-13 2024-01-24 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
WO2022173805A1 (en) * 2021-02-09 2022-08-18 Triana Biomedicines, Inc. Amide and ether substituted n-(1h-indol-7-yl)benzenesulfonamides and uses thereof

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US7834049B2 (en) 2010-11-16

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