WO2001023349A1 - Derives d'acylsulfonamide - Google Patents

Derives d'acylsulfonamide Download PDF

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Publication number
WO2001023349A1
WO2001023349A1 PCT/JP2000/006695 JP0006695W WO0123349A1 WO 2001023349 A1 WO2001023349 A1 WO 2001023349A1 JP 0006695 W JP0006695 W JP 0006695W WO 0123349 A1 WO0123349 A1 WO 0123349A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
substituent
ring
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
PCT/JP2000/006695
Other languages
English (en)
Japanese (ja)
Inventor
Yukio Aoyama
Maki Seki
Hirokazu Masuda
Yoshihiro Usui
Yuji Abe
Mayumi Shimada
Mutsuya Yamamoto
Original Assignee
Mitsubishi Chemical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corporation filed Critical Mitsubishi Chemical Corporation
Priority to JP2001526504A priority Critical patent/JP4556371B2/ja
Priority to AU74475/00A priority patent/AU7447500A/en
Publication of WO2001023349A1 publication Critical patent/WO2001023349A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Abstract

L'invention concerne des dérivés d'acylsulfonamide des formules (I) et (II). Elle concerne également des inhibiteurs de la chymase et des médicaments thérapeutiques et/ou préventifs contre l'hypertension ou analogue contenant ces dérivés en tant que principe actif.
PCT/JP2000/006695 1999-09-30 2000-09-28 Derives d'acylsulfonamide WO2001023349A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2001526504A JP4556371B2 (ja) 1999-09-30 2000-09-28 アシルスルホンアミド誘導体
AU74475/00A AU7447500A (en) 1999-09-30 2000-09-28 Acylsulfonamide derivatives

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP27837999 1999-09-30
JP11/278378 1999-09-30
JP11/278375 1999-09-30
JP27837899 1999-09-30
JP27837499 1999-09-30
JP27837799 1999-09-30
JP11/278374 1999-09-30
JP27837599 1999-09-30
JP11/278377 1999-09-30
JP11/278379 1999-09-30

Publications (1)

Publication Number Publication Date
WO2001023349A1 true WO2001023349A1 (fr) 2001-04-05

Family

ID=27530656

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2000/006695 WO2001023349A1 (fr) 1999-09-30 2000-09-28 Derives d'acylsulfonamide

Country Status (3)

Country Link
JP (1) JP4556371B2 (fr)
AU (1) AU7447500A (fr)
WO (1) WO2001023349A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004113316A1 (fr) * 2003-05-20 2004-12-29 Genentech, Inc. Benzofuranes inhibiteurs du facteur viia
EP1426360A4 (fr) * 2001-09-12 2006-04-12 Kaken Pharma Co Ltd Derive d'acide 2-phenyle-3-heteroarylpropionique ou son sel et medicaments le contenant
US7482462B2 (en) 2001-10-05 2009-01-27 Amarylla Horvath Acylsulfonamides as inhibitors of steroid sulfatase
WO2016132483A1 (fr) * 2015-02-18 2016-08-25 学校法人福岡大学 Inhibiteur de chymase humaine et médicament pour prévenir et traiter une maladie associée à une activité de chymase humaine
JP2020537657A (ja) * 2017-10-17 2020-12-24 ノバルティス インフラマソーム リサーチ，インコーポレイテッド Ｎｌｒｐ活性に関連する病態を治療するためのスルホンアミド及びその組成物
US11518757B2 (en) 2017-12-18 2022-12-06 NodThera Limited Sulphonyl urea derivatives as NLRP3 inflammasome modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0513533A2 (fr) * 1991-04-26 1992-11-19 Bayer Ag Dérivés substitués hétérocycliques de l'acide phenyl acétique, procédé pour leur fabrication et leur application comme médicaments
WO1995003295A1 (fr) * 1993-07-20 1995-02-02 Merck & Co., Inc. Antagonistes de l'endotheline
WO2000041531A2 (fr) * 1999-01-13 2000-07-20 Genentech, Inc. Inhibiteurs de la serine protease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389682A (en) * 1992-09-18 1995-02-14 Warner-Lambert Company Agents acting at cholecystokinin receptors
CN1188401C (zh) * 1995-04-27 2005-02-09 三菱制药株式会社 杂环类酰胺化合物及其医药用途
US5814631A (en) * 1995-09-28 1998-09-29 Suntory Limited Quinazoline derivatives and applications thereof
JPH1087567A (ja) * 1996-06-05 1998-04-07 Takeda Chem Ind Ltd フェノールエステル誘導体、その製造法及び用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0513533A2 (fr) * 1991-04-26 1992-11-19 Bayer Ag Dérivés substitués hétérocycliques de l'acide phenyl acétique, procédé pour leur fabrication et leur application comme médicaments
WO1995003295A1 (fr) * 1993-07-20 1995-02-02 Merck & Co., Inc. Antagonistes de l'endotheline
WO2000041531A2 (fr) * 1999-01-13 2000-07-20 Genentech, Inc. Inhibiteurs de la serine protease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DONKOR ISAAC ET AL.: "Synthesis and biological activities of aldose reductase inhibitors bearing acyl benzenesulfonamides as carboxylic acid surrogates", EUR. J. MED. CHEM., vol. 33, no. 1, 1998, pages 15 - 22, XP002935498 *
PORTEVIN BERNARD ET AL.: "Dual inhibition of human leukocyte elastase and lipid peroxidation", J. MED. CHEM., vol. 40, no. 12, 1997, pages 1906 - 1918, XP002935499 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1426360A4 (fr) * 2001-09-12 2006-04-12 Kaken Pharma Co Ltd Derive d'acide 2-phenyle-3-heteroarylpropionique ou son sel et medicaments le contenant
US7482462B2 (en) 2001-10-05 2009-01-27 Amarylla Horvath Acylsulfonamides as inhibitors of steroid sulfatase
WO2004113316A1 (fr) * 2003-05-20 2004-12-29 Genentech, Inc. Benzofuranes inhibiteurs du facteur viia
US7273886B2 (en) 2003-05-20 2007-09-25 Genentech, Inc. Benzofuran inhibitors of factor VIIa
WO2016132483A1 (fr) * 2015-02-18 2016-08-25 学校法人福岡大学 Inhibiteur de chymase humaine et médicament pour prévenir et traiter une maladie associée à une activité de chymase humaine
JP2020537657A (ja) * 2017-10-17 2020-12-24 ノバルティス インフラマソーム リサーチ，インコーポレイテッド Ｎｌｒｐ活性に関連する病態を治療するためのスルホンアミド及びその組成物
JP7157804B2 (ja) 2017-10-17 2022-10-20 ノバルティス アーゲー Ｎｌｒｐ活性に関連する病態を治療するためのスルホンアミド及びその組成物
US11718631B2 (en) 2017-10-17 2023-08-08 Novartis Ag Sulphonamides and compositions thereof for treating conditions associated with NLRP activity
US11518757B2 (en) 2017-12-18 2022-12-06 NodThera Limited Sulphonyl urea derivatives as NLRP3 inflammasome modulators

Also Published As

Publication number Publication date
JP4556371B2 (ja) 2010-10-06
AU7447500A (en) 2001-04-30

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