UA76969C2 - Lactams and their pharmaceutical use - Google Patents

Lactams and their pharmaceutical use Download PDF

Info

Publication number
UA76969C2
UA76969C2 UA2003055026A UA2003055026A UA76969C2 UA 76969 C2 UA76969 C2 UA 76969C2 UA 2003055026 A UA2003055026 A UA 2003055026A UA 2003055026 A UA2003055026 A UA 2003055026A UA 76969 C2 UA76969 C2 UA 76969C2
Authority
UA
Ukraine
Prior art keywords
substituent
group
acyl
alkyl
carbamoyl
Prior art date
Application number
UA2003055026A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of UA76969C2 publication Critical patent/UA76969C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
UA2003055026A 2000-12-01 2001-11-29 Lactams and their pharmaceutical use UA76969C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000367175 2000-12-01
PCT/JP2001/010435 WO2002044180A1 (fr) 2000-12-01 2001-11-29 Composes de lactame et leur utilisation medicale

Publications (1)

Publication Number Publication Date
UA76969C2 true UA76969C2 (en) 2006-10-16

Family

ID=18837660

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2003055026A UA76969C2 (en) 2000-12-01 2001-11-29 Lactams and their pharmaceutical use

Country Status (26)

Country Link
US (3) US7153850B2 (ko)
EP (1) EP1346993B1 (ko)
JP (2) JP3826400B2 (ko)
KR (1) KR100826818B1 (ko)
CN (2) CN1269818C (ko)
AT (1) ATE446297T1 (ko)
AU (3) AU2002218502B2 (ko)
BG (1) BG107857A (ko)
BR (1) BR0115852A (ko)
CA (1) CA2430124C (ko)
CZ (1) CZ20031520A3 (ko)
DE (1) DE60140270D1 (ko)
ES (1) ES2331299T3 (ko)
HU (1) HUP0400806A3 (ko)
IL (1) IL156158A0 (ko)
MX (1) MXPA03004876A (ko)
NO (1) NO325401B1 (ko)
NZ (1) NZ526164A (ko)
PL (1) PL362835A1 (ko)
RU (1) RU2287530C2 (ko)
SK (1) SK6582003A3 (ko)
TW (1) TWI241302B (ko)
UA (1) UA76969C2 (ko)
WO (1) WO2002044180A1 (ko)
YU (1) YU42603A (ko)
ZA (1) ZA200304100B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA76969C2 (en) 2000-12-01 2006-10-16 Ajinomoto Kk Lactams and their pharmaceutical use
JPWO2004069259A1 (ja) 2003-02-07 2006-05-25 味の素株式会社 糖尿病治療剤
JP4711228B2 (ja) 2003-10-31 2011-06-29 味の素株式会社 複素環を有する新規縮合多環式化合物及びその医薬用途
CA2553329A1 (en) * 2004-01-14 2005-07-28 Ajinomoto Co., Inc. New fused polycyclic compounds
ZA200709235B (en) * 2005-04-28 2009-09-30 Ajinomoto Kk Novel lactam compound
WO2008126920A1 (ja) * 2007-04-11 2008-10-23 Ajinomoto Co., Inc. 糖尿病治療薬
WO2008136394A1 (ja) * 2007-04-27 2008-11-13 Ajinomoto Co., Inc. ラクタム化合物の製造方法及びその製造中間体
WO2008139575A1 (ja) * 2007-04-27 2008-11-20 Ajinomoto Co., Inc. 経口投与用製剤
WO2008139574A1 (ja) * 2007-04-27 2008-11-20 Ajinomoto Co., Inc. ラクタム化合物の結晶形およびその製造方法
CN101619041B (zh) * 2008-07-02 2012-07-04 重庆华邦制药股份有限公司 一种二酮基含氮环化合物的合成方法及其中间体
JP2012180282A (ja) * 2009-07-02 2012-09-20 Ajinomoto Co Inc ラクタム化合物の製造方法およびその製造中間体
JP2012180283A (ja) * 2009-07-02 2012-09-20 Ajinomoto Co Inc ラクタム化合物の製造方法およびその製造中間体
US20170369494A1 (en) * 2014-12-22 2017-12-28 Ea Pharma Co., Ltd. Drug for treating disorders of corneal epithelium
US11548893B2 (en) 2017-07-15 2023-01-10 Arisan Therapeutics Inc. Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection
SG11202107678UA (en) * 2019-01-23 2021-08-30 Glycolysis Biomed Co Ltd Beta-lactam compounds or salts thereof for use in long-acting prevention or treatment of a glucose metabolism disorder

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US189597A (en) * 1877-04-17 Improvement in portable wash-stands
US48847A (en) * 1865-07-18 Improvement in vessels for reception and transportation of night-soil
HUP0003394A3 (en) 1997-07-30 2003-04-28 Wyeth Corp Pyrido[2,3-b][1,5]benzodiazepine derivatives, their use, process for their preparation and pharmaceutical compositions containing them
JP4204657B2 (ja) 1997-12-05 2009-01-07 有限会社ケムフィズ 糖尿病の予防・治療剤
UA76969C2 (en) 2000-12-01 2006-10-16 Ajinomoto Kk Lactams and their pharmaceutical use
JPWO2004069259A1 (ja) * 2003-02-07 2006-05-25 味の素株式会社 糖尿病治療剤

Also Published As

Publication number Publication date
US20040048847A1 (en) 2004-03-11
AU2006241377B2 (en) 2009-01-08
CN1911915A (zh) 2007-02-14
US20060189597A1 (en) 2006-08-24
EP1346993A1 (en) 2003-09-24
ES2331299T3 (es) 2009-12-29
MXPA03004876A (es) 2004-01-27
TWI241302B (en) 2005-10-11
HUP0400806A3 (en) 2007-11-28
JP4505753B2 (ja) 2010-07-21
RU2287530C2 (ru) 2006-11-20
CN1487940A (zh) 2004-04-07
CN100577651C (zh) 2010-01-06
YU42603A (sh) 2006-03-03
US7326701B2 (en) 2008-02-05
JP2006213732A (ja) 2006-08-17
NZ526164A (en) 2004-09-24
BR0115852A (pt) 2003-12-23
CA2430124C (en) 2011-01-11
DE60140270D1 (de) 2009-12-03
US20080096862A1 (en) 2008-04-24
CZ20031520A3 (cs) 2003-10-15
WO2002044180A1 (fr) 2002-06-06
US7153850B2 (en) 2006-12-26
NO325401B1 (no) 2008-04-21
AU2002218502B2 (en) 2006-09-21
CA2430124A1 (en) 2002-06-06
US7632830B2 (en) 2009-12-15
EP1346993A4 (en) 2005-12-21
EP1346993B1 (en) 2009-10-21
AU2006241377A1 (en) 2006-12-14
SK6582003A3 (en) 2003-09-11
KR100826818B1 (ko) 2008-05-02
ATE446297T1 (de) 2009-11-15
BG107857A (bg) 2004-06-30
JPWO2002044180A1 (ja) 2004-04-02
CN1269818C (zh) 2006-08-16
AU1850202A (en) 2002-06-11
ZA200304100B (en) 2004-08-22
NO20032439L (no) 2003-07-18
KR20030051893A (ko) 2003-06-25
JP3826400B2 (ja) 2006-09-27
HUP0400806A2 (hu) 2004-07-28
PL362835A1 (en) 2004-11-02
IL156158A0 (en) 2003-12-23
NO20032439D0 (no) 2003-05-28

Similar Documents

Publication Publication Date Title
UA76969C2 (en) Lactams and their pharmaceutical use
EP3307262B1 (en) Compounds for use in treating neuromuscular disorders
EP3517538A1 (en) Pyrazolopyridine derivative having glp-1 receptor agonist effect
TW215055B (ko)
CN103702561B (zh) 阿片样物质受体配体以及使用和制备其的方法
KR20220082092A (ko) 화합물
UA124026C2 (uk) Фенільні похідні
UA75660C2 (en) Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (mtp) and/or apolipoprotein b (apo b) secretion
UA76977C2 (en) Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
KR20030016376A (ko) 남성 성기능 장애의 치료
EP3150592B1 (en) Alk kinase inhibitor, and preparation method and use thereof
UA80162C2 (en) Novel alkyne compounds having an mch antagonistic effect and medicaments containing these compounds
KR20120087878A (ko) 1,3-프로판디설포닉 애시드의 수송을 위한 방법, 화합물 및 조성물
WO2012118562A1 (en) Compositions and methods for treating depression, adhd and other central nervous system disorders employing novel bupropion compounds, and methods for production and use of novel bupropion compounds and formulations
TW201231052A (en) 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
TW200938200A (en) Methyl-substituted piperidine derivative
JPH02503794A (ja) アルツハイマー病の治療のための化合物
CN116120314A (zh) 用于调节毛发生长的组合物和方法
WO2020007322A1 (zh) 一种靶向降解bet蛋白的化合物及其应用
RU2233278C2 (ru) Пиримидиновые соединения, способ их получения и фармацевтическая композиция
ES2882175T3 (es) Compuestos para su uso en el tratamiento de la hipertensión pulmonar
CN109071577A (zh) 甲状腺激素受体激动剂及其用途
JP5204484B2 (ja) リドカインから誘導される化合物、薬学的組成物、使用法、および疾患の治療、予防または抑制の方法
SA95160293B1 (ar) مشتقات حمض اميني حلقي cyclic amiono acid لها نشاط تثبيط انزيم ACE وNEP
TW200940543A (en) Maleate, besylate and L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine