UA73719C2 - Human interleukin-2 mutant which activates preferably t-cells as compared with natural killer cells, pharmaceutical composition, polynucleotide, vector, procariotic cell, a method for the stimulation of immune system - Google Patents
Human interleukin-2 mutant which activates preferably t-cells as compared with natural killer cells, pharmaceutical composition, polynucleotide, vector, procariotic cell, a method for the stimulation of immune system Download PDFInfo
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- UA73719C2 UA73719C2 UA2000127206A UA2000127206A UA73719C2 UA 73719 C2 UA73719 C2 UA 73719C2 UA 2000127206 A UA2000127206 A UA 2000127206A UA 2000127206 A UA2000127206 A UA 2000127206A UA 73719 C2 UA73719 C2 UA 73719C2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
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US8008098A | 1998-05-15 | 1998-05-15 | |
PCT/US1999/010643 WO1999060128A1 (en) | 1998-05-15 | 1999-05-13 | Il-2 selective agonists and antagonists |
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UA73719C2 true UA73719C2 (en) | 2005-09-15 |
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UA2000127206A UA73719C2 (en) | 1998-05-15 | 1999-05-13 | Human interleukin-2 mutant which activates preferably t-cells as compared with natural killer cells, pharmaceutical composition, polynucleotide, vector, procariotic cell, a method for the stimulation of immune system |
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EP (1) | EP1076704B1 (sl) |
JP (1) | JP4276783B2 (sl) |
KR (1) | KR100607609B1 (sl) |
CN (2) | CN101319247B (sl) |
AR (1) | AR020322A1 (sl) |
AT (1) | ATE351907T1 (sl) |
AU (1) | AU759697B2 (sl) |
BG (1) | BG65139B1 (sl) |
BR (1) | BRPI9910504B1 (sl) |
CA (1) | CA2327349C (sl) |
CO (1) | CO5070701A1 (sl) |
CU (2) | CU23273B7 (sl) |
CY (1) | CY1107533T1 (sl) |
CZ (1) | CZ302071B6 (sl) |
DE (1) | DE69934881T2 (sl) |
DK (1) | DK1076704T3 (sl) |
DZ (1) | DZ2788A1 (sl) |
ES (1) | ES2281175T3 (sl) |
HK (1) | HK1039963B (sl) |
HN (1) | HN1999000075A (sl) |
HU (1) | HU226142B1 (sl) |
IL (2) | IL139136A0 (sl) |
MY (1) | MY130274A (sl) |
NO (1) | NO329235B1 (sl) |
NZ (1) | NZ508098A (sl) |
PA (1) | PA8472601A1 (sl) |
PE (1) | PE20000475A1 (sl) |
PL (1) | PL201675B1 (sl) |
PT (1) | PT1076704E (sl) |
RO (1) | RO122150B1 (sl) |
RU (1) | RU2235729C2 (sl) |
SI (1) | SI20643B (sl) |
SK (1) | SK288100B6 (sl) |
SV (1) | SV1999000061A (sl) |
TN (1) | TNSN99090A1 (sl) |
TR (1) | TR200003354T2 (sl) |
TW (1) | TWI223663B (sl) |
UA (1) | UA73719C2 (sl) |
WO (1) | WO1999060128A1 (sl) |
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US7723102B2 (en) * | 2000-09-28 | 2010-05-25 | Bayer Corporation | Enhanced transfection system |
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EP2354791A1 (en) * | 2001-12-04 | 2011-08-10 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
ES2359473T3 (es) | 2003-07-21 | 2011-05-23 | Transgene S.A. | Citoquinas multifuncionales. |
EP2248830A1 (en) | 2003-11-04 | 2010-11-10 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
US7858081B2 (en) * | 2004-02-27 | 2010-12-28 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | IL-15 mutants having agonists/antagonists activity |
AU2005227263A1 (en) * | 2004-03-05 | 2005-10-06 | Novartis Vaccines And Diagnostics, Inc. | In vitro test system for predicting patient tolerability of therapeutic agents |
US8906356B2 (en) | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
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DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
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CN102101885B (zh) * | 2010-09-01 | 2013-06-05 | 南京发士达生物科技有限公司 | 低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途 |
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WO2012119093A1 (en) * | 2011-03-03 | 2012-09-07 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
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