UA73501C2 - b-ARYL-a-OXYSUBSTITUTED ALKYLCARBOXYLIC ACIDS, A METHOD FOR THE PREPARATION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION BASED THEREON (VARIANTS), METHODS FOR PREVENTION AND TREATMENT WITH USE THEREOF, INTERMEDIARY COMPOUNDS AND A METHOD FOR THE PREPARATION THEREOF (VARIANTS) - Google Patents
b-ARYL-a-OXYSUBSTITUTED ALKYLCARBOXYLIC ACIDS, A METHOD FOR THE PREPARATION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION BASED THEREON (VARIANTS), METHODS FOR PREVENTION AND TREATMENT WITH USE THEREOF, INTERMEDIARY COMPOUNDS AND A METHOD FOR THE PREPARATION THEREOF (VARIANTS) Download PDFInfo
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- UA73501C2 UA73501C2 UA2001118039A UA2001118039A UA73501C2 UA 73501 C2 UA73501 C2 UA 73501C2 UA 2001118039 A UA2001118039 A UA 2001118039A UA 2001118039 A UA2001118039 A UA 2001118039A UA 73501 C2 UA73501 C2 UA 73501C2
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- UA
- Ukraine
- Prior art keywords
- dihydro
- ethoxy
- phenyl
- acid
- benzoxazin
- Prior art date
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- 235000021588 free fatty acids Nutrition 0.000 claims 3
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
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- 102100022022 Protein adenylyltransferase SelO, mitochondrial Human genes 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
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- QCZKLKFGDITLCF-UHFFFAOYSA-N 2-ethoxyprop-2-enoic acid Chemical compound CCOC(=C)C(O)=O QCZKLKFGDITLCF-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241001331845 Equus asinus x caballus Species 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 241000755093 Gaidropsarus vulgaris Species 0.000 claims 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 1
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- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
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- 125000004429 atom Chemical group 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000003038 endothelium Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 210000004894 snout Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN484MA1999 | 1999-04-28 | ||
| PCT/IB2000/000501 WO2000066572A1 (en) | 1999-04-28 | 2000-04-25 | Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73501C2 true UA73501C2 (en) | 2005-08-15 |
Family
ID=11095336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001118039A UA73501C2 (en) | 1999-04-28 | 2000-04-25 | b-ARYL-a-OXYSUBSTITUTED ALKYLCARBOXYLIC ACIDS, A METHOD FOR THE PREPARATION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION BASED THEREON (VARIANTS), METHODS FOR PREVENTION AND TREATMENT WITH USE THEREOF, INTERMEDIARY COMPOUNDS AND A METHOD FOR THE PREPARATION THEREOF (VARIANTS) |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7348426B1 (no) |
| EP (1) | EP1175412A1 (no) |
| JP (1) | JP2002543194A (no) |
| KR (1) | KR100610578B1 (no) |
| CN (1) | CN1353699A (no) |
| AU (1) | AU781079B2 (no) |
| BG (1) | BG106146A (no) |
| BR (1) | BR0010139A (no) |
| CA (1) | CA2371757A1 (no) |
| CZ (1) | CZ20013832A3 (no) |
| EE (1) | EE200100540A (no) |
| HR (1) | HRP20010785A2 (no) |
| HU (1) | HUP0600105A3 (no) |
| IL (1) | IL146104A0 (no) |
| MX (1) | MXPA01010916A (no) |
| NO (1) | NO320805B1 (no) |
| NZ (1) | NZ515284A (no) |
| PL (1) | PL351987A1 (no) |
| RU (1) | RU2278114C2 (no) |
| SK (1) | SK15092001A3 (no) |
| TR (1) | TR200103848T2 (no) |
| UA (1) | UA73501C2 (no) |
| WO (1) | WO2000066572A1 (no) |
| YU (1) | YU75101A (no) |
| ZA (1) | ZA200108733B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002030914A1 (en) * | 2000-10-12 | 2002-04-18 | Dr. Reddy's Research Foundation | Salts of benzothiazine and benzoxazine derivatives and pharmaceutical compositions containing them |
| CA2458621A1 (en) * | 2001-08-29 | 2003-03-06 | Warner-Lambert Company Llc | Oral antidiabetic agents |
| WO2003024944A1 (en) * | 2001-09-20 | 2003-03-27 | Dr. Reddy's Laboratories Ltd. | An improved process for the preparation of bicyclic antidiabetic compounds |
| WO2003027084A1 (en) * | 2001-09-25 | 2003-04-03 | Dr. Reddy's Laboratories Ltd. | Improved process for the preparation of optically active phenoxazine derivatives as antidiabetic agents |
| WO2003033456A1 (en) * | 2001-10-16 | 2003-04-24 | Dr. Reddy's Laboratories Ltd. | NOVEL β-PHENYL-α-OXYSUBSTITUTED PROPIONIC DERIVATIVES: PROCESS FOR ITS PREPARATION AND THEIR USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COMPOUNDS |
| AU2003244514A1 (en) * | 2002-02-07 | 2003-09-02 | Dr. Reddy's Laboratories Limited | Novel polymorphic forms of bicyclic antidiabetic agents: process for their preparation and pharmaceutical compositions containing them |
| US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
| AU2003232472B2 (en) | 2002-04-30 | 2008-09-18 | Ucb Pharma | 2,6-quinolinyl and 2,6-naphthyl derivatives, processes for preparing them and their uses as VLA-4 inhibitors |
| WO2003099800A1 (en) * | 2002-05-23 | 2003-12-04 | Dr. Reddy's Laboratories Limited | An improved process for the preparation of bicyclic antidiabetic agents |
| ATE377419T1 (de) | 2002-11-08 | 2007-11-15 | Hoffmann La Roche | Substituierte 4-alkoxyoxazol derivate als ppar agonisten |
| US7262303B2 (en) * | 2003-09-29 | 2007-08-28 | Hoffman-La Roche Inc. | Process for the production of chiral propionic acid derivatives |
| DE202004002953U1 (de) * | 2004-02-26 | 2004-04-29 | Winkler, Wilhelm | Verbindungseinheit |
| US7579360B2 (en) | 2005-06-09 | 2009-08-25 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| AU2006254772B2 (en) | 2005-06-09 | 2011-06-02 | Ucb Pharma S.A. | 2,6 quinolinyl derivatives, processes for preparing them and their use as medicament |
| US7572807B2 (en) | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
| US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| RU2684779C2 (ru) * | 2016-02-05 | 2019-04-15 | АО "Институт химических наук им. А.Б. Бектурова" | Применение производного бета-морфолинопропиоамидоксима в качестве противодиабетического средства |
| CN110092774B (zh) * | 2018-01-29 | 2022-04-08 | 中国科学院上海药物研究所 | 芳香丙酸类衍生物、及其制备方法和用途 |
Family Cites Families (13)
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|---|---|---|---|---|
| DK173350B1 (da) * | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
| GB9027023D0 (en) * | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
| GB9225386D0 (en) | 1992-12-04 | 1993-01-27 | Smithkline Beecham Plc | Novel compounds |
| BR9508468A (pt) | 1994-07-29 | 1997-11-25 | Smithkline Beecham Plc | Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário |
| JPH0912575A (ja) * | 1995-06-28 | 1997-01-14 | Sankyo Co Ltd | ベンゾオキサジンおよびベンゾチアジン誘導体 |
| GB9600464D0 (en) | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| WO1997028149A1 (en) * | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| GB9606805D0 (en) * | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| WO1998002159A1 (en) | 1996-07-12 | 1998-01-22 | Smithkline Beecham Plc | Novel treatment of leptine resistance |
| AU752059B2 (en) * | 1997-10-27 | 2002-09-05 | Dr. Reddy's Laboratories Limited | Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| US6265401B1 (en) * | 1997-10-27 | 2001-07-24 | Reddy-Cheminor, Inc. | Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
| EP1082313A1 (en) * | 1998-05-27 | 2001-03-14 | Dr. Reddy's Research Foundation | Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
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- 2000-04-25 HU HU0600105A patent/HUP0600105A3/hu unknown
- 2000-04-25 CA CA002371757A patent/CA2371757A1/en not_active Abandoned
- 2000-04-25 EP EP00919081A patent/EP1175412A1/en not_active Withdrawn
- 2000-04-25 CZ CZ20013832A patent/CZ20013832A3/cs unknown
- 2000-04-25 IL IL14610400A patent/IL146104A0/xx unknown
- 2000-04-25 MX MXPA01010916A patent/MXPA01010916A/es active IP Right Grant
- 2000-04-25 KR KR1020017013604A patent/KR100610578B1/ko not_active IP Right Cessation
- 2000-04-25 YU YU75101A patent/YU75101A/sh unknown
- 2000-04-25 TR TR2001/03848T patent/TR200103848T2/xx unknown
- 2000-04-25 UA UA2001118039A patent/UA73501C2/uk unknown
- 2000-04-25 CN CN00808424A patent/CN1353699A/zh active Pending
- 2000-04-25 RU RU2001132085/04A patent/RU2278114C2/ru not_active IP Right Cessation
- 2000-04-25 BR BR0010139-7A patent/BR0010139A/pt not_active IP Right Cessation
- 2000-04-25 US US09/959,093 patent/US7348426B1/en not_active Expired - Fee Related
-
2001
- 2001-10-23 ZA ZA200108733A patent/ZA200108733B/en unknown
- 2001-10-24 HR HR20010785A patent/HRP20010785A2/hr not_active Application Discontinuation
- 2001-10-26 NO NO20015259A patent/NO320805B1/no unknown
- 2001-11-26 BG BG106146A patent/BG106146A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU75101A (sh) | 2005-07-19 |
| BG106146A (bg) | 2002-05-31 |
| US7348426B1 (en) | 2008-03-25 |
| AU781079B2 (en) | 2005-05-05 |
| NO320805B1 (no) | 2006-01-30 |
| JP2002543194A (ja) | 2002-12-17 |
| NO20015259L (no) | 2001-11-15 |
| NZ515284A (en) | 2004-12-24 |
| NO20015259D0 (no) | 2001-10-26 |
| CN1353699A (zh) | 2002-06-12 |
| SK15092001A3 (sk) | 2002-05-09 |
| IL146104A0 (en) | 2002-07-25 |
| ZA200108733B (en) | 2003-01-23 |
| KR20010113891A (ko) | 2001-12-28 |
| HRP20010785A2 (en) | 2003-02-28 |
| KR100610578B1 (ko) | 2006-08-09 |
| CA2371757A1 (en) | 2000-11-09 |
| CZ20013832A3 (cs) | 2002-04-17 |
| RU2278114C2 (ru) | 2006-06-20 |
| HUP0600105A2 (en) | 2006-05-29 |
| EP1175412A1 (en) | 2002-01-30 |
| TR200103848T2 (tr) | 2002-04-22 |
| AU3983100A (en) | 2000-11-17 |
| BR0010139A (pt) | 2004-03-02 |
| MXPA01010916A (es) | 2002-06-21 |
| WO2000066572A1 (en) | 2000-11-09 |
| HUP0600105A3 (en) | 2006-11-28 |
| EE200100540A (et) | 2002-12-16 |
| PL351987A1 (en) | 2003-07-14 |
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