TR200103848T2 - İkame edilmiş bisiklik heterosikller, bunların hazırlanması için işlem ve antiobesite için ve hipokolesterolemik maddeler olarak kullanımları. - Google Patents

İkame edilmiş bisiklik heterosikller, bunların hazırlanması için işlem ve antiobesite için ve hipokolesterolemik maddeler olarak kullanımları.

Info

Publication number
TR200103848T2
TR200103848T2 TR2001/03848T TR200103848T TR200103848T2 TR 200103848 T2 TR200103848 T2 TR 200103848T2 TR 2001/03848 T TR2001/03848 T TR 2001/03848T TR 200103848 T TR200103848 T TR 200103848T TR 200103848 T2 TR200103848 T2 TR 200103848T2
Authority
TR
Turkey
Prior art keywords
pharmaceutically acceptable
antiobesity
preparation
substituted bicyclic
bicyclic heterocycles
Prior art date
Application number
TR2001/03848T
Other languages
English (en)
Inventor
Bhushan Lohray Braj
Bhushan Lohray Vidya
Bajji Ashok Channaveerappa
Kalchar Shivaramayya
Madhavan Gurram Ranga
Rajagopalan Ramanujam
Ranjan Chakrabarti
Original Assignee
Dr. Reddy's Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Research Foundation filed Critical Dr. Reddy's Research Foundation
Publication of TR200103848T2 publication Critical patent/TR200103848T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Bu bulus, yeni antiobesite için ve hipokolesterolemik bilesiklere, bunlarin türevleri, analoglari, totomerik biçimleri, stereoizomerleri, polimorflari, farmasötik açidan kabul edilebilir tuzlari, farmasötik açidan kabul edilebilir solvatlari ve bunlari ihtiva eden farmasötik açidan kabul edilebilir bilesimlere iliskindir. Daha özel olarak ise, bu bulus, (I) genel formülünün yeni beta-aril-alfa-oksi-ikameli alkilkarboksilik asitleri, bunlarin türevleri, analoglari, totomerik biçimleri, stereoizomerleri, polimorflari, farmasötik açidan kabul edilebilir tuzlari, farmasötik açidan kabul edilebilir solvatlari ve bunlari ihtiva eden farmasötik açidan kabul edilebilir bilesimlere iliskindir.
TR2001/03848T 1999-04-28 2000-04-25 İkame edilmiş bisiklik heterosikller, bunların hazırlanması için işlem ve antiobesite için ve hipokolesterolemik maddeler olarak kullanımları. TR200103848T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN484MA1999 1999-04-28

Publications (1)

Publication Number Publication Date
TR200103848T2 true TR200103848T2 (tr) 2002-04-22

Family

ID=11095336

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03848T TR200103848T2 (tr) 1999-04-28 2000-04-25 İkame edilmiş bisiklik heterosikller, bunların hazırlanması için işlem ve antiobesite için ve hipokolesterolemik maddeler olarak kullanımları.

Country Status (25)

Country Link
US (1) US7348426B1 (tr)
EP (1) EP1175412A1 (tr)
JP (1) JP2002543194A (tr)
KR (1) KR100610578B1 (tr)
CN (1) CN1353699A (tr)
AU (1) AU781079B2 (tr)
BG (1) BG106146A (tr)
BR (1) BR0010139A (tr)
CA (1) CA2371757A1 (tr)
CZ (1) CZ20013832A3 (tr)
EE (1) EE200100540A (tr)
HR (1) HRP20010785A2 (tr)
HU (1) HUP0600105A3 (tr)
IL (1) IL146104A0 (tr)
MX (1) MXPA01010916A (tr)
NO (1) NO320805B1 (tr)
NZ (1) NZ515284A (tr)
PL (1) PL351987A1 (tr)
RU (1) RU2278114C2 (tr)
SK (1) SK15092001A3 (tr)
TR (1) TR200103848T2 (tr)
UA (1) UA73501C2 (tr)
WO (1) WO2000066572A1 (tr)
YU (1) YU75101A (tr)
ZA (1) ZA200108733B (tr)

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AU2002212672A1 (en) * 2000-10-12 2002-04-22 Dr. Reddy's Research Foundation Salts of benzothiazine and benzoxazine derivatives and pharmaceutical compositions containing them
WO2003018553A1 (en) * 2001-08-29 2003-03-06 Warner-Lambert Company Llc Oral antidiabetic agents
WO2003024944A1 (en) * 2001-09-20 2003-03-27 Dr. Reddy's Laboratories Ltd. An improved process for the preparation of bicyclic antidiabetic compounds
WO2003027084A1 (en) * 2001-09-25 2003-04-03 Dr. Reddy's Laboratories Ltd. Improved process for the preparation of optically active phenoxazine derivatives as antidiabetic agents
CN1589258A (zh) * 2001-10-16 2005-03-02 雷迪实验室有限公司 新的β－苯基－α－氧取代的丙酸衍生物,它的制备方法和它们制备药学上重要的化合物的应用
AU2003244514A1 (en) * 2002-02-07 2003-09-02 Dr. Reddy's Laboratories Limited Novel polymorphic forms of bicyclic antidiabetic agents: process for their preparation and pharmaceutical compositions containing them
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
KR100841165B1 (ko) * 2002-04-30 2008-06-24 유씨비 파마, 에스.에이. 2,6-퀴놀리닐 및 2,6-나프틸 유도체, 이의 제조 방법 및ｖｌａ-4 억제제로서의 용도
WO2003099800A1 (en) * 2002-05-23 2003-12-04 Dr. Reddy's Laboratories Limited An improved process for the preparation of bicyclic antidiabetic agents
AU2003276234B2 (en) * 2002-11-08 2007-04-19 F. Hoffmann-La Roche Ag Substituted 4-alkoxyoxazol derivatives as PPAR agonists
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DE202004002953U1 (de) * 2004-02-26 2004-04-29 Winkler, Wilhelm Verbindungseinheit
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
US7579360B2 (en) 2005-06-09 2009-08-25 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
NZ563739A (en) 2005-06-09 2009-12-24 Ucb Pharma Sa 2,6 Quinolinyl derivatives, processes for preparing them and their use as medicament
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
RU2684779C2 (ru) * 2016-02-05 2019-04-15 АО "Институт химических наук им. А.Б. Бектурова" Применение производного бета-морфолинопропиоамидоксима в качестве противодиабетического средства
CN110092774B (zh) * 2018-01-29 2022-04-08 中国科学院上海药物研究所 芳香丙酸类衍生物、及其制备方法和用途

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Also Published As

Publication number Publication date
HUP0600105A3 (en) 2006-11-28
KR100610578B1 (ko) 2006-08-09
ZA200108733B (en) 2003-01-23
SK15092001A3 (sk) 2002-05-09
NZ515284A (en) 2004-12-24
JP2002543194A (ja) 2002-12-17
CZ20013832A3 (cs) 2002-04-17
PL351987A1 (en) 2003-07-14
CA2371757A1 (en) 2000-11-09
AU781079B2 (en) 2005-05-05
NO320805B1 (no) 2006-01-30
UA73501C2 (en) 2005-08-15
HUP0600105A2 (en) 2006-05-29
IL146104A0 (en) 2002-07-25
EE200100540A (et) 2002-12-16
NO20015259L (no) 2001-11-15
AU3983100A (en) 2000-11-17
CN1353699A (zh) 2002-06-12
WO2000066572A1 (en) 2000-11-09
YU75101A (sh) 2005-07-19
KR20010113891A (ko) 2001-12-28
MXPA01010916A (es) 2002-06-21
HRP20010785A2 (en) 2003-02-28
EP1175412A1 (en) 2002-01-30
RU2278114C2 (ru) 2006-06-20
BG106146A (bg) 2002-05-31
US7348426B1 (en) 2008-03-25
BR0010139A (pt) 2004-03-02
NO20015259D0 (no) 2001-10-26

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