ZA200108733B - Substituted bicyclic herocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents. - Google Patents
Substituted bicyclic herocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents. Download PDFInfo
- Publication number
- ZA200108733B ZA200108733B ZA200108733A ZA200108733A ZA200108733B ZA 200108733 B ZA200108733 B ZA 200108733B ZA 200108733 A ZA200108733 A ZA 200108733A ZA 200108733 A ZA200108733 A ZA 200108733A ZA 200108733 B ZA200108733 B ZA 200108733B
- Authority
- ZA
- South Africa
- Prior art keywords
- dihydro
- phenyl
- ethoxy
- substituted
- benzoxazin
- Prior art date
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- 230000003579 anti-obesity Effects 0.000 title 1
- 239000000883 anti-obesity agent Substances 0.000 title 1
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- ATTHDPUAOALIJO-PLRJNAJWSA-N ethyl (Z)-3-[6-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]naphthalen-1-yl]-2-ethoxyprop-2-enoate Chemical compound C1CSC2=CC=CC=C2N1CCOC1=CC=C2C(/C=C(\OCC)C(=O)OCC)=CC=CC2=C1 ATTHDPUAOALIJO-PLRJNAJWSA-N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims 4
- VUMWEERYGJRFPZ-UHFFFAOYSA-N 3-[2-(2,3-dihydro-1,4-benzothiazin-4-ylmethyl)-1-benzofuran-5-yl]-2-ethoxypropanoic acid Chemical compound C1CSC2=CC=CC=C2N1CC1=CC2=CC(CC(OCC)C(O)=O)=CC=C2O1 VUMWEERYGJRFPZ-UHFFFAOYSA-N 0.000 claims 3
- XTADJISLWFZGIO-UHFFFAOYSA-N 3-[4-[(4-benzyl-2,3-dihydro-1,4-benzoxazin-2-yl)methoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(CC(OCC)C(O)=O)=CC=C1OCC1OC2=CC=CC=C2N(CC=2C=CC=CC=2)C1 XTADJISLWFZGIO-UHFFFAOYSA-N 0.000 claims 3
- ODYZDBJNDOGJKT-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-methyl-2-phenoxypropanoic acid Chemical compound C=1C=C(OCCN2C3=CC=CC=C3SCC2)C=CC=1CC(C)(C(O)=O)OC1=CC=CC=C1 ODYZDBJNDOGJKT-UHFFFAOYSA-N 0.000 claims 3
- NPIGSANZDQELNH-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxy-2-methylpropanoic acid Chemical compound C1=CC(CC(C)(OCC)C(O)=O)=CC=C1OCCN1C2=CC=CC=C2OCC1 NPIGSANZDQELNH-UHFFFAOYSA-N 0.000 claims 3
- BDCDPHXWHMTYJB-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanamide Chemical compound C1=CC(CC(OCC)C(N)=O)=CC=C1OCCN1C2=CC=CC=C2OCC1 BDCDPHXWHMTYJB-UHFFFAOYSA-N 0.000 claims 3
- KCOTUBYAAREJGC-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-methyl-2-phenoxypropanoic acid Chemical compound C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1CC(C)(C(O)=O)OC1=CC=CC=C1 KCOTUBYAAREJGC-UHFFFAOYSA-N 0.000 claims 3
- BAOZZIMJVLTJIQ-UHFFFAOYSA-N 3-[6-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]naphthalen-1-yl]-2-ethoxypropanoic acid Chemical compound C1CSC2=CC=CC=C2N1CCOC1=CC=C2C(CC(OCC)C(O)=O)=CC=CC2=C1 BAOZZIMJVLTJIQ-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- RJRKOQPJMZOZAQ-UHFFFAOYSA-N 2-butoxy-3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]propanoic acid Chemical compound C1=CC(CC(OCCCC)C(O)=O)=CC=C1OCCN1C2=CC=CC=C2OCC1 RJRKOQPJMZOZAQ-UHFFFAOYSA-N 0.000 claims 2
- DQDCKBWSBKGOQH-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-ethoxypropanamide Chemical compound C1=CC(CC(OCC)C(N)=O)=CC=C1OCCN1C2=CC=CC=C2SCC1 DQDCKBWSBKGOQH-UHFFFAOYSA-N 0.000 claims 2
- XSSLBZJZTWIQPZ-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-hydroxypropanoic acid Chemical compound C1=CC(CC(O)C(O)=O)=CC=C1OCCN1C2=CC=CC=C2SCC1 XSSLBZJZTWIQPZ-UHFFFAOYSA-N 0.000 claims 2
- BSDNCIHDROVWCO-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxy-n-methylpropanamide Chemical compound C1=CC(CC(OCC)C(=O)NC)=CC=C1OCCN1C2=CC=CC=C2OCC1 BSDNCIHDROVWCO-UHFFFAOYSA-N 0.000 claims 2
- GGAOXTIHFIYDPC-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(CC(OCC)C(O)=O)=CC=C1OCCN1C2=CC=CC=C2OCC1 GGAOXTIHFIYDPC-UHFFFAOYSA-N 0.000 claims 2
- BFLZHLOGOOYEAN-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-hexoxypropanoic acid Chemical compound C1=CC(CC(OCCCCCC)C(O)=O)=CC=C1OCCN1C2=CC=CC=C2OCC1 BFLZHLOGOOYEAN-UHFFFAOYSA-N 0.000 claims 2
- UVYZEYXMOFYLQT-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-hydroxypropanoic acid Chemical class C1=CC(CC(O)C(O)=O)=CC=C1OCCN1C2=CC=CC=C2OCC1 UVYZEYXMOFYLQT-UHFFFAOYSA-N 0.000 claims 2
- LVGVAOOYUUFWNS-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-phenylmethoxypropanoic acid Chemical class C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1CC(C(=O)O)OCC1=CC=CC=C1 LVGVAOOYUUFWNS-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- IKCYLYMMVOWCGZ-UHFFFAOYSA-N ethyl 3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-hydroxypropanoate Chemical compound C1=CC(CC(O)C(=O)OCC)=CC=C1OCCN1C2=CC=CC=C2SCC1 IKCYLYMMVOWCGZ-UHFFFAOYSA-N 0.000 claims 2
- ZOVHBEKKCBZCRQ-UHFFFAOYSA-N methyl 2-ethoxy-3-[4-[(4-methyl-2,3-dihydro-1,4-benzoxazin-2-yl)methoxy]phenyl]propanoate Chemical compound C1=CC(CC(OCC)C(=O)OC)=CC=C1OCC1OC2=CC=CC=C2N(C)C1 ZOVHBEKKCBZCRQ-UHFFFAOYSA-N 0.000 claims 2
- UNILYMLSNCMOMF-UHFFFAOYSA-N methyl 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-phenoxypropanoate Chemical compound C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1CC(C(=O)OC)OC1=CC=CC=C1 UNILYMLSNCMOMF-UHFFFAOYSA-N 0.000 claims 2
- PBZSAMQPGQTMLD-UHFFFAOYSA-N methyl 3-[6-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]naphthalen-1-yl]-2-ethoxypropanoate Chemical compound C1CSC2=CC=CC=C2N1CCOC1=CC=C2C(CC(OCC)C(=O)OC)=CC=CC2=C1 PBZSAMQPGQTMLD-UHFFFAOYSA-N 0.000 claims 2
- ACTNHJDHMQSOGL-UHFFFAOYSA-N n',n'-dibenzylethane-1,2-diamine Chemical compound C=1C=CC=CC=1CN(CCN)CC1=CC=CC=C1 ACTNHJDHMQSOGL-UHFFFAOYSA-N 0.000 claims 2
- QPMYZKIUFGMGKK-UHFFFAOYSA-N (4-nitrophenyl) 3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-ethoxypropanoate Chemical compound C=1C=C(OCCN2C3=CC=CC=C3SCC2)C=CC=1CC(OCC)C(=O)OC1=CC=C([N+]([O-])=O)C=C1 QPMYZKIUFGMGKK-UHFFFAOYSA-N 0.000 claims 1
- GRWKNBPOGBTZMN-UHFFFAOYSA-N 2-benzyl-3-phenylpropane-1,2-diamine Chemical compound C=1C=CC=CC=1CC(N)(CN)CC1=CC=CC=C1 GRWKNBPOGBTZMN-UHFFFAOYSA-N 0.000 claims 1
- ROHGIKOWUPXUPJ-UHFFFAOYSA-N 3-[4-[(4-benzyl-2,3-dihydro-1,4-benzoxazin-2-yl)methoxy]phenyl]-2-ethoxy-2-(4-nitrophenyl)propanoic acid Chemical compound C=1C=C([N+]([O-])=O)C=CC=1C(OCC)(C(O)=O)CC(C=C1)=CC=C1OCC(OC1=CC=CC=C11)CN1CC1=CC=CC=C1 ROHGIKOWUPXUPJ-UHFFFAOYSA-N 0.000 claims 1
- BTNSRAJLQDPUHB-UHFFFAOYSA-N 3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-ethoxy-n-methylpropanamide Chemical compound C1=CC(CC(OCC)C(=O)NC)=CC=C1OCCN1C2=CC=CC=C2SCC1 BTNSRAJLQDPUHB-UHFFFAOYSA-N 0.000 claims 1
- 108010052300 RA X peptide Proteins 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical class [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 150000008064 anhydrides Chemical group 0.000 claims 1
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 claims 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 125000004598 dihydrobenzofuryl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004586 dihydrobenzopyranyl group Chemical group O1C(CCC2=C1C=CC=C2)* 0.000 claims 1
- 238000005906 dihydroxylation reaction Methods 0.000 claims 1
- PONXTPCRRASWKW-KBPBESRZSA-N diphenylethylenediamine Chemical compound C1([C@H](N)[C@@H](N)C=2C=CC=CC=2)=CC=CC=C1 PONXTPCRRASWKW-KBPBESRZSA-N 0.000 claims 1
- CINHGPHCEQNNKA-HEHNFIMWSA-N ethyl (E)-3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-ethoxyprop-2-enoate Chemical compound C1=CC(\C=C(\OCC)C(=O)OCC)=CC=C1OCCN1C2=CC=CC=C2SCC1 CINHGPHCEQNNKA-HEHNFIMWSA-N 0.000 claims 1
- FDBUMAZMKYPOHP-LHLOQNFPSA-N ethyl (E)-3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-phenoxyprop-2-enoate Chemical compound C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1\C=C(C(=O)OCC)\OC1=CC=CC=C1 FDBUMAZMKYPOHP-LHLOQNFPSA-N 0.000 claims 1
- ATTHDPUAOALIJO-NCELDCMTSA-N ethyl (E)-3-[6-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]naphthalen-1-yl]-2-ethoxyprop-2-enoate Chemical compound C1CSC2=CC=CC=C2N1CCOC1=CC=C2C(\C=C(\OCC)C(=O)OCC)=CC=CC2=C1 ATTHDPUAOALIJO-NCELDCMTSA-N 0.000 claims 1
- CBJLDOAEMVGSDO-OEAKJJBVSA-N ethyl (e)-3-[2-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-1-benzofuran-5-yl]-2-ethoxyprop-2-enoate Chemical compound C1COC2=CC=CC=C2N1CC1=CC2=CC(\C=C(\OCC)C(=O)OCC)=CC=C2O1 CBJLDOAEMVGSDO-OEAKJJBVSA-N 0.000 claims 1
- FOGZPJPPKVOAEG-QQTULTPQSA-N ethyl (z)-3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-phenoxyprop-2-enoate Chemical compound C=1C=C(OCCN2C3=CC=CC=C3SCC2)C=CC=1/C=C(C(=O)OCC)\OC1=CC=CC=C1 FOGZPJPPKVOAEG-QQTULTPQSA-N 0.000 claims 1
- OPYWHBQNRJKQBY-XLNRJJMWSA-N ethyl (z)-3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxyprop-2-enoate Chemical compound C1=CC(/C=C(\OCC)C(=O)OCC)=CC=C1OCCN1C2=CC=CC=C2OCC1 OPYWHBQNRJKQBY-XLNRJJMWSA-N 0.000 claims 1
- FDBUMAZMKYPOHP-QOMWVZHYSA-N ethyl (z)-3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-phenoxyprop-2-enoate Chemical compound C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1/C=C(C(=O)OCC)\OC1=CC=CC=C1 FDBUMAZMKYPOHP-QOMWVZHYSA-N 0.000 claims 1
- CKYQFZCHIWADPF-UHFFFAOYSA-N ethyl 2-butoxy-3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]propanoate Chemical compound C1=CC(CC(OCCCC)C(=O)OCC)=CC=C1OCCN1C2=CC=CC=C2OCC1 CKYQFZCHIWADPF-UHFFFAOYSA-N 0.000 claims 1
- PQXCSWWRPIMVIP-UHFFFAOYSA-N ethyl 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-hexoxypropanoate Chemical compound C1=CC(CC(OCCCCCC)C(=O)OCC)=CC=C1OCCN1C2=CC=CC=C2OCC1 PQXCSWWRPIMVIP-UHFFFAOYSA-N 0.000 claims 1
- PEBWFGOQVARCHJ-UHFFFAOYSA-N ethyl 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-hydroxypropanoate Chemical compound C1=CC(CC(O)C(=O)OCC)=CC=C1OCCN1C2=CC=CC=C2OCC1 PEBWFGOQVARCHJ-UHFFFAOYSA-N 0.000 claims 1
- FJVZJKKVARYFMD-UHFFFAOYSA-N ethyl 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-phenylmethoxypropanoate Chemical compound C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1CC(C(=O)OCC)OCC1=CC=CC=C1 FJVZJKKVARYFMD-UHFFFAOYSA-N 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- MNQXEPWTCARIMG-UHFFFAOYSA-N methyl 2-[[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]methyl]-2-ethoxy-3-(2-fluorophenyl)propanoate Chemical compound C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1CC(OCC)(C(=O)OC)CC1=CC=CC=C1F MNQXEPWTCARIMG-UHFFFAOYSA-N 0.000 claims 1
- XFECTTWJODDBNV-UHFFFAOYSA-N methyl 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanoate Chemical compound C1=CC(CC(OCC)C(=O)OC)=CC=C1OCCN1C2=CC=CC=C2OCC1 XFECTTWJODDBNV-UHFFFAOYSA-N 0.000 claims 1
- GGPUBHNWQRASQZ-UHFFFAOYSA-N n-benzyl-3-[4-[2-(2,3-dihydro-1,4-benzothiazin-4-yl)ethoxy]phenyl]-2-ethoxypropanamide Chemical compound C=1C=C(OCCN2C3=CC=CC=C3SCC2)C=CC=1CC(OCC)C(=O)NCC1=CC=CC=C1 GGPUBHNWQRASQZ-UHFFFAOYSA-N 0.000 claims 1
- ITTKNPXOMGJVDP-UHFFFAOYSA-N n-benzyl-3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanamide Chemical compound C=1C=C(OCCN2C3=CC=CC=C3OCC2)C=CC=1CC(OCC)C(=O)NCC1=CC=CC=C1 ITTKNPXOMGJVDP-UHFFFAOYSA-N 0.000 claims 1
- 125000004957 naphthylene group Chemical group 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN484MA1999 | 1999-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200108733B true ZA200108733B (en) | 2003-01-23 |
Family
ID=11095336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200108733A ZA200108733B (en) | 1999-04-28 | 2001-10-23 | Substituted bicyclic herocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7348426B1 (no) |
| EP (1) | EP1175412A1 (no) |
| JP (1) | JP2002543194A (no) |
| KR (1) | KR100610578B1 (no) |
| CN (1) | CN1353699A (no) |
| AU (1) | AU781079B2 (no) |
| BG (1) | BG106146A (no) |
| BR (1) | BR0010139A (no) |
| CA (1) | CA2371757A1 (no) |
| CZ (1) | CZ20013832A3 (no) |
| EE (1) | EE200100540A (no) |
| HR (1) | HRP20010785A2 (no) |
| HU (1) | HUP0600105A3 (no) |
| IL (1) | IL146104A0 (no) |
| MX (1) | MXPA01010916A (no) |
| NO (1) | NO320805B1 (no) |
| NZ (1) | NZ515284A (no) |
| PL (1) | PL351987A1 (no) |
| RU (1) | RU2278114C2 (no) |
| SK (1) | SK15092001A3 (no) |
| TR (1) | TR200103848T2 (no) |
| UA (1) | UA73501C2 (no) |
| WO (1) | WO2000066572A1 (no) |
| YU (1) | YU75101A (no) |
| ZA (1) | ZA200108733B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002030914A1 (en) * | 2000-10-12 | 2002-04-18 | Dr. Reddy's Research Foundation | Salts of benzothiazine and benzoxazine derivatives and pharmaceutical compositions containing them |
| CA2458621A1 (en) * | 2001-08-29 | 2003-03-06 | Warner-Lambert Company Llc | Oral antidiabetic agents |
| WO2003024944A1 (en) * | 2001-09-20 | 2003-03-27 | Dr. Reddy's Laboratories Ltd. | An improved process for the preparation of bicyclic antidiabetic compounds |
| WO2003027084A1 (en) * | 2001-09-25 | 2003-04-03 | Dr. Reddy's Laboratories Ltd. | Improved process for the preparation of optically active phenoxazine derivatives as antidiabetic agents |
| WO2003033456A1 (en) * | 2001-10-16 | 2003-04-24 | Dr. Reddy's Laboratories Ltd. | NOVEL β-PHENYL-α-OXYSUBSTITUTED PROPIONIC DERIVATIVES: PROCESS FOR ITS PREPARATION AND THEIR USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COMPOUNDS |
| AU2003244514A1 (en) * | 2002-02-07 | 2003-09-02 | Dr. Reddy's Laboratories Limited | Novel polymorphic forms of bicyclic antidiabetic agents: process for their preparation and pharmaceutical compositions containing them |
| US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
| AU2003232472B2 (en) | 2002-04-30 | 2008-09-18 | Ucb Pharma | 2,6-quinolinyl and 2,6-naphthyl derivatives, processes for preparing them and their uses as VLA-4 inhibitors |
| WO2003099800A1 (en) * | 2002-05-23 | 2003-12-04 | Dr. Reddy's Laboratories Limited | An improved process for the preparation of bicyclic antidiabetic agents |
| ATE377419T1 (de) | 2002-11-08 | 2007-11-15 | Hoffmann La Roche | Substituierte 4-alkoxyoxazol derivate als ppar agonisten |
| US7262303B2 (en) * | 2003-09-29 | 2007-08-28 | Hoffman-La Roche Inc. | Process for the production of chiral propionic acid derivatives |
| DE202004002953U1 (de) * | 2004-02-26 | 2004-04-29 | Winkler, Wilhelm | Verbindungseinheit |
| US7579360B2 (en) | 2005-06-09 | 2009-08-25 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| AU2006254772B2 (en) | 2005-06-09 | 2011-06-02 | Ucb Pharma S.A. | 2,6 quinolinyl derivatives, processes for preparing them and their use as medicament |
| US7572807B2 (en) | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
| US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| RU2684779C2 (ru) * | 2016-02-05 | 2019-04-15 | АО "Институт химических наук им. А.Б. Бектурова" | Применение производного бета-морфолинопропиоамидоксима в качестве противодиабетического средства |
| CN110092774B (zh) * | 2018-01-29 | 2022-04-08 | 中国科学院上海药物研究所 | 芳香丙酸类衍生物、及其制备方法和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173350B1 (da) * | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
| GB9027023D0 (en) * | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
| GB9225386D0 (en) | 1992-12-04 | 1993-01-27 | Smithkline Beecham Plc | Novel compounds |
| BR9508468A (pt) | 1994-07-29 | 1997-11-25 | Smithkline Beecham Plc | Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário |
| JPH0912575A (ja) * | 1995-06-28 | 1997-01-14 | Sankyo Co Ltd | ベンゾオキサジンおよびベンゾチアジン誘導体 |
| GB9600464D0 (en) | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| WO1997028149A1 (en) * | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| GB9606805D0 (en) * | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| WO1998002159A1 (en) | 1996-07-12 | 1998-01-22 | Smithkline Beecham Plc | Novel treatment of leptine resistance |
| AU752059B2 (en) * | 1997-10-27 | 2002-09-05 | Dr. Reddy's Laboratories Limited | Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| US6265401B1 (en) * | 1997-10-27 | 2001-07-24 | Reddy-Cheminor, Inc. | Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
| EP1082313A1 (en) * | 1998-05-27 | 2001-03-14 | Dr. Reddy's Research Foundation | Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
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2000
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- 2000-04-25 AU AU39831/00A patent/AU781079B2/en not_active Ceased
- 2000-04-25 EE EEP200100540A patent/EE200100540A/xx unknown
- 2000-04-25 NZ NZ515284A patent/NZ515284A/xx unknown
- 2000-04-25 JP JP2000615602A patent/JP2002543194A/ja not_active Withdrawn
- 2000-04-25 PL PL00351987A patent/PL351987A1/xx not_active Application Discontinuation
- 2000-04-25 SK SK1509-2001A patent/SK15092001A3/sk unknown
- 2000-04-25 HU HU0600105A patent/HUP0600105A3/hu unknown
- 2000-04-25 CA CA002371757A patent/CA2371757A1/en not_active Abandoned
- 2000-04-25 EP EP00919081A patent/EP1175412A1/en not_active Withdrawn
- 2000-04-25 CZ CZ20013832A patent/CZ20013832A3/cs unknown
- 2000-04-25 IL IL14610400A patent/IL146104A0/xx unknown
- 2000-04-25 MX MXPA01010916A patent/MXPA01010916A/es active IP Right Grant
- 2000-04-25 KR KR1020017013604A patent/KR100610578B1/ko not_active IP Right Cessation
- 2000-04-25 YU YU75101A patent/YU75101A/sh unknown
- 2000-04-25 TR TR2001/03848T patent/TR200103848T2/xx unknown
- 2000-04-25 UA UA2001118039A patent/UA73501C2/uk unknown
- 2000-04-25 CN CN00808424A patent/CN1353699A/zh active Pending
- 2000-04-25 RU RU2001132085/04A patent/RU2278114C2/ru not_active IP Right Cessation
- 2000-04-25 BR BR0010139-7A patent/BR0010139A/pt not_active IP Right Cessation
- 2000-04-25 US US09/959,093 patent/US7348426B1/en not_active Expired - Fee Related
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2001
- 2001-10-23 ZA ZA200108733A patent/ZA200108733B/en unknown
- 2001-10-24 HR HR20010785A patent/HRP20010785A2/hr not_active Application Discontinuation
- 2001-10-26 NO NO20015259A patent/NO320805B1/no unknown
- 2001-11-26 BG BG106146A patent/BG106146A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU75101A (sh) | 2005-07-19 |
| UA73501C2 (en) | 2005-08-15 |
| BG106146A (bg) | 2002-05-31 |
| US7348426B1 (en) | 2008-03-25 |
| AU781079B2 (en) | 2005-05-05 |
| NO320805B1 (no) | 2006-01-30 |
| JP2002543194A (ja) | 2002-12-17 |
| NO20015259L (no) | 2001-11-15 |
| NZ515284A (en) | 2004-12-24 |
| NO20015259D0 (no) | 2001-10-26 |
| CN1353699A (zh) | 2002-06-12 |
| SK15092001A3 (sk) | 2002-05-09 |
| IL146104A0 (en) | 2002-07-25 |
| KR20010113891A (ko) | 2001-12-28 |
| HRP20010785A2 (en) | 2003-02-28 |
| KR100610578B1 (ko) | 2006-08-09 |
| CA2371757A1 (en) | 2000-11-09 |
| CZ20013832A3 (cs) | 2002-04-17 |
| RU2278114C2 (ru) | 2006-06-20 |
| HUP0600105A2 (en) | 2006-05-29 |
| EP1175412A1 (en) | 2002-01-30 |
| TR200103848T2 (tr) | 2002-04-22 |
| AU3983100A (en) | 2000-11-17 |
| BR0010139A (pt) | 2004-03-02 |
| MXPA01010916A (es) | 2002-06-21 |
| WO2000066572A1 (en) | 2000-11-09 |
| HUP0600105A3 (en) | 2006-11-28 |
| EE200100540A (et) | 2002-12-16 |
| PL351987A1 (en) | 2003-07-14 |
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